Nup98

Summary

Gene Symbol: Nup98
Description: nucleoporin 98
Alias: 4732457F17, AI849286, Nup96, nuclear pore complex protein Nup98-Nup96
Species: mouse
Products:     Nup98

Top Publications

  1. Moore M, Chung K, Plasilova M, Schuringa J, Shieh J, Zhou P, et al. NUP98 dysregulation in myeloid leukemogenesis. Ann N Y Acad Sci. 2007;1106:114-42 pubmed
    Nucleoporin 98 (NUP98) is a component of the nuclear pore complex that facilitates mRNA export from the nucleus. It is mapped to 11p15...
  2. Wu X, Kasper L, Mantcheva R, Mantchev G, Springett M, van Deursen J. Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Proc Natl Acad Sci U S A. 2001;98:3191-6 pubmed
    The NUP98 gene encodes precursor proteins that generate two nucleoplasmically oriented nucleoporins, NUP98 and NUP96...
  3. Shaughnessy J, Jenkins N, Copeland N. cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. Genomics. 1997;39:192-7 pubmed
    ..Southern blot analysis of DNA from interspecific backcross mice shows that Eif4g2 is localized to distal mouse chromosome 7 in a region syntenic with human chromosome 11p15. ..
  4. Puthiyaveetil A, Reilly C, Pardee T, Caudell D. Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome. Leuk Res. 2013;37:112-6 pubmed publisher
    ..To delineate the role of leukemic translocation NUP98-HOXD13 (NHD13) in secondary mutagenesis, DNA break and repair mechanisms in stimulated mouse B lymphocytes ..
  5. Slape C, Hartung H, Lin Y, Bies J, Wolff L, Aplan P. Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res. 2007;67:5148-55 pubmed
    The t(2;11)(q31;p15) chromosomal translocation results in a fusion between the NUP98 and HOXD13 genes and has been observed in patients with myelodysplastic syndrome (MDS) or acute myelogenous leukemia...
  6. Irwin S, Vandelft M, Pinchev D, Howell J, Graczyk J, Orr H, et al. RNA association and nucleocytoplasmic shuttling by ataxin-1. J Cell Sci. 2005;118:233-42 pubmed
    ..These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease. ..
  7. Dash A, Williams I, Kutok J, Tomasson M, Anastasiadou E, Lindahl K, et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A. 2002;99:7622-7 pubmed
    ..with acquisition of secondary chromosomal translocations, including the t(7;11)(p15;p15) resulting in the NUP98/HOXA9 fusion protein...
  8. Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L. Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Mol Biol Cell. 2016;27:35-47 pubmed publisher
    ..Taken together, these data highlight a previously unrecognized role of lamin B1 in dendrite development of mouse cortical neurons through regulation of nuclear shuttling of specific signaling molecules and NPC distribution. ..
  9. Stuwe T, von Borzyskowski L, Davenport A, Hoelz A. Molecular basis for the anchoring of proto-oncoprotein Nup98 to the cytoplasmic face of the nuclear pore complex. J Mol Biol. 2012;419:330-46 pubmed publisher
    ..Strikingly, the same Nup98 groove promiscuously interacts with Nup82 and Nup96 in a mutually excusive fashion...

More Information

Publications30

  1. Voronina E, Seydoux G. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules. Development. 2010;137:1441-50 pubmed publisher
    ..The C. elegans homolog of vertebrate Nup98 (CeNup98) is enriched in P granules and associates with the translationally repressed, P granule-enriched mRNA nos-..
  2. Humeniuk R, Koller R, Bies J, Aplan P, Wolff L. Brief report: Loss of p15Ink4b accelerates development of myeloid neoplasms in Nup98-HoxD13 transgenic mice. Stem Cells. 2014;32:1361-6 pubmed publisher
    ..This study examines the collaboration of the loss of p15Ink4b with Nup98-HoxD13 translocation in the development of hematological malignancies in a mouse model...
  3. Zhu Y, Lambert K, Corless C, Copeland N, Gilbert D, Jenkins N, et al. DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. J Biol Chem. 1997;272:51-7 pubmed
    ..Each induced DUB enzyme thereby regulates the degradation or the ubiquitination state of an unknown growth regulatory factor, resulting in a cytokine-specific growth response. ..
  4. Jeganathan K, Malureanu L, van Deursen J. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature. 2005;438:1036-9 pubmed
    ..in mitosis timely destruction of securin by APC is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98. We show that combined Rae1 and Nup98 haploinsufficiency in mice results in premature separation of sister ..
  5. Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T, Yoneda Y. The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. Mol Biol Cell. 2010;21:1885-96 pubmed publisher
    b>Nup98 is a mobile nucleoporin that forms distinct dots in the nucleus, and, although a role for Nup98 in nuclear transport has been suggested, its precise function remains unclear...
  6. Yung E, Sekulovic S, Argiropoulos B, Lai C, Leung M, Berg T, et al. Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions. Leuk Res. 2011;35:545-50 pubmed publisher
    To determine the contribution of the common N-terminal truncation of NUP98 in NUP98-translocations resulting in acute myeloid leukemia, we have conducted a structure-function analysis of NUP98 in the context of NUP98-HOXA10HD, a novel, ..
  7. Greenblatt S, Li L, Slape C, Nguyen B, Novak R, Duffield A, et al. Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model. Blood. 2012;119:2883-94 pubmed publisher
    ..combined the FLT3/ITD mutation with a model of myelodysplastic syndrome involving transgenic expression of the Nup98-HoxD13 (NHD13) fusion gene...
  8. Saw J, Curtis D, Hussey D, Dobrovic A, Aplan P, Slape C. The fusion partner specifies the oncogenic potential of NUP98 fusion proteins. Leuk Res. 2013;37:1668-73 pubmed publisher
    b>NUP98 is among the most promiscuously translocated genes in hematological diseases. Among the 28 known fusion partners, there are two categories: homeobox genes and non-homeobox genes...
  9. von Kobbe C -, van Deursen JM -, Rodrigues J, Sitterlin D, Bachi A, Wu X, et al. Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. Mol Cell. 2000;6:1243-52 pubmed
    ..Additionally, the nucleoporin Nup98 specifically interacts with M but not with M(D)...
  10. Puthiyaveetil A, Heid B, Reilly C, HogenEsch H, Caudell D. A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production. Exp Hematol. 2012;40:622-33 pubmed publisher
    ..Recent studies show that NUP98-HOXD13 (NHD13) fusion gene results in myelodysplastic syndrome and impairs lymphocyte differentiation in ..
  11. Chakraborty P, Wang Y, Wei J, van Deursen J, Yu H, Malureanu L, et al. Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell. 2008;15:657-67 pubmed publisher
    ..At mitosis, however, a member of the complex, Nup96, is preferentially downregulated. This occurs via the ubiquitin-proteasome pathway...
  12. Faria P, Chakraborty P, Levay A, Barber G, Ezelle H, Enninga J, et al. VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Mol Cell. 2005;17:93-102 pubmed
    ..Thus, these results demonstrate that VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. ..
  13. Cheng X, Byrne M, Brown K, Konopleva M, Kornblau S, Bennett R, et al. PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice. Blood. 2015;126:1585-94 pubmed publisher
    ..Furthermore, the age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene, ..
  14. Saito S, Yokokawa T, Iizuka G, Çiğdem S, Okuwaki M, Nagata K. Function of Nup98 subtypes and their fusion proteins, Nup98-TopII? and Nup98-SETBP1 in nuclear-cytoplasmic transport. Biochem Biophys Res Commun. 2017;487:96-102 pubmed publisher
    b>Nup98 is a component of the nuclear pore complex. The nup98-fusion genes derived by chromosome translocations are involved in hematopoietic malignancies...
  15. Choi C, Chung Y, Slape C, Aplan P. A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement. J Immunol. 2009;183:6227-35 pubmed publisher
    Expression of a NUP98-HOXD13 (NHD13) fusion gene leads to myelodysplastic syndrome in mice...
  16. Echeverria P, Mazaira G, Erlejman A, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009;29:4788-97 pubmed publisher
    ..Importantly, GR cross-linked to the hsp90 heterocomplex was able to translocate to the nucleus in digitonin-permeabilized cells treated with steroid, suggesting that GR could pass through the pore in its untransformed state. ..
  17. Xu H, Valerio D, Eisold M, Sinha A, Koche R, Hu W, et al. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016;30:863-878 pubmed publisher
    The nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies...
  18. Shaughnessy J, Largaespada D, Tian E, Fletcher C, Cho B, Vyas P, et al. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. Oncogene. 1999;18:2069-84 pubmed
    ..Experiments are in progress to test whether Mrvi1 is a tumor suppressor gene. ..
  19. Buchwalter A, Liang Y, Hetzer M. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell. 2014;25:2472-84 pubmed publisher
    ..However, Nup50 dynamics are independent of importin ?, Nup153, and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility...
  20. Faria A, Levay A, Wang Y, Kamphorst A, Rosa M, Nussenzveig D, et al. The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity. 2006;24:295-304 pubmed
    b>Nup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN...
  21. Pineault N, Buske C, Feuring Buske M, Abramovich C, Rosten P, Hogge D, et al. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. Blood. 2003;101:4529-38 pubmed
    ..member of the HOXD cluster not normally expressed in hematopoietic cells, was recently identified as a partner of NUP98 in a t(2;11) translocation associated with t-AML/MDS...