Gene Symbol: Nup50
Description: nucleoporin 50
Alias: 1700030K07Rik, AI413123, Npap60, nuclear pore complex protein Nup50, 50 kDa nucleoporin, nuclear pore associated protein 60 kDa, nucleoporin Nup50, nucleoprotein 50
Species: mouse
Products:     Nup50

Top Publications

  1. Tate P, Lee M, Tweedie S, Skarnes W, Bickmore W. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. J Cell Sci. 1998;111 ( Pt 17):2575-85 pubmed
    ..Motifs in two of the isolated genes suggest new links between cellular regulatory mechanisms (ubiquitination and phosphorylation) and mRNA splicing and chromosome structure/function. ..
  2. Smitherman M, Lee K, Swanger J, Kapur R, Clurman B. Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Mol Cell Biol. 2000;20:5631-42 pubmed
    ..We have identified a component of the nuclear pore complex (NPC), termed Nup50, through its two-hybrid interactions with p27(Kip1)...
  3. Onodera K, Shavit J, Motohashi H, Katsuoka F, Akasaka J, Engel J, et al. Characterization of the murine mafF gene. J Biol Chem. 1999;274:21162-9 pubmed
  4. Doufexis M, Storr H, King P, Clark A. Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. FASEB J. 2007;21:4095-100 pubmed
    ..This identified the nucleoporin Nup 50 (Npap60) as the major full-length interacting protein...
  5. Fan F, Liu C, Korobova O, Heyting C, Offenberg H, Trump G, et al. cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Genomics. 1997;40:444-53 pubmed
    We have cloned and characterized a cDNA, Npap60, encoding a rat nuclear pore-associated protein. The 3-kb cDNA was obtained by antibody screening of a rat testis expression library...
  6. Yang W, Mansour S. Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain. Dev Dyn. 1999;215:108-16 pubmed
    ..This could be due to functional redundancy as Northern blot hybridization analysis clearly demonstrated that prtb(gt) is likely to be a null allele. ..
  7. Muller D, Thieke K, Burgin A, Dickmanns A, Eilers M. Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. EMBO J. 2000;19:2168-80 pubmed
    ..Our results identify a novel component involved in p27(Kip1) degradation and suggest that degradation of p27(Kip1) is tightly linked to its intracellular transport. ..
  8. Plafker S, Macara I. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Mol Cell Biol. 2002;22:1266-75 pubmed
    ..Taken together, these results indicate that rpL12 uses a distinct nuclear import pathway that may contribute to a mechanism for regulating ribosome synthesis and/or maturation. ..
  9. Matsuura Y, Stewart M. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. EMBO J. 2005;24:3681-9 pubmed
    ..In vertebrates, import is stimulated by nucleoporin Nup50, which has been proposed to accompany the import complex through nuclear pores...

More Information


  1. Buchwalter A, Liang Y, Hetzer M. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell. 2014;25:2472-84 pubmed publisher
    ..Here we show that Nup50 is a mobile Nup with a pronounced presence both at the NPC and in the nucleoplasm that can move between these ..
  2. Park E, Lee B, Clurman B, Lee K. NUP50 is necessary for the survival of primordial germ cells in mouse embryos. Reproduction. 2016;151:51-8 pubmed publisher
    Nucleoporin 50 kDa (NUP50), a component of the nuclear pore complex, is highly expressed in male germ cells, but its role in germ cells is largely unknown...