nuclear mitotic apparatus protein 1


Gene Symbol: nuclear mitotic apparatus protein 1
Description: nuclear mitotic apparatus protein 1
Alias: 6720401E04Rik, AA764025, AL022610, AU014979, NuMA, nuclear mitotic apparatus protein 1
Species: mouse

Top Publications

  1. Poulson N, Lechler T. Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol. 2010;191:915-22 pubmed publisher
    ..there is robust control of division orientation as excessive ACDs are prevented by a change in the localization of NuMA, an effector of spindle orientation...
  2. Hilditch Maguire P, Trettel F, Passani L, Auerbach A, Persichetti F, MacDonald M. Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum Mol Genet. 2000;9:2789-97 pubmed
    ..Thus, organelles that require huntingtin to function suggest roles for the protein in RNA biogenesis, trafficking and iron homeostasis to be explored in HD pathogenesis. ..
  3. Cavalheiro G, Matos Rodrigues G, Zhao Y, Gomes A, Anand D, Predes D, et al. N-myc regulates growth and fiber cell differentiation in lens development. Dev Biol. 2017;429:105-117 pubmed publisher
  4. Sukhai M, Thomas M, Xuan Y, Chan L, Hamadanizadeh S, Zhang T, et al. Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia. Oncogene. 2008;27:4666-77 pubmed publisher
    ..To elucidate the role of RXRalpha in APL, we conditionally knocked out RXRalpha in the hCG-NuMA-RARalpha APL mouse model...
  5. Silk A, Holland A, Cleveland D. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol. 2009;184:677-90 pubmed publisher
    ..By construction and analysis of a conditional loss of mitotic function allele of the nuclear mitotic apparatus (NuMA) protein in mice and cultured primary cells, we demonstrate that NuMA is an essential mitotic component with ..
  6. Chiu C, Monat C, Robitaille M, Lacomme M, Daulat A, Macleod G, et al. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev Cell. 2016;36:50-62 pubmed publisher
    ..Proper spatiotemporal localization of the evolutionarily conserved Gαi-LGN-NuMA protein complex is critical for mitotic spindle orientation, but how this is achieved remains unclear...
  7. Rousselet A. Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers. Biol Cell. 2009;101:679-93 pubmed publisher
    ..Under these conditions, the formation of accessory poles containing gamma-tubulin, NuMA (nuclear-mitotic-apparatus) and B23 was induced at metaphase. No effect on centrosome number was observed...
  8. Saare M, Lulla S, Tõnissoo T, Meier R, Kask K, Ruisu K, et al. Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS ONE. 2015;10:e0129131 pubmed publisher
    ..RIC8 is also expressed at high level in female reproductive organs e.g. oviduct. Therefore we suggest a regulatory function for RIC8 in mammalian gametogenesis and fertility. ..
  9. Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
    ..These results imply for the first time that BRAP2 may have an important role in modulating subcellular localization during testicular development. ..

More Information


  1. El Hashash A, Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011;240:441-5 pubmed publisher
    ..Consistent with these findings, mInsc, LGN, and NuMA polarity proteins, which control spindle orientation, are asymmetrically localized in mitotic distal epithelial ..
  2. Seldin L, Poulson N, Foote H, Lechler T. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. Mol Biol Cell. 2013;24:3651-62 pubmed publisher
    ..A conserved cortical protein complex, including LGN, nuclear mitotic apparatus (NuMA), and dynein/dynactin, plays a key role in establishing proper spindle orientation during asymmetric divisions...
  3. Van Thuan N, Wakayama S, Kishigami S, Wakayama T. Donor centrosome regulation of initial spindle formation in mouse somatic cell nuclear transfer: roles of gamma-tubulin and nuclear mitotic apparatus protein 1. Biol Reprod. 2006;74:777-87 pubmed
    ..of spindle-chromosome complex depletion in the oocyte, it is unclear whether both gamma-tubulin and nuclear mitotic apparatus protein 1 (NUMA1), which are required for mitotic organization and spindle assembly, are removed...
  4. Chaffee B, Shang F, Chang M, Clement T, Eddy E, Wagner B, et al. Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development. 2014;141:3388-98 pubmed publisher
    ..These observations suggest that CDK1-dependent phosphorylations required for the initiation of nuclear membrane disassembly during mitosis are adapted for removal of nuclei during fiber cell differentiation. ..
  5. Kolano A, Brunet S, Silk A, Cleveland D, Verlhac M. Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A. 2012;109:E1858-67 pubmed publisher
    ..Cre recombinase-mediated removal in oocytes of the microtubule binding site of nuclear mitotic apparatus protein (NuMA), which is implicated in anchoring microtubules at poles, we determine that without functional NuMA, microtubules ..
  6. Lake B, Sokol S. Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol. 2009;185:59-66 pubmed publisher
    ..we observed a decreased frequency in asymmetric distribution of the LGN target nuclear mitotic apparatus protein (NuMa) in Lp/Lp cortical progenitors in vivo...
  7. Croyle M, Lehman J, O Connor A, Wong S, Malarkey E, Iribarne D, et al. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development. 2011;138:1675-85 pubmed publisher
    ..Collectively, these data indicate that epidermal primary cilia may function in stress responses and epidermal homeostasis involving pathways other than those typically associated with primary cilia. ..
  8. Seldin L, Muroyama A, Lechler T. NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. elife. 2016;5: pubmed publisher
    ..A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types...
  9. Wang X, Yang Y, Duan Q, Jiang N, Huang Y, Darzynkiewicz Z, et al. sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell. 2008;14:331-41 pubmed publisher
    ..Our studies strongly suggest that sSgo1 plays an essential role in protecting centriole cohesion, which is partly regulated by Plk1. ..