Genomes and Genes
Gene Symbol: Ntrk2
Description: neurotrophic tyrosine kinase, receptor, type 2
Alias: GP145-TrkB/GP95-TrkB, Tkrb, trk-B, trkB, BDNF/NT-3 growth factors receptor, neurotrophic tyrosine receptor kinase type 2, trkB tyrosine kinase
Publications152 found, 100 shown here
- Essential role for TrkB receptors in hippocampus-mediated learningL Minichiello
European Molecular Biology Laboratory, Heidelberg, Germany
Neuron 24:401-14. 1999Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility that BDNF/TrkB may be involved in cognitive functions...
- Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkBSirith Douma
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
Nature 430:1034-9. 2004..Here, we report the identification of TrkB, a neurotrophic tyrosine kinase receptor, as a potent and specific suppressor of caspase-associated anoikis of non-..
- Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brainTomi Rantamäki
Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Neuropsychopharmacology 32:2152-62. 2007Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are critically involved in the therapeutic actions of antidepressant drugs...
- The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptorD Soppet
Molecular Embryology Section, NCI Frederick Cancer Research and Development Center, Maryland 21702
Cell 65:895-903. 1991..Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kinase receptor is rapidly phosphorylated on ..
- Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cellsChristine R Rose
Institut fur Physiologie, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
Nature 426:74-8. 2003The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants...
- TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapsesBryan W Luikart
Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
J Neurosci 25:3774-86. 2005..To gain additional insight into the mechanism of BDNF and TrkB influence on synapse formation and synaptic plasticity, we generated a conditional knock-out for TrkB using the cre/..
- Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assemblyKazuhiko Namekata
Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
J Neurosci 32:264-74. 2012..These results suggest that Dock3 plays important roles downstream of BDNF signaling in the CNS, where it regulates cell polarity and promotes axonal outgrowth by stimulating dual pathways: actin polymerization and microtubule assembly...
- Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signalingAnnette Gärtner
Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
J Neurosci 26:3496-504. 2006..the role of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor [tyrosine receptor kinase B (TrkB)] is well documented, it still remains unresolved whether presynaptic or postsynaptic activation of TrkB is ..
- Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complexKazuhiko Namekata
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
Proc Natl Acad Sci U S A 107:7586-91. 2010..Brain-derived neurotrophic factor (BDNF)-TrkB signaling recruits the Dock3/WAVE1 complex to the plasma membrane, whereupon Dock3 activates Rac and dissociates ..
- Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitroMauricio G Martin
VIB and Department of Human Genetics, Catholic University of Leuven, B 3000 Leuven, Belgium
Mol Biol Cell 19:2101-12. 2008Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development...
- Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivoAnna Stenqvist
Unit of Molecular Neurobiology, MBB, Karolinska Institutet, Stockholm, Sweden
EMBO Rep 6:973-8. 2005..vivo studies of null mutant mice have suggested that neurotrophin 3 (NT 3) also signals through the non-preferred TrkB receptor...
- Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindlesTadasuke Komori
Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
J Comp Neurol 511:92-108. 2008....
- Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3Ralf Kleene
Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 85, 20246 Hamburg, Germany
J Biol Chem 285:28968-79. 2010..3 directly binds to the neural cell adhesion molecule (NCAM) and neurotrophin receptor TrkB. We identified the binding sites for NCAM and TrkB at the C-terminal intracellular domain of Kir3.3...
- Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formationNoriyoshi Usui
Department of Physiological Sciences, School of Life Science, The GraduateUniversity for Advanced Studies SOKENDAI, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
Development 139:1125-32. 2012..Taken together, we show that the motoneuron is a functional source of Ntf3 and motoneuron-derived Ntf3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons...
- Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neuronsE J Huang
Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Development 128:2421-32. 2001..Thus, Brn3a must control additional downstream genes that are required for axon pathfinding...
- Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and ratsRui P Galvão
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 28:13368-83. 2008..Here, we analyzed the role of BDNF and its receptor TrkB in adult SVZ neurogenesis...
- Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neuronsL Tessarollo
Molecular Embryology Section, Frederick Cancer Research and Development Center, MD 21702
Proc Natl Acad Sci U S A 91:11844-8. 1994..NT-3-deficient mice will permit further study of the role of this neurotrophin in neural development...
- trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissuesL Tessarollo
Molecular Embryology Section, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201
Development 118:463-75. 1993..Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells...
- Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neuronsPedro J Beltran
The Neuroscience Program and Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
J Comp Neurol 456:384-95. 2003....
- TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cellsGraeme S Pollock
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 23:10137-45. 2003..Null mutation of NT4 alone is ineffective. Null mutation of the full-length trkB (trkBFL) receptor catalytic domain produces a dose-dependent increase in the peak RGC death rate that is negatively ..
- TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neuronsS Tamura
Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, Wakayama, 641 8509 Japan
Neuroscience 130:223-8. 2005..These results suggest that TRPV2 is expressed predominantly in the NT-3-dependent subpopulation of DRG neurons throughout development and in adult mice...
- In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse modelSusan G Dorsey
Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
Neuron 51:21-8. 2006..Ts16 neurons have normal levels of the TrkB tyrosine kinase receptor but an upregulation of the TrkB.T1 truncated receptor isoform...
- The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neuronsKen ichi Inoue
Institute of Molecular and Cell Biology, Singapore 13 8673
J Biol Chem 282:24175-84. 2007..We identified putative regulatory elements of Ntrk2/NTRK2 (a gene that codes for TrkB) using an unbiased computational approach...
- The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domainR Klein
Department of Molecular Biology, Squibb Institute for Medical Research, Princeton, New Jersey 08543 4000
Cell 61:647-56. 1990We previously identified two tyrosine protein kinase genes, designated trk and trkB, that code for putative neurogenic cell surface receptors...
- Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal deathR Klein
Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
Cell 75:113-22. 1993We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene...
- Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neuronsL Minichiello
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Development 121:4067-75. 1995..However, double homozygous trkA-/-;trkB-/- DRG and trkB-/-;trkC-/- vestibular neurons showed the same degree of survival as single trkA-/- and trkB-/- mice,..
- Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivoI Farinas
Department of Physiology, University of California, San Francisco 94143, USA
Neuron 21:325-34. 1998..nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC...
- Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responsesL Minichiello
European Molecular Biology Laboratory, Heidelberg, Germany
Neuron 21:335-45. 1998..neurotrophic factor (BDNF) and neurotrophin-4 (NT4), bind and activate a single high-affinity receptor, TrkB. Experiments in cell culture have revealed that an intact Shc adaptor binding site on TrkB and subsequent ..
- Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root gangliaQ Ma
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Genes Dev 13:1717-28. 1999..classes of sensory neurons in dorsal root ganglia (DRG) are generated in two waves: large-diameter trkC+ and trkB+ neurons are born first, followed by small-diameter trkA+ neurons...
- Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsM Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 14:2839-54. 2000..BETA2/NeuroD1 is, thus, the first gene to be shown to regulate neuronal and sensory cell development in both the cochlear and vestibular systems...
- The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neuronsDitsa Levanon
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
EMBO J 21:3454-63. 2002..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans...
- TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migrationDiego L Medina
European Molecular Biology Laboratory, Monterotondo, Italy
EMBO J 23:3803-14. 2004..To understand the importance of TrkB signaling during these events, we have used conditional and knockin mutagenesis of the TrkB neurotrophin receptor, ..
- Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brainEija Koponen
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Brain Res Mol Brain Res 130:81-94. 2004..To specifically address the role of the trkB receptor, we have previously generated transgenic mice overexpressing the full-length trkB receptor and observed a ..
- Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic miceVandana Zaman
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Exp Neurol 190:337-46. 2004Brain-derived neurotrophic factor (BDNF) acts through the neurotrophin receptor TrkB and promotes survival and differentiation of dopaminergic ventral mesencephalic neurons...
- Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigraOliver Von Bohlen Und Halbach
Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
FASEB J 19:1740-2. 2005..This is consistent with their expression and that of their cognate receptors, trkB and trkC, in the nigrostriatal system...
- Dynamic regulation of the expression of neurotrophin receptors by Runx3Souichiro Nakamura
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
Development 135:1703-11. 2008..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...
- TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sitesGabriele Musumeci
Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Italy
J Neurosci 29:10131-43. 2009..TrkB (Ntrk2) neurotrophin receptor tyrosine kinase potently modulates synaptic plasticity and activates signal transduction ..
- Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNSM P Armanini
Department of Neuroscience, Genentech Inc, CA 94080, USA
Eur J Neurosci 7:1403-9. 1995Localization of mRNA encoding trkB indicates that two truncated isoforms of trkB, T1trkB and T2trkB, are differentially distributed in the rodent nervous system, and that each of these transcripts is co-expressed with catalytic trkB (TK+..
- Sympathetic neuroblasts undergo a developmental switch in trophic dependenceS J Birren
Division of Biology 216 76, California Institute of Technology, Pasadena 91125
Development 119:597-610. 1993..They also suggest that the acquisition of NGF-dependence may occur, at least in part, through the loss of receptors for these interim survival factors...
- TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivoA M Fagan
Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
J Neurosci 16:6208-18. 1996..5 and for proper innervation of their distal targets. In contrast, mice defective for either TrkC or TrkB tyrosine kinase receptors do not display detectable defects in their SCGs...
- TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neuronsL Minichiello
European Molecular Biology Laboratory, Heidelberg, Germany
Genes Dev 10:2849-58. 1996..However, in double mutant mice, we now show that reducing the expression of both TrkB and TrkC causes massive cell death of postnatal hippocampal and cerebellar granule neurons...
- Requirement for Brn-3.0 in differentiation and survival of sensory and motor neuronsR J McEvilly
Howard Hughes Medical Institute, University of California, San Diego, USA
Nature 384:574-7. 1996..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
- Expression and function of TrkB variants in developing sensory neuronsN Ninkina
School of Biological and Medical Sciences, University of St Andrews, UK
EMBO J 15:6385-93. 1996..During the stage of neurotrophin independence, transcripts encoding the BDNF receptor, TrkB, were expressed at very low levels...
- Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, miceA Schober
Department of Anatomy and Cell Biology III, University of Heidelberg, Germany
J Neurosci 17:891-903. 1997..In the present study we demonstrate that mice deficient for TrkA, but not the neurotrophin receptor TrkB, show an early postnatal progressive reduction of acetylcholinesterase (AChE) enzymatic activity in the adrenal ..
- Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic miceD J Liebl
Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
J Neurosci 17:9113-21. 1997..We suggest that neurotrophins may function in creating early heterogeneity that would enable ganglia to compensate for diverse modality requirements before the period of naturally occurring death...
- Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptorsI Silos-Santiago
Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
Eur J Neurosci 9:2045-56. 1997..In this study we generated mice defective in both TrkB and TrkC tyrosine kinase receptors to determine the biological effects of these receptors in the absence of ..
- The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron deathS X Bamji
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Cell Biol 140:911-23. 1998..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death...
- Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFRF L Rice
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Dev Biol 198:57-81. 1998..brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), tyrosine kinase (trk) A, trkB, trkC, or p75...
- TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connectionsA Martinez
Department of Animal and Plant Cell Biology, University of Barcelona, Barcelona 08028, Spain
J Neurosci 18:7336-50. 1998..in the development of neural connections in the CNS, we studied the ontogeny of hippocampal afferents in trkB (-/-) and trkC (-/-) mice...
- The combined effects of trkB and trkC mutations on the innervation of the inner earB Fritzsch
Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
Int J Dev Neurosci 16:493-505. 1998..In the vestibular system, trkC+/- heterozygosity aggravates the trkB-/- mutation effect and causes almost complete loss of vestibular neurons...
- Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkCE J Huang
Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723, USA
Development 126:2191-203. 1999..5 and E13.5. In order to identify the mechanisms for this deficit, we used antisera specific for TrkA, TrkB, and TrkC to characterize and compare the expression patterns of each Trk receptor in trigeminal ganglia of wild ..
- POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expressionE J Huang
Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723 USA
Development 126:2869-82. 1999..In this ganglion, neurons expressing the neurotrophin receptors, TrkB and TrkC, are born between E9.5 and E11.5...
- The mouse neurotrophin receptor trkB gene is transcribed from two different promotersD Barettino
Instituto de Investigaciones Biomédicas CSIC, Arturo Duperier, 4, 28029, Madrid, Spain
Biochim Biophys Acta 1446:24-34. 1999We have analysed a 7-kb region upstream of the mouse trkB coding sequence. The region showed promoter activity in transient transfection experiments and conferred tissue-specific expression to a reporter gene...
- Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activitiesG Fan
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Neurosci 3:350-7. 2000..The distinct activities of NT4 and BDNF may result partly from differential activation of the TrkB receptor and its down-stream signals.
- Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkBB Xu
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
Neuron 26:233-45. 2000To examine functions of TrkB in the adult CNS, TrkB has been removed from neurons expressing CaMKII, primarily pyramidal neurons, using Cre-mediated recombination...
- The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkBB Xu
Howard Hughes Medical Institute, Program in Neuroscience and Department of Physiology, University of California, San Francisco, California 94143, USA
J Neurosci 20:6888-97. 2000..Mutants in the BDNF receptor gene trkB and antibodies to its second receptor p75NTR have been used to determine the receptors and cells involved in this ..
- Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilizationM J Donovan
Millennium Pharmaceuticals, Cambridge, and the Department of Pathology, Children s Hospital, Boston, MA, USA
Development 127:4531-40. 2000..BDNF, is a neurotrophin best characterized for its survival and differentiative effects on neurons expressing the trk B receptor tyrosine kinase...
- NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during developmentW Y Kim
Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Development 128:417-26. 2001..The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting that the ability of NeuroD to support neuronal survival may be directly mediated through ..
- Neurotrophins are not required for normal embryonic development of olfactory neuronsS Nef
Center for Developmental Biology, Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75235 9133, USA
Dev Biol 234:80-92. 2001..For this, we generated mutant mice for TrkA, TrkB, TrkC, and also for BDNF and NT3 together with P2-IRES-tau-LacZ trangenic mice...
- Spatial shaping of cochlear innervation by temporally regulated neurotrophin expressionI Farinas
Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0724, USA
J Neurosci 21:6170-80. 2001..BDNF) and NT-3, using lacZ reporters in each gene and with expression of the specific neurotrophin receptors, trkB and trkC...
- Neurotrophin receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivoB Rohrer
Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
Exp Neurol 172:81-91. 2001..BDNF and NT-4, but not NGF, bind to all isoforms of the receptor TrkB, whether or not they contain a tyrosine kinase domain...
- trkB-receptor activation contributes to the kainate-induced increase in BDNF mRNA synthesisT Saarelainen
A I Virtanen Institute, University of Kuopio, Finland
Cell Mol Neurobiol 21:429-35. 2001..As BDNF also increases intracellular calcium levels through trkB activation, we have examined here whether BDNF also regulates the synthesis of its own mRNA. 2...
- TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellumBeatriz Rico
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
Nat Neurosci 5:225-33. 2002..Neurotrophin signaling is mediated by Trk family tyrosine kinases such as TrkA, TrkB and TrkC, as well as by the pan-neurotrophin receptor p75NTR...
- Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neuronsAntonio Postigo
European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
Genes Dev 16:633-45. 2002Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons...
- ShcB and ShcC activation by the Trk family of receptor tyrosine kinasesHui Yu Liu
Laboratory of Neural Signaling, Cell Biology Group, John P Robarts Research Institute, London, Ontario N6A 5K8, Canada
J Biol Chem 277:26046-56. 2002..manner via their N-terminal phosphotyrosine binding domain at Tyr(499) (TrkA) and Tyr(515) (TrkB), they are tyrosine-phosphorylated in response to neurotrophin stimulation, and they enhance the activation of ..
- Control of cortical interneuron migration by neurotrophins and PI3-kinase signalingFranck Polleux
INSERM U 371, 18 Avenue Doyen Lepine, 69675 Bron, France
Development 129:3147-60. 2002..by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling...
- Mechanism of TrkB-mediated hippocampal long-term potentiationLiliana Minichiello
European Molecular Biology Laboratory, Via Ramarini 32, 00016, Monterotondo, Italy
Neuron 36:121-37. 2002The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However, the downstream pathways required to mediate these functions are unknown...
- Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptorBaoji Xu
Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
Nat Neurosci 6:736-42. 2003..In addition, similar to MC4R mutants, mouse mutants that expresses the BDNF receptor TrkB at a quarter of the normal amount showed hyperphagia and excessive weight gain on higher-fat diets...
- Ca(2+)-dependent regulation of TrkB expression in neuronsTami J Kingsbury
Departments of Physiology and Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 278:40744-8. 2003..neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic ..
- Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive"Björn Zörner
Central Institute of Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
Biol Psychiatry 54:972-82. 2003..We investigated the hypothesis that mice with a forebrain-specific knockout of the trkB receptor, the main mediator of BDNF signaling, represent a genetic animal model for depression.
- Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learningEija Koponen
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Mol Cell Neurosci 26:166-81. 2004..physiological, and behavioral properties of transgenic mice overexpressing the full-length neurotrophin receptor trkB (trkB.TK+). The highest trkB...
- Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling modelXiao Ping He
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 43:31-42. 2004..We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated activation of TrkB is required for ..
- Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNSGeraldine S Maro
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Nat Neurosci 7:930-8. 2004..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS...
- A chemical-genetic approach to studying neurotrophin signalingXi Chen
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 46:13-21. 2005..or 1NaPP1, derivatives of the general kinase inhibitor PP1, inhibit NGF and BDNF signaling in TrkA(F592A) and TrkB(F616A) neurons, respectively, while no such Trk inhibition is observed in wild-type neurons...
- A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversificationIna Kramer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Neuron 49:379-93. 2006..neuronal cohort by promoting the differentiation of proprioceptive sensory neurons through erosion of TrkB expression in prospective TrkC+ sensory neurons...
- Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcriptionAnna Maria Calella
European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini, 00016 Monterotondo, Italy
Neural Dev 2:4. 2007....
- Retrolinkin, a membrane protein, plays an important role in retrograde axonal transportJia Jia Liu
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:2223-8. 2007..Our work lays the foundation for understanding fundamental issues of axonal transport and provides insights into the molecular mechanisms underlying human neurodegenerative disorders...
- Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retinaXiaorong Liu
Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 27:7256-67. 2007..transgenic overexpression of BDNF accelerated the laminar refinement of ganglion cell dendrites, whereas decreased TrkB expression or retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it...
- Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasisThomas R Geiger
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Cancer Res 67:6221-9. 2007..We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic...
- Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkBStefan Wiese
Institute for Clinical Neurobiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
Proc Natl Acad Sci U S A 104:17210-5. 2007..Moreover, survival of motoneurons directly required the activation of the BDNF receptor TrkB and an increase in Akt (AKT8 virus oncogene cellular homolog) activity...
- Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapseYang Z Huang
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:546-58. 2008The receptor tyrosine kinase, TrkB, is critical to diverse functions of the mammalian nervous system in health and disease...
- Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discriminationKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
J Neurosci 28:2383-93. 2008..Utilizing knock-out mouse lines, we identified BDNF and tyrosine receptor kinase B (TrkB) as the critical molecules for the observed impairments in neurogenesis, with p75 knock-out mice showing no effect ..
- Retinal TrkB receptors regulate neural development in the inner, but not outer, retinaRuslan N Grishanin
Neuroscience Program, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Mol Cell Neurosci 38:431-43. 2008BDNF signaling through its TrkB receptor plays a pivotal role in activity-dependent refinement of synaptic connectivity of retinal ganglion cells...
- Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP miceHiroshi Hasegawa
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Comp Neurol 511:543-56. 2008..Two-color in situ analysis revealed that almost all HS3ST-2 signals colocalized with TrkC but not with TrkA or TrkB mRNA...
- LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural developmentKenji Mandai
The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
Neuron 63:614-27. 2009..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching...
- Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signalingSteeve Bourane
INSERM U 583, F34091 Montpellier, France
Neuron 64:857-70. 2009..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs...
- Mutual regulation of Src family kinases and the neurotrophin receptor TrkBYang Z Huang
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 285:8207-17. 2010The neurotrophin receptor tyrosine kinase TrkB is critical to diverse biological processes...
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavoneSung Wuk Jang
Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:2687-92. 2010Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
- The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophinsRana S Moubarak
Institut de Neurociencies, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, Campus de Bellaterra Edifici M, 08193 Bellaterra, Spain
J Neurosci 30:6094-105. 2010..FLIP-L interacts with TrkA, and not with p75(NTR), in an NGF-dependent manner, and endogenous FLIP-L interacts with TrkB in whole-brain lysates from embryonic day 15 mice embryos...
- Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does notVassiliki Nikoletopoulou
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Nature 467:59-63. 2010..By contrast, TrkB (also known as Ntrk2), a closely related receptor primarily expressed in the central nervous system, does not...
- Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neuronsEduardo Gascon
Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique Université de la Méditerranée, 13288 Marseille, France
J Neurosci 30:12414-23. 2010..Together, our novel findings support a model in which peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance...
- Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine rewardMary Kay Lobo
Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Science 330:385-90. 2010..We show that deletion of TrkB, the brain-derived neurotrophic factor (BDNF) receptor, selectively from D1+ or D2+ neurons oppositely affects ..
- Epibranchial placode-derived neurons produce BDNF required for early sensory neuron developmentDANIELLE E HARLOW
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Dev Dyn 240:309-23. 2011..Only placodal neurons produce BDNF, however, which indicates that prior to innervation, early ganglionic BDNF produced by placode-derived cells promotes gustatory neuron development...
- Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in miceMaxime Cazorla
Neurobiology and Molecular Pharmacology, Centre de psychiatrie et Neurosciences, UMR 894 INSERM Université Paris Descartes, Paris, France
J Clin Invest 121:1846-57. 2011The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and depression...
- Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockadeTomi Rantamäki
Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
PLoS ONE 6:e20567. 2011Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this phenomenon remains unclear...
- The functional organization of cutaneous low-threshold mechanosensory neuronsLishi Li
The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 147:1615-27. 2011..These findings support a model of mechanosensation in which the activities of Aβ-, Aδ-, and C-LTMRs are integrated within dorsal horn LTMR columns and processed into outputs that underlie the perception of myriad touch sensations...
- Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron developmentYun Li
Department of Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 109:15491-6. 2012..Furthermore, striatal-specific ablation of TrkB, the gene encoding the high-affinity receptor for BDNF, is sufficient to elicit an array of striatal developmental ..
- Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targetsT Schimmang
Departamento Bioquimica, Biologia Molecular y Fisiologia, Facultad de Medicina, Universidad de Valladolid, CSIC, Spain
Development 121:3381-91. 1995The trkB and trkC genes are expressed during the formation of the vestibular and auditory system...
- Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1Nicole Wagner
Inserm U636, Centre de Biochimie, Faculte des Sciences, 06108 Nice, France
Genes Dev 19:2631-42. 2005..Activation of Wt1 in an inducible cell line significantly enhanced TrkB expression. The promoter of NTRK2, the gene encoding TrkB, was stimulated approximately 10-fold by transient cotransfection of a Wt1 expression ..
- The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortexTomi Rantamäki
Neuroscience Center, University of Helsinki, Finland
Neuropharmacology 50:421-7. 2006As brain-derived neurotrophic factor (BDNF) and its receptor trkB are linked to the etiology and treatment of mood disorders, we examined the effects of acute and long-term treatment of mood-stabilizer lithium on trkB activation and ..
- Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signallingL G Pinon
School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland, UK
Development 122:3255-61. 1996..timing of neuronal death in the trigeminal ganglia of embryos that are homozygous for null mutations in the trkA, trkB and trkC genes, which encode receptor tyrosine kinases for NGF, BDNF and NT3, respectively...
- TrkB.T1 as a Genetic Disease Modifier of Muscular DystrophyCHRISTOPHER WILLIAM WARD; Fiscal Year: 2010..DMD muscle biopsy samples we show that the truncated form of the Brain-derived Neurotrophic Factor (BDNF) receptor, trkB.T1, but not other trkB isoforms, is highly associated with TGF-( expression (Hoffman et al., unpublished)...
- Transgenic Rod Development and FunctionBaerbel Rohrer; Fiscal Year: 2005..This technique will be applied to further investigate the genotype of the neurotrophin receptor trkB-/- mouse...
- ROD NEURODEGENERATIVE AND PROTECTIVE GENESBaerbel Rohrer; Fiscal Year: 2005..1) To assess the involvement of BDNF acting through its receptor TrkB in photoreceptor development and function, we have developed a trkB knock-out mouse, which shows signs of ..
- The role of BDNF in taste receptor cell innervationROBIN KRIMM; Fiscal Year: 2003..This approach provides a new and powerful means to manipulate gene expression in the taste end organs, allowing study of the intrinsic factors that regulate taste organ development and innervation. ..
- Neurotrophins are chemotropic for taste developmentROBIN KRIMM; Fiscal Year: 2003..Uncovering these mechanisms will provide new insights into how taste neurons select their correct targets during development and following injury. ..
- Molecular Regulation of a Striatal DARPP-32 PhenotypeMichelle Ehrlich; Fiscal Year: 2008....
- Huntington's Disease and the StriatumMichelle E Ehrlich; Fiscal Year: 2010..And 2) Does loss of striatal brain-derived neurotrophic factor (BDNF) function via deletion of post-synaptic trkB receptors in the adult exacerbate an HD phenotype in a mouse model? Using this new mouse model and the knowledge of ..
- P75NTR and Apoptosis of Neointimal Smooth Muscle CellsRosemary Kraemer; Fiscal Year: 2004..These studies will allow us to test whether the absence of p75NTR increases neointimal formation following vascular injury. ..
- Inhibition of trkB Dephosphorylation: A Novel Approach to Promote Neuron SurvivalTami Kingsbury; Fiscal Year: 2008..BDNF promotes cell survival through the activation of the high affinity tyrosine receptor kinase trkB. Upon binding BDNF, trkB dimerizes and undergoes trans-autophosphorylation of critical tyrosine residues which ..