Gene Symbol: Ntrk2
Description: neurotrophic tyrosine kinase, receptor, type 2
Alias: GP145-TrkB/GP95-TrkB, Tkrb, trk-B, trkB, BDNF/NT-3 growth factors receptor, neurotrophic tyrosine receptor kinase type 2, trkB tyrosine kinase
Species: mouse
Products:     Ntrk2

Top Publications

  1. Moubarak R, Sole C, Pascual M, Gutierrez H, Llovera M, Perez Garcia M, et al. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. J Neurosci. 2010;30:6094-105 pubmed publisher
    ..FLIP-L interacts with TrkA, and not with p75(NTR), in an NGF-dependent manner, and endogenous FLIP-L interacts with TrkB in whole-brain lysates from embryonic day 15 mice embryos...
  2. Rice F, Albers K, Davis B, Silos Santiago I, Wilkinson G, LeMaster A, et al. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol. 1998;198:57-81 pubmed
    ..brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), tyrosine kinase (trk) A, trkB, trkC, or p75...
  3. Martin M, Perga S, Trovò L, Rasola A, Holm P, Rantamäki T, et al. Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell. 2008;19:2101-12 pubmed publisher
    Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development...
  4. Kim W, Fritzsch B, Serls A, Bakel L, Huang E, Reichardt L, et al. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001;128:417-26 pubmed
    ..The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting that the ability of NeuroD to support neuronal survival may be directly mediated through ..
  5. Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, et al. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999;24:401-14 pubmed
    Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility that BDNF/TrkB may be involved in cognitive functions...
  6. Xu B, Goulding E, Zang K, Cepoi D, Cone R, Jones K, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003;6:736-42 pubmed
    ..In addition, similar to MC4R mutants, mouse mutants that expresses the BDNF receptor TrkB at a quarter of the normal amount showed hyperphagia and excessive weight gain on higher-fat diets...
  7. Armanini M, McMahon S, Sutherland J, Shelton D, Phillips H. Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS. Eur J Neurosci. 1995;7:1403-9 pubmed
    Localization of mRNA encoding trkB indicates that two truncated isoforms of trkB, T1trkB and T2trkB, are differentially distributed in the rodent nervous system, and that each of these transcripts is co-expressed with catalytic trkB (TK+..
  8. Schimmang T, Minichiello L, Vazquez E, San Jose I, Giraldez F, Klein R, et al. Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets. Development. 1995;121:3381-91 pubmed
    The trkB and trkC genes are expressed during the formation of the vestibular and auditory system...
  9. Birren S, Lo L, Anderson D. Sympathetic neuroblasts undergo a developmental switch in trophic dependence. Development. 1993;119:597-610 pubmed
    ..They also suggest that the acquisition of NGF-dependence may occur, at least in part, through the loss of receptors for these interim survival factors. ..

More Information


  1. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos K, Zhang C, et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005;46:13-21 pubmed
    ..or 1NaPP1, derivatives of the general kinase inhibitor PP1, inhibit NGF and BDNF signaling in TrkA(F592A) and TrkB(F616A) neurons, respectively, while no such Trk inhibition is observed in wild-type neurons...
  2. Postigo A, Calella A, Fritzsch B, Knipper M, Katz D, Eilers A, et al. Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev. 2002;16:633-45 pubmed
    Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons...
  3. Von Bohlen Und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB J. 2005;19:1740-2 pubmed
    ..This is consistent with their expression and that of their cognate receptors, trkB and trkC, in the nigrostriatal system...
  4. Kingsbury T, Murray P, Bambrick L, Krueger B. Ca(2+)-dependent regulation of TrkB expression in neurons. J Biol Chem. 2003;278:40744-8 pubmed
    ..neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic ..
  5. Huang E, Wilkinson G, Farinas I, Backus C, Zang K, Wong S, et al. Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999;126:2191-203 pubmed
    ..5 and E13.5. In order to identify the mechanisms for this deficit, we used antisera specific for TrkA, TrkB, and TrkC to characterize and compare the expression patterns of each Trk receptor in trigeminal ganglia of wild ..
  6. Zaman V, Nelson M, Gerhardt G, Rohrer B. Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Exp Neurol. 2004;190:337-46 pubmed
    Brain-derived neurotrophic factor (BDNF) acts through the neurotrophin receptor TrkB and promotes survival and differentiation of dopaminergic ventral mesencephalic neurons...
  7. Zörner B, Wolfer D, Brandis D, Kretz O, Zacher C, Madani R, et al. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive". Biol Psychiatry. 2003;54:972-82 pubmed
    ..We investigated the hypothesis that mice with a forebrain-specific knockout of the trkB receptor, the main mediator of BDNF signaling, represent a genetic animal model for depression...
  8. Jeanneteau F, Lambert W, Ismaili N, Bath K, Lee F, Garabedian M, et al. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012;109:1305-10 pubmed publisher
    ..ectopic expression of BDNF in vivo increased CRH, whereas reduced expression of BDNF, or its receptor TrkB, decreased CRH expression and normal HPA functions...
  9. Inoue K, Ito K, Osato M, Lee B, Bae S, Ito Y. The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. J Biol Chem. 2007;282:24175-84 pubmed
    ..We identified putative regulatory elements of Ntrk2/NTRK2 (a gene that codes for TrkB) using an unbiased computational approach...
  10. Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, et al. Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008;135:1703-11 pubmed publisher
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons. ..
  11. Minichiello L, Piehl F, Vazquez E, Schimmang T, Hokfelt T, Represa J, et al. Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development. 1995;121:4067-75 pubmed
    ..However, double homozygous trkA-/-;trkB-/- DRG and trkB-/-;trkC-/- vestibular neurons showed the same degree of survival as single trkA-/- and trkB-/- mice,..
  12. Conover J, Erickson J, Katz D, Bianchi L, Poueymirou W, McClain J, et al. Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature. 1995;375:235-8 pubmed
    Nerve growth factor and other neurotrophins signal to neurons through the Trk family of receptor tyrosine kinases. TrkB is relatively promiscuous in vitro, acting as a receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-4 (..
  13. Li L, Rutlin M, Abraira V, Cassidy C, Kus L, Gong S, et al. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011;147:1615-27 pubmed publisher
    ..These findings support a model of mechanosensation in which the activities of A?-, A?-, and C-LTMRs are integrated within dorsal horn LTMR columns and processed into outputs that underlie the perception of myriad touch sensations. ..
  14. Donovan M, Lin M, Wiegn P, Ringstedt T, Kraemer R, Hahn R, et al. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000;127:4531-40 pubmed
    ..BDNF, is a neurotrophin best characterized for its survival and differentiative effects on neurons expressing the trk B receptor tyrosine kinase...
  15. Fritzsch B, Barbacid M, Silos Santiago I. The combined effects of trkB and trkC mutations on the innervation of the inner ear. Int J Dev Neurosci. 1998;16:493-505 pubmed
    ..In the vestibular system, trkC+/- heterozygosity aggravates the trkB-/- mutation effect and causes almost complete loss of vestibular neurons...
  16. Lobo M, Covington H, Chaudhury D, Friedman A, Sun H, Damez Werno D, et al. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 2010;330:385-90 pubmed publisher
    ..We show that deletion of TrkB, the brain-derived neurotrophic factor (BDNF) receptor, selectively from D1+ or D2+ neurons oppositely affects ..
  17. Kupferman M, Jiffar T, el Naggar A, Yilmaz T, Zhou G, Xie T, et al. TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. 2010;29:2047-59 pubmed publisher
    ..and here we present experimental evidence for a direct role of the cell surface receptor tyrosine kinase, TrkB, in HNSCC tumor progression...
  18. Liu H, Meakin S. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. J Biol Chem. 2002;277:26046-56 pubmed
    ..manner via their N-terminal phosphotyrosine binding domain at Tyr(499) (TrkA) and Tyr(515) (TrkB), they are tyrosine-phosphorylated in response to neurotrophin stimulation, and they enhance the activation of ..
  19. McEvilly R, Erkman L, Luo L, Sawchenko P, Ryan A, Rosenfeld M. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature. 1996;384:574-7 pubmed
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations. ..
  20. Farinas I, Wilkinson G, Backus C, Reichardt L, Patapoutian A. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998;21:325-34 pubmed
    ..nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC...
  21. Cazorla M, Premont J, Mann A, Girard N, Kellendonk C, Rognan D. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011;121:1846-57 pubmed publisher
    The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and depression...
  22. Liebl D, Tessarollo L, Palko M, Parada L. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997;17:9113-21 pubmed
    ..We suggest that neurotrophins may function in creating early heterogeneity that would enable ganglia to compensate for diverse modality requirements before the period of naturally occurring death. ..
  23. Liu Y, Rutlin M, Huang S, Barrick C, Wang F, Jones K, et al. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012;338:1357-60 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF), emanating from mammary mesenchyme and signaling through its receptor TrkB on sensory axons, is required for establishing mammary gland sensory innervation of both sexes at early ..
  24. Medina D, Sciarretta C, Calella A, Von Bohlen Und Halbach O, Unsicker K, Minichiello L. TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J. 2004;23:3803-14 pubmed
    ..To understand the importance of TrkB signaling during these events, we have used conditional and knockin mutagenesis of the TrkB neurotrophin receptor, ..
  25. Dorsey S, Renn C, Carim Todd L, Barrick C, Bambrick L, Krueger B, et al. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. 2006;51:21-8 pubmed
    ..Ts16 neurons have normal levels of the TrkB tyrosine kinase receptor but an upregulation of the TrkB.T1 truncated receptor isoform...
  26. Yoshii A, Constantine Paton M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci. 2007;10:702-11 pubmed
    ..In visual cortical neurons in young rodents, the neurotrophin receptor TrkB is associated with PSD-95...
  27. Rohrer B, LaVail M, Jones K, Reichardt L. Neurotrophin receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivo. Exp Neurol. 2001;172:81-91 pubmed
    ..BDNF and NT-4, but not NGF, bind to all isoforms of the receptor TrkB, whether or not they contain a tyrosine kinase domain...
  28. Xu B, Gottschalk W, Chow A, Wilson R, Schnell E, Zang K, et al. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J Neurosci. 2000;20:6888-97 pubmed
    ..Mutants in the BDNF receptor gene trkB and antibodies to its second receptor p75NTR have been used to determine the receptors and cells involved in this ..
  29. Ma Q, Fode C, Guillemot F, Anderson D. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 1999;13:1717-28 pubmed
    ..classes of sensory neurons in dorsal root ganglia (DRG) are generated in two waves: large-diameter trkC+ and trkB+ neurons are born first, followed by small-diameter trkA+ neurons...
  30. Martinez A, Alcantara S, Borrell V, Del Rio J, Blasi J, Otal R, et al. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J Neurosci. 1998;18:7336-50 pubmed
    ..in the development of neural connections in the CNS, we studied the ontogeny of hippocampal afferents in trkB (-/-) and trkC (-/-) mice...
  31. Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
    ..Here we show that the sorting receptor sortilin interacts with TrkA, TrkB and TrkC and enables their anterograde axonal transport, thereby enhancing neurotrophin signaling...
  32. Schober A, Minichiello L, Keller M, Huber K, Layer P, Roig Lopez J, et al. Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice. J Neurosci. 1997;17:891-903 pubmed
    ..In the present study we demonstrate that mice deficient for TrkA, but not the neurotrophin receptor TrkB, show an early postnatal progressive reduction of acetylcholinesterase (AChE) enzymatic activity in the adrenal ..
  33. Galvão R, Garcia Verdugo J, Alvarez Buylla A. Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats. J Neurosci. 2008;28:13368-83 pubmed publisher
    ..Here, we analyzed the role of BDNF and its receptor TrkB in adult SVZ neurogenesis...
  34. Nikoletopoulou V, Lickert H, Frade J, Rencurel C, Giallonardo P, Zhang L, et al. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature. 2010;467:59-63 pubmed publisher
    ..By contrast, TrkB (also known as Ntrk2), a closely related receptor primarily expressed in the central nervous system, does not...
  35. Kermani P, Rafii D, Jin D, Whitlock P, Schaffer W, Chiang A, et al. Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest. 2005;115:653-63 pubmed
    ..development through direct angiogenic actions on endothelial cells expressing the tropomysin receptor kinase B (TrkB)...
  36. Fei D, Krimm R. Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PLoS ONE. 2013;8:e83460 pubmed publisher
    ..These two neurotrophins both activate the tropomyosin-related kinase B (TrkB) receptor and the pan-neurotrophin receptor p75...
  37. Liu M, Pereira F, Price S, Chu M, Shope C, Himes D, et al. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev. 2000;14:2839-54 pubmed
    ..BETA2/NeuroD1 is, thus, the first gene to be shown to regulate neuronal and sensory cell development in both the cochlear and vestibular systems...
  38. He X, Minichiello L, Klein R, McNamara J. Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. J Neurosci. 2002;22:7502-8 pubmed
    Genetic and pharmacological perturbations suggest that tyrosine receptor kinase B (trkB) receptor activation promotes limbic epileptogenesis, but whether or where trkB activation occurs during epileptogenesis is uncertain...
  39. Fritzsch B, Sarai P, Barbacid M, Silos Santiago I. Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. Int J Dev Neurosci. 1997;15:563-76 pubmed
    ..in developing animals is investigated using a mouse model with a targeted deletion of the tyrosine kinase receptor trkB for the neurotrophin BDNF...
  40. Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada L, et al. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A. 2010;107:7586-91 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF)-TrkB signaling recruits the Dock3/WAVE1 complex to the plasma membrane, whereupon Dock3 activates Rac and dissociates ..
  41. Klein R, Smeyne R, Wurst W, Long L, Auerbach B, Joyner A, et al. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 1993;75:113-22 pubmed
    We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene...
  42. Jang S, Liu X, Yepes M, Shepherd K, Miller G, Liu Y, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A. 2010;107:2687-92 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
  43. Wagner N, Wagner K, Theres H, Englert C, Schedl A, Scholz H. Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 2005;19:2631-42 pubmed
    ..Activation of Wt1 in an inducible cell line significantly enhanced TrkB expression. The promoter of NTRK2, the gene encoding TrkB, was stimulated approximately 10-fold by transient cotransfection of a Wt1 expression ..
  44. Minichiello L, Klein R. TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. Genes Dev. 1996;10:2849-58 pubmed
    ..However, in double mutant mice, we now show that reducing the expression of both TrkB and TrkC causes massive cell death of postnatal hippocampal and cerebellar granule neurons...
  45. Levanon D, Bettoun D, Harris Cerruti C, Woolf E, Negreanu V, Eilam R, et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002;21:3454-63 pubmed
    ..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans. ..
  46. Hasegawa H, Wang F. Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. J Comp Neurol. 2008;511:543-56 pubmed publisher
    ..Two-color in situ analysis revealed that almost all HS3ST-2 signals colocalized with TrkC but not with TrkA or TrkB mRNA...
  47. Soppet D, Escandon E, Maragos J, Middlemas D, Reid S, Blair J, et al. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 1991;65:895-903 pubmed
    ..Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kinase receptor is rapidly phosphorylated on ..
  48. Huang Y, McNamara J. Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem. 2010;285:8207-17 pubmed publisher
    The neurotrophin receptor tyrosine kinase TrkB is critical to diverse biological processes...
  49. Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, et al. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009;64:857-70 pubmed publisher
    ..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs. ..
  50. Maro G, Vermeren M, Voiculescu O, Melton L, Cohen J, Charnay P, et al. Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat Neurosci. 2004;7:930-8 pubmed
    ..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS. ..
  51. Huang T, Krimm R. Developmental expression of Bdnf, Ntf4/5, and TrkB in the mouse peripheral taste system. Dev Dyn. 2010;239:2637-46 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT4), and their TrkB receptor regulate taste system development...
  52. Wiese S, Jablonka S, Holtmann B, Orel N, Rajagopal R, Chao M, et al. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc Natl Acad Sci U S A. 2007;104:17210-5 pubmed
    ..Moreover, survival of motoneurons directly required the activation of the BDNF receptor TrkB and an increase in Akt (AKT8 virus oncogene cellular homolog) activity...
  53. Geiger T, Peeper D. Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. Cancer Res. 2007;67:6221-9 pubmed
    ..We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic...
  54. Liu X, Grishanin R, Tolwani R, RENTERIA R, Xu B, Reichardt L, et al. Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retina. J Neurosci. 2007;27:7256-67 pubmed
    ..transgenic overexpression of BDNF accelerated the laminar refinement of ganglion cell dendrites, whereas decreased TrkB expression or retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it...
  55. Pollock G, Robichon R, Boyd K, Kerkel K, Kramer M, Lyles J, et al. TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells. J Neurosci. 2003;23:10137-45 pubmed
    ..Null mutation of NT4 alone is ineffective. Null mutation of the full-length trkB (trkBFL) receptor catalytic domain produces a dose-dependent increase in the peak RGC death rate that is negatively ..
  56. Huang Y, Pan E, Xiong Z, McNamara J. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. Neuron. 2008;57:546-58 pubmed publisher
    The receptor tyrosine kinase, TrkB, is critical to diverse functions of the mammalian nervous system in health and disease...
  57. Bath K, Mandairon N, Jing D, Rajagopal R, Kapoor R, Chen Z, et al. Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci. 2008;28:2383-93 pubmed publisher
    ..Utilizing knock-out mouse lines, we identified BDNF and tyrosine receptor kinase B (TrkB) as the critical molecules for the observed impairments in neurogenesis, with p75 knock-out mice showing no effect ..
  58. Polleux F, Whitford K, Dijkhuizen P, Vitalis T, Ghosh A. Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling. Development. 2002;129:3147-60 pubmed
    ..by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling...
  59. Minichiello L, Casagranda F, Tatche R, Stucky C, Postigo A, Lewin G, et al. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron. 1998;21:335-45 pubmed
    ..neurotrophic factor (BDNF) and neurotrophin-4 (NT4), bind and activate a single high-affinity receptor, TrkB. Experiments in cell culture have revealed that an intact Shc adaptor binding site on TrkB and subsequent ..
  60. Luo W, Enomoto H, Rice F, Milbrandt J, Ginty D. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009;64:841-56 pubmed publisher
    ..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception. ..
  61. Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, et al. Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharmacology. 2007;32:2152-62 pubmed
    Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are critically involved in the therapeutic actions of antidepressant drugs...
  62. Luikart B, Nef S, Shipman T, Parada L. In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. Neuroscience. 2003;117:847-58 pubmed
    The mammalian trkB locus undergoes alternative splicing to produce two different types of brain-derived neurotrophic factor receptors...
  63. Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, et al. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci. 2004;26:166-81 pubmed
    ..physiological, and behavioral properties of transgenic mice overexpressing the full-length neurotrophin receptor trkB (trkB.TK+). The highest trkB...
  64. Silos Santiago I, Fagan A, Garber M, Fritzsch B, Barbacid M. Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors. Eur J Neurosci. 1997;9:2045-56 pubmed
    ..In this study we generated mice defective in both TrkB and TrkC tyrosine kinase receptors to determine the biological effects of these receptors in the absence of ..
  65. Bamji S, Majdan M, Pozniak C, Belliveau D, Aloyz R, Kohn J, et al. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol. 1998;140:911-23 pubmed
    ..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death. ..
  66. Huang E, Zang K, Schmidt A, Saulys A, Xiang M, Reichardt L. POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development. 1999;126:2869-82 pubmed
    ..In this ganglion, neurons expressing the neurotrophin receptors, TrkB and TrkC, are born between E9.5 and E11.5...
  67. Grishanin R, Yang H, Liu X, Donohue Rolfe K, Nune G, Zang K, et al. Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci. 2008;38:431-43 pubmed publisher
    BDNF signaling through its TrkB receptor plays a pivotal role in activity-dependent refinement of synaptic connectivity of retinal ganglion cells...
  68. Farinas I, Jones K, Tessarollo L, Vigers A, Huang E, Kirstein M, et al. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci. 2001;21:6170-80 pubmed
    ..BDNF) and NT-3, using lacZ reporters in each gene and with expression of the specific neurotrophin receptors, trkB and trkC...
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    ..Thus, Brn3a must control additional downstream genes that are required for axon pathfinding. ..
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    ..The transcripts for their receptor, TrkB, were detectable throughout the early embryonic stages with an increase after the early blastocyst stage...
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    ..We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated activation of TrkB is required for ..
  72. Musumeci G, Sciarretta C, Rodríguez Moreno A, Al Banchaabouchi M, Negrete Díaz V, Costanzi M, et al. TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites. J Neurosci. 2009;29:10131-43 pubmed publisher
    ..TrkB (Ntrk2) neurotrophin receptor tyrosine kinase potently modulates synaptic plasticity and activates signal transduction ..
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    ..Together, our novel findings support a model in which peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance. ..
  74. Saarelainen T, Vaittinen S, Castren E. trkB-receptor activation contributes to the kainate-induced increase in BDNF mRNA synthesis. Cell Mol Neurobiol. 2001;21:429-35 pubmed
    ..As BDNF also increases intracellular calcium levels through trkB activation, we have examined here whether BDNF also regulates the synthesis of its own mRNA. 2...
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    ..Neurotrophin signaling is mediated by Trk family tyrosine kinases such as TrkA, TrkB and TrkC, as well as by the pan-neurotrophin receptor p75NTR...
  76. Kramer I, Sigrist M, de Nooij J, Taniuchi I, Jessell T, Arber S. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006;49:379-93 pubmed
    ..neuronal cohort by promoting the differentiation of proprioceptive sensory neurons through erosion of TrkB expression in prospective TrkC+ sensory neurons...
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    ..5 and for proper innervation of their distal targets. In contrast, mice defective for either TrkC or TrkB tyrosine kinase receptors do not display detectable defects in their SCGs...
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    ..To specifically address the role of the trkB receptor, we have previously generated transgenic mice overexpressing the full-length trkB receptor and observed a ..