Ntrk1

Summary

Gene Symbol: Ntrk1
Description: neurotrophic tyrosine kinase, receptor, type 1
Alias: C80751, Tkr, TrkA, trk, high affinity nerve growth factor receptor
Species: mouse
Products:     Ntrk1

Top Publications

  1. Cronk K, Wilkinson G, Grimes R, Wheeler E, Jhaveri S, Fundin B, et al. Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC. Development. 2002;129:3739-50 pubmed
    ..Some endings transiently express trkA during their initial development, whereas others express trkC throughout their development...
  2. Pinon L, Minichiello L, Klein R, Davies A. Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. Development. 1996;122:3255-61 pubmed
    ..the timing of neuronal death in the trigeminal ganglia of embryos that are homozygous for null mutations in the trkA, trkB and trkC genes, which encode receptor tyrosine kinases for NGF, BDNF and NT3, respectively...
  3. White F, Behar O. The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin3A null mutant mice. Dev Biol. 2000;225:79-86 pubmed
    ..In conclusion, these findings suggest the existence of correction mechanisms that eliminate most sensory axon pathfinding errors early in development. ..
  4. Levanon D, Bettoun D, Harris Cerruti C, Woolf E, Negreanu V, Eilam R, et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002;21:3454-63 pubmed
    ..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans. ..
  5. Schmidt H, Stonkute A, Jüttner R, Schaffer S, Buttgereit J, Feil R, et al. The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007;179:331-40 pubmed
    ..Hence, our data demonstrate that Npr2 and cGKI are essential constituents of the signaling pathway underlying axonal bifurcation at the DREZ and neuronal connectivity in the dorsal spinal cord. ..
  6. Kuruvilla R, Zweifel L, Glebova N, Lonze B, Valdez G, Ye H, et al. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell. 2004;118:243-55 pubmed
    ..We report that the related neurotrophins NGF and NT-3, acting through a common receptor, TrkA, are required for sequential stages of sympathetic axon growth and, thus, innervation of target fields...
  7. Bodmer D, Ascano M, Kuruvilla R. Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron. 2011;70:1085-99 pubmed publisher
    ..Here, we report that Nerve Growth Factor (NGF) promotes endocytosis of its TrkA receptors and axon growth by calcineurin-mediated dephosphorylation of the endocytic GTPase dynamin1...
  8. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..LIGs, including Linx, are expressed in subsets of somatosensory and motor neurons, and select members interact with TrkA and Ret RTKs...
  9. Rice F, Albers K, Davis B, Silos Santiago I, Wilkinson G, LeMaster A, et al. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol. 1998;198:57-81 pubmed
    ..The cumulative results indicated that NGF/trkA signaling plays a major role in the outgrowth and proliferation of sensory axons, whereas NT-3/ trkA signaling ..

More Information

Publications65

  1. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos K, Zhang C, et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005;46:13-21 pubmed
    ..of either 1NMPP1 or 1NaPP1, derivatives of the general kinase inhibitor PP1, inhibit NGF and BDNF signaling in TrkA(F592A) and TrkB(F616A) neurons, respectively, while no such Trk inhibition is observed in wild-type neurons...
  2. Patel T, Jackman A, Rice F, Kucera J, Snider W. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron. 2000;25:345-57 pubmed
    ..we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is ..
  3. Arber S, Ladle D, Lin J, Frank E, Jessell T. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000;101:485-98 pubmed
    ..ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord. ..
  4. Huang E, Wilkinson G, Farinas I, Backus C, Zang K, Wong S, et al. Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999;126:2191-203 pubmed
    ..5 and E13.5. In order to identify the mechanisms for this deficit, we used antisera specific for TrkA, TrkB, and TrkC to characterize and compare the expression patterns of each Trk receptor in trigeminal ganglia of ..
  5. Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, et al. Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008;135:1703-11 pubmed publisher
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type...
  6. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  7. Smeyne R, Klein R, Schnapp A, Long L, Bryant S, Lewin A, et al. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature. 1994;368:246-9 pubmed
    ..NGF interacts with the low-affinity p75 receptor and with Trk, a receptor tyrosine kinase encoded by the trk proto-oncogene...
  8. Klein R, Jing S, Nanduri V, O ROURKE E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 1991;65:189-97 pubmed
    ..In this study we show that the product of the human trk proto-oncogene (gp140trk) binds NGF with high affinity...
  9. Tometten M, Klapp B, Joachim R, Fest S, Zenclussen A, Peters E, et al. Nerve growth factor and its functional receptor TrkA are up-regulated in murine decidual tissue of stress-triggered and substance P-mediated abortion. Am J Reprod Immunol. 2004;51:86-93 pubmed
    ..in the responsiveness of immune-competent cells through its functional receptor, tropomyosin receptor kinase (TrkA)...
  10. Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, et al. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 2002;5:946-54 pubmed
    ..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons. ..
  11. Moqrich A, Earley T, Watson J, Andahazy M, Backus C, Martin Zanca D, et al. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004;7:812-8 pubmed
    ..have an instructive role in sensory specification, we expressed rat TrkC from the TrkA (also known as Ntrk1) locus in mice...
  12. Lei L, Zhou J, Lin L, Parada L. Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons. Dev Biol. 2006;300:758-69 pubmed
    The zinc finger protein Klf7 and POU homeodomain protein Brn3a are each required for efficient transcription of TrkA in primary sensory neurons...
  13. Abram M, Wegmann M, Fokuhl V, Sonar S, Luger E, Kerzel S, et al. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol. 2009;182:4705-12 pubmed publisher
    ..These findings were supported in vivo. When the NGF pathway was blocked by intranasal application of a selective TrkA inhibitor, sensitized mice showed reduced numbers of pulmonary plasma cells and developed lower levels of allergen-..
  14. Fundin B, Silos Santiago I, Ernfors P, Fagan A, Aldskogius H, DeChiara T, et al. Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol. 1997;190:94-116 pubmed
    ..neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), the three tyrosine kinase receptors (trkA, trkB, trkC), and the low-affinity nerve growth factor receptor p75...
  15. Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, et al. Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013;33:5399-410 pubmed publisher
    ..The regulation of Eph receptor-mediated developmental processes by protein tyrosine phosphatases has diverged between chick and mouse. ..
  16. Ma L, Merenmies J, Parada L. Molecular characterization of the TrkA/NGF receptor minimal enhancer reveals regulation by multiple cis elements to drive embryonic neuron expression. Development. 2000;127:3777-88 pubmed
    Neural development relies on stringent regulation of key genes that mediate specialized function. TrkA is primarily expressed in neural crest-derived sensory and sympathetic neurons where it transmits critical survival information...
  17. Watanabe K, Tamamaki N, Furuta T, Ackerman S, Ikenaka K, Ono K. Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord. Development. 2006;133:1379-87 pubmed
    ..These results are the first direct evidence that netrin 1 in the dorsal spinal cord acts as an inhibitory cue for primary sensory axons and is a crucial signal for the formation of sensory afferent neural networks. ..
  18. Dykes I, Tempest L, Lee S, Turner E. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011;31:9789-99 pubmed publisher
  19. Ma L, Tessier Lavigne M. Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons. J Neurosci. 2007;27:6843-51 pubmed
    ..Together, our studies reveal that Slit/Robo signaling contributes to patterning both the peripheral and central branches of sensory neurons but via distinct positive branching and negative guidance actions, respectively. ..
  20. Von Bohlen Und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB J. 2005;19:1740-2 pubmed
    ..We conclude that impairment in trkB and/or trkC signaling induces a phenotype in the aged SN, which includes two hallmarks of PD, losses of TH positive neurons and axons along with massive neuronal deposits of alpha-synuclein. ..
  21. Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, et al. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009;64:857-70 pubmed publisher
    ..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs. ..
  22. Maro G, Vermeren M, Voiculescu O, Melton L, Cohen J, Charnay P, et al. Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat Neurosci. 2004;7:930-8 pubmed
    ..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS. ..
  23. Lee E, Hu N, Yuan S, Cox L, Bradley A, Lee W, et al. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994;8:2008-21 pubmed
    ..Preferential reduction in the expression of TrkA, TrkB, and the low-affinity neurotrophin receptor p75LNGFR may be relevant to neuronal cell death and lack of ..
  24. Lonze B, Riccio A, Cohen S, Ginty D. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002;34:371-85 pubmed
    ..Thus, during their period of neurotrophin dependency, peripheral neurons require CREB-mediated gene expression for both survival and growth in vivo. ..
  25. Gu C, Rodriguez E, Reimert D, Shu T, Fritzsch B, Richards L, et al. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003;5:45-57 pubmed
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system. ..
  26. Hasegawa H, Wang F. Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. J Comp Neurol. 2008;511:543-56 pubmed publisher
    ..Two-color in situ analysis revealed that almost all HS3ST-2 signals colocalized with TrkC but not with TrkA or TrkB mRNA...
  27. Molliver D, Wright D, Leitner M, Parsadanian A, Doster K, Wen D, et al. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997;19:849-61 pubmed
    ..gene-related peptide (CGRP) and that downregulate the nerve growth factor (NGF) receptor tyrosine kinase, TrkA, after birth...
  28. Deppmann C, Mihalas S, Sharma N, Lonze B, Niebur E, Ginty D. A model for neuronal competition during development. Science. 2008;320:369-73 pubmed publisher
    ..Target-derived nerve growth factor (NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA-mediated signals...
  29. Ma Q, Fode C, Guillemot F, Anderson D. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 1999;13:1717-28 pubmed
    ..DRG) are generated in two waves: large-diameter trkC+ and trkB+ neurons are born first, followed by small-diameter trkA+ neurons...
  30. Nikoletopoulou V, Lickert H, Frade J, Rencurel C, Giallonardo P, Zhang L, et al. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature. 2010;467:59-63 pubmed publisher
    ..we show here that the neurotrophin receptors TrkA and TrkC (tropomyosin receptor kinase A and C, also known as Ntrk1 and Ntrk3, respectively) instruct developing neurons to die, both in vitro and in vivo...
  31. Guo T, Mandai K, Condie B, Wickramasinghe S, Capecchi M, Ginty D. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci. 2011;14:31-6 pubmed publisher
    ..Thus, conserved growth factors control divergent neuronal transcriptional events that mediate interspecies differences in neural circuits and the behaviors that they control. ..
  32. White F, Silos Santiago I, Molliver D, Nishimura M, Phillips H, Barbacid M, et al. Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. J Neurosci. 1996;16:4662-72 pubmed
    ..in the NT-3 receptor TrkC, suggesting that NT-3 may support many DRG neurons via actions on the NGF receptor TrkA. To assess the possibility of ligand-receptor cross-talk as a developmental mechanism, we have compared the onset ..
  33. Miranda C, Greco A, Miele C, Pierotti M, Van Obberghen E. IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. J Cell Physiol. 2001;186:35-46 pubmed
    TRK-T1 oncogene is generated by the rearrangement of the NGF receptor TrkA with TPR. This gives rise to the constitutive tyrosine autophosphorylation and activation of the kinase...
  34. Coppola V, Barrick C, Southon E, Celeste A, Wang K, Chen B, et al. Ablation of TrkA function in the immune system causes B cell abnormalities. Development. 2004;131:5185-95 pubmed
    The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions outside the nervous system...
  35. Fagan A, Zhang H, Landis S, Smeyne R, Silos Santiago I, Barbacid M. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J Neurosci. 1996;16:6208-18 pubmed
    ..Transcripts encoding TrkC are detected in early sympathetic development, before the coalescence of the SCG. trkA expression appears at E13.5, becoming robust from E15.5 onward...
  36. Gascon E, Gaillard S, Malapert P, Liu Y, Rodat Despoix L, Samokhvalov I, et al. Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010;30:12414-23 pubmed publisher
    ..Together, our novel findings support a model in which peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance. ..
  37. McEvilly R, Erkman L, Luo L, Sawchenko P, Ryan A, Rosenfeld M. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature. 1996;384:574-7 pubmed
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations. ..
  38. Harrington A, St Hillaire C, Zweifel L, Glebova N, Philippidou P, Halegoua S, et al. Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell. 2011;146:421-34 pubmed publisher
    ..Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuronal survival...
  39. Ma L, Lei L, Eng S, Turner E, Parada L. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development. 2003;130:3525-34 pubmed
    The TrkA/NGF receptor is essential for the survival and differentiation of sensory neurons. The molecular mechanisms regulating tissue and stage-specific expression of TrkA are largely unknown...
  40. Farinas I, Wilkinson G, Backus C, Reichardt L, Patapoutian A. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998;21:325-34 pubmed
    ..Neurotrophins act, in large part, through Trk receptor tyrosine kinases: nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via ..
  41. Schmidt H, Werner M, Heppenstall P, Henning M, Moré M, Kühbandner S, et al. cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol. 2002;159:489-98 pubmed
    ..lamina-specific innervation, especially by nociceptive sensory neurons, is strongly reduced as deduced from anti-trkA staining...
  42. Kramer I, Sigrist M, de Nooij J, Taniuchi I, Jessell T, Arber S. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006;49:379-93 pubmed
    ..In contrast, Runx1 controls neuronal diversification within Ngn1-dependent TrkA+ neurons by repression of neuropeptide CGRP expression and controlling the fine pattern of laminar termination in ..
  43. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..of normal neuronal size, axonal innervation of the epidermis, and postnatal extinction of the NGF receptor TrkA. Moreover, NGF controls expression of several other genes characteristic of nonpeptidergic neurons, such as TrpC3, ..
  44. Liebl D, Tessarollo L, Palko M, Parada L. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997;17:9113-21 pubmed
    Gene-targeting experiments of Trk receptors and neurotrophins has confirmed the expectation that embryonic sensory and sympathetic neurons require neurotrophin function for survival...
  45. Huang E, Zang K, Schmidt A, Saulys A, Xiang M, Reichardt L. POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development. 1999;126:2869-82 pubmed
    ..Most neurons expressing the neurotrophin receptor TrkA are generated between E11.5 and E13...
  46. Luo W, Enomoto H, Rice F, Milbrandt J, Ginty D. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009;64:841-56 pubmed publisher
    ..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception. ..
  47. Zhong J, Li X, McNamee C, Chen A, Baccarini M, Snider W. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007;10:598-607 pubmed
    ..We conclude that Raf function is crucial for several aspects of DRG neuron development, including differentiation and axon growth. ..
  48. Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T. Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci. 2010;43:296-307 pubmed publisher
    ..These findings suggest that Runx3 is required for the specification of TrkC-expressing TG neurons, conveying mechanoreceptive signals from the Merkel cells in the ORS of the whisker vibrissae to the Sp5I. ..
  49. Abdo H, Li L, Lallemend F, Bachy I, Xu X, Rice F, et al. Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011;34:1529-41 pubmed publisher
    ..These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin. ..
  50. Tessarollo L, Vogel K, Palko M, Reid S, Parada L. Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. Proc Natl Acad Sci U S A. 1994;91:11844-8 pubmed
    ..NT-3-deficient mice will permit further study of the role of this neurotrophin in neural development. ..
  51. Wolpowitz D, Mason T, Dietrich P, Mendelsohn M, Talmage D, Role L. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000;25:79-91 pubmed
  52. Borden P, Houtz J, Leach S, Kuruvilla R. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Rep. 2013;4:287-301 pubmed publisher
    ..This study reveals that islet architecture requires extrinsic inductive cues from neighboring tissues such as sympathetic nerves and suggests that early perturbations in sympathetic innervation might underlie metabolic disorders. ..
  53. Costa B, Kean M, Ast V, Knight J, Mett A, Levy Z, et al. STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin. J Biol Chem. 2012;287:29285-9 pubmed publisher
    The TrkA receptor tyrosine kinase induces death in medulloblastoma cells via an interaction with the cerebral cavernous malformation 2 (CCM2) protein...
  54. Sajgo S, Ali S, Popescu O, Badea T. Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol. 2016;524:1033-61 pubmed publisher
    ..However, loss of Brn3b does not affect the anatomy of the other cranial nerves normally expressing this transcription factor. ..
  55. Thakur M, Paramanik V. Expression of Trk A and Src and their interaction with ER? ligand binding domain show age and sex dependent alteration in mouse brain. Neurochem Res. 2012;37:448-53 pubmed publisher
    ..Therefore, using pull down assay, immunoprecipitation and immunoblotting, we report that cell signaling molecules Trk A and Src interacted with ER?LBD, and showed alteration in the level of interaction and expression in the brain of ..
  56. Fell S, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al. Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA. Genes Dev. 2017;31:1036-1053 pubmed publisher
    ..for nerve growth factor (NGF)-dependent neuronal differentiation through anterograde transport of the NGF receptor TRKA. Moreover, pathogenic KIF1B? mutations identified in neuroblastoma impair TRKA transport...