Nt5e

Summary

Gene Symbol: Nt5e
Description: 5' nucleotidase, ecto
Alias: 2210401F01Rik, 5'-NT, AI447961, CD73, Nt5, eNT, 5'-nucleotidase, ecto-5'-nucleotidase
Species: mouse
Products:     Nt5e

Top Publications

  1. Yang L, Kobie J, Mosmann T. CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells. J Immunol. 2005;175:6458-64 pubmed
    ..Using Affymetrix GeneChips followed by FACS analysis, we found that in vitro-derived Thpp cells expressed CD73 but not Ly-6A/E, whereas Th1 and Th2 cells showed the reciprocal pattern...
  2. Mills J, Thompson L, Mueller C, Waickman A, Jalkanen S, Niemela J, et al. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2008;105:9325-30 pubmed publisher
    b>CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine...
  3. Yegutkin G, Marttila Ichihara F, Karikoski M, Niemela J, Laurila J, Elima K, et al. Altered purinergic signaling in CD73-deficient mice inhibits tumor progression. Eur J Immunol. 2011;41:1231-41 pubmed publisher
    b>CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti-tumor immunity has not been studied...
  4. Deaglio S, Dwyer K, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-65 pubmed
    ..We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells...
  5. Hasko G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson L, et al. Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol. 2011;187:4256-67 pubmed publisher
    ..In this study, we investigated the role of the adenosine-generating ectoenzyme, ecto-5'-nucleotidase (CD73), in regulating immune and organ function during sepsis...
  6. Hart M, Much C, Gorzolla I, Schittenhelm J, Kloor D, Stahl G, et al. Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterology. 2008;135:1739-1750.e3 pubmed publisher
    ..We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP...
  7. Louis N, Robinson A, MacManus C, Karhausen J, Scully M, Colgan S. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol. 2008;180:4246-55 pubmed
    ..Ecto-5'-nucleotidase (CD73) is a central surface enzyme generating extracellular adenosine...
  8. Koszalka P, Ozüyaman B, Huo Y, Zernecke A, Flogel U, Braun N, et al. Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 2004;95:814-21 pubmed
    ..the role of adenosine formed extracellularly in vascular homeostasis, mice with a targeted deletion of the cd73/ecto-5'-nucleotidase were generated...
  9. Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri K, Eltzschig H. Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J. 2009;23:473-82 pubmed publisher
    ..two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73)...
  10. Thompson L, Eltzschig H, Ibla J, Van De Wiele C, Resta R, Morote Garcia J, et al. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004;200:1395-405 pubmed
    ..nucleotide intermediates, and is regulated by the terminal enzymatic step catalyzed by ecto-5'-nucleotidase (CD73)...

Detail Information

Publications61

  1. Yang L, Kobie J, Mosmann T. CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells. J Immunol. 2005;175:6458-64 pubmed
    ..Using Affymetrix GeneChips followed by FACS analysis, we found that in vitro-derived Thpp cells expressed CD73 but not Ly-6A/E, whereas Th1 and Th2 cells showed the reciprocal pattern...
  2. Mills J, Thompson L, Mueller C, Waickman A, Jalkanen S, Niemela J, et al. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2008;105:9325-30 pubmed publisher
    b>CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine...
  3. Yegutkin G, Marttila Ichihara F, Karikoski M, Niemela J, Laurila J, Elima K, et al. Altered purinergic signaling in CD73-deficient mice inhibits tumor progression. Eur J Immunol. 2011;41:1231-41 pubmed publisher
    b>CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti-tumor immunity has not been studied...
  4. Deaglio S, Dwyer K, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-65 pubmed
    ..We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells...
  5. Hasko G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson L, et al. Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol. 2011;187:4256-67 pubmed publisher
    ..In this study, we investigated the role of the adenosine-generating ectoenzyme, ecto-5'-nucleotidase (CD73), in regulating immune and organ function during sepsis...
  6. Hart M, Much C, Gorzolla I, Schittenhelm J, Kloor D, Stahl G, et al. Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterology. 2008;135:1739-1750.e3 pubmed publisher
    ..We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP...
  7. Louis N, Robinson A, MacManus C, Karhausen J, Scully M, Colgan S. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol. 2008;180:4246-55 pubmed
    ..Ecto-5'-nucleotidase (CD73) is a central surface enzyme generating extracellular adenosine...
  8. Koszalka P, Ozüyaman B, Huo Y, Zernecke A, Flogel U, Braun N, et al. Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 2004;95:814-21 pubmed
    ..the role of adenosine formed extracellularly in vascular homeostasis, mice with a targeted deletion of the cd73/ecto-5'-nucleotidase were generated...
  9. Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri K, Eltzschig H. Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J. 2009;23:473-82 pubmed publisher
    ..two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73)...
  10. Thompson L, Eltzschig H, Ibla J, Van De Wiele C, Resta R, Morote Garcia J, et al. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004;200:1395-405 pubmed
    ..nucleotide intermediates, and is regulated by the terminal enzymatic step catalyzed by ecto-5'-nucleotidase (CD73)...
  11. Zernecke A, Bidzhekov K, Ozüyaman B, Fraemohs L, Liehn E, Lüscher Firzlaff J, et al. CD73/ecto-5'-nucleotidase protects against vascular inflammation and neointima formation. Circulation. 2006;113:2120-7 pubmed
    Although CD73/ecto-5'-nucleotidase has been implicated in maintaining vasoprotection, its role in regulating endothelial adhesion molecule or inflammatory monocyte recruitment (eg, in the context of vascular injury) remains to be defined...
  12. Romio M, Reinbeck B, Bongardt S, Hüls S, Burghoff S, Schrader J. Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells. Am J Physiol Cell Physiol. 2011;301:C530-9 pubmed publisher
    b>CD73-derived adenosine acts as potent inhibitor of inflammation, and regulatory T cells (Treg) have been shown to express CD73 as a novel marker...
  13. Volmer J, Thompson L, Blackburn M. Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J Immunol. 2006;176:4449-58 pubmed
    ..In addition, increased activity of ecto-5'-nucleotidase (CD73) was found in the lungs in conjunction with adenosine elevations...
  14. Kobie J, Shah P, Yang L, Rebhahn J, Fowell D, Mosmann T. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol. 2006;177:6780-6 pubmed
    b>CD73 (5'-ectonucleotidase) is expressed by two distinct mouse CD4 T cell populations: CD25+ (FoxP3+) T regulatory (Treg) cells that suppress T cell proliferation but do not secrete IL-2, and CD25- uncommitted primed precursor Th (Thpp) ..
  15. Hasegawa T, Bouïs D, Liao H, Visovatti S, Pinsky D. Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy. Circ Res. 2008;103:1410-21 pubmed publisher
    Ecto-5'-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5'-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function...
  16. Martín Satué M, Lavoie E, Fausther M, Lecka J, Aliagas E, Kukulski F, et al. High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract. Histochem Cell Biol. 2010;133:659-68 pubmed publisher
    ..profile of the main enzyme responsible for the generation of adenosine from AMP, namely the ecto-5'-nucleotidase (CD73)...
  17. Thompson L, Takedachi M, Ebisuno Y, Tanaka T, Miyasaka M, Mills J, et al. Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine. Nucleosides Nucleotides Nucleic Acids. 2008;27:755-60 pubmed publisher
    b>CD73-deficient mice are valuable for evaluating the ability of CD73-generated adenosine to modulate adenosine receptor-mediated responses. Here we report the role of CD73 in regulating lymphocyte migration across two distinct barriers...
  18. Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F, et al. Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice. J Clin Invest. 2004;114:634-42 pubmed
    ..NaCl-dependent GFR regulation (tubuloglomerular feedback) in mice with targeted deletion of ecto-5'-nucleotidase/CD73 (e-5'NT/CD73), the enzyme responsible for adenosine formation from AMP...
  19. Hart M, Henn M, Kohler D, Kloor D, Mittelbronn M, Gorzolla I, et al. Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J. 2008;22:2784-97 pubmed publisher
    ..from its precursor molecule adenosine-monophosphate (AMP) through the enzyme ecto-5'-nucleotidase (CD73), we examined the contribution of CD73-dependent adenosine production in modulation of intestinal ischemia-..
  20. Ohtsuka T, Changelian P, Bouïs D, Noon K, Harada H, Lama V, et al. Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation. J Immunol. 2010;185:1321-9 pubmed publisher
    ..This study tested the hypothesis that CD73 (ecto-5'nucleotidase), an enzyme that catalyzes the conversion of AMP to adenosine, is a critical negative ..
  21. Kiss J, Yegutkin G, Koskinen K, Savunen T, Jalkanen S, Salmi M. IFN-beta protects from vascular leakage via up-regulation of CD73. Eur J Immunol. 2007;37:3334-8 pubmed
    ..mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a novel inducer of CD73...
  22. Takedachi M, Oohara H, Smith B, Iyama M, Kobashi M, Maeda K, et al. CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol. 2012;227:2622-31 pubmed publisher
    ..roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73-generated adenosine in bone tissue are largely unknown...
  23. Tsukamoto H, Chernogorova P, Ayata K, Gerlach U, Rughani A, Ritchey J, et al. Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood. 2012;119:4554-64 pubmed publisher
    ..We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5'-nucleotidase in GVHD...
  24. Algars A, Karikoski M, Yegutkin G, Stoitzner P, Niemela J, Salmi M, et al. Different role of CD73 in leukocyte trafficking via blood and lymph vessels. Blood. 2011;117:4387-93 pubmed publisher
    b>CD73 is involved in the extracellular ATP metabolism by dephosphorylating extracellular AMP to adenosine and thus regulating permeability of the blood vessels and leukocyte traffic into the tissues...
  25. Eckle T, Krahn T, Grenz A, Kohler D, Mittelbronn M, Ledent C, et al. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007;115:1581-90 pubmed
    Ecto-5'-nucleotidase (CD73)-dependent adenosine generation has been implicated in tissue protection during acute injury. Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR)...
  26. Eltzschig H, Thompson L, Karhausen J, Cotta R, Ibla J, Robson S, et al. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004;104:3986-92 pubmed
    ..CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5'-nucleotidase (CD73 converts AMP to adenosine)...
  27. Sowa N, Taylor Blake B, Zylka M. Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. J Neurosci. 2010;30:2235-44 pubmed publisher
    Ecto-5'-nucleotidase (NT5E, CD73) is a membrane-anchored protein that hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in diverse tissues but has not been directly studied in nociceptive neurons...
  28. Regateiro F, Howie D, Nolan K, Agorogiannis E, Greaves D, Cobbold S, et al. Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-?. Eur J Immunol. 2011;41:2955-65 pubmed publisher
    ..anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs)...
  29. Wang L, Fan J, Thompson L, Zhang Y, Shin T, Curiel T, et al. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest. 2011;121:2371-82 pubmed publisher
    b>CD73 is overexpressed in many types of human and mouse cancers and is implicated in the control of tumor progression. However, the specific contribution from tumor or host CD73 expression to tumor growth remains unknown to date...
  30. Stagg J, Divisekera U, Duret H, Sparwasser T, Teng M, Darcy P, et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 2011;71:2892-900 pubmed publisher
    b>CD73 is a cell-surface enzyme that suppresses immune responses by producing extracellular adenosine...
  31. Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan E, et al. Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J. 2008;22:2263-72 pubmed publisher
    ..Because ecto-5'-nucleotidase (CD73) catalyzes the terminal step in extracellular adenosine formation from AMP, we determined whether CD73 plays a role ..
  32. Mahamed D, Mills J, Egan C, Denkers E, Bynoe M. CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system. Proc Natl Acad Sci U S A. 2012;109:16312-7 pubmed publisher
    ..Here, we show that CD73(-/-) mice, which lack the ability to generate extracellular adenosine, are protected from T...
  33. Yegutkin G, Hytönen J, Samburski S, Yrjänäinen H, Jalkanen S, Viljanen M. Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice. J Immunol. 2010;184:5112-20 pubmed publisher
    ..upregulations of adenosine triphosphatase/ectonucleoside triphosphate diphosphohydrolase and ecto-5'-nucleotidase/CD73 on CD4(+)CD8(+) T lymphocytes and adenosine deaminase activity on B220(+) B lymphocytes...
  34. Huang D, Vallon V, Zimmermann H, Koszalka P, Schrader J, Osswald H. Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo. Am J Physiol Renal Physiol. 2006;291:F282-8 pubmed
    ..To test the role of extracellular formation of adenosine by ecto-5'-nucleotidase (cd73) in TGF, in regulation of GFR, and in tubular reabsorption, renal clearance and micropunture experiments were ..
  35. Alam M, Kurtz C, Rowlett R, Reuter B, Wiznerowicz E, Das S, et al. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009;199:494-504 pubmed publisher
    Regulatory T cells (known as "Treg") express apyrases (CD39) and ecto-5'-nucleotidase (CD73) and contribute to their inhibitory function by generating adenosine...
  36. Chalmin F, Mignot G, Bruchard M, Chevriaux A, Vegran F, Hichami A, et al. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity. 2012;36:362-73 pubmed publisher
    ..Here, we showed that in vitro Th17 cells generated with the cytokines IL-6 and TGF-? expressed CD39 and CD73 ectonucleotidases, leading to adenosine release and the subsequent suppression of CD4(+) and CD8(+) T cell effector ..
  37. Keller L, Kuchler Bopp S, Lesot H. Restoring physiological cell heterogeneity in the mesenchyme during tooth engineering. Int J Dev Biol. 2012;56:737-46 pubmed publisher
    ..Besides tissue oxygenation and its role in mineralization of dental matrices, vascularization is involved in the progressive increase in mesenchymal cell heterogeneity, by allowing external cells to enter the mesenchyme...
  38. Arab S, Kheshtchin N, Ajami M, Ashurpoor M, Safvati A, Namdar A, et al. Increased efficacy of a dendritic cell-based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor. Tumour Biol. 2017;39:1010428317695021 pubmed publisher
    ..In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell-based cancer vaccine...
  39. Augusto E, Matos M, Sevigny J, El Tayeb A, Bynoe M, Muller C, et al. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci. 2013;33:11390-9 pubmed publisher
    ..We now show that ecto-5'-nucleotidase (CD73), the major enzyme able to convert extracellular AMP into adenosine, colocalizes with A2ARs in the basal ganglia...
  40. Yang J, Jian R, Yu J, Zhi X, Liao X, Yu J, et al. CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation. IUBMB Life. 2015;67:853-60 pubmed publisher
    Extracellular adenosine, generated by ecto-5'-nucleotidase (CD73) via enzymatic catalyzation, has been found to facilitate atherosclerosis (AS). Thus, suppressing CD73 may attenuate AS...
  41. Li X, Zhou T, Zhi X, Zhao F, Yin L, Zhou P. Effect of hypoxia/reoxygenation on CD73 (ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines. Microvasc Res. 2006;72:48-53 pubmed
    ..A primary determinant of localized production of adenosine at tissue interfaces is ecto-5'-nucleotidase (CD73). In our experiments, we used bEnd...
  42. Fernandez P, Perez Aso M, Smith G, Wilder T, Trzaska S, Chiriboga L, et al. Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis. Am J Pathol. 2013;183:1740-1746 pubmed publisher
    ..phosphohydrolysis of released ATP by nucleoside triphosphate diphosphohydrolase (CD39) and ecto-5'-nucleotidase (CD73)...
  43. Singh A, Lester C, Drapp R, Hu D, Glimcher L, Jones D. Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties. Development. 2015;142:438-43 pubmed publisher
    ..In addition, we have used Thy1.2 and the ectonucleotidase CD73 to identify subsets within the CD9(+) population that lead to endochondral or intramembranous-like bone formation...
  44. Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, et al. Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature. 2016;538:392-396 pubmed publisher
    ..Thus, PLVAP selectively controls the exit of macrophage precursors from the fetal liver and, to our knowledge, is the first molecule identified in any organ as regulating the migratory events during embryonic macrophage ontogeny. ..
  45. Zielinski M, Taishi P, Clinton J, Krueger J. 5'-Ectonucleotidase-knockout mice lack non-REM sleep responses to sleep deprivation. Eur J Neurosci. 2012;35:1789-98 pubmed publisher
    ..1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5'-ectonuleotidase enzyme CD73. We investigated the role of CD73 in sleep regulation...
  46. Chen X, Shao H, Zhi Y, Xiao Q, Su C, Dong L, et al. CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses. Stem Cells Dev. 2016;25:337-46 pubmed publisher
    ..Here, we investigated the role of the CD73/adenosine pathway in immune modulation by MSCs using a mouse model of experimental autoimmune uveitis (EAU)...
  47. Dayton T, Gocheva V, Miller K, Israelsen W, Bhutkar A, Clish C, et al. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 2016;30:1020-33 pubmed publisher
    ..Therefore, in addition to its role in cancer metabolism, PKM2 plays a role in controlling systemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechanism. ..
  48. Wang L, Fan J, Chen S, Zhang Y, Curiel T, Zhang B. Graft-versus-host disease is enhanced by selective CD73 blockade in mice. PLoS ONE. 2013;8:e58397 pubmed publisher
    b>CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models...
  49. Sauer A, Brigida I, Carriglio N, Hernandez R, Scaramuzza S, Clavenna D, et al. Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID. Blood. 2012;119:1428-39 pubmed publisher
    ..Untreated murine ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73 ectonucleotidase machinery and limited suppressive activity via extracellular adenosine...
  50. Lu Z, Fassett J, Xu X, Hu X, Zhu G, French J, et al. Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation. 2008;118:1713-21 pubmed publisher
    ..In mice in which extracellular adenosine production was impaired by CD73 KO, TAC caused greater hypertrophy and dysfunction and increased myocardial 3'-nitrotyrosine...
  51. Ena S, De Backer J, Schiffmann S, de Kerchove d Exaerde A. FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning. J Neurosci. 2013;33:8794-809 pubmed publisher
    ..Thereby, we demonstrate that ecto-5'-nucleotidase (NT5e) is specifically expressed in STP neurons and is at the origin of most of the extracellular adenosine produced in ..
  52. Francois V, Shehade H, Acolty V, Preyat N, Delree P, Moser M, et al. Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection. Mucosal Immunol. 2015;8:773-84 pubmed publisher
    The ectonucleotidases CD39 and CD73 sequentially degrade the extracellular ATP pool and release immunosuppressive adenosine, thereby regulating inflammatory responses...
  53. D Alise A, Ergun A, Hill J, Mathis D, Benoist C. A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice. Proc Natl Acad Sci U S A. 2011;108:8737-42 pubmed publisher
    ..group of differentially expressed genes, including genes relevant for suppressive activity (Lrrc32, Ctla4, and Cd73). Many of these transcripts form a coregulated cluster in a broader analysis of T-cell differentiation...
  54. Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-94 pubmed publisher
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction. ..
  55. Rajakumar S, Lu B, Crikis S, Robson S, d Apice A, Cowan P, et al. Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury. Transplantation. 2010;90:1260-4 pubmed publisher
    ..by the ectonucleotidase CD39 and the subsequent hydrolysis of adenosine monophosphate (AMP) by the ectonucleotidase CD73. CD39 activity is protective in kidney IRI, whereas the role of CD73 remains unclear...
  56. Böring Y, Flogel U, Jacoby C, Heil M, Schaper W, Schrader J. Lack of ecto-5'-nucleotidase (CD73) promotes arteriogenesis. Cardiovasc Res. 2013;97:88-96 pubmed publisher
    ..We have previously reported that mice lacking ecto-5'-nucleotidase (CD73-/-) show enhanced monocyte adhesion to the endothelium after ischaemia, which is considered to be an important ..
  57. Forte G, Sorrentino R, Montinaro A, Luciano A, Adcock I, Maiolino P, et al. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J Immunol. 2012;189:2226-33 pubmed publisher
    b>CD73 is a cell surface enzyme that suppresses T cell-mediated immune responses by producing extracellular adenosine. Growing evidence suggests that targeting CD73 in cancer may be useful for an effective therapeutic outcome...
  58. Koszałka P, Gołuńska M, Stanisławowski M, Urban A, Stasiłojć G, Majewski M, et al. CD73 on B16F10 melanoma cells in CD73-deficient mice promotes tumor growth, angiogenesis, neovascularization, macrophage infiltration and metastasis. Int J Biochem Cell Biol. 2015;69:1-10 pubmed publisher
    Ecto-5'-nucleotidase (CD73), an enzyme providing interstitial adenosine, mediates diverse physiological and pathological responses...
  59. Tak E, Ridyard D, Kim J, Zimmerman M, Werner T, Wang X, et al. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014;25:547-63 pubmed publisher
    Nucleotide phosphohydrolysis by the ecto-5'-nucleotidase (CD73) is the main source for extracellular generation of adenosine...
  60. Flores Santibáñez F, Fernández D, Meza D, Tejón G, Vargas L, Varela Nallar L, et al. CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells. Immunology. 2015;146:582-94 pubmed publisher
    The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule...
  61. D Souza L, Gupta S, Bal V, Rath S, George A. CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent. Immunology. 2017;152:602-612 pubmed publisher
    ..Further, expression of CD73, CD80 and CD273 has allowed the categorization of B-cell memory into multiple subsets, with combinatorial ..