Nt5e

Summary

Gene Symbol: Nt5e
Description: 5' nucleotidase, ecto
Alias: 2210401F01Rik, 5'-NT, AI447961, CD73, Nt5, eNT, 5'-nucleotidase, ecto-5'-nucleotidase
Species: mouse

Top Publications

  1. ncbi Species-specific patterns of glycoprotein expression in the developing rodent caudoputamen: association of 5'-nucleotidase activity with dopamine islands and striosomes in rat, but with extrastriosomal matrix in mouse
    S W Schoen
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    J Comp Neurol 333:578-96. 1993
  2. ncbi CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 175:6458-64. 2005
  3. pmc CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
    Jeffrey H Mills
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 105:9325-30. 2008
  4. doi Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:1231-41. 2011
  5. pmc Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease
    Hiroki Tsukamoto
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 119:4554-64. 2012
  6. doi Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 135:1739-1750.e3. 2008
  7. doi Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    FASEB J 23:473-82. 2009
  8. pmc Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy
    Tomomi Hasegawa
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Res 103:1410-21. 2008
  9. pmc CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice
    Mohammad S Alam
    Digestive Health Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0708, USA
    J Infect Dis 199:494-504. 2009
  10. pmc CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system
    Deeqa A Mahamed
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 109:16312-7. 2012

Research Grants

  1. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
  2. Tolerance induction in EAE by epicutaneous immunization
    MARGARET BYNOE; Fiscal Year: 2006
  3. Regulation of EAE by skin immunization with self-peptide
    MARGARET BYNOE; Fiscal Year: 2008
  4. ADENOSINE DEAMINASE DEFICIENCY
    Linda Thompson; Fiscal Year: 2007

Scientific Experts

  • L F Thompson
  • Nancy A Louis
  • Edwin Jackson
  • Anju Singh
  • Weiqun Yu
  • A Zlomuzica
  • Mark J Wall
  • MARGARET BYNOE
  • Rafael F Zanin
  • J Stagg
  • Gennady G Yegutkin
  • Holger K Eltzschig
  • Jurgen Schrader
  • Melanie L Hart
  • Simon C Robson
  • Jurgen Schnermann
  • Florian Bönner
  • Marko Salmi
  • Long Wang
  • Sirpa Jalkanen
  • Masahide Takedachi
  • Zhongsheng Peng
  • Tobias Eckle
  • Hayo Castrop
  • Almut Grenz
  • Nathaniel A Sowa
  • Ulrich Flogel
  • Diane Bouïs
  • David J Pinsky
  • Jeffrey H Mills
  • Iris C Gorzolla
  • Jean Sevigny
  • Sean P Colgan
  • Zhongbing Lu
  • Xin Xu
  • Michael R Blackburn
  • Talya L Dayton
  • Farhad Jadidi-Niaragh
  • Michel Mittelbronn
  • Xiteng Chen
  • Pia Rantakari
  • Fernando Cartón-García
  • Dominik Eichin
  • Pavel Chrobak
  • X Hou
  • Famke Aeffner
  • Laura J Conter
  • Shilpak Chatterjee
  • Thorsten Gnad
  • Eunyoung Tak
  • James J Kobie
  • Christa E Muller
  • Ali El-Tayeb
  • Heidi Ehrentraut
  • Li Yang
  • Yang Chul Böring
  • Elisabete Augusto
  • Sabrina L Ena
  • Alma Zernecke
  • Christoph Jacoby
  • Masanori Ohta
  • Nadine Borg
  • Fanny Chalmin
  • Jie Fan
  • Bin Zhang
  • Deeqa A Mahamed
  • Boris P Klyuch
  • Cornelia Blume
  • Rongrong Jian
  • Ditte Lovatt
  • Robin Dando
  • Hiroki Tsukamoto
  • Tyler J Curiel
  • Dali Zhang
  • Yi Zhang
  • Aisha V Sauer
  • Danica Petrovic-Djergovic
  • Sandra Burghoff
  • Anna Morena D'Alise
  • Annika Algars
  • Frederico S Regateiro
  • Marion Hölscher
  • Sarah E Street
  • Gyorgy Hasko
  • Michael Romio
  • Mark J Zylka
  • Bonnie Taylor-Blake
  • C E Chadjichristos
  • Shinya Murakami
  • Jiang Fan Chen

Detail Information

Publications90

  1. ncbi Species-specific patterns of glycoprotein expression in the developing rodent caudoputamen: association of 5'-nucleotidase activity with dopamine islands and striosomes in rat, but with extrastriosomal matrix in mouse
    S W Schoen
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    J Comp Neurol 333:578-96. 1993
    ....
  2. ncbi CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 175:6458-64. 2005
    ..Using Affymetrix GeneChips followed by FACS analysis, we found that in vitro-derived Thpp cells expressed CD73 but not Ly-6A/E, whereas Th1 and Th2 cells showed the reciprocal pattern...
  3. pmc CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
    Jeffrey H Mills
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 105:9325-30. 2008
    b>CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine...
  4. doi Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:1231-41. 2011
    b>CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti-tumor immunity has not been studied...
  5. pmc Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease
    Hiroki Tsukamoto
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 119:4554-64. 2012
    ..We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5'-nucleotidase in GVHD...
  6. doi Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 135:1739-1750.e3. 2008
    ..We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP.
  7. doi Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs
    Jörg Reutershan
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    FASEB J 23:473-82. 2009
    ..two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73)...
  8. pmc Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy
    Tomomi Hasegawa
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Res 103:1410-21. 2008
    Ecto-5'-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5'-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function...
  9. pmc CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice
    Mohammad S Alam
    Digestive Health Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0708, USA
    J Infect Dis 199:494-504. 2009
    Regulatory T cells (known as "Treg") express apyrases (CD39) and ecto-5'-nucleotidase (CD73) and contribute to their inhibitory function by generating adenosine...
  10. pmc CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system
    Deeqa A Mahamed
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 109:16312-7. 2012
    ..Here, we show that CD73(-/-) mice, which lack the ability to generate extracellular adenosine, are protected from T...
  11. pmc Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center and Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:2235-44. 2010
    Ecto-5'-nucleotidase (NT5E, CD73) is a membrane-anchored protein that hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in diverse tissues but has not been directly studied in nociceptive neurons...
  12. doi Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    J Immunol 184:5112-20. 2010
    ..upregulations of adenosine triphosphatase/ectonucleoside triphosphate diphosphohydrolase and ecto-5'-nucleotidase/CD73 on CD4(+)CD8(+) T lymphocytes and adenosine deaminase activity on B220(+) B lymphocytes...
  13. doi High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract
    Mireia Martín-Satué
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, Canada
    Histochem Cell Biol 133:659-68. 2010
    ..profile of the main enzyme responsible for the generation of adenosine from AMP, namely the ecto-5'-nucleotidase (CD73)...
  14. pmc Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation
    Takashi Ohtsuka
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:1321-9. 2010
    ..This study tested the hypothesis that CD73 (ecto-5'nucleotidase), an enzyme that catalyzes the conversion of AMP to adenosine, is a critical negative ..
  15. doi Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    Fanny Chalmin
    INSERM, U866, 21000 Dijon, France
    Immunity 36:362-73. 2012
    ..Here, we showed that in vitro Th17 cells generated with the cytokines IL-6 and TGF-β expressed CD39 and CD73 ectonucleotidases, leading to adenosine release and the subsequent suppression of CD4(+) and CD8(+) T cell effector ..
  16. pmc Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine
    Linda F Thompson
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Nucleosides Nucleotides Nucleic Acids 27:755-60. 2008
    b>CD73-deficient mice are valuable for evaluating the ability of CD73-generated adenosine to modulate adenosine receptor-mediated responses. Here we report the role of CD73 in regulating lymphocyte migration across two distinct barriers...
  17. pmc Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 187:4256-67. 2011
    ..In this study, we investigated the role of the adenosine-generating ectoenzyme, ecto-5'-nucleotidase (CD73), in regulating immune and organ function during sepsis...
  18. doi CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis
    John Stagg
    Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 71:2892-900. 2011
    b>CD73 is a cell-surface enzyme that suppresses immune responses by producing extracellular adenosine...
  19. doi Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    Annika Algars
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 117:4387-93. 2011
    b>CD73 is involved in the extracellular ATP metabolism by dephosphorylating extracellular AMP to adenosine and thus regulating permeability of the blood vessels and leukocyte traffic into the tissues...
  20. pmc Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor
    Melanie L Hart
    Department of Anesthesiology and Critical Care Medicine, Tubingen University Hospital, D 72074 Tubingen, Germany
    J Immunol 186:4367-74. 2011
    ..factor (HIF)-1-elicited enhancement of extracellular adenosine production via ecto-5'-nucleotidase (CD73) and signaling through the A2B adenosine receptor (A2BAR), we targeted HIF-1 during IR using pharmacological or ..
  21. pmc CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
    Long Wang
    Cancer Therapy and Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Clin Invest 121:2371-82. 2011
    b>CD73 is overexpressed in many types of human and mouse cancers and is implicated in the control of tumor progression. However, the specific contribution from tumor or host CD73 expression to tumor growth remains unknown to date...
  22. pmc CD73-generated adenosine promotes osteoblast differentiation
    Masahide Takedachi
    Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 227:2622-31. 2012
    ..roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73-generated adenosine in bone tissue are largely unknown...
  23. doi Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells
    Michael Romio
    Department of Cardiovascular Physiology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Am J Physiol Cell Physiol 301:C530-9. 2011
    b>CD73-derived adenosine acts as potent inhibitor of inflammation, and regulatory T cells (Treg) have been shown to express CD73 as a novel marker...
  24. doi Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β
    Frederico S Regateiro
    Sir William Dunn School of Pathology, University of Oxford, UK
    Eur J Immunol 41:2955-65. 2011
    ..anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs)...
  25. pmc Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 114:634-42. 2004
    ..NaCl-dependent GFR regulation (tubuloglomerular feedback) in mice with targeted deletion of ecto-5'-nucleotidase/CD73 (e-5'NT/CD73), the enzyme responsible for adenosine formation from AMP...
  26. ncbi CD73/ecto-5'-nucleotidase protects against vascular inflammation and neointima formation
    Alma Zernecke
    Institute of Molecular Cardiovascular Research, Rheinisch Westfälische Technisch Hochschule, Aachen, Germany
    Circulation 113:2120-7. 2006
    Although CD73/ecto-5'-nucleotidase has been implicated in maintaining vasoprotection, its role in regulating endothelial adhesion molecule or inflammatory monocyte recruitment (eg, in the context of vascular injury) remains to be defined.
  27. ncbi Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury
    Jonathan B Volmer
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, 77030, USA
    J Immunol 176:4449-58. 2006
    ..In addition, increased activity of ecto-5'-nucleotidase (CD73) was found in the lungs in conjunction with adenosine elevations...
  28. ncbi T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
    b>CD73 (5'-ectonucleotidase) is expressed by two distinct mouse CD4 T cell populations: CD25+ (FoxP3+) T regulatory (Treg) cells that suppress T cell proliferation but do not secrete IL-2, and CD25- uncommitted primed precursor Th (Thpp) ..
  29. ncbi Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007
    Ecto-5'-nucleotidase (CD73)-dependent adenosine generation has been implicated in tissue protection during acute injury. Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR)...
  30. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
    ..We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells...
  31. pmc Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia
    Linda F Thompson
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    J Exp Med 200:1395-405. 2004
    ..nucleotide intermediates, and is regulated by the terminal enzymatic step catalyzed by ecto-5'-nucleotidase (CD73)...
  32. ncbi IFN-beta protects from vascular leakage via up-regulation of CD73
    Jan Kiss
    MediCity Research Laboratory, University of Turku, Department of Medical Microbiology, and Turku University Hospital, Department of Surgery, Finland
    Eur J Immunol 37:3334-8. 2007
    ..mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a novel inducer of CD73...
  33. ncbi Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response
    Patrycja Koszalka
    Department of Cardiovascular Physiology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Circ Res 95:814-21. 2004
    ..the role of adenosine formed extracellularly in vascular homeostasis, mice with a targeted deletion of the cd73/ecto-5'-nucleotidase were generated...
  34. ncbi Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
    Holger K Eltzschig
    Brigham and Women s Hospital, Harvard Medical School, Thorn Building 704, 75 Francis Street, Boston, MA 02115, USA
    Blood 104:3986-92. 2004
    ..CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5'-nucleotidase (CD73 converts AMP to adenosine)...
  35. doi Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
    Zhongsheng Peng
    Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    FASEB J 22:2263-72. 2008
    ..Because ecto-5'-nucleotidase (CD73) catalyzes the terminal step in extracellular adenosine formation from AMP, we determined whether CD73 plays a role ..
  36. ncbi Control of IFN-alphaA by CD73: implications for mucosal inflammation
    Nancy A Louis
    Neonatology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:4246-55. 2008
    ..Ecto-5'-nucleotidase (CD73) is a central surface enzyme generating extracellular adenosine...
  37. pmc Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 22:2784-97. 2008
    ..from its precursor molecule adenosine-monophosphate (AMP) through the enzyme ecto-5'-nucleotidase (CD73), we examined the contribution of CD73-dependent adenosine production in modulation of intestinal ischemia-..
  38. ncbi Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo
    Dan Yang Huang
    Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Am J Physiol Renal Physiol 291:F282-8. 2006
    ..To test the role of extracellular formation of adenosine by ecto-5'-nucleotidase (cd73) in TGF, in regulation of GFR, and in tubular reabsorption, renal clearance and micropunture experiments were ..
  39. pmc Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
    Talya L Dayton
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 30:1020-33. 2016
    ..Therefore, in addition to its role in cancer metabolism, PKM2 plays a role in controlling systemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechanism...
  40. pmc Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury
    Famke Aeffner
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio
    Am J Physiol Lung Cell Mol Physiol 309:L1313-22. 2015
    ..Because AMP hydrolysis by the ecto-5'-nucleotidase (CD73) plays a central role in and is rate-limiting for generation of adenosine in the normal lung, we hypothesized that ..
  41. doi CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses
    Xiteng Chen
    1 Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry and Ophthalmology, Tianjin, China
    Stem Cells Dev 25:337-46. 2016
    ..Here, we investigated the role of the CD73/adenosine pathway in immune modulation by MSCs using a mouse model of experimental autoimmune uveitis (EAU)...
  42. doi Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Tumour Biol 37:8403-12. 2016
    ..be secreted by both tumor and immune cells trough action of two cell surface ecto-nucleotidase molecules CD39 and CD73. Blocking the adenosine generating molecules has emerged as an effective immunotherapeutic approach for treatment ..
  43. doi CD73 plays a protective role in collagen-induced arthritis
    Pavel Chrobak
    Centre de Recherche du Centre Hospitalier l Université de Montréal, Faculté de Pharmacie de l Université de Montréal et Institut du Cancer de Montréal, Montreal, Quebec H2X 0A9, Canada and
    J Immunol 194:2487-92. 2015
    ..come from two sources: transport of intracellular adenosine and hydrolysis of extracellular adenine nucleotides by CD73. In this study, we investigated the susceptibility of CD73-deficient C57BL/6 mice to collagen-induced arthritis (..
  44. pmc CD73 Activity is Dispensable for the Polarization of M2 Macrophages
    Dominik Eichin
    MediCity Research Laboratory, University of Turku, Turku, Finland
    PLoS ONE 10:e0134721. 2015
    The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine...
  45. pmc Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury
    Cornelia Blume
    Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e37100. 2012
    Extracellular adenosine formed by 5'-ectonucleotidase (CD73) is involved in tubulo-glomerular feedback in the kidney but is also known to be an important immune modulator...
  46. pmc Myo5b knockout mice as a model of microvillus inclusion disease
    Fernando Cartón-García
    1 Group of Molecular Oncology, CIBBIM Nanomedicine, Vall d Hebron University Hospital Research Institute VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain 2 CIBER de Bioingeniería, Biomateriales y Nanomedicina CIBER BBN, Zaragoza, Spain
    Sci Rep 5:12312. 2015
    ....
  47. pmc CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury
    Heidi Ehrentraut
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    FASEB J 27:2207-19. 2013
    ..Similarly, genetic deletion of cd73, the pacemaker for extracellular adenosine generation, was associated with increased mortality (0% wild-type and 40%..
  48. doi Ecto-5'-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines
    X Hou
    Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Neuroscience 297:118-26. 2015
    ..Ecto-5'-nucleotidase (CD73), which dephosphorylates AMP to adenosine, is considered to catalyze the rate-limiting step in the generation of ..
  49. pmc CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy
    Eunyoung Tak
    Department of Anesthesiology
    J Am Soc Nephrol 25:547-63. 2014
    Nucleotide phosphohydrolysis by the ecto-5'-nucleotidase (CD73) is the main source for extracellular generation of adenosine...
  50. pmc CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence
    Laura J Conter
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 9:e92009. 2014
    b>CD73 catalyzes the conversion of extracellular nucleosides to adenosine, modulating inflammatory and T cell responses...
  51. pmc Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors
    Shilpak Chatterjee
    Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina
    Cancer Res 74:6048-59. 2014
    ..protocols for ex vivo programming of Th17 cells, which include TGFβ exposure, increase the expression of CD39 and CD73, two cell surface ATP ectonucleotidases that reduce T-cell effector functions and promote immunosuppression...
  52. doi Fetal liver endothelium regulates the seeding of tissue-resident macrophages
    Pia Rantakari
    MediCity Research Laboratory, University of Turku, Turku, FI 20520, Finland
    Nature 538:392-396. 2016
    ..Thus, PLVAP selectively controls the exit of macrophage precursors from the fetal liver and, to our knowledge, is the first molecule identified in any organ as regulating the migratory events during embryonic macrophage ontogeny...
  53. doi Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
    Thorsten Gnad
    Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Nature 516:395-9. 2014
    ..Those findings reveal new possibilities for developing novel obesity therapies...
  54. pmc PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine
    Sarah E Street
    Department of Cell and Molecular Physiology, University of North Carolina, CB 7545, Chapel Hill, North Carolina 27599, USA
    Mol Pain 7:80. 2011
    Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ..
  55. pmc Adenosine enhances sweet taste through A2B receptors in the taste bud
    Robin Dando
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 32:322-30. 2012
    ..Adenosine is generated during taste stimulation mainly by the action of the ecto-5'-nucleotidase, NT5E, and to a lesser extent, prostatic acid phosphatase...
  56. doi Lack of ecto-5'-nucleotidase (CD73) promotes arteriogenesis
    Yang Chul Böring
    Department of Molecular Cardiology, Heinrich Heine University of Dusseldorf, Moorenstr 5, Dusseldorf 40225, Germany
    Cardiovasc Res 97:88-96. 2013
    ..We have previously reported that mice lacking ecto-5'-nucleotidase (CD73-/-) show enhanced monocyte adhesion to the endothelium after ischaemia, which is considered to be an important ..
  57. pmc Tissue-resident ecto-5' nucleotidase (CD73) regulates leukocyte trafficking in the ischemic brain
    Danica Petrovic-Djergovic
    Center for Clinical and Translational Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Immunol 188:2387-98. 2012
    Ectoenzymes expressed on the surface of vascular cells and leukocytes modulate the ambient nucleotide milieu. CD73 is an ecto-5' nucleotidase that catalyzes the terminal phosphohydrolysis of AMP and resides in the brain on glial cells, ..
  58. doi Ecto-5'-nucleotidase on immune cells protects from adverse cardiac remodeling
    Florian Bönner
    Department of Molecular Cardiology, Heinrich Heine University Dusseldorf, Germany
    Circ Res 113:301-12. 2013
    Ecto-5'-nucleotidase (CD73) on immune cells is emerging as a critical pathway and therapeutic target in cardiovascular and autoimmune disorders.
  59. doi Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release
    Boris P Klyuch
    School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Neurosci 32:3842-7. 2012
    ..Here, we have used mice that lack the CD73 gene (encoding ecto-5'-nucleotidase that converts AMP to adenosine) to test whether action potential-dependent ..
  60. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
    ..We report here that multiple enzymes degrade extracellular ATP in brain tissue, whereas only Nt5e degrades AMP to adenosine...
  61. doi CD73-deficient mice are resistant to carcinogenesis
    John Stagg
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 72:2190-6. 2012
    b>CD73 is a cell surface 5'-nucleotidase that converts AMP to adenosine, an immune suppressive molecule...
  62. pmc Graft-versus-host disease is enhanced by selective CD73 blockade in mice
    Long Wang
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 8:e58397. 2013
    b>CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models...
  63. pmc Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase
    Masanori Ohta
    Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Arterioscler Thromb Vasc Biol 33:629-36. 2013
    ..Cell surface ecto-5'-nucleotidase (CD73) rapidly dephosphorylates extracellular adenosine 5'-monophosphate to adenosine...
  64. doi FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning
    Sabrina L Ena
    Laboratory of Neurophysiology, ULB Neuroscience Institute, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    J Neurosci 33:8794-809. 2013
    ..Thereby, we demonstrate that ecto-5'-nucleotidase (NT5e) is specifically expressed in STP neurons and is at the origin of most of the extracellular adenosine produced in ..
  65. pmc Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73
    Dali Zhang
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 7:e39772. 2012
    ..The present study was performed to test the importance of CD73 (ecto-5'-nucleotidase) for basal and hypoxic/ischemic adenosine production...
  66. pmc Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury
    Florian Bönner
    Department of Molecular Cardiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 7:e34730. 2012
    The ectoenzymes CD39 and CD73 are expressed by a broad range of immune cells and promote the extracellular degradation of nucleotides to anti-inflammatory adenosine...
  67. pmc Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions
    Elisabete Augusto
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    J Neurosci 33:11390-9. 2013
    ..We now show that ecto-5'-nucleotidase (CD73), the major enzyme able to convert extracellular AMP into adenosine, colocalizes with A2ARs in the basal ganglia...
  68. pmc Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase
    Rafael Fernandes Zanin
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil
    PLoS ONE 7:e31205. 2012
    ..such as members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family and ecto-5'-nucleotidase/CD73 (ecto-5'-NT)...
  69. doi CD73 protects kidney from ischemia-reperfusion injury through reduction of free radicals
    Rongrong Jian
    Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, China
    APMIS 120:130-8. 2012
    ..Extracellular adenosine is anti-inflammatory especially during hypoxemia. As ecto-5'-nucleotidase (CD73) is the rate-limiting enzyme for extracellular adenosine generation, it may protect renal IRI through adenosine ..
  70. pmc Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID
    Aisha V Sauer
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan, Italy
    Blood 119:1428-39. 2012
    ..Untreated murine ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73 ectonucleotidase machinery and limited suppressive activity via extracellular adenosine...
  71. pmc CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes
    Masahide Takedachi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 180:6288-96. 2008
    ..In this study, we show that CD73 (ecto-5'-nucleotidase) plays an important role in regulating this process...
  72. doi Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice
    Mona Oppermann
    National Institute of Digestive and Diabetes and Kidney Diseases, National Institute of Health, 10 Center Drive MSC 1370, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 294:F965-70. 2008
    ....
  73. pmc Ecto-5'-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction
    Xin Xu
    Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hypertension 51:1557-64. 2008
    ..was performed on mice deficient in extracellular adenosine production as the result of genetic deletion of CD73. Although there was no difference in left ventricular size or function between CD73-deficient mice (knockout [KO] ..
  74. ncbi Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB
    L R Berkemeier
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080
    Neuron 7:857-66. 1991
    ..Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections...
  75. ncbi Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Center for Biomedical Research, Tubingen University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Immunol 178:8127-37. 2007
    ..Because ectoapyrase (CD39) and ecto-5'-nucleotidase (CD73) are rate limiting for extracellular adenosine generation, we examined their contribution to ALI...
  76. ncbi Effect of hypoxia/reoxygenation on CD73 (ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines
    Xiaobo Li
    Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China
    Microvasc Res 72:48-53. 2006
    ..A primary determinant of localized production of adenosine at tissue interfaces is ecto-5'-nucleotidase (CD73). In our experiments, we used bEnd...
  77. ncbi Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice
    Y Tsuji
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 50:1455-63. 2001
    ....
  78. ncbi Murine ecto-5'-nucleotidase (CD73): cDNA cloning and tissue distribution
    R Resta
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104
    Gene 133:171-7. 1993
    ..Messenger RNA levels were in general proportional to enzyme activity, except in the lung and glandular stomach where mRNA levels were higher than expected, based on enzyme activity.(ABSTRACT TRUNCATED AT 250 WORDS)..
  79. ncbi Distribution of 5'-nucleotidase in the developing mouse retina
    N Braun
    Biozentrum der J W Goethe Universität, AK Neurochemie, Zoologisches Institut, Frankfurt am Main, Germany
    Brain Res Dev Brain Res 88:79-86. 1995
    ..Müller cells thus share not only functional characteristics of astrocytes and oligodendrocytes, as previously revealed, but also of ependymal cells to which they are closely related...
  80. pmc Extracellular cAMP-adenosine pathways in the mouse kidney
    Edwin K Jackson
    Dept of Pharmacology and Chemical Biology, Univ of Pittsburgh School of Medicine, PA 15219, USA
    Am J Physiol Renal Physiol 301:F565-73. 2011
    ..0071), but it did not increase 3',5'-cAMP secretion. The 2',3'-cAMP-adenosine pathway was quantitatively similar in CD73 -/- vs. +/+ kidneys. However, 3',5'-cAMP induced a 6...
  81. doi Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
    Pflugers Arch 457:431-40. 2008
    Adenosine is formed from extracellular purines by ecto-5'-nucleotidase (CD73) and is an essential player in allergic airway inflammation...
  82. pmc Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle
    Zhongbing Lu
    Center for Vascular Biology, University of Minnesota, Minneapolis, MN 55455, USA
    Circulation 118:1713-21. 2008
    ..Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known...
  83. pmc PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases
    Thomas Weissmüller
    Division of Gastroenterology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    J Clin Invest 118:3682-92. 2008
    ..ATP, which was metabolized to adenosine via a 2-step enzymatic reaction mediated by ecto-nucleotidases, including CD73 and ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases), expressed on the apical membrane of the ..
  84. pmc Adenosine signaling contributes to ethanol-induced fatty liver in mice
    Zhongsheng Peng
    New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Clin Invest 119:582-94. 2009
    ....
  85. doi Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
    C E Chadjichristos
    Division of Cardiology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Circulation 121:123-31. 2010
    ..The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease...
  86. doi Changes in expression and activity levels of ecto-5'-nucleotidase/CD73 along the mouse female estrous cycle
    E Aliagas
    Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona IDIBELL, Barcelona, Spain
    Acta Physiol (Oxf) 199:191-7. 2010
    ..Cell Biol.131, 2009, 615). The purpose of the present study was to characterize in this system the expression profile of ecto-5'-nucleotidase (CD73), the enzyme generating adenosine from AMP.
  87. pmc Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts
    Carmen Methner
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    Am J Physiol Heart Circ Physiol 299:H1262-4. 2010
    ..5'-Ectonucleotidase (CD73) is thought to be necessary for the production of adenosine during ischemia...
  88. doi Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury
    Siddharth V Rajakumar
    Immunology Research Centre, St Vincent s Hospital, Melbourne, Victoria, Australia
    Transplantation 90:1260-4. 2010
    ..and adenosine diphosphate by the ectonucleotidase CD39 and the subsequent hydrolysis of adenosine monophosphate (AMP) by the ectonucleotidase CD73. CD39 activity is protective in kidney IRI, whereas the role of CD73 remains unclear.
  89. pmc Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
    Marion Hölscher
    Department of Cardiovascular Physiology, Universitatsmedizin Gottingen, Georg August University Gottingen, Gottingen, Germany
    J Biol Chem 286:11185-94. 2011
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction...
  90. pmc A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice
    Anna Morena D'Alise
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:8737-42. 2011
    ..group of differentially expressed genes, including genes relevant for suppressive activity (Lrrc32, Ctla4, and Cd73). Many of these transcripts form a coregulated cluster in a broader analysis of T-cell differentiation...

Research Grants4

  1. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  2. Tolerance induction in EAE by epicutaneous immunization
    MARGARET BYNOE; Fiscal Year: 2006
    ..Finally, we will carry out experiments to test whether epicutaneous immunization with autoantigenic peptides is capable of ameliorating EAE. ..
  3. Regulation of EAE by skin immunization with self-peptide
    MARGARET BYNOE; Fiscal Year: 2008
    ..These studies will serve to advance our knowledge of autoimmune disease regulation both at the peripheral level and at the CNS level and could be beneficial to MS and other autoimmune diseases. ..
  4. ADENOSINE DEAMINASE DEFICIENCY
    Linda Thompson; Fiscal Year: 2007
    ..Our data will contribute to the growing knowledge base needed to understand and control the vulnerability of the developing human immune system to environmental threats and infectious agents. ..