Gene Symbol: Nrxn3
Description: neurexin III
Alias: neurexin 3, neurexin-3-alpha
Species: mouse
Products:     Nrxn3

Top Publications

  1. Dudanova I, Tabuchi K, Rohlmann A, Sudhof T, Missler M. Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation. J Comp Neurol. 2007;502:261-74 pubmed
    ..Therefore, alpha-neurexins are not essential for the formation of the vast majority of synapses in vivo but rather regulate the function of these synapses. ..
  2. Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer R, Gottmann K, et al. Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003;423:939-48 pubmed
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery. ..
  3. Missler M, Hammer R, Sudhof T. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998;273:34716-23 pubmed
    ..The results support the notion that neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. ..
  4. Ushkaryov Y, Hata Y, Ichtchenko K, Moomaw C, Afendis S, Slaughter C, et al. Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins. J Biol Chem. 1994;269:11987-92 pubmed
    ..Thus, beta-neurexins are essentially N terminally truncated alpha-neurexins. ..
  5. Mao C, Cho J, Wang J, Gao Z, Pan P, Tsai W, et al. Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development. 2013;140:541-51 pubmed publisher
    ..Additionally, ChIP-Seq analysis identified an Atoh7-dependent enhancer within the intronic region of Nrxn3. The enhancer recognized and used Atoh7 in the developing retina to regulate expression of Nrxn3, but could be ..
  6. Uemura T, Lee S, Yasumura M, Takeuchi T, Yoshida T, Ra M, et al. Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell. 2010;141:1068-79 pubmed publisher
    ..These results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1. ..
  7. Lim S, Kwon S, Lee M, Moon J, Jeong D, Park E, et al. Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn. EMBO J. 2009;28:3564-78 pubmed publisher
  8. Kolozsi E, MacKenzie R, Roullet F, deCatanzaro D, Foster J. Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice. Neuroscience. 2009;163:1201-10 pubmed publisher examine expression of three NLGN genes (NLGN1, NLGN2, and NLGN3) and three NRXN genes (NRXN1, NRXN2, and NRXN3). Expression levels of NLGN1, NLGN2, NRXN1, NRXN2, and NRXN3 were observed to be similar in VPA and control mice...
  9. Dudanova I, Sedej S, Ahmad M, Masius H, Sargsyan V, Zhang W, et al. Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci. 2006;26:10599-613 pubmed
    ..Our data support a general and essential role for alpha-neurexins in Ca2+-triggered exocytosis that is similarly important for secretion from neurons and endocrine cells. ..

More Information


  1. Tabuchi K, Sudhof T. Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics. 2002;79:849-59 pubmed
    ..Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing. ..
  2. Puschel A, Betz H. Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995;15:2849-56 pubmed
    ..These expression profiles are consistent with the hypothesis that the neurexins have a function in early neuronal differentiation and axogenesis. ..
  3. Sons M, Busche N, Strenzke N, Moser T, Ernsberger U, Mooren F, et al. alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction. Neuroscience. 2006;138:433-46 pubmed
    ..Our data suggest that alpha-neurexins are required for efficient neurotransmitter release at neuromuscular junctions, and that they may perform a role in the molecular mechanism of synaptic homeostasis at these peripheral synapses. ..
  4. Harrington A, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, et al. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. elife. 2016;5: pubmed publisher
  5. Geppert M, Khvotchev M, Krasnoperov V, Goda Y, Missler M, Hammer R, et al. Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem. 1998;273:1705-10 pubmed
  6. Andres C, Beeri R, Friedman A, Lev Lehman E, Henis S, Timberg R, et al. Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration. Proc Natl Acad Sci U S A. 1997;94:8173-8 pubmed
  7. Brown S, Clapcote S, Millar J, Torrance H, Anderson S, Walker R, et al. Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry. 2011;16:585-7 pubmed publisher
  8. Chen L, Jiang M, Zhang B, Gokce O, Südhof T. Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron. 2017;94:611-625.e4 pubmed publisher
    ..Thus, neurexins function primarily as context-dependent specifiers of synapses. ..
  9. Sato Y, Suzuki S, Iijima Y, Iijima T. Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures. Biochem Biophys Res Commun. 2017;493:1030-1036 pubmed publisher
    ..Furthermore, Nrxn3 is responsible for the NL-induced assembly of GABAergic synapses in co-culture...
  10. Anderson G, Aoto J, Tabuchi K, Földy C, Covy J, Yee A, et al. β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015;162:593-606 pubmed publisher
  11. Aoto J, Földy C, Ilcus S, Tabuchi K, Südhof T. Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nat Neurosci. 2015;18:997-1007 pubmed publisher
    ..Thus, our data indicate that neurexin-3 performs distinct essential pre- or postsynaptic functions in different brain regions by distinct mechanisms. ..
  12. Aoto J, Martinelli D, Malenka R, Tabuchi K, Sudhof T. Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell. 2013;154:75-88 pubmed publisher
  13. Kelai S, Maussion G, Noble F, Boni C, Ramoz N, Moalic J, et al. Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction. Neuroreport. 2008;19:751-5 pubmed publisher
    ..Human NRXN3 has recently been linked to several addictions...
  14. Missler M, Sudhof T. Neurexins: three genes and 1001 products. Trends Genet. 1998;14:20-6 pubmed
    ..This review describes the properties of the neurexin protein family and their potential roles in neuronal cell adhesion and intercellular signaling. ..
  15. Dachtler J, Glasper J, Cohen R, Ivorra J, Swiffen D, Jackson A, et al. Deletion of α-neurexin II results in autism-related behaviors in mice. Transl Psychiatry. 2014;4:e484 pubmed publisher
    ..Our findings demonstrate a causal role for the loss of Nrxn2α in the genesis of autism-related behaviors in mice. ..
  16. Kattenstroth G, Tantalaki E, Sudhof T, Gottmann K, Missler M. Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proc Natl Acad Sci U S A. 2004;101:2607-12 pubmed
    ..Our data suggest that, in addition to the previously described presynaptic impairments, loss of alpha-neurexins induces postsynaptic changes by a cell-autonomous mechanism. ..