Nrp1

Summary

Gene Symbol: Nrp1
Description: neuropilin 1
Alias: C530029I03, NP-1, NPN-1, Npn1, Nrp, A5 protein, Neuropilin-1 precursor (A5 protein), neuropilin-1, transmembrane receptor
Species: mouse

Top Publications

  1. ncbi Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis
    Masae Morishima
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 228:95-104. 2003
  2. ncbi Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
  3. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
  4. ncbi Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification
    Quenten Schwarz
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 106:6164-9. 2009
  5. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
  6. ncbi Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
  7. ncbi Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Blood 114:3707-16. 2009
  8. ncbi Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Neuron 59:733-45. 2008
  9. ncbi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
  10. ncbi Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
    Anna Salikhova
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 103:e71-9. 2008

Research Grants

  1. Role of Glypicans in HGF Mediated Cell Morphogenesis
    Anil Karihaloo; Fiscal Year: 2006
  2. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2007
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
  4. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
  5. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis
    Masae Morishima
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 228:95-104. 2003
    ..The latter function is likely related to the known role of the Endothelin-1 pathway in neural crest function...
  2. ncbi Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..those that promote the angiogenic switch in cancer, including the expression of the cell-surface proteins TIE2 and NRP1. Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could ..
  3. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..Neuropilin-1 (Nrp-1) is a transmembrane receptor with a repulsive function in axon guidance...
  4. ncbi Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification
    Quenten Schwarz
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 106:6164-9. 2009
    ..Here we show that the repulsive guidance cue SEMA3A and its receptor neuropilin 1 (NRP1) are essential to direct the intermediate wave NCC precursors of peripheral neurons from a default ..
  5. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
    ..Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries...
  6. ncbi Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
    ..of somata and axons of the facial nerve is regulated independently by two secreted ligands for the transmembrane receptor neuropilin 1 (Nrp1), the semaphorin Sema3A and the VEGF164 isoform of Vascular Endothelial Growth Factor...
  7. ncbi Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Blood 114:3707-16. 2009
    ..Expression of Flk1 and Neuropilin-1 (NRP1), which form a selective and sensitive receptor for VEGF(165), was increased only in CA-PKA-expressing progenitors, ..
  8. ncbi Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Neuron 59:733-45. 2008
    ..Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells...
  9. ncbi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
    ..In this study, we show how to distinguish between genetic defects caused by targeted inactivation of the neuropilin 1 (Nrp1) receptor and hemodynamic defects occurring in homozygous knockout embryos...
  10. ncbi Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
    Anna Salikhova
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 103:e71-9. 2008
    The neuropilin (Nrp)1 receptor is essential for both nervous and vascular system development. Nrp1 is unusually versatile, because it transmits both chemoattractive and repulsive signals in response to vascular endothelial growth factor (..
  11. ncbi Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  12. ncbi Higher mortality in heterozygous neuropilin-1 mice after cardiac pressure overload
    Fei Li
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 370:317-21. 2008
    ..Furthermore, we found that NP-1 formed complexes with VEGFR1 and VEGFR2, respectively, in cardiomyocytes. These findings suggest that NP-1 should play beneficial role in heart failure...
  13. ncbi Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
    Qi Pan
    Tumor Biology and Angiogenesis, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cancer Cell 11:53-67. 2007
    Neuropilin-1 (NRP1) guides the development of the nervous and vascular systems. Binding to either semaphorins or VEGF, NRP1 acts with plexins to regulate neuronal guidance, or with VEGFR2 to mediate vascular development...
  14. ncbi Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression
    Thomas Cimato
    National Human Genome Research Institute, and National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Circulation 119:2170-8. 2009
    ..The objective of our study was to identify a single population of endothelial precursors with common identifying features from both human and murine embryonic stem cells...
  15. ncbi VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  16. ncbi Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ..Here, we found that in two rat models of liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs, which exhibit the highly motile myofibroblast phenotype...
  17. ncbi Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London, UK
    Hum Mol Genet 20:336-44. 2011
    ..Strikingly, mice lacking SEMA3A or semaphorin signalling through both NRP1 and NRP2 recapitulate the anatomical features of a single case of KS analysed so far, and may therefore be used as ..
  18. ncbi Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
    ..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
  19. ncbi Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns
    Corinna Haupt
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
    Eur J Neurosci 31:1164-72. 2010
    ..Thus, Sema3A-Npn-1 signaling plays an important role in the guidance and fasciculation of motor and sensory axons but does not contribute to the developmental elimination of these neurons...
  20. ncbi Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons
    Susan X Jiang
    Experimental NeuroTherapeutics Laboratory, National Research Council NRC Institute for Biological Sciences, NRC Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 285:9908-18. 2010
    ..The interaction of Sema3A/NRP1 during development leads to the collapse of growth cones...
  21. ncbi VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm
    Lynda Erskine
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Neuron 70:951-65. 2011
    ..By combining genetic analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projection in mammals...
  22. ncbi Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    Nat Med 5:495-502. 1999
  23. ncbi Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
    Claudia Prahst
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
    J Biol Chem 283:25110-4. 2008
    ..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...
  24. ncbi VEGF expression and receptor activation in the choroid during development and in the adult
    Magali Saint-Geniez
    Schepens Eye Research Institute, The Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3135-42. 2006
    ....
  25. ncbi Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
    Chenghua Gu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Science 307:265-8. 2005
    ..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning...
  26. ncbi Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  27. ncbi Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice
    Sachie Hiratsuka
    Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 25:346-54. 2005
    ..These results strongly suggest that the membrane-fixed ligand-binding region of VEGFR1 traps VEGF for the appropriate regulation of VEGF signaling in vascular endothelial cells during early embryogenesis...
  28. ncbi Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
    R J Giger
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 25:29-41. 2000
    ..Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections...
  29. ncbi Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
    Yoh suke Mukouyama
    Division of Biology 216 76, California Institute of Technology, 1201 E California Boulevard, Pasadena, CA 91125, USA
    Development 132:941-52. 2005
    ..Arteriogenesis also requires endothelial expression of NRP1, an artery-specific coreceptor for VEGF(164) that is itself induced by VEGF...
  30. ncbi Dual functional activity of semaphorin 3B is required for positioning the anterior commissure
    Julien Falk
    NMDA, UMR CNRS 6156, Institut de Biologie du Developpement de Marseille, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France
    Neuron 48:63-75. 2005
    ....
  31. ncbi Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability
    Patrice M Becker
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 96:1257-65. 2005
    ..complexes in VEGF-induced endothelial barrier dysfunction, endothelial cells were stably transfected with Npn1 or VEGFR2 alone (PAE/Npn and PAE/KDR, respectively), or VEGFR2 and Npn-1 (PAE/KDR/Npn-1)...
  32. ncbi Pre-target axon sorting establishes the neural map topography
    Takeshi Imai
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Science 325:585-90. 2009
    ..Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons...
  33. ncbi Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation
    Catherine Corbel
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Comp Immunol 31:1082-94. 2007
    b>Neuropilin 1 (NP1) is a receptor for both semaphorin and vascular endothelial growth factor expressed by subpopulations of neuronal and endothelial cells. In the immune system, NP1 is present on dendritic and regulatory T cells...
  34. ncbi Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum
    Michael Piper
    Queensland Brain Institute, The University of Queensland, Queensland, Australia
    Cereb Cortex 19:i11-21. 2009
    ..We demonstrate that neuropilin 1 (Npn1) plays an integral role in the development of the CC...
  35. ncbi Advanced glycation end products suppress neuropilin-1 expression in podocytes by a reduction in Sp1-dependent transcriptional activity
    Tzvetanka Bondeva
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Am J Nephrol 30:336-45. 2009
    Neuropilin-1 (NRP1) is a transmembrane glycoprotein, initially defined as a receptor for members of the semaphorin family...
  36. ncbi Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons
    Yumiko Hatanaka
    Department of Molecular Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Comp Neurol 514:215-25. 2009
    ..Here we examined the role of neuropilin 1 (NRP1) in these developmental events...
  37. ncbi Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells
    Donatella Valdembri
    Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    PLoS Biol 7:e25. 2009
    b>Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A)...
  38. ncbi Advanced glycation end-products suppress neuropilin-1 expression in podocytes
    Tzvetanka Bondeva
    Klinik fur Innere Medizin III, Friedrich Schiller University, Jena, Germany
    Kidney Int 75:605-16. 2009
    ..The decreased migration could lead to adherence of uncovered areas of the glomerular basement membrane to Bowman's capsule contributing to focal glomerulosclerosis...
  39. ncbi Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema
    Anne Le
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 180:396-406. 2009
    ..Cigarette smoke (CS) exposure is an important risk factor for chronic obstructive pulmonary disease; however, not all smokers develop disease, suggesting that other factors influence disease development...
  40. ncbi C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    Tambet Teesalu
    Vascular Mapping Center, The Burnham Institute for Medical Research at University of California, Santa Barbara, CA 93106 9610, USA
    Proc Natl Acad Sci U S A 106:16157-62. 2009
    ..Affinity chromatography showed that the CendR peptides bind to neuropilin-1 (NRP-1) on the target cells...
  41. ncbi Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
    Emma J Gordon
    Division of Haematology, The Hanson Institute, Adelaide, South Australia, Australia
    Dev Dyn 237:1901-9. 2008
    ..Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels...
  42. ncbi Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity
    Yelena Glinka
    Department of Laboratory Medicine, St Michael s Hospital, 30 Bond Street, Room 2 013CC, Toronto, Ontario, Canada M5B 1W8
    J Leukoc Biol 84:302-10. 2008
    Neuropilin-1 (Nrp1) is a multifunctional protein, identified principally as a receptor for the class 3 semaphorins and members of the vascular endothelial growth factor (VEGF) family, but it is capable of other interactions...
  43. ncbi Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
    Milka Sarris
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Immunity 28:402-13. 2008
    ..We found that Neuropilin-1 (Nrp-1), which is expressed by most Treg cells but not naive Th cells, promoted prolonged interactions with immature DCs ..
  44. ncbi Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development
    Sophie Chauvet
    Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Neuron 56:807-22. 2007
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
  45. ncbi Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance
    Fumikazu Suto
    Division of Developmental Genetics, National Institute of Genetics, Mishima 411 8540, Japan
    J Neurosci 25:3628-37. 2005
    ..Our results imply that plexin-A4 mediates multiple semaphorin signals and regulates axon guidance in vivo...
  46. ncbi Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1
    Mireille Rossignol
    Institute of Signaling, Developmental Biology, and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
    J Cell Biochem 88:744-57. 2003
    Neuropilin-1 (NRP1) is a receptor for the vascular endothelial growth factor (VEGF) family of angiogenesis factors and for the semaphorin family of secreted neuronal guidance polypeptides...
  47. ncbi The basic helix-loop-helix transcription factor, dHAND, is required for vascular development
    H Yamagishi
    Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 105:261-70. 2000
    ..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway...
  48. ncbi Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation
    J B Halder
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Genesis 26:213-24. 2000
    ..Recent evidence suggests that neuropilin-1 (NRP1), a receptor involved in neuronal cell guidance, is expressed in endothelial cells, binds to VEGF(165) and enhances ..
  49. ncbi Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Japan
    Exp Neurol 182:103-12. 2003
    ..1-deficient mice, the abnormal crossing of ascending DA axons observed may be attributed to the elimination of these chemorepulsive signals in the medial part of the mutant hypothalamus...
  50. ncbi Neuropilin-1 participates in wound angiogenesis
    Annette M Matthies
    Burn and Shock Trauma Institute and the Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Am J Pathol 160:289-96. 2002
    ..These results provide both in vitro and in vivo evidence for a critical role of neuropilin-1 in wound angiogenesis...
  51. ncbi Determination of cell adhesion sites of neuropilin-1
    M Shimizu
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, USA
    J Cell Biol 148:1283-93. 2000
    ..In addition, we demonstrated that the cell adhesion ligands for neuropilin-1 were proteins and distributed in embryonic mesenchymal cells but distinct from the class 3 semaphorins, VEGF, or plexins...
  52. ncbi Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs
    T Kitsukawa
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    Development 121:4309-18. 1995
    ..Correct spatiotemporal expression of neuropilin seems to be essential for normal development of the cardiovascular system, nervous system and limbs...
  53. ncbi Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
    Hideyasu Oh
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 99:383-8. 2002
    ..In the present study, we first show that VEGF selectively up-regulates NRP1 but not NRP2 via the VEGF receptor 2-dependent pathway...
  54. ncbi Semaphorin 3A is required for guidance of olfactory axons in mice
    G A Schwarting
    The Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 20:7691-7. 2000
    ..These observations indicate that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB...
  55. ncbi A requirement for neuropilin-1 in embryonic vessel formation
    T Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 126:4895-902. 1999
    ..The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance...
  56. ncbi Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney
    Guillermo Villegas
    Department of Pediatrics Nephrology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mech Dev 119:S149-53. 2002
    ..Their expression pattern and function outside the nervous system are unknown. Neuropilin 1 and 2 (NP-1, NP-2) are natural ligands for semaphorins 3A and 3F, respectively...
  57. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
    ..These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons...
  58. ncbi Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1
    T Makinen
    Molecular Cancer Biology Laboratory, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 274:21217-22. 1999
    ..In this study, we show that both splice isoforms of VEGF-B bind specifically to Neuropilin-1 (NRP1), a receptor for collapsins/semaphorins and for the VEGF(165) isoform...
  59. ncbi Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections
    D Bagnard
    INSERM Unité 371 Cerveau et Vision, 69500 Bron, France
    Development 125:5043-53. 1998
    ..The coordinated expression of different semaphorins, together with their specific activities on cortical axons, suggests that multiple guidance signals contribute to the formation of precise corticofugal pathways...
  60. ncbi The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
    Andreas Fischer
    Theodor Boveri Institut für Biowissenschaften Biozentrum, Physiologische Chemie I, Universitat Wurzburg, 97074 Wurzburg, Germany
    Genes Dev 18:901-11. 2004
    ..This indicates that Hey1/Hey2 are essential transducers of Notch signals in cardiovascular development that may mediate arterial cell fate decision...
  61. ncbi Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract
    Y Sato
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurosci 18:7800-10. 1998
    ..Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons...
  62. ncbi Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
    Seiji Takashima
    Department of Internal Medicine and Therapeutics, Department of Nutrition and Physiological Chemistry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 99:3657-62. 2002
    ..Their abnormal vascular phenotype resembled those of VEGF and VEGFR-2 knockouts. These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required...
  63. ncbi Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon
    Amanda G Wright
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:13667-79. 2007
    ..between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections...
  64. ncbi Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis
    Y Yamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, University School of Medicine, Kumamoto, Japan
    Blood 97:1671-8. 2001
    b>Neuropilin 1 (NP-1) is a receptor for vascular endothelial growth factor (VEGF) 165 (VEGF165) and acts as a coreceptor that enhances VEGF165 function through tyrosine kinase VEGF receptor 2 (VEGFR-2)...
  65. ncbi Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1
    Anna Gualandris
    Department of Oncological Sciences, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, 10060, Candiolo TO, Italy
    FASEB J 23:68-78. 2009
    ..discrete, nonclonal cell population expressing the two vascular endothelial growth factor receptors neuropilin-1 (Nrp1) and Flk1 that differentiates in vitro toward endothelial or neural phenotypes depending on microenvironmental cues...
  66. ncbi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  67. ncbi HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  68. ncbi A molecular analysis of matrix remodeling and angiogenesis during long bone development
    C I Colnot
    Department of Orthopedic Surgery, University of California at San Francisco, CA 94143 0514, USA
    Mech Dev 100:245-50. 2001
    ..Here, we have produced a 'molecular map' of the initial vascularization of the developing skeleton that provides a framework in which to interpret a wide range of fetal skeletal malformations, disruptions, and dysplasias...
  69. ncbi Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity...
  70. ncbi The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain
    Guoxin Ying
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 29:3045-61. 2009
    ..These results demonstrate that the protocadherin Celsr3 gene is essential for both tangential and radial interneuron migrations in a class-specific manner...
  71. ncbi Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation
    Julaine Roffers-Agarwal
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 136:1879-88. 2009
    ..We now expand these results to show that Nrp2 patterns initial motor axon outgrowth as well. Later, Nrp1/Sema3A signaling is essential for segmental dorsal root gangliogenesis and motor axonal fasciculation into ventral ..
  72. ncbi Soluble neuropilin targeted to the skin inhibits vascular permeability
    Roni Mamluk
    Vascular Biology Program, Children s Hospital and Harvard Medical School, Karp Family Research Building, Boston, Massachusetts 02115, USA
    Angiogenesis 8:217-27. 2005
    b>Neuropilin 1 (NRP1) is a co-receptor for vascular endothelial growth factor (VEGF(165)), an inducer of vascular permeability and angiogenesis...
  73. ncbi Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    Jin Sun Kong
    The Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:179-90. 2010
    ..To delineate the role of neuropilin-1 (NP-1), a vascular endothelial growth factor receptor (VEGFR), in rheumatoid inflammation and to determine whether blockade of NP-1 could suppress synoviocyte survival and angiogenesis...
  74. ncbi Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system
    A Kawakami
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    J Neurobiol 29:1-17. 1996
    ..These observations suggest that neuropilin is involved in growth, fasciculation, and targeting for a particular groups of axons...
  75. ncbi Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Mech Dev 97:35-45. 2000
    ..These results provide evidence that Sema3A inhibits branching morphogenesis in lung bud organ cultures via NP-1 as a receptor or a component of a possible multimeric Sema3A receptor complex...
  76. ncbi Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system
    Takahiko Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:671-80. 2002
    b>Neuropilin 1 is the specific receptor for Sema3A and plays a role in nerve fiber guidance...
  77. ncbi The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    ..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
  78. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  79. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  80. ncbi Selective requirements for NRP1 ligands during neurovascular patterning
    Joaquim Miguel Vieira
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 134:1833-43. 2007
    ..The transmembrane protein NRP1 is present on blood vessels and nerves...
  81. ncbi Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  82. ncbi Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2
    Trung N Le
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Biol Chem 282:19071-81. 2007
    ..However, the molecular basis for these defects downstream of loss of Dlx1/Dlx2 function is unknown. Neuropilin-2 (NRP-2) is a receptor for Class III semaphorins, which inhibit neuronal migration...
  83. ncbi The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Dev Biol 294:458-70. 2006
    ..Taken together, our results demonstrate that Foxc transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development...
  84. ncbi Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1
    Hong Zhang
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Curr Biol 13:1625-9. 2003
    ..The contribution of PlGF toward stromal signals that regulate epithelial differentiation suggests novel functions for a growth factor previously implicated in reactive angiogenesis...
  85. ncbi The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    ..Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis...
  86. ncbi Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  87. ncbi Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme
    Paivi Kettunen
    Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Development 132:323-34. 2005
    ..By analyzing Sema3a and its receptor Npn1 knockout mouse embryos, we found that Sema3a regulates dental trigeminal axon navigation and patterning, as well as ..
  88. ncbi Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling
    Heike Beck
    Institute of Neurology Edinger Institute, JWG University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:339-50. 2002
    ..Possibly, the loss of semaphorins facilitates binding of the competing ligands (VEGF/PLGF), thus inducing angiogenesis. In addition, the observed expression patterns further suggest a neurotrophic/neuroprotective role of VEGF/PLGF...
  89. ncbi Semaphorin-3A guides radial migration of cortical neurons during development
    Gang Chen
    Institute of Neuroscience and Key State Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Shanghai, China
    Nat Neurosci 11:36-44. 2008
    ..In addition, transwell chemotaxis assays show that isolated newborn neurons are attracted by Sema3A. Thus, Sema3A may function as a chemoattractive guidance signal for the radial migration of newborn cortical neurons toward upper layers...
  90. ncbi Semaphorin3a inhibits ureteric bud branching morphogenesis
    Alda Tufro
    Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer Building, Room 708, Bronx, NY 10461, USA
    Mech Dev 125:558-68. 2008
    ..Collectively, these data suggest that Sema3a is an endogenous antagonist of ureteric bud branching and hence, plays a role in patterning the renal collecting system as a negative regulator...
  91. ncbi Plexin-A4 negatively regulates T lymphocyte responses
    Midori Yamamoto
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Int Immunol 20:413-20. 2008
    ..Collectively, these results suggest that plexin-A4, as a component of the receptor complex for class III semaphorins, negatively regulates T cell-mediated immune responses...
  92. ncbi Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
    Quenten Schwarz
    Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Development 135:1605-13. 2008
    ..receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting ..
  93. ncbi Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse
    Joaquim Miguel Vieira
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V9EL, UK
    Novartis Found Symp 283:230-5; discussion 235-41. 2007
    ..identified as a repulsive cue for developing axons that acts by signalling through receptor complexes containing NRP1 and A-type plexins...
  94. ncbi Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons
    Jean François Cloutier
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 33:877-92. 2002
    ..Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system...
  95. ncbi Role of semaphorin III in the developing rodent trigeminal system
    E Ulupinar
    Department of Cell Biology and Anatomy and Neuroscience Center, LSU Medical Center, New Orleans, Louisiana, USA
    Mol Cell Neurosci 13:281-92. 1999
    ..Other molecular and cellular mechanisms must act in concert with semaphorins in ensuring target recognition, topographic order of projections, and patterning of neural connections...
  96. ncbi Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage
    C Lillesaar
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Neuroscience 125:149-61. 2004
    ..We conclude that developing mandibular/dental mesenchyme can inhibit/repel neurite growth in vitro. Our results support the hypothesis that semaphorins may be involved in this interaction...
  97. ncbi Semaphorins III and IV repel hippocampal axons via two distinct receptors
    A Chedotal
    INSERM U106, Hopital de la Salpetriere, France
    Development 125:4313-23. 1998
    ..Thus, chemorepulsion plays a role in axon guidance in the hippocampus, secreted semaphorins are likely to be responsible for this action, and the same axons can be repelled by two distinct semaphorins via two different receptors...
  98. ncbi Coordinated functions of Netrin-1 and Class 3 secreted Semaphorins in the guidance of reciprocal septohippocampal connections
    Marta Pascual
    Department of Cell Biology, University of Barcelona, and IRBB Barcelona Science Park, Barcelona 08028, Spain
    Mol Cell Neurosci 26:24-33. 2004
    ....
  99. ncbi Chronotopic organization of olfactory bulb axons in the lateral olfactory tract
    Hitoshi Yamatani
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    J Comp Neurol 475:247-60. 2004
    ....
  100. ncbi Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 99:59-69. 1999
    ..Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes...

Research Grants10

  1. Role of Glypicans in HGF Mediated Cell Morphogenesis
    Anil Karihaloo; Fiscal Year: 2006
    ..These specific aims are designed to hopefully lead to a better understanding of the role of Gpc expression during kidney development vis-a-vis HGF. ..
  2. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2007
    ..Understanding basic mechanisms contributing to the development of pulmonary edema in ARDS may suggest novel therapeutic strategies for managing critically ill patients with this disorder. ..
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
    ..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
  4. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
    ....
  5. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2009
    ..Understanding basic mechanisms contributing to the development of pulmonary edema in ARDS may suggest novel therapeutic strategies for managing critically ill patients with this disorder. ..