Nrp1

Summary

Gene Symbol: Nrp1
Description: neuropilin 1
Alias: C530029I03, NP-1, NPN-1, Npn1, Nrp, A5 protein, Neuropilin-1 precursor (A5 protein), neuropilin-1, transmembrane receptor
Species: mouse

Top Publications

  1. ncbi Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis
    Masae Morishima
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 228:95-104. 2003
  2. pmc Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    Mahesh Yadav
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94122, USA
    J Exp Med 209:1713-22, S1-19. 2012
  3. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
  4. ncbi Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
  5. pmc Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
    Milka Sarris
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Immunity 28:402-13. 2008
  6. ncbi Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    T Kitsukawa
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    Neuron 19:995-1005. 1997
  7. pmc VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 138:3723-33. 2011
  8. doi Pre-target axon sorting establishes the neural map topography
    Takeshi Imai
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Science 325:585-90. 2009
  9. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
  10. pmc Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity
    Yelena Glinka
    Department of Laboratory Medicine, St Michael s Hospital, 30 Bond Street, Room 2 013CC, Toronto, Ontario, Canada M5B 1W8
    J Leukoc Biol 84:302-10. 2008

Research Grants

  1. Role of Glypicans in HGF Mediated Cell Morphogenesis
    Anil Karihaloo; Fiscal Year: 2006
  2. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2007
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
  4. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
  5. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications137 found, 100 shown here

  1. ncbi Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis
    Masae Morishima
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 228:95-104. 2003
    ..The latter function is likely related to the known role of the Endothelin-1 pathway in neural crest function...
  2. pmc Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    Mahesh Yadav
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94122, USA
    J Exp Med 209:1713-22, S1-19. 2012
    ..self-antigen specificity and conventional mouse models, we demonstrate that a cell surface molecule, neuropilin-1 (Nrp-1), is expressed at high levels on nT reg cells and can be used to separate nT reg versus iT reg cells in certain ..
  3. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
    ..We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other ..
  4. ncbi Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  5. pmc Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
    Milka Sarris
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Immunity 28:402-13. 2008
    ..We found that Neuropilin-1 (Nrp-1), which is expressed by most Treg cells but not naive Th cells, promoted prolonged interactions with immature DCs ..
  6. ncbi Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    T Kitsukawa
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    Neuron 19:995-1005. 1997
    ..Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents...
  7. pmc VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 138:3723-33. 2011
    ..We previously reported that the class 3 semaphorin SEMA3A signals through its neuropilin receptors, NRP1 and NRP2, to organise the axons that guide migrating GnRH neurons from their birthplace into the brain...
  8. doi Pre-target axon sorting establishes the neural map topography
    Takeshi Imai
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Science 325:585-90. 2009
    ..Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons...
  9. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..those that promote the angiogenic switch in cancer, including the expression of the cell-surface proteins TIE2 and NRP1. Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could ..
  10. pmc Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity
    Yelena Glinka
    Department of Laboratory Medicine, St Michael s Hospital, 30 Bond Street, Room 2 013CC, Toronto, Ontario, Canada M5B 1W8
    J Leukoc Biol 84:302-10. 2008
    Neuropilin-1 (Nrp1) is a multifunctional protein, identified principally as a receptor for the class 3 semaphorins and members of the vascular endothelial growth factor (VEGF) family, but it is capable of other interactions...
  11. ncbi Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 99:59-69. 1999
    ..Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes...
  12. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
    ..Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries...
  13. ncbi Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
    Qi Pan
    Tumor Biology and Angiogenesis, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cancer Cell 11:53-67. 2007
    Neuropilin-1 (NRP1) guides the development of the nervous and vascular systems. Binding to either semaphorins or VEGF, NRP1 acts with plexins to regulate neuronal guidance, or with VEGFR2 to mediate vascular development...
  14. ncbi Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  15. pmc VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm
    Lynda Erskine
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Neuron 70:951-65. 2011
    ..By combining genetic analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projection in mammals...
  16. ncbi Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
    R J Giger
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 25:29-41. 2000
    ..Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections...
  17. doi Osteoprotection by semaphorin 3A
    Mikihito Hayashi
    Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nature 485:69-74. 2012
    ..The binding of Sema3A to neuropilin-1 (Nrp1) inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation by inhibiting ..
  18. doi Neuropilin-1 expression in cancer and development
    Adrian M Jubb
    Department of Pathology, Genentech Inc, South San Francisco, CA 94080, USA
    J Pathol 226:50-60. 2012
    ..Preclinical data suggest that blockade of NRP1 suppresses tumour growth by inhibiting angiogenesis, in addition to directly inhibiting tumour cell proliferation ..
  19. pmc C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    Tambet Teesalu
    Vascular Mapping Center, The Burnham Institute for Medical Research at University of California, Santa Barbara, CA 93106 9610, USA
    Proc Natl Acad Sci U S A 106:16157-62. 2009
    ..Affinity chromatography showed that the CendR peptides bind to neuropilin-1 (NRP-1) on the target cells...
  20. doi IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression
    Pierre Milpied
    Centre National de la Recherche Scientifique, Universite Paris Descartes, Paris, France
    Blood 118:2993-3002. 2011
    ..In the present study, we show that neuropilin-1 (Nrp-1), a transmembrane receptor mainly found on T-regulatory (Treg) cells in the murine immune system, is specifically expressed on RTE ..
  21. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..Neuropilin-1 (Nrp-1) is a transmembrane receptor with a repulsive function in axon guidance...
  22. pmc VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  23. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  24. doi Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London, UK
    Hum Mol Genet 20:336-44. 2011
    ..Strikingly, mice lacking SEMA3A or semaphorin signalling through both NRP1 and NRP2 recapitulate the anatomical features of a single case of KS analysed so far, and may therefore be used as ..
  25. pmc Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis
    Benjamin D Solomon
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:2040-5. 2011
    Neuropilin-1 (Nrp1) is a cell surface molecule originally identified for its role in neuronal development...
  26. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..beta3 integrin can regulate negatively VEGF-mediated angiogenesis by limiting the interaction of the co-receptor NRP1 (neuropilin-1) with VEGFR2...
  27. pmc Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia
    Quenten Schwarz
    Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Development 136:1785-9. 2009
    ..Specifically, SEMA3A/NRP1 signalling first directs one population of NCCs from the intersomitic path into the sclerotome, and SEMA3F/NRP2 ..
  28. doi Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    Jin Sun Kong
    The Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:179-90. 2010
    ..To delineate the role of neuropilin-1 (NP-1), a vascular endothelial growth factor receptor (VEGFR), in rheumatoid inflammation and to determine whether blockade of NP-1 could suppress synoviocyte survival and angiogenesis...
  29. pmc Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1
    Kakali Dhar
    Cancer Research Unit, VA Medical Center, 4801 Linwood Blvd, Kansas City, Missouri 64128, USA
    Mol Cancer 9:209. 2010
    ..This study focuses on the role of human tumor cells in governing the differentiation of mouse mesenchymal stem cells (MSCs) to pericytes and their recruitment in the tumor angiogenesis process...
  30. doi Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling
    Mathieu Berge
    Institut des Vaisseaux et du Sang, Hopital Lariboisiere, Universite Paris 7, France
    J Hepatol 55:866-75. 2011
    Neuropilin-1 (NRP1) is a transmembrane co-receptor for semaphorins and heparin-binding pro-angiogenic cytokines, principally members of the vascular endothelial growth factor family...
  31. doi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
    ..In this study, we show how to distinguish between genetic defects caused by targeted inactivation of the neuropilin 1 (Nrp1) receptor and hemodynamic defects occurring in homozygous knockout embryos...
  32. pmc Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth
    Wiebke Hansen
    Institute of Medical Microbiology, University Hospital Essen, University Duisburg Essen, 45122 Essen, Germany
    J Exp Med 209:2001-16. 2012
    ..We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3(+) T reg cells, regulates the immunological anti-tumor control by guiding T ..
  33. doi Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation
    Yelena Glinka
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, ON, Canada M5B 1W8
    Biochem Biophys Res Commun 425:775-80. 2012
    ..We also examined the role of neuropilin-1 (Nrp1), which is a growth factor coreceptor linked to the tumorigenicity of some CSCs...
  34. ncbi Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions
    O Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143, USA
    Science 293:872-5. 2001
    ....
  35. pmc Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype
    Ying Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 285:31840-8. 2010
    ..Recently, neuropilin-1 (NRP-1) was reported to bind and activate the latent form of TGF-β1 (LAP-TGF-β1)...
  36. pmc Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
    ..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
  37. pmc Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
    Seiji Takashima
    Department of Internal Medicine and Therapeutics, Department of Nutrition and Physiological Chemistry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 99:3657-62. 2002
    ..Their abnormal vascular phenotype resembled those of VEGF and VEGFR-2 knockouts. These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required...
  38. ncbi Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis
    M Kagoshima
    Department of Pharmacology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Genes Cells 6:559-71. 2001
    ..Sema3A inhibits branching morphogenesis of embryonic lung in organ culture...
  39. ncbi Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system
    A Kawakami
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    J Neurobiol 29:1-17. 1996
    ..These observations suggest that neuropilin is involved in growth, fasciculation, and targeting for a particular groups of axons...
  40. ncbi A requirement for neuropilin-1 in embryonic vessel formation
    T Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 126:4895-902. 1999
    ..The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance...
  41. ncbi Adenylyl cyclase-dependent axonal targeting in the olfactory system
    Julien A Dal Col
    Department of Zoology and Animal Biology, and NCCR Frontiers in Genetics, University of Geneva, Geneva, Switzerland
    Development 134:2481-9. 2007
    ..Moreover, the cyclase depletion leads to the prevention of neuropilin 1 (Nrp1) expression in olfactory sensory neuron axonal projections...
  42. pmc Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
    ..of somata and axons of the facial nerve is regulated independently by two secreted ligands for the transmembrane receptor neuropilin 1 (Nrp1), the semaphorin Sema3A and the VEGF164 isoform of Vascular Endothelial Growth Factor...
  43. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
    ..These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons...
  44. ncbi Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
    Chenghua Gu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Science 307:265-8. 2005
    ..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning...
  45. pmc Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development
    Quenten Schwarz
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Dev Biol 324:1-9. 2008
    ..Loss of either SEMA3A/NRP1 or SEMA3F/NRP2 caused defasciculation and ectopic projection of facial branchiomotor axons...
  46. doi Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
    Emma J Gordon
    Division of Haematology, The Hanson Institute, Adelaide, South Australia, Australia
    Dev Dyn 237:1901-9. 2008
    ..Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels...
  47. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ..Here, we found that in two rat models of liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs, which exhibit the highly motile myofibroblast phenotype...
  48. pmc Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Neuron 59:733-45. 2008
    ..Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells...
  49. doi Semaphorin-3A and its receptor neuropilin-1 are predominantly expressed in endothelial cells along the rostral migratory stream of young and adult mice
    Esperanza Meléndez-Herrera
    Departamento de Biologia Celular y Fisiologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, D F, Mexico
    Cell Tissue Res 333:175-84. 2008
    ..Moreover, the present work outlines the potential role of blood vessels on neuroblast migration in the postnatal rostral migratory stream...
  50. doi Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1
    Anna Gualandris
    Department of Oncological Sciences, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, 10060, Candiolo TO, Italy
    FASEB J 23:68-78. 2009
    ..discrete, nonclonal cell population expressing the two vascular endothelial growth factor receptors neuropilin-1 (Nrp1) and Flk1 that differentiates in vitro toward endothelial or neural phenotypes depending on microenvironmental cues...
  51. ncbi Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance
    Fumikazu Suto
    Division of Developmental Genetics, National Institute of Genetics, Mishima 411 8540, Japan
    J Neurosci 25:3628-37. 2005
    ..Our results imply that plexin-A4 mediates multiple semaphorin signals and regulates axon guidance in vivo...
  52. pmc The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Development 138:4185-91. 2011
    b>Neuropilin 1 (NRP1) is a transmembrane glycoprotein that is essential for blood vessel development in vertebrates...
  53. pmc Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation
    Karine Bouvrée
    CIRB Collège de France CNRS UMR 7241 INSERM U1050, Paris, France
    Circ Res 111:437-45. 2012
    ..Defective formation of lymphatic valves leads to lymphedema, a progressive and debilitating condition for which curative treatments are currently unavailable. How lymphatic valve formation is regulated remains largely unknown...
  54. doi The influence of neuropilin-1 silencing on semaphorin 3A and 3C activity in B16(F10) murine melanoma cells
    A M Mazurek
    Maria Sklodowska Curie Memorial Cancer Center, Gliwice, Poland
    Neoplasma 59:43-51. 2012
    Neuropilin-1 (Nrp1), originally characterized as an adhesion molecule in the nervous system, is a co-receptor for class-3 semaphorins...
  55. ncbi Neuropilin-1 on hematopoietic cells as a source of vascular development
    Yoshihiro Yamada
    Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 101:1801-9. 2003
    ..In NP-1-/- embryos, vascular sprouting is impaired at the central nervous system (CNS) and pericardium where VEGF is not abundant, indicating that NP-1-expressing cells are required for normal vascular development...
  56. pmc Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment
    Usman Yaqoob
    Gastroenterology Research Unit and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 72:4047-59. 2012
    ..Here, we report that neuropilin-1 (NRP-1) orchestrates communications between myofibroblasts and soluble fibronectin that promote α5β1 integrin-..
  57. pmc Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression
    Thomas Cimato
    National Human Genome Research Institute, and National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Circulation 119:2170-8. 2009
    ..The objective of our study was to identify a single population of endothelial precursors with common identifying features from both human and murine embryonic stem cells...
  58. pmc Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
    Anna Salikhova
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 103:e71-9. 2008
    The neuropilin (Nrp)1 receptor is essential for both nervous and vascular system development. Nrp1 is unusually versatile, because it transmits both chemoattractive and repulsive signals in response to vascular endothelial growth factor (..
  59. doi Higher mortality in heterozygous neuropilin-1 mice after cardiac pressure overload
    Fei Li
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 370:317-21. 2008
    ..Furthermore, we found that NP-1 formed complexes with VEGFR1 and VEGFR2, respectively, in cardiomyocytes. These findings suggest that NP-1 should play beneficial role in heart failure...
  60. doi Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns
    Corinna Haupt
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
    Eur J Neurosci 31:1164-72. 2010
    ..Thus, Sema3A-Npn-1 signaling plays an important role in the guidance and fasciculation of motor and sensory axons but does not contribute to the developmental elimination of these neurons...
  61. pmc Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons
    Susan X Jiang
    Experimental NeuroTherapeutics Laboratory, National Research Council NRC Institute for Biological Sciences, NRC Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 285:9908-18. 2010
    ..The interaction of Sema3A/NRP1 during development leads to the collapse of growth cones...
  62. ncbi VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  63. pmc FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse
    Ahmad Bechara
    Universite de Lyon, Centre de Génétique Moléculaire et Cellulaire UMR CNRS 5534, Villeurbanne, France
    EMBO J 27:1549-62. 2008
    ..In the developing cerebral cortex, the Ig superfamily cell adhesion molecule L1 associates with Nrp1. Intriguingly, the genetic removal of L1 blocks axon responses of cortical neurons to Sema3A in vitro despite the ..
  64. ncbi Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
    Yoh suke Mukouyama
    Division of Biology 216 76, California Institute of Technology, 1201 E California Boulevard, Pasadena, CA 91125, USA
    Development 132:941-52. 2005
    ..Arteriogenesis also requires endothelial expression of NRP1, an artery-specific coreceptor for VEGF(164) that is itself induced by VEGF...
  65. ncbi Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Mech Dev 97:35-45. 2000
    ..These results provide evidence that Sema3A inhibits branching morphogenesis in lung bud organ cultures via NP-1 as a receptor or a component of a possible multimeric Sema3A receptor complex...
  66. ncbi Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    Nat Med 5:495-502. 1999
  67. doi Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Blood 114:3707-16. 2009
    ..Expression of Flk1 and Neuropilin-1 (NRP1), which form a selective and sensitive receptor for VEGF(165), was increased only in CA-PKA-expressing progenitors, ..
  68. pmc Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification
    Quenten Schwarz
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 106:6164-9. 2009
    ..Here we show that the repulsive guidance cue SEMA3A and its receptor neuropilin 1 (NRP1) are essential to direct the intermediate wave NCC precursors of peripheral neurons from a default ..
  69. pmc Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
    Quenten Schwarz
    Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Development 135:1605-13. 2008
    ..receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting ..
  70. pmc Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum
    Michael Piper
    Queensland Brain Institute, The University of Queensland, Queensland, Australia
    Cereb Cortex 19:i11-21. 2009
    ..We demonstrate that neuropilin 1 (Npn1) plays an integral role in the development of the CC...
  71. pmc Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema
    Anne Le
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 180:396-406. 2009
    ..Cigarette smoke (CS) exposure is an important risk factor for chronic obstructive pulmonary disease; however, not all smokers develop disease, suggesting that other factors influence disease development...
  72. doi Advanced glycation end products suppress neuropilin-1 expression in podocytes by a reduction in Sp1-dependent transcriptional activity
    Tzvetanka Bondeva
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Am J Nephrol 30:336-45. 2009
    Neuropilin-1 (NRP1) is a transmembrane glycoprotein, initially defined as a receptor for members of the semaphorin family...
  73. doi Advanced glycation end-products suppress neuropilin-1 expression in podocytes
    Tzvetanka Bondeva
    Klinik fur Innere Medizin III, Friedrich Schiller University, Jena, Germany
    Kidney Int 75:605-16. 2009
    ..The decreased migration could lead to adherence of uncovered areas of the glomerular basement membrane to Bowman's capsule contributing to focal glomerulosclerosis...
  74. pmc Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
    Claudia Prahst
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
    J Biol Chem 283:25110-4. 2008
    ..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...
  75. pmc Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells
    Donatella Valdembri
    Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    PLoS Biol 7:e25. 2009
    b>Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A)...
  76. doi Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons
    Yumiko Hatanaka
    Department of Molecular Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Comp Neurol 514:215-25. 2009
    ..Here we examined the role of neuropilin 1 (NRP1) in these developmental events...
  77. ncbi Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract
    Y Sato
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurosci 18:7800-10. 1998
    ..Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons...
  78. ncbi Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability
    Patrice M Becker
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 96:1257-65. 2005
    ..complexes in VEGF-induced endothelial barrier dysfunction, endothelial cells were stably transfected with Npn1 or VEGFR2 alone (PAE/Npn and PAE/KDR, respectively), or VEGFR2 and Npn-1 (PAE/KDR/Npn-1)...
  79. pmc Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice
    Sachie Hiratsuka
    Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 25:346-54. 2005
    ..These results strongly suggest that the membrane-fixed ligand-binding region of VEGFR1 traps VEGF for the appropriate regulation of VEGF signaling in vascular endothelial cells during early embryogenesis...
  80. ncbi Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Japan
    Exp Neurol 182:103-12. 2003
    ..1-deficient mice, the abnormal crossing of ascending DA axons observed may be attributed to the elimination of these chemorepulsive signals in the medial part of the mutant hypothalamus...
  81. pmc The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
    Andreas Fischer
    Theodor Boveri Institut für Biowissenschaften Biozentrum, Physiologische Chemie I, Universitat Wurzburg, 97074 Wurzburg, Germany
    Genes Dev 18:901-11. 2004
    ..This indicates that Hey1/Hey2 are essential transducers of Notch signals in cardiovascular development that may mediate arterial cell fate decision...
  82. ncbi Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney
    Guillermo Villegas
    Department of Pediatrics Nephrology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mech Dev 119:S149-53. 2002
    ..Their expression pattern and function outside the nervous system are unknown. Neuropilin 1 and 2 (NP-1, NP-2) are natural ligands for semaphorins 3A and 3F, respectively...
  83. ncbi Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1
    Mireille Rossignol
    Institute of Signaling, Developmental Biology, and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
    J Cell Biochem 88:744-57. 2003
    Neuropilin-1 (NRP1) is a receptor for the vascular endothelial growth factor (VEGF) family of angiogenesis factors and for the semaphorin family of secreted neuronal guidance polypeptides...
  84. ncbi Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs
    T Kitsukawa
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    Development 121:4309-18. 1995
    ..Correct spatiotemporal expression of neuropilin seems to be essential for normal development of the cardiovascular system, nervous system and limbs...
  85. pmc Neuropilin-1 participates in wound angiogenesis
    Annette M Matthies
    Burn and Shock Trauma Institute and the Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Am J Pathol 160:289-96. 2002
    ..These results provide both in vitro and in vivo evidence for a critical role of neuropilin-1 in wound angiogenesis...
  86. pmc Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
    Hideyasu Oh
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 99:383-8. 2002
    ..In the present study, we first show that VEGF selectively up-regulates NRP1 but not NRP2 via the VEGF receptor 2-dependent pathway...
  87. ncbi Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation
    J B Halder
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Genesis 26:213-24. 2000
    ..Recent evidence suggests that neuropilin-1 (NRP1), a receptor involved in neuronal cell guidance, is expressed in endothelial cells, binds to VEGF(165) and enhances ..
  88. pmc The basic helix-loop-helix transcription factor, dHAND, is required for vascular development
    H Yamagishi
    Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 105:261-70. 2000
    ..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway...
  89. ncbi Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1
    T Makinen
    Molecular Cancer Biology Laboratory, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 274:21217-22. 1999
    ..In this study, we show that both splice isoforms of VEGF-B bind specifically to Neuropilin-1 (NRP1), a receptor for collapsins/semaphorins and for the VEGF(165) isoform...
  90. ncbi Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections
    D Bagnard
    INSERM Unité 371 Cerveau et Vision, 69500 Bron, France
    Development 125:5043-53. 1998
    ..The coordinated expression of different semaphorins, together with their specific activities on cortical axons, suggests that multiple guidance signals contribute to the formation of precise corticofugal pathways...
  91. ncbi Dual functional activity of semaphorin 3B is required for positioning the anterior commissure
    Julien Falk
    NMDA, UMR CNRS 6156, Institut de Biologie du Developpement de Marseille, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France
    Neuron 48:63-75. 2005
    ....
  92. ncbi VEGF expression and receptor activation in the choroid during development and in the adult
    Magali Saint-Geniez
    Schepens Eye Research Institute, The Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3135-42. 2006
    ....
  93. ncbi Semaphorin 3A is required for guidance of olfactory axons in mice
    G A Schwarting
    The Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 20:7691-7. 2000
    ..These observations indicate that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB...
  94. ncbi Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon
    Amanda G Wright
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:13667-79. 2007
    ..between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections...
  95. ncbi Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation
    Catherine Corbel
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Comp Immunol 31:1082-94. 2007
    b>Neuropilin 1 (NP1) is a receptor for both semaphorin and vascular endothelial growth factor expressed by subpopulations of neuronal and endothelial cells. In the immune system, NP1 is present on dendritic and regulatory T cells...
  96. pmc Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development
    Sophie Chauvet
    Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Neuron 56:807-22. 2007
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
  97. pmc Determination of cell adhesion sites of neuropilin-1
    M Shimizu
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, USA
    J Cell Biol 148:1283-93. 2000
    ..In addition, we demonstrated that the cell adhesion ligands for neuropilin-1 were proteins and distributed in embryonic mesenchymal cells but distinct from the class 3 semaphorins, VEGF, or plexins...
  98. ncbi Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  99. ncbi Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system
    Takahiko Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:671-80. 2002
    b>Neuropilin 1 is the specific receptor for Sema3A and plays a role in nerve fiber guidance...
  100. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  101. ncbi Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1
    Hong Zhang
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Curr Biol 13:1625-9. 2003
    ..The contribution of PlGF toward stromal signals that regulate epithelial differentiation suggests novel functions for a growth factor previously implicated in reactive angiogenesis...

Research Grants10

  1. Role of Glypicans in HGF Mediated Cell Morphogenesis
    Anil Karihaloo; Fiscal Year: 2006
    ..These specific aims are designed to hopefully lead to a better understanding of the role of Gpc expression during kidney development vis-a-vis HGF. ..
  2. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2007
    ..Understanding basic mechanisms contributing to the development of pulmonary edema in ARDS may suggest novel therapeutic strategies for managing critically ill patients with this disorder. ..
  3. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
    ..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
  4. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
    ....
  5. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2009
    ..Understanding basic mechanisms contributing to the development of pulmonary edema in ARDS may suggest novel therapeutic strategies for managing critically ill patients with this disorder. ..