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Genomes and Genes
| NrlSummaryGene Symbol: Nrl Description: neural retina leucine zipper gene Alias: D14H14S46E, neural retina-specific leucine zipper protein Species: mouse Top Publications
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Publications
Regulation of lens fiber cell differentiation by transcription factor c-MafS Kawauchi
Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
J Biol Chem 274:19254-60. 1999..for members of the large Maf family, which are expressed in the mouse lens, and found three, c-Maf, MafB, and Nrl. Of these, the earliest factor expressed in the lens was c-Maf...- RPE65 is essential for the function of cone photoreceptors in NRL-deficient miceAndreas Wenzel
Laboratory for Retinal Cell Biology, Eye Clinic, University Hospital Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 48:534-42. 2007..In the current study, neural retina leucine zipper-deficient (Nrl(-/-)) and rod opsin (Rho(-/-))-deficient mice were used, two mouse models that have been described as having a &.. 
MATH5 controls the acquisition of multiple retinal cell fatesLiang Feng
Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Mol Brain 3:36. 2010..Collectively, these data suggest that Math5 regulates the generation of multiple retinal cell types via different mechanisms during retinogenesis...- Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptorsP K Swain
Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan 48105, USA
J Biol Chem 276:36824-30. 2001b>NRL, a bZIP transcription factor of the Maf subfamily, interacts with the homeodomain protein CRX and synergistically regulates rhodopsin expression... 
Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segmentsKecia L Feathers
Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Invest Ophthalmol Vis Sci 49:1126-35. 2008..in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of ..- The cis-regulatory logic of the mammalian photoreceptor transcriptional networkTimothy H C Hsiau
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 2:e643. 2007..and computational analysis of the network controlled by the mammalian photoreceptor transcription factors, Crx, Nrl, and Nr2e3... - Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptorsMasayuki Akimoto
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Proc Natl Acad Sci U S A 103:3890-5. 2006The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the Nrl gene in mice leads to functional cones at the expense of rods. We show that a 2... - Notch 1 inhibits photoreceptor production in the developing mammalian retinaAshutosh P Jadhav
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 133:913-23. 2006..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type... - Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanismsSergei S Nikonov
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Gen Physiol 125:287-304. 2005The retinas of mice null for the neural retina leucine zipper transcription factor (Nrl-/-) contain no rods but are populated instead with photoreceptors that on ultrastructural, histochemical, and molecular criteria appear cone like... - Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activitySteven J Pittler
Department of Physiological Optics, Vision Science Research Center, School of Optometry, University of Alabama at Birmingham, 924 18th Street S, Birmingham, AL 35294, USA
J Biol Chem 279:19800-7. 2004..The most active segment contained a 177-bp upstream sequence including apparent Crx and Nrl transcription factor binding sites... - GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retinaXuemei Zhu
The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Department of Cell and Neurobiology, The Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9112, USA
J Neurosci 23:6152-60. 2003..Using the "pure-cone" retinas of the neural retina leucine zipper (Nrl) knock-out (KO, -/-) mice (Mears et al... - Nrl is required for rod photoreceptor developmentA J Mears
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA
Nat Genet 29:447-52. 2001The protein neural retina leucine zipper (Nrl) is a basic motif-leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. It acts synergistically with Crx to regulate rhodopsin transcription... - Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouseLauren L Daniele
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
Invest Ophthalmol Vis Sci 46:2156-67. 2005To test the hypothesis that Nrl(-)(/)(-) photoreceptors are cones, by comparing them with WT rods and cones using morphological, molecular, histochemical, and electrophysiological criteria. - A typology of photoreceptor gene expression patterns in the mouseJoseph C Corbo
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:12069-74. 2007..study, we carried out microarray and in situ hybridization analyses of the mouse Neural retina leucine zipper gene (Nrl) mutant, which shows an en masse conversion of rods into cones, to establish a typology of photoreceptor gene .. - Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarraysJindan Yu
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48015, USA
J Biol Chem 279:42211-20. 2004..the gene expression profile of the rod-dominated retina of wild type mouse with that of the cone-only retina of Nrl(-/-) (Neural retina leucine zipper knockout) mouse... - The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genesGuang Hua Peng
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Mol Genet 14:747-64. 2005..Altogether, our findings suggest that Nr2e3 is a dual-function transcriptional regulator that acts in concert with Crx to promote and maintain the function of rod photoreceptors... - MicroRNA profile of the developing mouse retinaLaszlo Hackler
Departments of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 51:1823-31. 2010..Conclusions. Global expression profiling revealed dozens of miRNAs with significant expression changes in the developing retina. Precise patterns of expression of miRNAs suggest their specific roles in development... - Deciphering the structure and function of Als2cr4 in the mouse retinaFreddi I Zuniga
Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Los Angeles, CA 90033 9224, USA
Invest Ophthalmol Vis Sci 51:4407-15. 2010..Previous in situ hybridization and gene expression profiles show that the mRNAs encoding Als2cr4 are abundant in the eye, hippocampus, cerebellum, and olfactory bulb... - Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by lightEkaterina S Lobanova
Albert Eye Research Institute, Duke University, Durham, North Carolina 27710, USA
J Neurosci 30:6815-24. 2010.... - Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinantCynthia L Montana
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 286:36921-31. 2011The transcription factor neural retina leucine zipper (Nrl) is a critical determinant of rod photoreceptor cell fate and a key regulator of rod differentiation... - The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneuronsJimmy de Melo
Department of Neuroscience, Johns Hopkins University School of Medicine, 733 N Broadway Avenue, Baltimore, MD 21287, USA
Development 138:2325-36. 2011.... - Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomographyM Dominik Fischer
Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
PLoS ONE 4:e7507. 2009..Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration... - Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanismXi Qin Ding
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Hum Mol Genet 18:4770-80. 2009..Hence, we show that loss of CNGB3 reduces biosynthesis of CNGA3 and impairs cone CNG channel function. We suggest that down-regulation of CNGA3 contributes to the pathogenic mechanism by which CNGB3 mutations lead to human cone disease... - Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor networkGuang Hua Peng
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 108:17821-6. 2011..binding by three key photoreceptor transcription factors-cone--rod homeobox (CRX), neural retina leucine zipper (NRL), and nuclear receptor subfamily 2, group E, member 3 (NR2E3)--is required for the appropriate local chromosomal .. - AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assemblySaravanan Kolandaivelu
Department of Ophthalmology, Sensory Neuroscience Research Center, West Virginia University, Morgantown, West Virginia 26506, USA
J Biol Chem 284:30853-61. 2009..Our studies establish that AIPL1 interacts with the catalytic subunit (alpha) of PDE6 and is needed for the proper assembly of functional rod PDE6 subunits... - Rdh12 activity and effects on retinoid processing in the murine retinaJared D Chrispell
Departments of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
J Biol Chem 284:21468-77. 2009..were greater than in Rpe65-Met(450) mice and increased during postnatal development in wild-type mice and Nrl-deficient mice having an all-cone retina... - Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiationJerome E Roger
Neurobiology Neurodegeneration and Repair Laboratory, NEI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:25637-44. 2010..in the mammalian retina is critically dependent on the basic motif-leucine zipper transcription factor NRL (neural retina leucine zipper)... - Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal developmentLily Ng
NIDDK, Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1772, USA
J Neurosci 31:11118-25. 2011..Mice deleted for thyroid hormone receptor β2 (TRβ2) and neural retina leucine zipper factor (NRL) lack M cones and rods, respectively, but gain S cones... - Neovascularization, enhanced inflammatory response, and age-related cone dystrophy in the Nrl-/-Grk1-/- mouse retinaRosanne M Yetemian
Doheny Eye Institute, Department of Ophthalmology, Division of Retinal Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9224, USA
Invest Ophthalmol Vis Sci 51:6196-206. 2010..and light exposure on cone photoreceptor survival were compared between mouse retinas of neural retina leucine zipper knockout (Nrl(-/-)) mice and double-knockout mice lacking G-protein-coupled receptor kinase 1 (Nrl(-/-)Grk1(-/-)). - Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathyArtur V Cideciyan
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Mol Genet 20:1411-23. 2011..To produce a model of the all-cone human fovea in NPHP6-LCA, we generated rd16;Nrl-/- double-mutant mice... - Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouseArthur Krigel
Département de Neurobiologie des Rythmes, CNRS UPR 3212, Institut des Neurosciences Cellulaires et Integratives, Strasbourg, France
Mol Vis 16:2873-81. 2010..To characterize the light and circadian control of cone photoreceptor phagocytosis in mice, we capitalized on the blue cone-like phenotype of neural retina leucine zipper gene (Nrl) null mice (Nrl(-/-)). - Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor developmentJung Woong Kim
Department of Life Science BK21 program, College of Natural Sciences, Chung Ang University, Seoul, Korea
FEBS J 277:5051-60. 2010..of protein phosphatase 2A) expression was regulated by the transcription factor neural retina leucine-zipper (Nrl) through enhancement of its transcriptional activity on the Ppp2r5c promoter... - Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degenerationDebarshi Mustafi
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
FASEB J 25:3157-76. 2011..The neural retina leucine zipper transcription factor-knockout (Nrl(-/-)) mouse model demonstrates many phenotypic features of human ESCS, including unstable S-cone-positive .. - Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunitSaravanan Kolandaivelu
Departments of Ophthalmology and Biochemistry, Center for Neuroscience, West Virginia University, Morgantown, West Virginia 26506, USA
J Biol Chem 286:33252-9. 2011..To study this issue, we generated a cone-dominated mouse model lacking cone PDE6 (Nrl(-/-) cpfl1)... - Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursorsHong Cheng
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
Hum Mol Genet 20:4102-15. 2011The orphan nuclear receptor NR2E3 is a direct transcriptional target of NRL, the key basic motif leucine zipper transcription factor that dictates rod versus cone photoreceptor cell fate in the mammalian retina... - XIAP therapy increases survival of transplanted rod precursors in a degenerating host retinaJingyu Yao
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
Invest Ophthalmol Vis Sci 52:1567-72. 2011..To assess the survival of rod precursor cells transplanted into the Rd9 mouse, a model of X-linked retinal degeneration, and the effect of antiapoptotic therapy with X-linked inhibitor of apoptosis (XIAP) on preventing cell loss... - Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDSDibyendu Chakraborty
Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, BMSB 781, Oklahoma City, OK 73104, USA
Hum Mol Genet 19:4799-812. 2010..Here, we express oligomerization-incompetent RDS (C150S-RDS) in the cone-dominant nrl(-/-) mouse... - CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptorsJoseph C Corbo
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1024, USA
Genome Res 20:1512-25. 2010..CRX ChIP-seq was also performed on Nrl(-/-) retinas, which represent an enriched source of cone photoreceptors... - Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacementKannan Kunchithapautham
Department of Neurosciences, Division of Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Invest Ophthalmol Vis Sci 50:4858-64. 2009..Here, we determine the consequences of 11-cis retinal withdrawal and supplementation on cone development in the all-cone Nrl(-/-) retina. - Formation of all-trans retinol after visual pigment bleaching in mouse photoreceptorsChunhe Chen
Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA
Invest Ophthalmol Vis Sci 50:3589-95. 2009..all-trans retinol is formed after visual pigment bleaching through the reduction of all-trans retinal in a reaction involving NADPH. This reduction begins the recycling of the chromophore for the regeneration of the visual pigment... - Recruitment of the rod pathway by cones in the absence of rodsEnrica Strettoi
Istituto di Neuroscienze del Consiglio Nazionale delle Ricerche, 56100 Pisa, Italy
J Neurosci 24:7576-82. 2004In mammalian retinas, rods and cones connect to distinct sets of bipolar cells. In the retina of Nrl (neural retina leucine zipper) knock-out mice, in which rods fail to form and all photoreceptors are cones, rod bipolar cells have .. - A conserved retina-specific gene encodes a basic motif/leucine zipper domainA Swaroop
Department of Opthalmology, University of Michigan, Kellogg Eye Center, Ann Arbor 48105
Proc Natl Acad Sci U S A 89:266-70. 1992..The gene for AS321 is conserved during evolution and is expressed in vertebrate retina. We propose to name the gene NRL (neural retina leucine zipper. - Connexin 36 in photoreceptor cells: studies on transgenic rod-less and cone-less mouse retinasLoan Dang
Eye Research Institute, Oakland University, Rochester, MI 48309 4481, USA
Mol Vis 10:323-7. 2004..It remains unresolved, however, whether rods, cones or both express connexin 36. We have tried to address this question with the use of transgenic rod-less and cone-less mice... - Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressorKenneth P Mitton
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Hum Mol Genet 12:365-73. 2003b>NRL (neural retina leucine zipper) is a basic motif leucine zipper transcription factor of the Maf-subfamily. Multiple phosphorylated isoforms of NRL are detected specifically in rod photoreceptors... - Evaluation and optimization of procedures for target labeling and hybridization of cDNA microarraysJindan Yu
Departments of Ophthalmology and Visual Sciences, Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Mol Vis 8:130-7. 2002..Standardized protocols that consistently produce low background and high intensity hybridization with small amounts of starting RNA are needed to extract differentially expressed genes from a pool of thousands of unaltered genes... - Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye developmentL C Bibb
Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
Hum Mol Genet 10:1571-9. 2001..These data support concerns about the extent to which we can extrapolate from rodent models regarding embryonic development and disease pathophysiology... - The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesisS S Apte
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 272:25511-7. 1997..The stringent co-expression of these two genes suggests common regulatory pathways that may have important functional implications for the activation of pro-gelatinase A in health and disease... - Expression of the bZIP transcription factor gene Nrl in the developing nervous systemQ Liu
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Oncogene 12:207-11. 1996Proteins of the Maf/Nrl subfamily of bZIP transcription factors are involved in the regulation of tissue-specific gene expression... - Molecular characterization of the murine neural retina leucine zipper gene, NrlQ Farjo
Department of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor 48105
Genomics 18:216-22. 1993The NRL gene (D14S46E) is expressed in cells of human retina and encodes a putative DNA-binding protein of the leucine zipper family. Here we describe the analysis of the murine homolog of the NRL gene, Nrl... - Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptorsRafal Farjo
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Cell Biol 173:59-68. 2006..This study provides novel insight into the distinct role of Rds in the OS development of rods and cones... - In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal developmentHong Cheng
Neuroscience Graduate Program, Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
Hum Mol Genet 15:2588-602. 2006Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation... - Baf60c is a component of the neural progenitor-specific BAF complex in developing retinaDeepak A Lamba
Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
Dev Dyn 237:3016-23. 2008..Finally, we show that Baf60c is re-expressed in the Müller glial cells that re-enter the cell cycle after neurotoxic damage... - Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- miceAlexander V Matveev
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Neurochem 106:2042-55. 2008..using the cone-dominant retina in mice deficient in the transcription factor neural retina leucine zipper (Nrl)... - Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domainsXi Qin Ding
Department of Cell Biology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA
Biochemistry 47:3677-87. 2008.... - Retinoid processing in cone and Müller cell linesYogita Kanan
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Exp Eye Res 86:344-54. 2008..Alternatively, this could be due to the potential that rMC-1, as a transformed cell line, has stopped expressing the proteins needed for the regeneration of 11-cis retinoids... - Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epitheliumLauren L Daniele
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 505:166-76. 2007..Recent studies reported that Jam-C mRNA was increased threefold in the all-cone retina of the Nrl(-/-) mouse, suggesting that Jam-C is required for maturation and polarization of cone photoreceptors cells... - Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrityRafal Farjo
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Comp Neurol 504:619-30. 2007..structural, and functional consequences on cone photoreceptors of the neural retinal leucine zipper knockout (Nrl(-/-)) mice when only one allele of retinal degeneration slow (Rds) is present (Rds(+/-)/Nrl(-/-))... - Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylationGuang Hua Peng
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Mol Genet 16:2433-52. 2007..of HATs, (iii) the acetylation of histone H3, then (iv) binding of other photoreceptor transcription factors (Nrl and Nr2e3) and RNA polymerase II... - Afferent control of horizontal cell morphology revealed by genetic respecification of rods and conesMary A Raven
Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106, USA
J Neurosci 27:3540-7. 2007..by innervation from their respective afferents: genetic respecification of all cones to become rods, in Crxp-Nrl transgenic mice, produces an atrophic dendritic field yet leaves the axon terminal system largely intact... - Slowed photoresponse recovery and age-related degeneration in cones lacking G protein-coupled receptor kinase 1Xuemei Zhu
Mary D. Allen Laboratory for Vision Research, Doheny Eye Institute, Department of Ophthalmology and Cell and Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033-9224, USA
Adv Exp Med Biol 572:133-9. 2006 - Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRLEdwin C T Oh
Program in Neuroscience and Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA
Proc Natl Acad Sci U S A 104:1679-84. 2007..Rod photoreceptor differentiation requires the basic motif-leucine zipper (bZIP) transcription factor NRL, because loss of Nrl in mice (Nrl-/-) results in complete transformation of rods to functional cones... - Mapping of the neural retina leucine zipper gene, Nrl, to mouse chromosome 14I N Bespalova
Mental Health Research Institute, University of Michigan, Ann Arbor 48109
Mamm Genome 4:618-20. 1993
Research Grants
- INNER RETINAL NEURONS IN NORMAL AND DEGENERATING MICEEnrica Strettoi; Fiscal Year: 2005..If selective alterations are identified, they have to be taken into account when devising new therapeutic strategies. They would also become candidates as contributors to the secondary degeneration of cones that follows loss of rods. ..
- Mechanism of Cone Degeneration Resulting from CNG Channel DeficiencyXi Qin Ding; Fiscal Year: 2010..We will perform the proposed studies using the CNGA3-/-/Nrl-/- and CNGB3-/-/Nrl-/- mouse lines...
- STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORSKRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2010..The importance of the protein family for human health makes this effort worthwhile. ..
- Using Nanotechnology to Rescue Visual Loss in A Model of Human Blinding DisorderXi Qin Ding; Fiscal Year: 2007..Information obtained from the proposed study will open a new pathway for therapeutic interventions of retinal degeneration and will have significant impact on the clinical treatment of human retinal diseases. ..
- Gene Regulatory Networks in Rod Photoreceptor CellsJoseph Corbo; Fiscal Year: 2007..In addition, a second TF required for normal rod differentiation, NRL, has been implicated in retinitis pigmentosa. The target genes of this latter TF largely remain to be identified...
- IMAGING OF ROD OUTER SEGMENT BY CRYO-ELECTRON TOMOGRAPHYKrzysztof Palczewski; Fiscal Year: 2007..These studies will add significantly to our understanding of the normal and disease stage organization of the rod outer segments. ..
- VERTEBRATE CAROTENOID ISOMERASESKrzysztof Palczewski; Fiscal Year: 2005..Lastly, the contribution of these enzymes to retinoid processing and, hence, to vision will be studied using transgenic animal models. ..
- STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORSKrzysztof Palczewski; Fiscal Year: 2007..The importance of the protein family for human health makes this effort worthwhile. ..
- INNER RETINAL NEURONS IN NORMAL AND DEGENERATING MICEEnrica Strettoi; Fiscal Year: 2007..This is very important to design mutation-independent therapies. ..
- QUANTITATIVE ANALYSIS AND ENGINEERING OF THE PHOTORECEPTOR TRANSCRIPTION NETWORKJoseph C Corbo; Fiscal Year: 2010..model of the photoreceptor transcriptional network controlled by the transcription factors (TFs), Crx and Nrl. In the course of this work, we developed a computational algorithm, Phastfind, to predict CREs around hundreds of ..
- STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORSKRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2010..The importance of the protein family for human health makes this effort worthwhile. ..
- Analysis of retina rod photoreceptor GARP and cGMP-gated cation channelSteven J Pittler; Fiscal Year: 2010..The studies may also yield new targets for intervention as possible treatments for certain forms of hereditary retina degeneration. ..
- QUANTITATIVE ANALYSIS AND ENGINEERING OF THE PHOTORECEPTOR TRANSCRIPTION NETWORKJoseph Corbo; Fiscal Year: 2009..model of the photoreceptor transcriptional network controlled by the transcription factors (TFs), Crx and Nrl. In the course of this work, we developed a computational algorithm, Phastfind, to predict CREs around hundreds of ..
- RETINOIDS IN VISIONKrzysztof Palczewski; Fiscal Year: 2009..Studies proposed in this application will add new biochemical and physiological information to steps in the retinoid cycle that are as yet poorly understood but which are critical for the normal function of photoreceptors. ..
- INNER RETINAL NEURONS IN NORMAL AND DEGENERATING Enrica Strettoi; Fiscal Year: 2009..This is very important to design mutation-independent therapies. ..
- Analysis of retina rod photoreceptor GARP and cGMP-gated cation channelSTEVEN PITTLER; Fiscal Year: 2009..The studies may also yield new targets for intervention as possible treatments for certain forms of hereditary retina degeneration. ..
- RETINOIDS IN VISIONKrzysztof Palczewski; Fiscal Year: 2007..abstract_text> ..
- STRUCTURAL STUDIES OF ARRESTIN AND RHODOPSIN PHOSPHATASEKrzysztof Palczewski; Fiscal Year: 1993..4) to characterize beta-arrestin, a homolog of arrestin, including its functional and immunological properties. (5) to definitively identify the rhodopsin phosphatase and an inhibitor of its activity...
- PHOTOTRANSDUCTION ENZYMESKrzysztof Palczewski; Fiscal Year: 2003....
- STRUCTURE AND REGULATION OF RETINAL CGMP PDE ALPHA GENESTEVEN PITTLER; Fiscal Year: 2002..Ultimately, experiments will be carried out to examine the functional consequences of PDE6 mutations that have been linked to human RP. ..
- STRUCTURAL STUDIES OF ARRESTINSKrzysztof Palczewski; Fiscal Year: 2001....