Nrip1

Summary

Gene Symbol: Nrip1
Description: nuclear receptor interacting protein 1
Alias: 6030458L20Rik, 8430438I05Rik, 9630050P12, AA959574, AW456757, RIP140, nuclear receptor-interacting protein 1, nrip1, nuclear factor RIP140, receptor-interacting protein 140
Species: mouse
Products:     Nrip1

Top Publications

  1. Gupta P, Park S, Farooqui M, Wei L. Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1. Nucleic Acids Res. 2007;35:2269-82 pubmed
    ..cells, whereas it triggers recruitment of histone deacetylase-containing/GRIP1/receptor-interacting protein 140 (RIP140) complex in differentiated cells. GRIP1 directly interacts with RIP140 through its carboxyl terminal AD2 domain...
  2. Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker M. RIP140-targeted repression of gene expression in adipocytes. Mol Cell Biol. 2005;25:9383-91 pubmed
    ..To investigate the intrinsic role of the corepressor RIP140, we have monitored gene expression profiles in cells that express or lack the RIP140 gene and that can be induced ..
  3. Huq M, Ha S, Barcelona H, Wei L. Lysine methylation of nuclear co-repressor receptor interacting protein 140. J Proteome Res. 2009;8:1156-67 pubmed publisher
    b>Receptor interacting protein 140 (RIP140) undergoes extensive post-translational modifications (PTMs), including phosphorylation, acetylation, arginine methylation, and pyridoxylation...
  4. Gupta P, Ho P, Huq M, Khan A, Tsai N, Wei L. PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation. PLoS ONE. 2008;3:e2658 pubmed publisher
    b>Receptor interacting protein 140 (RIP140) is a versatile transcriptional co-repressor that plays roles in diverse metabolic processes including fat accumulation in adipocytes...
  5. Heim K, Gamsby J, Hever M, Freemantle S, Loros J, Dunlap J, et al. Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140. PLoS ONE. 2009;4:e7639 pubmed publisher
    ..Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregulator that represses the transactivation of agonist-bound nuclear receptors...
  6. Park S, Huang W, Persaud S, Wei L. RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation. Nucleic Acids Res. 2009;37:7085-94 pubmed publisher
    ..T3 repression of Crabp1 requires receptor interacting protein 140 (RIP140)...
  7. Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth S, White R, et al. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J. 2007;26:4831-40 pubmed
    ..b>RIP140 is a corepressor for nuclear receptors that suppresses transcription from a broad programme of metabolic genes and ..
  8. Wei L, Hu X. Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. Mol Cell Endocrinol. 2004;218:39-48 pubmed
    Over-expression of receptor interacting protein 140 (RIP140) suppressed thyroid hormone (T3) induction of cellular retinoic acid binding I protein (CRABPI) gene in P19 embryonal carcinoma cells...
  9. Ho P, Lin Y, Tsui Y, Gupta P, Wei L. A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160. Cell Metab. 2009;10:516-23 pubmed publisher
    Receptor-interacting protein 140 (RIP140), a nuclear receptor corepressor, is important for lipid and glucose metabolism...

More Information

Publications71

  1. Nautiyal J, Steel J, Rosell M, Nikolopoulou E, Lee K, DeMayo F, et al. The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology. 2010;151:2923-32 pubmed publisher
    The nuclear receptor cofactor receptor-interacting protein 140 (RIP140) is essential for cumulus cell-oocyte complex (COC) expansion, follicular rupture, and oocyte release during ovulation...
  2. Huq M, Khan S, Park S, Wei L. Mapping of phosphorylation sites of nuclear corepressor receptor interacting protein 140 by liquid chromatography-tandem mass spectroscopy. Proteomics. 2005;5:2157-66 pubmed
    Receptor interacting protein (RIP140) is a versatile coregulator for many nuclear receptors and transcription factors...
  3. Tullet J, Pocock V, Steel J, White R, Milligan S, Parker M. Multiple signaling defects in the absence of RIP140 impair both cumulus expansion and follicle rupture. Endocrinology. 2005;146:4127-37 pubmed
    The nuclear receptor corepressor RIP140 is essential in the ovary for ovulation, but is not required for follicle growth and luteinization...
  4. Park S, Hu X, Gupta P, Lin Y, Ha S, Wei L. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007;14:68-75 pubmed
    ..SUMOylation of Tr2 induces an exchange of its coregulators: corepressor Rip140 replaces coactivator Pcaf, which switches Tr2 from an activator to a repressor...
  5. Ho P, Gupta P, Tsui Y, Ha S, Huq M, Wei L. Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation. Cell Signal. 2008;20:1911-9 pubmed publisher
    ..Previous mass spectrometry studies showed that either phosphorylation or lysine acetylation of RIP140 directly enhanced its trans-repressive activity...
  6. Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, et al. Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Mol Endocrinol. 2007;21:1581-92 pubmed
    ..adipocytes derived from brown or white adipose tissue devoid of the nuclear receptor corepressor receptor interacting protein 140 (RIP140)...
  7. Ho P, Chuang Y, Hung C, Wei L. Cytoplasmic receptor-interacting protein 140 (RIP140) interacts with perilipin to regulate lipolysis. Cell Signal. 2011;23:1396-403 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is abundantly expressed in mature adipocyte and modulates gene expression involved in lipid and glucose metabolism...
  8. Huq M, Wei L. Post-translational modification of nuclear co-repressor receptor-interacting protein 140 by acetylation. Mol Cell Proteomics. 2005;4:975-83 pubmed
    Receptor-interacting protein 140 (RIP140) is a versatile co-regulator for nuclear receptors and many transcription factors and contains several autonomous repressive domains...
  9. Leonardsson G, Steel J, Christian M, Pocock V, Milligan S, Bell J, et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A. 2004;101:8437-42 pubmed
    ..Mice devoid of the corepressor protein RIP140 are lean, show resistance to high-fat diet-induced obesity and hepatic steatosis, and have increased oxygen ..
  10. Virtue S, Feldmann H, Christian M, Tan C, Masoodi M, Dale M, et al. A new role for lipocalin prostaglandin d synthase in the regulation of brown adipose tissue substrate utilization. Diabetes. 2012;61:3139-47 pubmed publisher
    ..Taken together, these results suggest that L-PGDS plays an important role in the regulation of glucose utilization in vivo. ..
  11. Leonardsson G, Jacobs M, White R, Jeffery R, Poulsom R, Milligan S, et al. Embryo transfer experiments and ovarian transplantation identify the ovary as the only site in which nuclear receptor interacting protein 1/RIP140 action is crucial for female fertility. Endocrinology. 2002;143:700-7 pubmed
    ..In this study we investigated whether the nuclear receptor corepressor nuclear receptor interacting protein 1 (Nrip1)/RIP140, which is essential for ovulation, is also required for postovulatory events, ..
  12. Tsai N, Lin Y, Wei L. MicroRNA mir-346 targets the 5'-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression. Biochem J. 2009;424:411-8 pubmed publisher
    b>RIP140 (receptor-interacting protein 140) is a transcriptional co-repressor that regulates diverse genes such as those responsive to hormones and involved in metabolic processes...
  13. Herzog B, Hallberg M, Seth A, Woods A, White R, Parker M. The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor. Mol Endocrinol. 2007;21:2687-97 pubmed
    ..In this study, we demonstrate that receptor-interacting protein 140 (RIP140) is a cofactor for LXR in liver...
  14. Lee C, Chinpaisal C, Wei L. Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. Mol Cell Biol. 1998;18:6745-55 pubmed
    The mouse homologue of the human receptor-interacting protein 140 (RIP140) was isolated from a mouse embryonic cDNA library in yeast two-hybrid screening experiments by using the ligand binding domain (LBD) of nuclear orphan receptor TR2 ..
  15. White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M. The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility. Nat Med. 2000;6:1368-74 pubmed
    ..Here we show that the co-repressor nuclear-receptor-interacting protein 1 (Nrip1; encoded by the gene Nrip1) is essential for ovulation...
  16. Powelka A, Seth A, Virbasius J, Kiskinis E, Nicoloro S, Guilherme A, et al. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006;116:125-36 pubmed
    Using an siRNA-based screen, we identified the transcriptional corepressor RIP140 as a negative regulator of insulin-responsive hexose uptake and oxidative metabolism in 3T3-L1 adipocytes...
  17. Lee C, Wei L. Characterization of receptor-interacting protein 140 in retinoid receptor activities. J Biol Chem. 1999;274:31320-6 pubmed
    Receptor-interacting protein 140 (RIP140) contains multiple receptor interaction domains and interacts with retinoic acid receptors in a ligand-dependent manner...
  18. Ho P, Chang K, Chuang Y, Wei L. Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J. 2011;25:1758-66 pubmed publisher
    b>Receptor interacting protein 140 (RIP140) is a nuclear receptor coregulator that affects a wide spectrum of biological processes...
  19. Wei L, Farooqui M, Hu X. Ligand-dependent formation of retinoid receptors, receptor-interacting protein 140 (RIP140), and histone deacetylase complex is mediated by a novel receptor-interacting motif of RIP140. J Biol Chem. 2001;276:16107-12 pubmed
    Receptor-interacting protein 140 (RIP140) interacts with retinoic acid receptor and retinoid X receptor in a ligand-dependent manner and suppresses retinoic acid (RA) induction of its target genes...
  20. Hallberg M, Morganstein D, Kiskinis E, Shah K, Kralli A, Dilworth S, et al. A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA. Mol Cell Biol. 2008;28:6785-95 pubmed publisher
    ..The corepressor RIP140 and the PPAR coactivator 1alpha (PGC-1alpha) both play key roles in the regulated transcription of genes involved ..
  21. Berriel Diaz M, Krones Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, et al. Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice. Hepatology. 2008;48:782-91 pubmed publisher
    ..Liver-specific knockdown of RIP140 led to increased hepatic TG release and alleviated hepatic steatosis in tumor-bearing, cachectic animals...
  22. Persaud S, Huang W, Park S, Wei L. Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol. 2011;25:1689-98 pubmed publisher
    b>Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes...
  23. Zschiedrich I, Hardeland U, Krones Herzig A, Berriel Diaz M, Vegiopoulos A, Müggenburg J, et al. Coactivator function of RIP140 for NFkappaB/RelA-dependent cytokine gene expression. Blood. 2008;112:264-76 pubmed publisher
    ..Here we describe an unexpected coactivator function for the nuclear receptor interacting protein 140 (RIP140) for nuclear factor kappaB (NFkappaB), a master transcriptional regulator of inflammation in ..
  24. Seth A, Steel J, Nichol D, Pocock V, Kumaran M, Fritah A, et al. The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle. Cell Metab. 2007;6:236-45 pubmed
    ..In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle...
  25. Wei L, Hu X, Chandra D, Seto E, Farooqui M. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem. 2000;275:40782-7 pubmed
    Receptor-interacting protein 140 (RIP140) encodes a histone deacetylase (HDAC) inhibitor-sensitive repressive activity...
  26. Vo N, Fjeld C, Goodman R. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. Mol Cell Biol. 2001;21:6181-8 pubmed
    ..In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself...
  27. Christian M, Tullet J, Parker M. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. J Biol Chem. 2004;279:15645-51 pubmed
    ..We have characterized four distinct autonomous repression domains in RIP140, termed RD1-4, that are highly conserved in mammals and birds...
  28. Flaisher Grinberg S, Tsai H, Feng X, Wei L. Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus. Brain Behav Immun. 2014;40:226-34 pubmed publisher
    Receptor-interacting protein (RIP140) is a transcription co-regulator highly expressed in macrophages to regulate inflammatory and metabolic processes...
  29. Duclot F, Lapierre M, Fritsch S, White R, Parker M, Maurice T, et al. Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression. Genes Brain Behav. 2012;11:69-78 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a negative transcriptional coregulator of nuclear receptors such as estrogen, retinoic acid or glucocorticoid receptors...
  30. Farooqui M, Franco P, Thompson J, Kagechika H, Chandraratna R, Banaszak L, et al. Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity. Biochemistry. 2003;42:971-9 pubmed
    b>Receptor interacting protein 140 (RIP140) interacts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) constitutively, but hormone binding enhances this interaction...
  31. He Y, Zhang L, Li Z, Gao H, Yue Z, Liu Z, et al. RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor. FEBS Lett. 2015;589:455-60 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown...
  32. Wu C, Persaud S, Wei L. Retinoic Acid Induces Ubiquitination-Resistant RIP140/LSD1 Complex to Fine-Tune Pax6 Gene in Neuronal Differentiation. Stem Cells. 2016;34:114-23 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a wide-spectrum coregulator for hormonal regulation of gene expression, but its activity in development/stem cell differentiation is unknown...
  33. Wang H, Zhang Y, Yehuda Shnaidman E, Medvedev A, Kumar N, Daniel K, et al. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008;28:2187-200 pubmed publisher
    ..The mechanism of inhibition involves the differential recruitment of the corepressor RIP140 to an LXRalpha binding site that overlaps with the PPARgamma/PGC-1alpha response element, resulting in the ..
  34. Fritah A, Steel J, Parker N, Nikolopoulou E, Christian M, Carling D, et al. Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK. PLoS ONE. 2012;7:e32520 pubmed publisher
    ..b>RIP140 is a transcriptional coregulator with a central role in metabolic tissues and we tested the effect of modulating ..
  35. Perissi V, Aggarwal A, Glass C, Rose D, Rosenfeld M. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004;116:511-26 pubmed
    ..The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors. ..
  36. Kim Y, Comte I, Szabo G, Hockberger P, Szele F. Adult mouse subventricular zone stem and progenitor cells are sessile and epidermal growth factor receptor negatively regulates neuroblast migration. PLoS ONE. 2009;4:e8122 pubmed publisher
    ..This result suggests an additional role for EGFr signaling in the SVZ. ..
  37. Poliandri A, Gamsby J, Christian M, Spinella M, Loros J, Dunlap J, et al. Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J Biol Rhythms. 2011;26:187-99 pubmed publisher
    ..b>Receptor interacting protein 140 (RIP140) is a coregulator for nuclear receptors and other transcription factors that represses ..
  38. Gupta P, Ho P, Huq M, Ha S, Park S, Khan A, et al. Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Proc Natl Acad Sci U S A. 2008;105:11424-9 pubmed publisher
    ..associates with promyelocytic leukemia (PML) nuclear bodies, becomes SUMOylated, and recruits corepressor RIP140 to act as a repressor for its target, Oct4...
  39. Feng X, Krogh K, Wu C, Lin Y, Tsai H, Thayer S, et al. Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Nat Commun. 2014;5:4487 pubmed publisher
    ..protein response (UPR) in neurons induces rapid translocation of nuclear receptor-interacting protein 140 (RIP140) to the cytoplasm. In the cytoplasm, RIP140 localizes to the ER by binding to the IP3R...
  40. Huang J, Bi Y, Zhu G, He Y, Su Y, He B, et al. Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009;29:1569-81 pubmed publisher
    ..RA was further shown to induce glycogen synthesis in HP14.5 cells, an important function of mature hepatocytes. Our results strongly suggest that RA signalling may play an important role in regulating hepatic differentiation. ..
  41. Frier B, Hancock C, Little J, Fillmore N, Bliss T, Thomson D, et al. Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content. J Appl Physiol (1985). 2011;111:688-95 pubmed publisher
    Receptor interacting protein 1 (RIP140) has recently been demonstrated to be a key player in the regulation of skeletal muscle mitochondrial content...
  42. Piao H, Chu X, Lv W, Zhao Y. Involvement of receptor-interacting protein 140 in estrogen-mediated osteoclasts differentiation, apoptosis, and bone resorption. J Physiol Sci. 2017;67:141-150 pubmed publisher
    ..Taken together, receptor-interacting protein 140 might be a critical player in estrogen-mediated osteoclastogenesis and bone resorption. ..
  43. Herbst E, Bonen A, Holloway G. Changes in nuclear receptor corepressor RIP140 do not influence mitochondrial content in the cortex. Appl Physiol Nutr Metab. 2015;40:1086-8 pubmed publisher
    Changes in nuclear receptor interacting protein 140 (RIP140) influences mitochondrial content in skeletal muscle; however, the translation of these findings to the brain has not been investigated...
  44. Aziz M, Chen X, Zhang Q, Defrain C, Osland J, Luo Y, et al. Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo. Oncotarget. 2015;6:39714-24 pubmed publisher
    ..Earlier age at menarche is a major risk factor for breast cancer. Our previous study identified Nrip1 (also known as Rip140) as a candidate gene for delaying female sexual maturation (FSM) and found that knocking out Nrip1 could ..
  45. Vivante A, Mann N, Yonath H, Weiss A, Getwan M, Kaminski M, et al. A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling. J Am Soc Nephrol. 2017;28:2364-2376 pubmed publisher
    ..279delG, p.Trp93fs*) of the nuclear receptor interacting protein 1 gene (NRIP1) in all seven affected members...
  46. Peppler W, Miotto P, Holloway G, Wright D. CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140-/- mice independent of alterations in lipolysis. Biochem Biophys Res Commun. 2017;486:486-491 pubmed publisher
    ..The purpose of this study was to determine if ablation of the nuclear receptor, receptor-inactivating protein 140 (RIP140), altered this response...
  47. Heimel J, Hermans J, Sommeijer J, Levelt C. Genetic control of experience-dependent plasticity in the visual cortex. Genes Brain Behav. 2008;7:915-23 pubmed publisher
    ..The locus encompasses 13 genes, two of which--Stch and Nrip1--contain missense polymorphisms...
  48. Martyn A, Choleris E, Gillis D, Armstrong J, Amor T, McCluggage A, et al. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Mol Cell Biol. 2012;32:5140-50 pubmed publisher
    ..LRF was found to colocalize with the known GR repressor, RIP140/NRIP1, which inhibits the activity by GR within specific nuclear punctates that are similar to LRF nuclear bodies...
  49. Luan C, Chen X, Hu Y, Hao Z, Osland J, Chen X, et al. Overexpression and potential roles of NRIP1 in psoriasis. Oncotarget. 2016;7:74236-74246 pubmed publisher
    b>Nuclear receptor interacting protein 1 (NRIP1, also known as RIP140) is a co-regulator for various transcriptional factors and nuclear receptors, and has been shown to take part in many biological and pathological processes, such as ..
  50. Kiskinis E, Chatzeli L, Curry E, Kaforou M, Frontini A, Cinti S, et al. RIP140 represses the "brown-in-white" adipocyte program including a futile cycle of triacylglycerol breakdown and synthesis. Mol Endocrinol. 2014;28:344-56 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues...
  51. Katsanis N, Ives J, Groet J, Nizetic D, Fisher E. Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998;102:221-3 pubmed
    ..1 and 21q22.3. Here, we report the mapping of the gene for receptor interacting protein 140 (RIP140) on 21q11 by means of YACs, PACs and hybrid cell lines...
  52. Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih S, Krier R, et al. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A. 2012;109:8224-9 pubmed publisher
    ..Bioinformatic analysis identified Nrip1 at Vpq3 as a candidate gene...
  53. Sanyal S, Matthews J, Bouton D, Kim H, Choi H, Treuter E, et al. Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gamma. Mol Endocrinol. 2004;18:312-25 pubmed
    ..A search for novel coregulators of ERR gamma led to the identification of receptor interacting protein 140 as a potent corepressor and peroxisome proliferator-activated receptor gamma coactivator 1 as a ..
  54. Lapierre M, Bonnet S, Bascoul Mollevi C, Ait Arsa I, Jalaguier S, Del Rio M, et al. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest. 2014;124:1899-913 pubmed publisher
    ..Here, we demonstrate that the transcriptional coregulator RIP140 regulates intestinal homeostasis and tumorigenesis...
  55. Ho P, Tsui Y, Feng X, Greaves D, Wei L. NF-?B-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance. Nat Immunol. 2012;13:379-86 pubmed publisher
    ..The receptor-interacting protein RIP140 interacts with the transcription factor NF-?B to regulate the expression of genes encoding proinflammatory ..
  56. Lee K, Singh M, Ussar S, Wetzel P, Hirshman M, Goodyear L, et al. Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054 pubmed publisher
    ..Thus, Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism. ..
  57. Xie L, Yu W, Liang R, Zhang X, Chao S, Zhao H, et al. [Effects of receptor interacting protein 140 on the biological activity of glia cells]. Zhonghua Yi Xue Za Zhi. 2011;91:2648-52 pubmed
    ..The BV-2 RIP140 overexpression model (BV-2-1) was constructed by Lipofection and G418 selection, then validated by real-time PCR ..
  58. Ho P, Wei L. Negative regulation of adiponectin secretion by receptor interacting protein 140 (RIP140). Cell Signal. 2012;24:71-6 pubmed publisher
    b>RIP140 (receptor-interacting protein 140) is highly expressed in mature adipocytes and functions as a co-repressor for gene expression involved in lipid and glucose metabolism...
  59. Blondrath K, Steel J, Katsouri L, Ries M, Parker M, Christian M, et al. The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation. Neurobiol Aging. 2016;47:180-191 pubmed publisher
    The receptor interacting protein-140 (RIP140) is a cofactor for several nuclear receptors and has been involved in the regulation of metabolic and inflammatory genes...
  60. Nautiyal J, Steel J, Mane M, Oduwole O, Poliandri A, Alexi X, et al. The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013;140:1079-89 pubmed publisher
    Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth ..
  61. Lim H, Moon I, Han K. Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology. 2004;145:2886-95 pubmed
    ..steroid receptor coactivator (SRC)-2, SRC-3, PPAR-interacting protein, receptor-interacting protein 140 (RIP140), nuclear receptor corepressor (N-CoR), and silencing mediator for retinoid and thyroid hormone receptor (SMRT) ..
  62. Grenier J, Trousson A, Chauchereau A, Amazit L, Lamirand A, Leclerc P, et al. Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells. Mol Endocrinol. 2004;18:2866-79 pubmed
    ..We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system. ..