Gene Symbol: NRIF
Description: zinc finger protein 110
Alias: 2900024E01Rik, N28112, NRIF, Nrif1, neurotrophin receptor-interacting factor 1, neurotrophin receptor interacting factor
Species: mouse
Products:     NRIF

Top Publications

  1. Casademunt E, Carter B, Benzel I, Frade J, Dechant G, Barde Y. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. EMBO J. 1999;18:6050-61 pubmed
    NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc finger protein of the Kr├╝ppel family which interacts with the neurotrophin receptor p75(NTR)...
  2. Collins T, Stone J, Williams A. All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol. 2001;21:3609-15 pubmed
  3. Geetha T, Kenchappa R, Wooten M, Carter B. TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 2005;24:3859-68 pubmed
    ..Recently, TRAF6 was shown to bind to another p75 cytoplasmic interactor, NRIF, and promote its nuclear localization...
  4. Yeiser E, Rutkoski N, Naito A, Inoue J, Carter B. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. J Neurosci. 2004;24:10521-9 pubmed
    ..These results indicate that TRAF6 plays an essential role in mediating p75 signal transduction and induction of apoptosis. ..
  5. Linggi M, Burke T, Williams B, Harrington A, Kraemer R, Hempstead B, et al. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. J Biol Chem. 2005;280:13801-8 pubmed
    ..Here we report that the neurotrophin receptor interacting factor (NRIF) is necessary for p75-dependent JNK activation and apoptosis...
  6. Kenchappa R, Zampieri N, Chao M, Barker P, Teng H, Hempstead B, et al. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 2006;50:219-32 pubmed
    ..This cleavage resulted in ubiquitination and subsequent nuclear translocation of NRIF, a DNA binding protein essential for p75-mediated apoptosis...
  7. Korade Z, Kenchappa R, Mirnics K, Carter B. NRIF is a regulator of neuronal cholesterol biosynthesis genes. J Mol Neurosci. 2009;38:152-8 pubmed publisher
    ..Most of the cellular effects of p75NTR are mediated via interacting proteins, including neurotrophin receptor interacting factor (NRIF)...
  8. Liang Y, Huimei Hong F, Ganesan P, Jiang S, Jauch R, Stanton L, et al. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. Nucleic Acids Res. 2012;40:8721-32 pubmed
  9. Honer C, Chen P, Toth M, Schumacher C. Identification of SCAN dimerization domains in four gene families. Biochim Biophys Acta. 2001;1517:441-8 pubmed

More Information


  1. Benzel I, Barde Y, Casademunt E. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Gene. 2001;281:19-30 pubmed
    The zinc finger protein NRIF (neurotrophin receptor interacting factor) was originally identified by virtue of its interaction with the neurotrophin receptor p75NTR and its participation in embryonic apoptosis...
  2. Kendall S, Ryczko M, Mehan M, Verdi J. Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis. Brain Res Dev Brain Res. 2003;144:151-8 pubmed
    ..Two such effector proteins, p75NTR-associated cell death executor (NADE) and neurotrophin receptor interacting factor (NRIF) promote p75NTR-mediated apoptosis, whereas Schwann cell factor-1 (SC-1) mediates ..