Nrg1

Summary

Gene Symbol: Nrg1
Description: neuregulin 1
Alias: 6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, HRG, HRGalpha, Hgl, NDF, SMDF, pro-neuregulin-1, membrane-bound isoform, heregulin, type I neuregulin 1, type III neuregulin 1
Species: mouse
Products:     Nrg1

Top Publications

  1. Deakin I, Law A, Oliver P, Schwab M, Nave K, Harrison P, et al. Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice. Neuroreport. 2009;20:1523-8 pubmed publisher
    Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased...
  2. Meyer D, Yamaai T, Garratt A, Riethmacher Sonnenberg E, Kane D, Theill L, et al. Isoform-specific expression and function of neuregulin. Development. 1997;124:3575-86 pubmed
    Neuregulin (also known as NDF, heregulin, ARIA, GGF or SMDF), induces cell growth and differentiation. Biological effects of neuregulin are mediated by members of the erbB family of tyrosine kinase receptors...
  3. Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert M, Fischer T, Rossner M, et al. Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination. Glia. 2012;60:203-17 pubmed publisher
    Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process...
  4. Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998;12:1825-36 pubmed
    Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family...
  5. Gerlai R, Pisacane P, Erickson S. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav Brain Res. 2000;109:219-27 pubmed
    ..Mammals may not be able to compensate for the lack of heregulin, a single ligand for multiple ErbB receptors, however, compensation is expected when a single ErbB receptor is ..
  6. Zhang D, Sliwkowski M, Mark M, Frantz G, Akita R, Sun Y, et al. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997;94:9562-7 pubmed
    ..the identification of Neuregulin-3 (NRG3), a novel protein that is structurally related to the neuregulins (NRG1). The NRG1/neuregulins are a diverse family of proteins that arise by alternative splicing from a single gene...
  7. Freese C, Garratt A, Fahrenholz F, Endres K. The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1. FEBS J. 2009;276:1568-80 pubmed publisher
    ..Adverse reactions of an ADAM10-based therapy of Alzheimer's disease due to neuregulin-1 cleavage are therefore unlikely. ..
  8. Stassart R, Fledrich R, Velanac V, Brinkmann B, Schwab M, Meijer D, et al. A role for Schwann cell-derived neuregulin-1 in remyelination. Nat Neurosci. 2013;16:48-54 pubmed publisher
    ..Upon testing this hypothesis, we found that axonal neuregulin-1 (NRG1) type III and, unexpectedly, also NRG1 type I restored normal myelination when overexpressed in transgenic mice...
  9. Brinkmann B, Agarwal A, Sereda M, Garratt A, Muller T, Wende H, et al. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron. 2008;59:581-95 pubmed publisher
    ..Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS...

More Information

Publications69

  1. Kao S, Wu H, Xie J, Chang C, Ranish J, Graef I, et al. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009;323:651-4 pubmed publisher
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells. ..
  2. Chen S, Velardez M, Warot X, Yu Z, Miller S, Cros D, et al. Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function. J Neurosci. 2006;26:3079-86 pubmed
    ..In vitro assays revealed that neuregulin-1 (NRG1) induces expression of myelin protein zero (P0)...
  3. Chen Y, Johnson M, Lieberman M, Goodchild R, Schobel S, Lewandowski N, et al. Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components. J Neurosci. 2008;28:6872-83 pubmed publisher
    Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration, myelination, and synaptic maintenance. The Nrg1 gene is a schizophrenia susceptibility gene...
  4. Boucher A, Arnold J, Duffy L, Schofield P, Micheau J, Karl T. Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol. Psychopharmacology (Berl). 2007;192:325-36 pubmed
    ..Human and animal research indicates that neuregulin 1 (Nrg1) is a susceptibility gene for schizophrenia...
  5. Ehrlichman R, Luminais S, White S, Rudnick N, Ma N, Dow H, et al. Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain Res. 2009;1294:116-27 pubmed publisher
    Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling...
  6. Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, et al. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009;12:1506-13 pubmed publisher
    ..Furthermore, NRDc enhanced ectodomain shedding of neuregulin1 (NRG1), which is a master regulator of myelination in the PNS...
  7. Syed N, Reddy K, Yang D, Taveggia C, Salzer J, Maurel P, et al. Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination. J Neurosci. 2010;30:6122-31 pubmed publisher
    Members of the neuregulin-1 (Nrg1) growth factor family play important roles during Schwann cell development. Recently, it has been shown that the membrane-bound type III isoform is required for Schwann cell myelination...
  8. Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, et al. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci U S A. 1998;95:13024-9 pubmed
  9. Erickson S, O Shea K, Ghaboosi N, Loverro L, Frantz G, Bauer M, et al. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997;124:4999-5011 pubmed
    ..We have generated ErbB3-, ErbB2- and heregulin-deficient mice to assess their roles in development and differentiation...
  10. Long L, Chesworth R, Arnold J, Karl T. A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice. Psychopharmacology (Berl). 2010;211:277-89 pubmed publisher
    ..We showed previously that male heterozygous neuregulin 1 transmembrane domain (Nrg1 HET) mice are more sensitive to some effects of the psychotropic cannabis constituent Delta(9)-tetrahydrocannabinol ..
  11. Ma Z, Wang J, Song F, Loeb J. Critical period of axoglial signaling between neuregulin-1 and brain-derived neurotrophic factor required for early Schwann cell survival and differentiation. J Neurosci. 2011;31:9630-40 pubmed publisher
    ..Alternatively spliced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve ..
  12. Cotter L, Ozcelik M, Jacob C, Pereira J, Locher V, Baumann R, et al. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science. 2010;328:1415-8 pubmed publisher
    ..Indeed, the Dlg1 brake is no longer functional in a mouse model of Charcot-Marie-Tooth disease. Therefore, negative regulation of myelination appears to be essential for optimization of nerve conduction velocity and myelin maintenance. ..
  13. Bjarnadottir M, Misner D, Haverfield Gross S, Bruun S, Helgason V, Stefansson H, et al. Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice. J Neurosci. 2007;27:4519-29 pubmed
    We previously identified Neuregulin1 (NRG1) as a gene contributing to the risk of developing schizophrenia...
  14. Zhong C, DU C, Hancock M, Mertz M, Talmage D, Role L. Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors. J Neurosci. 2008;28:9111-6 pubmed publisher
    Both the neuregulin 1 (Nrg1) and alpha7 nicotinic acetylcholine receptor (alpha7*nAChRs) genes have been linked to schizophrenia and associated sensory-motor gating deficits...
  15. Rimer M, Barrett D, Maldonado M, Vock V, Gonzalez Lima F. Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibition. Neuroreport. 2005;16:271-5 pubmed
    ..These results suggest that Ig-Nrg-1's contribute to some - but not all - aspects of the schizophrenia-like phenotype of nrg-1 mutants, and further support nrg-1 as a candidate gene for schizophrenia. ..
  16. O Tuathaigh C, Babovic D, O Sullivan G, Clifford J, Tighe O, Croke D, et al. Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1. Neuroscience. 2007;147:18-27 pubmed
    Neuregulin-1 (NRG1) has been identified as a candidate susceptibility gene for schizophrenia...
  17. Fricker F, Zhu N, Tsantoulas C, Abrahamsen B, Nassar M, Thakur M, et al. Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance. J Neurosci. 2009;29:7667-78 pubmed publisher
    ..A limitation to studying its role in adulthood is the embryonic lethality of global Nrg1 gene deletion...
  18. Carraway K. Involvement of the neuregulins and their receptors in cardiac and neural development. Bioessays. 1996;18:263-6 pubmed
    ..The observed defects, together with the localization of expression of the neuregulin signaling components within these tissues, highlight a paracrine mechanism for neuregulin-mediated intercellular communication. ..
  19. Duffy L, Cappas E, Lai D, Boucher A, Karl T. Cognition in transmembrane domain neuregulin 1 mutant mice. Neuroscience. 2010;170:800-7 pubmed publisher
    Neuregulin 1 (NRG1), which has been implicated in the development of schizophrenia, is expressed widely throughout the brain and influences key neurodevelopmental processes such as myelination and neuronal migration...
  20. Karl T, Burne T, van den Buuse M, Chesworth R. Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?. Behav Brain Res. 2011;223:336-41 pubmed publisher
    ..that the heterozygous transmembrane domain mutant mouse model for the schizophrenia candidate gene neuregulin 1 (Nrg1 HET) exhibits a deficit in prepulse inhibition (PPI). However, not all mouse models for Nrg1 exhibit PPI deficits...
  21. Sandrock A, Dryer S, Rosen K, Gozani S, Kramer R, Theill L, et al. Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. Science. 1997;276:599-603 pubmed
    b>ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in cultured myotubes, is a member of the neuregulin family and is present at motor ..
  22. Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36:1035-49 pubmed
    ..We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse...
  23. O Tuathaigh C, O Connor A, O Sullivan G, Lai D, Harvey R, Croke D, et al. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:462-6 pubmed
    Clinical genetic studies have implicated neuregulin-1 [NRG1] as a leading susceptibility gene for schizophrenia...
  24. Lopez Bendito G, Cautinat A, Sanchez J, Bielle F, Flames N, Garratt A, et al. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006;125:127-42 pubmed
    ..Our results also demonstrate that in this process two different products of the Neuregulin-1 gene, CRD-NRG1 and Ig-NRG1, mediate the guidance of thalamocortical axons...
  25. Li L, Cleary S, Mandarano M, Long W, Birchmeier C, Jones F. The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland. Oncogene. 2002;21:4900-7 pubmed
    ..EGF family member HRGalpha is the only HRG1 isoform expressed in the mouse mammary gland and our previous experiments suggest that HRG1 has ..
  26. La Marca R, Cerri F, Horiuchi K, Bachi A, Feltri M, Wrabetz L, et al. TACE (ADAM17) inhibits Schwann cell myelination. Nat Neurosci. 2011;14:857-65 pubmed publisher
    ..We report that TACE cleaves neuregulin-1 (NRG1) type III in the epidermal growth factor domain, probably inactivating it (as assessed by deficient activation of ..
  27. Herndon C, Ankenbruck N, Lester B, Bailey J, Fromm L. Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF-CREB-binding site. Exp Cell Res. 2013;319:718-30 pubmed publisher
    ..Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in muscle cells that are contacted...
  28. Savonenko A, Melnikova T, Laird F, Stewart K, Price D, Wong P. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A. 2008;105:5585-90 pubmed publisher
    ..addition to its role in endoproteolysis of APP, BACE1 participates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of central and peripheral axons...
  29. Bao J, Wolpowitz D, Role L, Talmage D. Back signaling by the Nrg-1 intracellular domain. J Cell Biol. 2003;161:1133-41 pubmed
    ..Thus, regulated proteolytic processing of Nrg-1 results in retrograde signaling that appears to mediate contact and activity-dependent survival of Nrg-1-expressing neurons. ..
  30. Hancock M, Canetta S, Role L, Talmage D. Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons. J Cell Biol. 2008;181:511-21 pubmed publisher
    Type III Neuregulin1 (Nrg1) isoforms are membrane-tethered proteins capable of participating in bidirectional juxtacrine signaling...
  31. Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature. 1995;378:386-90 pubmed
    Neuregulin (also called NDF, heregulin, GGF and ARIA) is a member of the EGF family which induces growth and differentiation of epithelial, glial and muscle cells in culture...
  32. Weinstein E, Leder P. The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. Cancer Res. 2000;60:3856-61 pubmed
    b>Heregulin (HRG) is a member of the neuregulin family of ligands that have been shown to interact with and activate erbB receptors...
  33. Flames N, Long J, Garratt A, Fischer T, Gassmann M, Birchmeier C, et al. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron. 2004;44:251-61 pubmed
    ..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system. ..
  34. Liu Y, Ford B, Mann M, Fischbach G. Neuregulin-1 increases the proliferation of neuronal progenitors from embryonic neural stem cells. Dev Biol. 2005;283:437-45 pubmed
    ..These results suggest that neuregulins are mitogenic to NRPs, thus endogenous neuregulins may play important roles during CNS neurogenesis. ..
  35. O Tuathaigh C, O Sullivan G, Kinsella A, Harvey R, Tighe O, Croke D, et al. Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. Neuroreport. 2006;17:79-83 pubmed
    ..These studies elaborate a pleiotropic role of neuregulin-1 in development, plasticity and function, including sexual dimorphism, by defining the elemental, temporal and sex-specific characteristics of the neuregulin-1 mutant ethogram. ..
  36. Kramer R, Bucay N, Kane D, Martin L, Tarpley J, Theill L. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996;93:4833-8 pubmed
    ..The trigeminal ganglion is reduced in size and lacks projections toward the brain stem and mandible. We conclude that IgL-domain-containing neuregulins play a major role in cardiac and neuronal development. ..
  37. Garratt A, Britsch S, Birchmeier C. Neuregulin, a factor with many functions in the life of a schwann cell. Bioessays. 2000;22:987-96 pubmed
    ..They serve as a model to study glia-nerve interactions in vivo and indicate that Schwann cells provide important neurotrophic signals, and also cues that regulate perineurium development and nerve fasciculation. ..
  38. Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron. 2005;47:681-94 pubmed
    ..We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their ensheathment fate...
  39. Arthur Farraj P, Wanek K, Hantke J, Davis C, Jayakar A, Parkinson D, et al. Mouse schwann cells need both NRG1 and cyclic AMP to myelinate. Glia. 2011;59:720-33 pubmed publisher
    ..source of information about the molecular control of Schwann-cell myelin formation, and the role of ?-neuregulin 1 (NRG1) in this process in vivo...
  40. Fazzari P, Paternain A, Valiente M, Pla R, Lujan R, Lloyd K, et al. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. 2010;464:1376-80 pubmed publisher
    ..Several independent studies have identified neuregulin 1 (NRG1) and its receptor ERBB4 as important risk genes for schizophrenia, although their precise role in the disease ..
  41. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002;71:877-92 pubmed
    ..and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia...
  42. Yokozeki T, Wakatsuki S, Hatsuzawa K, Black R, Wada I, Sehara Fujisawa A. Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells. Genes Cells. 2007;12:329-43 pubmed
    ..The Golgi apparatus is a site of processing Neuregulin beta1 by Meltrin beta. ..
  43. Yang X, Arber S, William C, Li L, Tanabe Y, Jessell T, et al. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron. 2001;30:399-410 pubmed
    ..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation. ..
  44. Dean B, Karl T, Pavey G, Boer S, Duffy L, Scarr E. Increased levels of serotonin 2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice. Schizophr Res. 2008;99:341-9 pubmed
    ..These data are the first evidence to suggest that NRG1 gene expression may be involved in regulating the development of the serotonergic system in the mammalian CNS.
  45. Chen Y, Hancock M, Role L, Talmage D. Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons. J Neurosci. 2010;30:9199-208 pubmed publisher
    Neuregulin 1 (NRG1) signaling is critical to various aspects of neuronal development and function...
  46. Krivosheya D, Tapia L, Levinson J, Huang K, Kang Y, Hines R, et al. ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J Biol Chem. 2008;283:32944-56 pubmed publisher
    Perturbations in neuregulin-1 (NRG1)/ErbB4 function have been associated with schizophrenia...
  47. Wen L, Lu Y, Zhu X, Li X, Woo R, Chen Y, et al. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A. 2010;107:1211-6 pubmed publisher
    Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent studies suggest that it may regulate neurotransmission, mechanisms of which remain elusive...
  48. Bare D, Becker Catania S, DeVries G. Differential localization of neuregulin-1 type III in the central and peripheral nervous system. Brain Res. 2011;1369:10-20 pubmed publisher
    In the developing PNS, axonal neuregulin-1 (NRG1) type III is the key determinant for myelination. However, the specific role for NRG1 (III) in the CNS has not been established...
  49. Chen Y, Zhang M, Yin D, Wen L, Ting A, Wang P, et al. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A. 2010;107:21818-23 pubmed publisher
    Neuregulin 1 (NRG1) is a trophic factor that acts by stimulating ErbB receptor tyrosine kinases and has been implicated in neural development and synaptic plasticity...
  50. Bielle F, Marcos Mondejar P, Keita M, Mailhes C, Verney C, Nguyen Ba Charvet K, et al. Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution. Neuron. 2011;69:1085-98 pubmed publisher
    ..Our study reveals that subtle differences in the migration of conserved intermediate target neurons trigger large-scale changes in thalamic connectivity, and opens perspectives on Slit functions and the evolution of brain wiring. ..
  51. Karl T, Duffy L, Scimone A, Harvey R, Schofield P. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes Brain Behav. 2007;6:677-87 pubmed
    Human genetic studies have shown that neuregulin 1 (NRG1) is a potential susceptibility gene for schizophrenia. Nrg1 influences various neurodevelopmental processes, which are potentially related to schizophrenia...
  52. Huijbregts R, Roth K, Schmidt R, Carroll S. Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells. J Neurosci. 2003;23:7269-80 pubmed
    ..Furthermore, overexpression of this NRG-1 isoform frequently induces neoplastic Schwann cell proliferation within PNS ganglia, suggesting that NRG-1 may contribute to human Schwann cell neoplasia. ..
  53. Michailov G, Sereda M, Brinkmann B, Fischer T, Haug B, Birchmeier C, et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science. 2004;304:700-3 pubmed
    ..We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells...
  54. Fricker F, Lago N, Balarajah S, Tsantoulas C, Tanna S, Zhu N, et al. Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood. J Neurosci. 2011;31:3225-33 pubmed publisher
    Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the peripheral nervous system, but its importance in adulthood after peripheral nerve injury remains unclear...
  55. Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa Sehara A. Roles of Meltrin beta /ADAM19 in the processing of neuregulin. J Biol Chem. 2001;276:9352-8 pubmed
    ..Furthermore, the effects of the secretory pathway inhibitors suggested that meltrin beta participates in the intracellular processing of NRGs rather than the cleavage on the cell surface. ..
  56. Fisahn A, Neddens J, Yan L, Buonanno A. Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia. Cereb Cortex. 2009;19:612-8 pubmed publisher
    ..This study provides the first plausible link between NRG-1/ErbB4 signaling and rhythmic network activity that may be altered in persons with schizophrenia. ..
  57. Wolpowitz D, Mason T, Dietrich P, Mendelsohn M, Talmage D, Role L. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000;25:79-91 pubmed
  58. Tao Y, Dai P, Liu Y, Marchetto S, Xiong W, Borg J, et al. Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009;106:9477-82 pubmed publisher
    Neuregulin 1 (NRG1) plays a critical role in myelination. However, little is known about regulatory mechanisms of NRG1 signaling...
  59. Willem M, Garratt A, Novak B, Citron M, Kaufmann S, Rittger A, et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. 2006;314:664-6 pubmed
    ..Deficiency of BACE1 resulted in the accumulation of unprocessed neuregulin 1 (NRG1), an axonally expressed factor required for glial cell development and myelination...
  60. Kato T, Kasai A, Mizuno M, Fengyi L, Shintani N, Maeda S, et al. Phenotypic characterization of transgenic mice overexpressing neuregulin-1. PLoS ONE. 2010;5:e14185 pubmed publisher
    Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and implicated in the neurotrophic regulation of GABAergic and dopaminergic neurons, myelination, and NMDA receptor function...