Gene Symbol: Nrd1
Description: nardilysin, N-arginine dibasic convertase, NRD convertase 1
Alias: 2600011I06Rik, AI875733, NRD-C, Nrdc, nardilysin, N-arginine dibasic convertase, NRD convertase, nardilysin convertase
Species: mouse
Products:     Nrd1

Top Publications

  1. Chow K, Ma Z, Cai J, Pierce W, Hersh L. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim Biophys Acta. 2005;1723:292-301 pubmed
    Gel filtration chromatography showed that nardilysin activity in a rat testis or rat brain extract exhibited an apparent molecular weight of approximately 300 kDa compared to approximately 187 kDa for the purified enzyme...
  2. Ma Z, Wang X, Hockman S, Snow E, Hersh L. Subcellular localization of nardilysin during mouse oocyte maturation. Arch Biochem Biophys. 2005;434:187-94 pubmed
    We have previously shown that the peptidase, nardilysin, contains a bipartite nuclear localization signal that permits the enzyme to cycle between the nucleus and cytoplasm...
  3. Li J, Chu M, Wang S, CHAN D, Qi S, Wu M, et al. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. J Biol Chem. 2012;287:10089-98 pubmed publisher
    ..In this study, we identified nardilysin (NRDc), a member of M16 family metalloendopeptidases, as a novel dimethyl-H3K4 (H3K4me2)-binding protein...
  4. Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, et al. Nardilysin prevents amyloid plaque formation by enhancing ?-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging. 2014;35:213-22 pubmed publisher
    ..We previously reported that a metalloendopeptidase, nardilysin (N-arginine dibasic convertase; NRDc) enhances ?-cleavage of APP, which results in the decreased generation of A?..
  5. Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem Biophys Res Commun. 2008;370:154-8 pubmed publisher
    ..At present, however, it is poorly understood how its catalytic activity is regulated. Here, we show that nardilysin (N-arginine dibasic convertase; NRDc) enhanced TNF-alpha shedding...
  6. Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, et al. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009;12:1506-13 pubmed publisher
    ..We found that nardilysin (N-arginine dibasic convertase, also known as Nrd1 and NRDc), a metalloendopeptidase enhancer of protein ..
  7. Ishizu Higashi S, Seno H, Nishi E, Matsumoto Y, Ikuta K, Tsuda M, et al. Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes. PLoS ONE. 2014;9:e98017 pubmed publisher
    ..Tumor necrosis factor (TNF)-? is one of the key molecules in initiating the vicious circle of inflammations. Nardilysin (N-arginine dibasic convertase; Nrd1), a zinc metalloendopeptidase of the M16 family, enhances ectodomain ..
  8. Nishi E. [Regulation of protein ectodomain shedding by nardilysin--a critical role of nardilysin in axonal maturation and myelination]. Seikagaku. 2010;82:931-9 pubmed
  9. Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, et al. Nardilysin Is Required for Maintaining Pancreatic ?-Cell Function. Diabetes. 2016;65:3015-27 pubmed publisher
    ..Here we demonstrate that nardilysin (N-arginine dibasic convertase; Nrd1 and NRDc) critically regulates ?-cell function through MafA...

More Information


  1. Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, et al. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. Genomics. 1998;47:238-45 pubmed
    We report the cloning of the human homologue of the rat metalloprotease N-arginine dibasic convertase (NRD convertase)...
  2. Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, et al. Critical roles of nardilysin in the maintenance of body temperature homoeostasis. Nat Commun. 2014;5:3224 pubmed publisher
    ..Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis...
  3. Bernstein H, Steiner J, Bogerts B, Stricker R, Reiser G. Nardilysin, ADAM10, and Alzheimer's disease: of mice and men. Neurobiol Aging. 2014;35:e1 pubmed publisher
  4. Rorick N, Kinoshita A, Weirather J, Peyrard Janvid M, de Lima R, Dunnwald M, et al. Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Am J Med Genet A. 2011;155A:1314-21 pubmed publisher
    ..The expression and mutation data were consistent with the hypothesis that WDR65 was a novel gene involved in oral clefting. ..
  5. Chow K, Oakley O, Goodman J, Ma Z, Juliano M, Juliano L, et al. Nardilysin cleaves peptides at monobasic sites. Biochemistry. 2003;42:2239-44 pubmed
    b>Nardilysin (N-arginine dibasic convertase, EC was first identified on the basis of its ability to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys...
  6. Ma Z, Csuhai E, Chow K, Hersh L. Expression of the acidic stretch of nardilysin as a functional binding domain. Biochemistry. 2001;40:9447-52 pubmed
    Kinetic evidence suggests an acidic region in nardilysin binds polyamines and acts as a regulatory domain. The binding of approximately 5 mol of spermine/mol of nardilysin was demonstrated...
  7. Fontes G, Lajoix A, Bergeron F, Cadel S, Prat A, Foulon T, et al. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Endocrinology. 2005;146:702-12 pubmed
    ..We observed that glucagon is a substrate for N-arginine dibasic convertase (NRDc), a metalloendoprotease, and that aminopeptidase B cleaves in vitro the intermediate cleavage products sequentially,..
  8. Ma Z, Chow K, Csuhai E, Hersh L. The use of proteolysis to study the structure of nardilysin. Arch Biochem Biophys. 2002;401:198-204 pubmed
    Treatment of a 128 kDa mouse nardilysin with trypsin initially produced an active 105 kDa N-terminally cleaved form. Continued trypsin digestion occurred at the C-terminus, producing inactive core species of approximately 92, 76...
  9. Winter A, Pierotti A. Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. Biochem J. 2000;351 Pt 3:755-64 pubmed
    b>NRD convertase (N-arginine dibasic convertase, NRD-C) is a dibasic selective metalloprotease which cleaves on the N-terminal side of an arginine residue in a dibasic pair...