Gene Symbol: Nr4a1
Description: nuclear receptor subfamily 4, group A, member 1
Alias: GFRP1, Gfrp, Hbr-1, Hbr1, Hmr, N10, NGFI-B, NGFIB, NP10, NUR77-1, NUR77-2, TIS1, TR3, nur77, nuclear receptor subfamily 4 group A member 1, hormone receptor, nuclear hormone receptor NUR/77, nuclear protein N10, orphan nuclear receptor HMR
Species: mouse
Products:     Nr4a1

Top Publications

  1. Lee S, Wesselschmidt R, Linette G, Kanagawa O, Russell J, Milbrandt J. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science. 1995;269:532-5 pubmed
    T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells...
  2. French P, O CONNOR V, Voss K, Stean T, Hunt S, Bliss T. Seizure-induced gene expression in area CA1 of the mouse hippocampus. Eur J Neurosci. 2001;14:2037-41 pubmed
    ..8-2-fold) confirmed the differential expression of a single gene that encodes for the nuclear hormone receptor NGFI-B (Nur77, N10)...
  3. Song K, Park Y, Park K, Hong C, Park J, Shong M, et al. The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol. 2004;18:1929-40 pubmed
    ..In this study, we have found that DAX-1 is a novel coregulator of the orphan nuclear receptor Nur77 (NR4A1). We demonstrate that DAX-1 represses the Nur77 transactivation by transient transfection assays...
  4. Wingate A, Campbell D, Peggie M, Arthur J. Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J. 2006;393:715-24 pubmed
    b>Nur77 is a nuclear orphan receptor that is able to activate transcription independently of exogenous ligand, and has also been shown to promote apoptosis on its localization to mitochondria...
  5. Lavoie P, Budry L, Balsalobre A, Drouin J. Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. Mol Endocrinol. 2008;22:1647-57 pubmed publisher
    ..These data contrast the sustained dependence throughout development on the same regulatory elements with the highly dynamic patterns of TF expression and the modulation of their activity in response to signaling pathways. ..
  6. Lee S, Park E, Kim S, Ahn R, Ko C, Lee K. ER?/E2 signaling suppresses the expression of steroidogenic enzyme genes via cross-talk with orphan nuclear receptor Nur77 in the testes. Mol Cell Endocrinol. 2012;362:91-103 pubmed publisher
    ..Here, we investigate the effect of estrogen and ER? on Nur77, a major transcription factor that regulates the expression of steroidogenic enzyme genes...
  7. De Waard V, Arkenbout E, Vos M, Mocking A, Niessen H, Stooker W, et al. TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells. Am J Pathol. 2006;168:2027-35 pubmed
    ..We studied the function of TR3 nuclear orphan receptor (TR3) in the early response of SMCs to mechanical strain, a major initiator of vein-graft ..
  8. Fu Y, Luo L, Luo N, Zhu X, Garvey W. NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance. J Biol Chem. 2007;282:31525-33 pubmed
    After observing that expression of two NR4A orphan nuclear receptors, NR4A3 and NR4A1, was altered by insulin in cDNA microarray analyses of human skeletal muscle, we studied whether these receptors could modulate insulin sensitivity...
  9. Pei L, Castrillo A, Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol. 2006;20:786-94 pubmed
    Members of the nuclear hormone receptor superfamily have emerged as important regulators of macrophage gene expression in inflammation and disease...

More Information


  1. Pols T, Ottenhoff R, Vos M, Levels J, Quax P, Meijers J, et al. Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Biochem Biophys Res Commun. 2008;366:910-6 pubmed
    ..Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism...
  2. Zhang J, DeYoung A, Kasler H, Kabra N, Kuang A, Diehl G, et al. Receptor-mediated apoptosis in T lymphocytes. Cold Spring Harb Symp Quant Biol. 1999;64:363-71 pubmed
  3. Stasik I, Rapak A, Kalas W, Ziolo E, Strzadala L. Ionomycin-induced apoptosis of thymocytes is independent of Nur77 NBRE or NurRE binding, but is accompanied by Nur77 mitochondrial targeting. Biochim Biophys Acta. 2007;1773:1483-90 pubmed
    The induction of thymocyte apoptosis through the Nur77-mediated intrinsic pathway can be of physiological importance in the clonal deletion of autoreactive thymocytes during negative selection in the thymus and/or in thymocytes ..
  4. Cheng L, Chan F, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997;16:1865-75 pubmed
    The transcription factor Nur77 (NGFI-B), a member of the steroid nuclear receptor superfamily, is induced to a high level during T-cell receptor (TCR)-mediated apoptosis...
  5. Pei L, Waki H, Vaitheesvaran B, Wilpitz D, Kurland I, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med. 2006;12:1048-55 pubmed
    ..Hepatic expression of Nur77, Nurr1 and NOR1 is induced by the cAMP axis in response to glucagon and fasting in vivo and is increased in ..
  6. Ding L, Yan G, Ge Q, Yu F, Zhao X, Diao Z, et al. FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells. FEBS Lett. 2011;585:2437-44 pubmed publisher
    ..In the present study, FSH induced the expression of Nur77 and GDNF in mouse testis tissue and human fetal Sertoli cells...
  7. Crawford P, Sadovsky Y, Woodson K, Lee S, Milbrandt J. Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol. 1995;15:4331-16 pubmed
  8. Zetterström R, Solomin L, Mitsiadis T, Olson L, Perlmann T. Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol Endocrinol. 1996;10:1656-66 pubmed
    NGFI-B, Nurr1, and Nor1 are three closely related orphan members of the steroid/thyroid hormone receptor superfamily. These receptors can bind to DNA as monomers and exhibit constitutive transcriptional activity...
  9. Qamar I, Gong E, Kim Y, Song C, Lee H, Chun S, et al. Anti-steroidogenic factor ARR19 inhibits testicular steroidogenesis through the suppression of Nur77 transactivation. J Biol Chem. 2010;285:22360-9 pubmed publisher
    ..In the present study, we demonstrate that ARR19 inhibits the transactivation of orphan nuclear receptor Nur77, which is one of the major transcription factors that regulate the expression of steroidogenic enzyme genes in ..
  10. Rajpal A, Cho Y, Yelent B, Koza Taylor P, Li D, Chen E, et al. Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J. 2003;22:6526-36 pubmed
    b>Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear...
  11. Cunningham N, Artim S, Fornadel C, Sellars M, Edmonson S, Scott G, et al. Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation. J Immunol. 2006;177:6660-6 pubmed
    The orphan steroid receptor, Nur77, is thought to be a central participant in events leading to TCR-mediated clonal deletion of immature thymocytes...
  12. Lee K, Ma L, Yan X, Liu B, Zhang X, Cohen P. Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J Biol Chem. 2005;280:16942-8 pubmed
    ..Here we describe that in response to IGFBP-3, the RXRalpha binding partner nuclear receptor Nur77 rapidly undergoes translocation from the nucleus to the mitochondria, initiating an apoptotic cascade resulting in ..
  13. Nomiyama T, Zhao Y, Gizard F, Findeisen H, Heywood E, Jones K, et al. Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation. 2009;119:577-86 pubmed publisher
    ..receptor-1 (NOR1) belongs to the evolutionary highly conserved and most ancient NR4A subfamily of the nuclear hormone receptor superfamily...
  14. Chao L, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva O, et al. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009;58:2788-96 pubmed publisher
    b>Nur77 is an orphan nuclear receptor with pleotropic functions. Previous studies have identified Nur77 as a transcriptional regulator of glucose utilization genes in skeletal muscle and gluconeogenesis in liver...
  15. Martin L, Tremblay J. Nuclear receptors in Leydig cell gene expression and function. Biol Reprod. 2010;83:3-14 pubmed publisher
    ..g., NR2F2 and NR5A1) have been shown to play essential roles in Leydig cells, whereas for others (e.g., NR2B1 and NR4A1), the assessment of their function has been precluded by the early embryonic lethality associated with null mice ..
  16. Calnan B, Szychowski S, Chan F, Cado D, Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 1995;3:273-82 pubmed
    The transcription factor Nur77, an orphan member of the nuclear hormone receptor superfamily, is highly expressed during T cell receptor-signaled apoptosis, suggesting a possible role for Nur77 in negative selection...
  17. Zhou F, Drabsch Y, Dekker T, de Vinuesa A, Li Y, Hawinkels L, et al. Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling. Nat Commun. 2014;5:3388 pubmed publisher
    ..Here using a genome-wide cDNA screen, we identify nuclear receptor NR4A1 as a strong activator of TGF-? signalling...
  18. Smith A, Luk N, Newton R, Roberts D, Sturm R, Muscat G. Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. J Biol Chem. 2008;283:12564-70 pubmed publisher
    ..Using small interference RNA-mediated attenuation of NR4A1 and NR4A2 expression in melanocytes, the ability to remove cyclobutane pyrimidine dimers following UV irradiation ..
  19. Nakai A, Kartha S, Sakurai A, Toback F, DeGroot L. A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol Endocrinol. 1990;4:1438-43 pubmed
    When a human fetal muscle cDNA library was screened with the human thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA...
  20. Chen H, Liu Q, Li L, Wang W, Yao L, Yang M, et al. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. Gut. 2012;61:714-24 pubmed publisher
    ..Dysregulation of the Wnt signalling pathway has been linked to colorectal cancer. The orphan nuclear receptor TR3 plays important roles in proliferation and apoptosis...
  21. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005;280:29256-62 pubmed
    ..macrophages with lipopolysaccharide (LPS), cytokines, or oxidized lipids triggers the transcriptional induction of Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3) expression...
  22. Hazel T, Nathans D, Lau L. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci U S A. 1988;85:8444-8 pubmed
    ..These results suggest that the growth factor-inducible immediate early gene nur/77 encodes a ligand-binding protein that regulates the genomic response to growth factors. ..
  23. Weih F, Ryseck R, Chen L, Bravo R. Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc Natl Acad Sci U S A. 1996;93:5533-8 pubmed
    The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas...
  24. Maira M, Martens C, Philips A, Drouin J. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol Cell Biol. 1999;19:7549-57 pubmed
    We have recently shown that the orphan nuclear receptor Nur77 (NGFI-B) is most active in transcription when it is interacting with a cognate DNA sequence as a homodimer...
  25. Maxwell M, Cleasby M, Harding A, Stark A, Cooney G, Muscat G. Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway. J Biol Chem. 2005;280:12573-84 pubmed
    ..skeletal muscle cells strikingly activated (>100-fold) the expression of the mRNA encoding the nuclear hormone receptor, Nur77...
  26. Ramirez Herrick A, Mullican S, Sheehan A, Conneely O. Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice. Blood. 2011;117:2681-90 pubmed publisher
    The NR4A subfamily of nuclear receptors (NR4A1, NR4A2, and NR4A3) function as transcription factors that transduce diverse extracellular signals into altered gene transcription to coordinate apoptosis, proliferation, cell cycle arrest, ..
  27. Pires N, Pols T, De Vries M, Van Tiel C, Bonta P, Vos M, et al. Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation. Circulation. 2007;115:493-500 pubmed
    ..We have shown that the nuclear receptor Nur77 protects against SMC-rich lesion formation, and it has been demonstrated that 6-mercaptopurine (6-MP) enhances ..
  28. Mullican S, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J, et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med. 2007;13:730-5 pubmed
    b>Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes...
  29. Darragh J, Soloaga A, Beardmore V, Wingate A, Wiggin G, Peggie M, et al. MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling. Biochem J. 2005;390:749-59 pubmed
    ..Here we show that the MSKs are involved in regulating the transcription of the immediate early gene Nur77. Stimulation of mouse embryonic fibroblasts with PMA, EGF (epidermal growth factor), TNF (tumour necrosis factor) ..
  30. Chao L, Bensinger S, Villanueva C, Wroblewski K, Tontonoz P. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008;22:2596-608 pubmed publisher
    ..We show here that although Nur77 expression is acutely induced by cAMP agonists in 3T3-L1 cells, it is not induced by other adipogenic stimuli, ..
  31. Hanna R, Shaked I, Hubbeling H, Punt J, Wu R, Herrley E, et al. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res. 2012;110:416-27 pubmed publisher
    NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown...
  32. Shao Q, Shen L, Hu L, Pu J, Qi M, Li W, et al. Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL. J Mol Cell Cardiol. 2010;49:304-11 pubmed publisher
    ..Orphan nuclear receptor Nur77 is potently induced in macrophages by diverse stimuli, suggesting that it may be a key regulator of inflammation ..
  33. Hanna R, Carlin L, Hubbeling H, Nackiewicz D, Green A, Punt J, et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes. Nat Immunol. 2011;12:778-85 pubmed publisher
    ..Here we found that the orphan nuclear receptor NR4A1 controlled the differentiation of Ly6C- monocytes...
  34. Thompson J, Winoto A. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med. 2008;205:1029-36 pubmed publisher
    Apoptosis accompanying negative selection is a central but poorly understood event in T cell development. The Nur77 nuclear steroid receptor and Bim, a proapoptotic BH3-only member of the Bcl-2 family, are two molecules implicated in ..
  35. Balasubramanian S, Jansen M, Valerius M, Humphreys B, Strom T. Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. J Am Soc Nephrol. 2012;23:674-86 pubmed publisher
    b>Nur77 and its family members Nurr1 and Nor-1 are inducible orphan nuclear receptors that orchestrate cellular responses to diverse extracellular signals...
  36. Fumoto T, Yamaguchi T, Hirose F, Osumi T. Orphan nuclear receptor Nur77 accelerates the initial phase of adipocyte differentiation in 3T3-L1 cells by promoting mitotic clonal expansion. J Biochem. 2007;141:181-92 pubmed
    b>Nur77 is an orphan member of the nuclear receptor superfamily that is expressed in various types of cells and mediates diverse biological processes...
  37. Wang S, Myers S, Eriksson N, Fitzsimmons R, Muscat G. Nr4a1 siRNA expression attenuates ?-MSH regulated gene expression in 3T3-L1 adipocytes. Mol Endocrinol. 2011;25:291-306 pubmed publisher
    ..These observations, and the latest reports highlighting the emerging role of the nuclear hormone receptor (NR) 4A subgroup in metabolism, have prompted us to investigate the cross talk between [Nle(4), d-Phe(7)] (..
  38. Hamers A, Vos M, Rassam F, Marinković G, Marincovic G, Kurakula K, et al. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circ Res. 2012;110:428-38 pubmed publisher
    Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle cells...
  39. Ryseck R, Macdonald Bravo H, Mattei M, Ruppert S, Bravo R. Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J. 1989;8:3327-35 pubmed
    ..a nuclear protein of 601 amino acids with a significant similarity to members of the steroid and thyroid hormone receptor families. The gene is rapidly but transiently induced by several mitogens...
  40. Law S, Conneely O, DeMayo F, O Malley B. Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992;6:2129-35 pubmed
    ..acid sequence of the protein is closely related to an additional family member and immediate early gene product, Nur77, and the novel factor is referred to as Nurr1 (Nur-related factor 1)...
  41. Zhou T, Cheng J, Yang P, Wang Z, Liu C, Su X, et al. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J Exp Med. 1996;183:1879-92 pubmed
    The Nur77/Nurr1 family of DNA binding proteins has been reported to be required for the signal transduction of CD3/T cell receptor (TCR)-mediated apoptosis in T cell hybridomas...
  42. Zeng H, Qin L, Zhao D, Tan X, Manseau E, van Hoang M, et al. Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity. J Exp Med. 2006;203:719-29 pubmed
    ..that human VEGF-A exerts much of its angiogenic activity by up-regulating the expression of TR3 (mouse homologue Nur77), an immediate-early response gene and orphan nuclear receptor transcription factor previously implicated in tumor ..
  43. Maira M, Martens C, Batsche E, Gauthier Y, Drouin J. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol. 2003;23:763-76 pubmed
    The NGFI-B (Nur77) subfamily of orphan nuclear receptors (NRs), which also includes Nurr1 and NOR1, bind the NurRE regulatory element as either homo- or heterodimers formed between subfamily members...
  44. Kurakula K, Vos M, Logiantara A, Roelofs J, Nieuwenhuis M, Koppelman G, et al. Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-κB Activity in Lung Epithelial Cells. J Immunol. 2015;195:1388-98 pubmed publisher
    ..Nuclear receptor Nur77 plays a pivotal role in distinct immune and inflammatory cells and is expressed in eosinophils and lung epithelium...
  45. Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher
    We previously showed that the orphan nuclear receptor Nur77 (Nr4a1) plays an important role in the regulation of glucose homeostasis and oxidative metabolism in skeletal muscle...
  46. Chao L, Soto E, Hong C, Ito A, Pei L, Chawla A, et al. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013;54:806-15 pubmed publisher
    ..Transplantation of wild-type, Nur77?/?, or Nor1?/? null hematopoetic precursors into LDL receptor (LDLR)?/? recipient mice led to comparable ..
  47. Xu A, Liu J, Liu P, Jia M, Wang H, Tao L. Mitochondrial translocation of Nur77 induced by ROS contributed to cardiomyocyte apoptosis in metabolic syndrome. Biochem Biophys Res Commun. 2014;446:1184-9 pubmed publisher
    ..b>Nur77, a nuclear orphan receptor, is involved in such various cellular events as apoptosis, proliferation, and glucose ..
  48. Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, et al. Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 2016;35:1730-44 pubmed publisher
    ..Our data provide new cellular and molecular insights into the origin and developmental pathways of tissue M?. ..
  49. Abdou H, Robert N, Tremblay J. Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements. J Mol Endocrinol. 2016;56:151-61 pubmed publisher
    The nuclear receptor NR4A1 is expressed in steroidogenic Leydig cells where it plays pivotal roles by regulating the expression of several genes involved in steroidogenesis and male sex differentiation including Star, HSD3B2, and Insl3 ..
  50. Nowyhed H, Huynh T, Blatchley A, Wu R, Thomas G, Hedrick C. The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3. Sci Rep. 2015;5:9059 pubmed publisher
    The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the role of Nr4a1 in CD8(+) T cells remains undefined...
  51. Fujii Y, Matsuda S, Takayama G, Koyasu S. ERK5 is involved in TCR-induced apoptosis through the modification of Nur77. Genes Cells. 2008;13:411-9 pubmed publisher
    b>Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection when immature T cells are strongly activated through interaction with self peptide-MHC complexes...
  52. Dinkel A, Warnatz K, Ledermann B, Rolink A, Zipfel P, Burki K, et al. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells. J Exp Med. 1998;188:2215-24 pubmed
    ..expression pattern of potential Egr-1 target genes revealed that Egr-1 enhances the expression of the aminopeptidase BP-1/6C3 in pre-B and immature B cells and upregulates expression of the orphan nuclear receptor nur77 in IgM+ B cells.
  53. Tóth B, Ludanyi K, Kiss I, Reichert U, Michel S, Fesus L, et al. Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells. Eur J Immunol. 2004;34:827-836 pubmed publisher
    ..The apoptosis is dependent on new mRNA and protein synthesis and involves up-regulation of nur77. Two groups of nuclear receptors for retinoic acids (RA) have been identified: retinoic acid receptors (RAR) and ..
  54. Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 2015;212:1623-40 pubmed publisher
    ..These findings demonstrate that Nr4a factors play crucial roles in mature T reg cells by directly controlling a genetic program indispensable for T reg cell maintenance and function. ..
  55. Briseño C, Haldar M, Kretzer N, Wu X, Theisen D, Kc W, et al. Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells. Cell Rep. 2016;15:2462-74 pubmed publisher
    ..Thus, cDCs and Mo-DCs require distinct transcriptional programs of differentiation in acquiring the capacity to prime CD8(+) T cells. These differences may be of consideration in the use of therapeutic DC vaccines based on Mo-DCs. ..
  56. Austdal L, Mathisen G, Løberg E, Paulsen R. Calcium-induced apoptosis of developing cerebellar granule neurons depends causally on NGFI-B. Int J Dev Neurosci. 2016;55:82-90 pubmed publisher
    ..This resulted in a complete inhibition of apoptosis after CaI exposure. Together these findings suggest that NGFI-B plays a role in controlling correct cerebellar development. ..
  57. Lammi J, Aarnisalo P. FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts. Mol Cell Endocrinol. 2008;295:87-93 pubmed publisher
    ..In conclusion, FGF-8b induces the expression of NR4A orphan nuclear receptors that are involved in mediating the growth promoting effect of FGF-8b in osteoblasts. ..
  58. Kunst S, Wolloscheck T, Kelleher D, Wolfrum U, Sargsyan S, Iuvone P, et al. Pgc-1α and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina. Invest Ophthalmol Vis Sci. 2015;56:6084-94 pubmed publisher
    ..transcriptional regulators important for retinal physiology and/or pathology (Dbp, Egr-1, Fos, Nr1d1, Nr2e3, Nr4a1, Pgc-1α, Rorβ) for circadian regulation and dependence on melatonin signaling/MT1 receptors or dopamine ..
  59. Myers S, Eriksson N, Burow R, Wang S, Muscat G. Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues. Mol Cell Endocrinol. 2009;309:101-8 pubmed publisher
    The nuclear hormone receptor (NR) 4A subgroup of orphan nuclear receptors includes three members, Nur77 (NR4A1), Nurr1 (NR4A2) and Nor-1 (NR4A3)...
  60. Thomas G, Hanna R, Vasudevan N, Hamers A, Romanoski C, McArdle S, et al. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity. 2016;45:975-987 pubmed publisher
    ..Using Nr4a1-dependent Ly6Clow monocytes, we present a proof-of-principle approach that addresses these limitations...
  61. Bland M, Fowkes R, Ingraham H. Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol. 2004;18:941-52 pubmed
    ..Our findings underscore the need for full SF-1 gene dosage early in adrenal development, but not in the adult adrenal, where compensatory mechanisms restore near normal function. ..
  62. Daems C, Martin L, Brousseau C, Tremblay J. MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1. Mol Endocrinol. 2014;28:886-98 pubmed publisher
    ..In Leydig cells, MEF2 was found to activate the expression of Nr4a1, a nuclear receptor important for hormone-induced steroidogenesis...
  63. Moldovan S, Nervina J, Tetradis S, Camargo P. Regulation of Nur77 gene expression by prostanoids in cementoblastic cells. Arch Oral Biol. 2009;54:412-9 pubmed publisher
    ..cells revealed that one of the primary response genes preferentially induced by flup is the transcription factor Nur77. The objective of this study was to examine the signal transduction cascades regulating prostanoid induction of ..
  64. Zhang Y, He J, Zhao J, Xu M, Lou D, Tso P, et al. Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochem Biophys Res Commun. 2017;487:327-332 pubmed publisher
    ..The transcriptional response of SERPINA3 to ApoA4 is regulated through the binding of ApoA4 with nuclear receptors NR4A1 and NR1D1 on the SERPINA3 promoter, which was verified with ChIP, Luciferase activity assay and RNA interference-..