Nr2e1

Summary

Gene Symbol: Nr2e1
Description: nuclear receptor subfamily 2, group E, member 1
Alias: Mtl1, Mtll, TLL, Tlx, XTLL, fierce, frc, tailless, nuclear receptor subfamily 2 group E member 1, nuclear receptor TLX, protein tailless homolog, tailless homolog
Species: mouse
Products:     Nr2e1

Top Publications

  1. Liu H, Belz T, Bock D, Takacs A, Wu H, Lichter P, et al. The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev. 2008;22:2473-8 pubmed publisher
    The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG)...
  2. Zhao C, Sun G, Li S, Lang M, Yang S, Li W, et al. MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Proc Natl Acad Sci U S A. 2010;107:1876-81 pubmed publisher
    ..stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased ..
  3. Li S, Sun G, Murai K, Ye P, Shi Y. Characterization of TLX expression in neural stem cells and progenitor cells in adult brains. PLoS ONE. 2012;7:e43324 pubmed publisher
    b>TLX has been shown to play an important role in regulating the self-renewal and proliferation of neural stem cells in adult brains. However, the cellular distribution of endogenous TLX protein in adult brains remains to be elucidated...
  4. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, et al. The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci. 2004;24:8333-45 pubmed
    The tailless (tlx) gene is a forebrain-restricted transcription factor. Tlx mutant animals exhibit a reduction in the size of the cerebral hemispheres and associated structures (Monaghan et al., 1997)...
  5. Monaghan A, Grau E, Bock D, Schutz G. The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development. 1995;121:839-53 pubmed
    The Drosophila tailless gene is a member of the orphan nuclear receptor subfamily. In Drosophila, the tailless gene is required for pattern formation in embryonic poles...
  6. Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y. Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain. Mol Endocrinol. 2008;22:56-64 pubmed
    b>TLX is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although TLX is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown...
  7. Yu R, Chiang M, Tanabe T, Kobayashi M, Yasuda K, Evans R, et al. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci U S A. 2000;97:2621-5 pubmed
    ..The localized expression of the orphan nuclear receptor Tlx in the optic cup and discrete parts of the central nervous system suggested the possible role of Tlx in the ..
  8. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu R, et al. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004;427:78-83 pubmed
    The finding of neurogenesis in the adult brain led to the discovery of adult neural stem cells. TLX was initially identified as an orphan nuclear receptor expressed in vertebrate forebrains and is highly expressed in the adult brain...
  9. Monaghan A, Bock D, Gass P, Schwager A, Wolfer D, Lipp H, et al. Defective limbic system in mice lacking the tailless gene. Nature. 1997;390:515-7 pubmed
    The gene tailless is a member of the superfamily of genes that encode transcription factors of the ligand-activated nuclear receptor type, and is expressed in the invertebrate and vertebrate brain...

More Information

Publications62

  1. Zhang C, Zou Y, He W, Gage F, Evans R. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008;451:1004-7 pubmed publisher
    ..The adult neural stem cell pool is composed of orphan nuclear receptor TLX-positive cells...
  2. Obernier K, Simeonova I, Fila T, Mandl C, Hölzl Wenig G, Monaghan Nichols P, et al. Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone. Stem Cells. 2011;29:1415-26 pubmed publisher
    ..The mechanisms regulating this balance are scarcely known. Recent observations indicate that the orphan nuclear receptor Tlx is an intrinsic factor essential in maintaining this balance...
  3. Zhao C, Sun G, Ye P, Li S, Shi Y. MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis. Sci Rep. 2013;3:1329 pubmed publisher
    ..has been implicated in cocaine addiction and other neurological disorders, targets the neural stem cell regulator TLX. Overexpression of let-7d in vivo reduced neural stem cell proliferation and promoted premature neuronal ..
  4. Stenman J, Wang B, Campbell K. Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J Neurosci. 2003;23:10568-76 pubmed
    We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g...
  5. Chavali P, Saini R, Matsumoto Y, Agren H, Funa K. Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. J Biol Chem. 2011;286:9393-404 pubmed publisher
    ..Here, we have identified the nuclear orphan receptor TLX as a mediator for proliferation and pluripotency of neural progenitors upon hypoxia...
  6. Elmi M, Matsumoto Y, Zeng Z, Lakshminarasimhan P, Yang W, Uemura A, et al. TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors. Mol Cell Neurosci. 2010;45:121-31 pubmed publisher
    The orphan nuclear receptor TLX has been proposed to act as a repressor of cell cycle inhibitors to maintain the neural stem cells in an undifferentiated state, and prevents commitment into astrocyte lineages...
  7. Sun G, Ye P, Murai K, Lang M, Li S, Zhang H, et al. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun. 2011;2:529 pubmed publisher
    ..addition, we show that the histone lysine-specific demethylase 1 (LSD1), a transcriptional co-repressor of nuclear receptor TLX, is a downstream target of miR-137...
  8. Niu W, Zou Y, Shen C, Zhang C. Activation of postnatal neural stem cells requires nuclear receptor TLX. J Neurosci. 2011;31:13816-28 pubmed publisher
    ..Here, we show that nuclear receptor TLX (NR2E1) controls the activation status of postnatal NSCs in mice...
  9. Schmouth J, Banks K, Mathelier A, Gregory Evans C, Castellarin M, Holt R, et al. Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice. Mol Cell Biol. 2012;32:1296-311 pubmed publisher
    b>Nr2e1 encodes a stem cell fate determinant of the mouse forebrain and retina. Abnormal regulation of this gene results in retinal, brain, and behavioral abnormalities in mice...
  10. Zhao C, Sun G, Li S, Shi Y. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol. 2009;16:365-71 pubmed publisher
    ..We showed previously that the nuclear receptor TLX is an essential regulator of neural stem cell self-renewal...
  11. Liu H, Wang Y, Belz T, Bock D, Takacs A, Radlwimmer B, et al. The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev. 2010;24:683-95 pubmed publisher
    ..Here we demonstrate that the nuclear receptor tailless (Tlx), which in the adult is expressed exclusively in astrocyte-like B cells of the subventricular zone, acts as ..
  12. Sun G, Yu R, Evans R, Shi Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007;104:15282-7 pubmed
    b>TLX is a transcription factor that is essential for neural stem cell proliferation and self-renewal. However, the molecular mechanism of TLX-mediated neural stem cell proliferation and self-renewal is largely unknown...
  13. Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, et al. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol. 2010;30:1997-2005 pubmed publisher
    ..LSD1 is recruited by nuclear receptor TLX, an essential neural stem cell regulator, to the promoters of TLX target genes to repress the expression of ..
  14. Yu J, Guo Q, Mu J, Zhang T, Li R, Xie J. Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain. Biomed Environ Sci. 2017;30:185-193 pubmed publisher
    This study aimed to investigate the expression pattern and function of Nuclear receptor subfamily 2 group E member 1 (Nr2e1) in retinoic acid (RA)-induced brain abnormality...
  15. Zhu Z, Khan M, Weiler M, Blaes J, Jestaedt L, Geibert M, et al. Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. Cell Stem Cell. 2014;15:185-98 pubmed publisher
    ..Using a GFP reporter driven by the promoter of the nuclear receptor tailless (Tlx), we demonstrate that Tlx(+) cells in primary brain tumors are mostly quiescent...
  16. Corso Díaz X, de Leeuw C, Alonso V, Melchers D, Wong B, Houtman R, et al. Co-activator candidate interactions for orphan nuclear receptor NR2E1. BMC Genomics. 2016;17:832 pubmed
    b>NR2E1 (Tlx) is an orphan nuclear receptor that regulates the maintenance and self-renewal of neural stem cells, and promotes tumourigenesis. Nr2e1-null mice exhibit reduced cortical and limbic structures and pronounced retinal dystrophy...
  17. Juárez P, Valdovinos M, May M, Lloyd B, Couppis M, Kennedy C. Serotonin?A/C receptors mediate the aggressive phenotype of TLX gene knockout mice. Behav Brain Res. 2013;256:354-61 pubmed publisher
    Deleting the tailless (TLX) gene in mice produces a highly aggressive phenotype yet to be characterized in terms of heterozygous animals or neurotransmitter mechanisms...
  18. Huang Y, Liu X, Wang Y. MicroRNA-378 regulates neural stem cell proliferation and differentiation in vitro by modulating Tailless expression. Biochem Biophys Res Commun. 2015;466:214-20 pubmed publisher
    ..In this study, we showed that miR-378 can target Tailless (TLX), a critical regulator of NSC, to regulate NSC proliferation and differentiation...
  19. Shi X, Deng H, Dai Z, Xu Y, Xiong X, Ma P, et al. Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells. Oxid Med Cell Longev. 2016;2016:9648769 pubmed publisher
    b>Nuclear receptor subfamily 2 group E member 1 (Nr2e1) has been regarded as an essential regulator of the growth of neural stem cells. However, its function elsewhere is unknown...
  20. Land P, Monaghan A. Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Cereb Cortex. 2003;13:921-31 pubmed
    The gene tailless (tlx) encodes a forebrain-restricted transcription factor that is robustly expressed in progenitor cells of the ventricular and subventricular zones during neurogenesis...
  21. Hu Y, Luo M, Ni N, Den Y, Xia J, Chen J, et al. Reciprocal actions of microRNA-9 and TLX in the proliferation and differentiation of retinal progenitor cells. Stem Cells Dev. 2014;23:2771-81 pubmed publisher
    ..The expression of miR-9 was inversely correlated with that of the nuclear receptor TLX, which is an essential regulator of neural stem cell self-renewal...
  22. Kumar R, Chan K, Wong A, Little K, Rajcan Separovic E, Abrahams B, et al. Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice. Genesis. 2004;38:51-7 pubmed
    ..Here we show that the single gene mutation, Nr2e1(frc) (fierce), which was responsible for the brain-behavior phenotype, existed in the embryonic stem (ES) cell even before the ..
  23. Schuurmans C, Armant O, Nieto M, Stenman J, Britz O, Klenin N, et al. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004;23:2892-902 pubmed
    ..neurons are specified in an Ngn-independent manner, requiring instead the synergistic activities of Pax6 and Tlx, which also control a binary choice between cortical/glutamatergic and subcortical/GABAergic fates...
  24. Zou Y, Niu W, Qin S, Downes M, Burns D, Zhang C. The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol. 2012;32:4811-20 pubmed publisher
    ..The orphan nuclear receptor TLX is required for proliferation of adult NSCs, and its upregulation promotes brain tumor formation...
  25. Belz T, Liu H, Bock D, Takacs A, Vogt M, Wintermantel T, et al. Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye. Eur J Neurosci. 2007;26:2222-7 pubmed
    During embryogenesis, tailless, an orphan member of the nuclear receptor family, is expressed in the germinal zones of the brain and the developing retina, and is involved in regulating the cell cycle of progenitor cells...
  26. Chalhoub N, Benachenhou N, Vacher J. Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21. Mamm Genome. 2001;12:887-92 pubmed
    ..The physical and transcriptional map presented here will provide novel resources to isolate the gl locus associated with osteopetrosis, and will also provide candidate loci for other defects mapped on human Chr 6q. ..
  27. O Leary J, Kozareva D, Hueston C, O Leary O, Cryan J, Nolan Y. The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood. Behav Brain Res. 2016;306:36-47 pubmed publisher
    The nuclear receptor Tlx is a key regulator of embryonic and adult hippocampal neurogenesis and has been genetically linked to bipolar disorder...
  28. Uemura A, Kusuhara S, Wiegand S, Yu R, Nishikawa S. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest. 2006;116:369-77 pubmed
    ..We show that in the postnatal mouse retina, the orphan nuclear receptor tailless (Tlx) is strongly expressed in the proangiogenic astrocytes, which secrete VEGF and fibronectin...
  29. Huang Y, Yu X, Sun N, Qiao N, Cao Y, Boyd Kirkup J, et al. Single-cell-level spatial gene expression in the embryonic neural differentiation niche. Genome Res. 2015;25:570-81 pubmed publisher
  30. Young K, Berry M, Mahaffey C, Saionz J, Hawes N, Chang B, et al. Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res. 2002;132:145-58 pubmed
    ..named fierce (frc) is deleted for the nuclear receptor Nr2e1 gene (also known as Tlx, mouse homolog of Drosophila tailless)...
  31. Chan C, Fulton J, Montiel Duarte C, Collins H, Bharti N, Wadelin F, et al. A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013;41:9663-79 pubmed publisher
    ..Two copies of this motif (named here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), whereas RID1, but not RID2, binds PNR (NR2E3)...
  32. Iwahara N, Hisahara S, Hayashi T, Horio Y. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. Biochem Biophys Res Commun. 2009;386:671-5 pubmed publisher
    An orphan nuclear receptor TLX is a transcriptional repressor that promotes the proliferation and self-renewal of neural precursor cells (NPCs)...
  33. Sehgal R, Sheibani N, Rhodes S, Belecky Adams T. BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression. Dev Biol. 2009;332:429-43 pubmed publisher
    ..BMP and SHH pathway members can interact separately or together with TLX, a repressor protein in the tailless transcription factor family...
  34. Abrahams B, Kwok M, Trinh E, Budaghzadeh S, Hossain S, Simpson E. Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1. J Neurosci. 2005;25:6263-70 pubmed
    quot;Fierce" mice, homozygous for the deletion of nuclear receptor 2E1 (NR2E1), show abnormal brain-eye development and pathological aggression...
  35. Christie B, Li A, Redila V, Booth H, Wong B, Eadie B, et al. Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neuroscience. 2006;137:1031-7 pubmed
    The spontaneous or targeted deletion of the nuclear receptor transcription factor Nr2e1 produces a mouse that shows hypoplasia of the hippocampal formation and reduced neurogenesis in adult mice...
  36. Islam M, Smith D, Niu W, Fang S, Iqbal N, Sun G, et al. Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming. Stem Cell Reports. 2015;5:805-15 pubmed
    The orphan nuclear receptor TLX is a master regulator of postnatal neural stem cell (NSC) self-renewal and neurogenesis; however, it remains unclear how TLX expression is precisely regulated in these tissue-specific stem cells...
  37. Tran P, Banisadr G, Ren D, Chenn A, Miller R. Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol. 2007;500:1007-33 pubmed
    ..In order to do this we used nestin-EGFP and TLX-LacZ transgenic mice, as well as labeling for Ki67, a marker for dividing cells...
  38. Chalhoub N, Benachenhou N, Rajapurohitam V, Pata M, Ferron M, Frattini A, et al. Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med. 2003;9:399-406 pubmed
    ..Mutation in the human GL gene leads to severe recessive osteopetrosis. Our studies show that mouse Gl protein function is absolutely required for osteoclast and melanocyte maturation and function...
  39. Land P, Monaghan A. Abnormal development of zinc-containing cortical circuits in the absence of the transcription factor Tailless. Brain Res Dev Brain Res. 2005;158:97-101 pubmed
    Absence of the transcription factor tailless (tlx) leads to premature laminar development and thinning of neocortex. We used zinc autometallography to determine if tailless deletion alters the organization of cortical circuits...
  40. O Loghlen A, Martin N, Krusche B, Pemberton H, Alonso M, Chandler H, et al. The nuclear receptor NR2E1/TLX controls senescence. Oncogene. 2015;34:4069-4077 pubmed publisher
    The nuclear receptor NR2E1 (also known as TLX or tailless) controls the self-renewal of neural stem cells (NSCs) and has been implied as an oncogene which initiates brain tumors including glioblastomas...
  41. Abrahams B, Mak G, Berry M, Palmquist D, Saionz J, Tay A, et al. Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci. Genomics. 2002;80:45-53 pubmed
    b>Fierce (frc) mice are deleted for nuclear receptor 2e1 (Nr2e1), and exhibit cerebral hypoplasia, blindness, and extreme aggression...
  42. Song J, Kang S, Kim E, Kim C, Song H, Lee J. Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study. Cell Death Dis. 2015;6:e1844 pubmed publisher
    ..of NSCs through the p53/p21 pathway and the proliferation- and differentiation-related factors of NSCs via tailless (TLX)...
  43. Wong B, Hossain S, Trinh E, Ottmann G, Budaghzadeh S, Zheng Q, et al. Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice. Genes Brain Behav. 2010;9:681-94 pubmed publisher
    The NR2E1 region on Chromosome 6q21-22 has been repeatedly linked to bipolar disorder (BP) and NR2E1 has been associated with BP, and more specifically bipolar I disorder (BPI)...
  44. Wu D, Yu S, Jia L, Zou C, Xu Z, Xiao L, et al. Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. J Pathol. 2015;236:103-15 pubmed publisher
    ..Overcoming this process is a critical step in early cancer development. The druggable orphan nuclear receptor TLX (NR2E1) is characterized as an important regulator of neural stem cells and is also implicated in the ..
  45. Shimozaki K, Zhang C, Suh H, Denli A, Evans R, Gage F. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012;287:5969-78 pubmed publisher
    ..Here we show that SRY-box-containing gene 2 (Sox2) and nuclear receptor tailless (TLX) form a molecular network in adult NSCs...
  46. Beiting D, Hidano S, Baggs J, Geskes J, Fang Q, Wherry E, et al. The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. PLoS Biol. 2015;13:e1002200 pubmed publisher
    ..transcription factors that enhance STAT1 function in the nucleus, including the orphan nuclear hormone receptor TLX. Expression profiling revealed that upon IFN-γ treatment TLX enhances the output of a subset of IFN-γ target ..
  47. Stenman J, Yu R, Evans R, Campbell K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003;130:1113-22 pubmed
    We have examined the role of Tlx, an orphan nuclear receptor, in dorsal-ventral patterning of the mouse telencephalon. Tlx is expressed broadly in the ventricular zone, with the exception of the dorsomedial and ventromedial regions...
  48. Wang Y, Liu H, Schutz G. Role of the nuclear receptor Tailless in adult neural stem cells. Mech Dev. 2013;130:388-90 pubmed publisher
    b>Tailless (Tlx) is an orphan nuclear receptor which is specifically expressed in the neural stem cells of the two largest germinal neurogenesis zones in the adult mouse brain, the subventricular zone (SVZ) of the lateral ventricle and the ..
  49. Corso Díaz X, Simpson E. Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis. Mol Brain. 2015;8:37 pubmed publisher
    b>Nr2e1 is a nuclear receptor crucial for neural stem cell proliferation and maintenance. In the retina, lack of Nr2e1 results in premature neurogenesis, aberrant blood vessel formation and dystrophy...
  50. Shi X, Xiong X, Dai Z, Deng H, Sun L, Hu X, et al. Nuclear orphan receptor TLX affects gene expression, proliferation and cell apoptosis in beta cells. Biochem Biophys Res Commun. 2015;468:387-93 pubmed publisher
    Nuclear orphan receptor TLX is an essential regulator of the growth of neural stem cells. However, its exact function in pancreatic islet cells is still unknown...
  51. Miyawaki T, Uemura A, Dezawa M, Yu R, Ide C, Nishikawa S, et al. Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci. 2004;24:8124-34 pubmed
    b>Tlx belongs to a class of orphan nuclear receptors that underlies many aspects of neural development in the CNS. However, the fundamental roles played by Tlx in the control of eye developmental programs remain elusive...
  52. Roy K, Thiels E, Monaghan A. Loss of the tailless gene affects forebrain development and emotional behavior. Physiol Behav. 2002;77:595-600 pubmed
    We are studying the role of the evolutionarily conserved tlx gene in forebrain development in mice. Tlx is expressed in the ventricular zone that gives rise to neurons and glia of the forebrain...
  53. Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, et al. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. Nat Commun. 2016;7:10965 pubmed publisher
    ..We show here that the nuclear receptor TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing...