Nr2c2

Summary

Gene Symbol: Nr2c2
Description: nuclear receptor subfamily 2, group C, member 2
Alias: TAK1, Tr4, mKIAA4145, nuclear receptor subfamily 2 group C member 2, nuclear receptor subfamily 2, group H, member 2, orphan nuclear receptor TAK1, orphan nuclear receptor TR4, orphan receptor, TR4, testicular receptor 4
Species: mouse
Products:     Nr2c2

Top Publications

  1. Kang H, Okamoto K, Kim Y, Takeda Y, Bortner C, Dang H, et al. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes. 2011;60:177-88 pubmed publisher
    The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis...
  2. Lee Y, Young W, Burbach J, Chang C. Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily. J Biol Chem. 1998;273:13437-43 pubmed
    Amino acid sequence analysis indicates that the human TR4 orphan receptor (TR4) is a member of the estrogen/thyroid receptor subfamily of the steroid/thyroid receptor superfamily and recognizes the AGGTCA direct repeat (DR) of the ..
  3. Young W, Lee Y, Smith S, Chang C. A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway. J Biol Chem. 1998;273:20877-85 pubmed
    Previously, we reported that the nuclear orphan receptor TR4 could induce transcriptional activity via the 5th intron of the ciliary neurotrophic factor (CNTF) alpha receptor gene (CNTFR-I5)...
  4. Lee C, Chinpaisal C, Wei L. A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. J Biol Chem. 1998;273:25209-15 pubmed
    A unique heterodimerization pathway involving orphan receptors TR2 and TR4 is demonstrated. TR2 and TR4 preferentially form heterodimers in solution as well as on DNA elements containing a direct repeat-5 (DR5)...
  5. Chen Y, Collins L, Chang S, Chang C. The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum. 2008;7:9-17 pubmed publisher
    Since Testicular Receptor 4 (TR4) was cloned, efforts have been made to elucidate its physiological function. To examine the putative functions of TR4, the conventional TR4 knockout (TR4(-/-)) mouse model was generated...
  6. Chen L, Wang R, Lee Y, Liu N, Chang Y, Wu C, et al. Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4. Mol Endocrinol. 2008;22:858-67 pubmed publisher
    Testicular orphan nuclear receptor 4 (TR4) plays essential roles for normal spermatogenesis in male mice. However, its roles in female fertility and ovarian function remain largely unknown...
  7. Tsai N, Huq M, Gupta P, Yamamoto K, Kagechika H, Wei L. Activation of testicular orphan receptor 4 by fatty acids. Biochim Biophys Acta. 2009;1789:734-40 pubmed publisher
    ..length and level of unsaturation could activate the mouse orphan nuclear receptor, testicular orphan receptor 4 (TR4)...
  8. Young W, Smith S, Chang C. Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily. J Biol Chem. 1997;272:3109-16 pubmed
    ..the 5th intron of the alpha component of the ciliary neurotrophic factor receptor (CNTFRalpha) gene for the human TR4 orphan receptor (TR4). Electrophoretic mobility shift assay showed a specific binding with high affinity (Kd = 0...
  9. Lee Y, Lee H, Chang C. Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily. J Steroid Biochem Mol Biol. 2002;81:291-308 pubmed
    The human testicular receptor 2 (TR2) and TR4 orphan receptors are two evolutionarily related proteins belonging to the nuclear receptor superfamily...

More Information

Publications62

  1. Kim E, Xie S, Yeh S, Lee Y, Collins L, Hu Y, et al. Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. J Biol Chem. 2003;278:46919-26 pubmed
    ..Here we demonstrate that the TR4 orphan nuclear receptor (TR4) can induce apoE expression in HepG2 cells...
  2. Collins L, Lee Y, Heinlein C, Liu N, Chen Y, Shyr C, et al. Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proc Natl Acad Sci U S A. 2004;101:15058-63 pubmed
    Testicular orphan nuclear receptor 4 (TR4) is a member of the nuclear receptor superfamily for which a ligand has not yet been found...
  3. Chen Y, Collins L, Uno H, Chang C. Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4. Mol Cell Biol. 2005;25:2722-32 pubmed
    Since testicular orphan nuclear receptor 4 (TR4) was cloned, its physiological function has remained largely unknown...
  4. Liu H, Xie M, Schneider M, Chen Z. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A. 2006;103:11677-82 pubmed
    The protein kinase TAK1 mediates the activation of NF-kappaB in response to stimulation by proinflammatory cytokines and microbial pathogens in the innate immunity pathways...
  5. Kim E, Liu N, Yu I, Lin H, Lee Y, Sparks J, et al. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes. 2011;60:1493-503 pubmed publisher
    b>TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro...
  6. Hirose T, Fujimoto W, Tamaai T, Kim K, Matsuura H, Jetten A. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol. 1994;8:1667-80 pubmed
    ..the DNA-binding domain of the nuclear receptor superfamily, we identified and cloned a novel orphan receptor, named TAK1. The open reading frame of TAK1 encodes a protein of 596 amino acid residues...
  7. Liu N, Lin W, Kim E, Collins L, Lin H, Yu I, et al. Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes. 2007;56:2901-9 pubmed
    ..Here, we identified the testicular orphan nuclear receptor 4 (TR4) as a key PEPCK regulator modulating PEPCK gene via a transcriptional mechanism...
  8. Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, et al. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci. 2013;126:5704-13 pubmed publisher
    b>TAK1 is a MAP3K that mediates non-canonical TGF-? and BMP signaling...
  9. Tanabe O, Shen Y, Liu Q, Campbell A, Kuroha T, Yamamoto M, et al. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes Dev. 2007;21:2832-44 pubmed
    When the orphan nuclear receptors TR2 and TR4, the DNA-binding subunits of the DRED repressor complex, are forcibly expressed in erythroid cells of transgenic mice, embryos exhibit a transient mid-gestational anemia as a consequence of a ..
  10. Zhang Y, Chen Y, Xie S, Wang L, Lee Y, Chang S, et al. Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain. Mol Endocrinol. 2007;21:908-20 pubmed
    Testicular orphan nuclear receptor 4 (TR4) has been suggested to play important roles in the development and functioning of the central nervous system (CNS)...
  11. Xie S, Lee Y, Kim E, Chen L, Ni J, Fang L, et al. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci U S A. 2009;106:13353-8 pubmed publisher
    Testicular orphan nuclear receptor 4 (TR4) is an orphan member of the nuclear receptor superfamily with diverse physiological functions...
  12. Kim Y, Harry G, Kang H, Goulding D, Wine R, Kissling G, et al. Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum. 2010;9:310-23 pubmed publisher
    Previously, deficiency in the expression of the nuclear orphan receptor TAK1 was found to be associated with delayed cerebellar granule cell migration and Purkinje cell maturation with a permanent deficit in foliation of lobules VI–..
  13. Tran P, Ho S, Kim B, Vuong T, Leem Y, Bae G, et al. TGF-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J Biol Chem. 2012;287:11602-15 pubmed publisher
    ..Two MAP3Ks, TAK1 and ASK1, can activate p38MAPK via MKK6 in various cell systems...
  14. Lin S, Ho H, Lee Y, Liu N, Liu S, Li G, et al. Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reprod Biol Endocrinol. 2012;10:43 pubmed
    Early studies suggested that TR4 nuclear receptor might play important roles in the skeletal development, yet its detailed mechanism remains unclear...
  15. Liu S, Yan S, Lee Y, Liu N, Ting H, Li G, et al. Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair. J Biol Chem. 2011;286:38103-8 pubmed publisher
    ..We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) ..
  16. Chen Y, Collins L, Uno H, Chou S, Meshul C, Chang S, et al. Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor. Brain Res. 2007;1168:72-82 pubmed
    Since testicular orphan nuclear receptor 4 (TR4) was cloned, its physiological functions remain largely unknown. In this study, the TR4 knockout (TR4(-/-)) mouse model was used to investigate the role of TR4 in the adult cerebellum...
  17. Cui S, Kolodziej K, Obara N, Amaral Psarris A, Demmers J, Shi L, et al. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic ?-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011;31:3298-311 pubmed publisher
    Nuclear receptors TR2 and TR4 (TR2/TR4) were previously shown to bind in vitro to direct repeat elements in the mouse and human embryonic and fetal ?-type globin gene promoters and to play critical roles in the silencing of these genes...
  18. Xu X, Fan Z, Qi X, Shao Y, Wu Y. The role of TGF-?-activated kinase 1 in db/db mice and high glucose-induced macrophage. Int Immunopharmacol. 2016;38:120-31 pubmed publisher
    ..the development of diabetic nephropathy (DN), little information is available about the TGF-?-activated kinase 1 (TAK1) signal pathway activating inflammatory response in DN...
  19. Collins L, Lee Y, Ting H, Lin W, Liu N, Meshul C, et al. The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice. Reprod Biol Endocrinol. 2011;9:138 pubmed publisher
    ..b>TR4 nuclear receptor is known to be involved in male fertility via controlling spermatogenesis, yet its roles in ..
  20. Park S, Kim S, Choi H, Chang C, Kim E. TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression. FEBS Lett. 2014;588:3947-53 pubmed publisher
    We show that testicular orphan nuclear receptor 4 (TR4) increases the expression of pyruvate carboxylase (PC) gene in 3T3-L1 adipocytes by direct binding to a TR4 responsive element in the murine PC promoter...
  21. Vink P, Smout W, Driessen Engels L, de Bruin A, Delsing D, Krajnc Franken M, et al. In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PLoS ONE. 2013;8:e57348 pubmed publisher
    b>TAK1 (TGF-β Activated Kinase 1) is a MAPK kinase kinase, which activates the p38- and JNK-MAPK and NF-κB pathways downstream of receptors such as Toll-Like-, cytokine- and T-cell and B-cell receptors...
  22. Law S, Conneely O, O Malley B. Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2. Gene Expr. 1994;4:77-84 pubmed
    ..The identification of a subfamily of TR2 receptors together with the existence of variant mRNAs for these receptors prompts a close examination of the tissue-specific regulatory role of this subfamily of nuclear receptors. ..
  23. Xie S, Ni J, Lee Y, Liu S, Li G, Shyr C, et al. Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J Biol Chem. 2011;286:21129-36 pubmed publisher
    The nuclear receptor TR4 is a key regulator for many physiological processes, including growth, development, and metabolism...
  24. Lee Y, Liu S, Liu N, Wang R, Chen L, Lin W, et al. Premature aging with impaired oxidative stress defense in mice lacking TR4. Am J Physiol Endocrinol Metab. 2011;301:E91-8 pubmed publisher
    Early studies suggest that TR4 nuclear receptor is a key transcriptional factor regulating various biological activities, including reproduction, cerebella development, and metabolism...
  25. Sumiya E, Negishi Koga T, Nagai Y, Suematsu A, Suda T, Shinohara M, et al. Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation. Biochem Biophys Res Commun. 2015;463:1284-90 pubmed publisher
    b>TAK1 (encoded by Map3k7) is a mitogen-activated protein kinase kinase kinase (MAP3K), which activates the transcription factors AP-1 and NF-κB in response to receptor activator of NF-κB ligand (RANKL) stimulation, thus constituting ..
  26. Lee M, Tanabe O, Shi L, Jearawiriyapaisarn N, Lucas D, Engel J. The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation. Blood. 2017;130:2537-2547 pubmed publisher
    The orphan nuclear receptors TR4 (NR2C2) and TR2 (NR2C1) are the DNA-binding subunits of the macromolecular complex, direct repeat erythroid-definitive, which has been shown to repress ?- and ?-globin transcription during ..
  27. Srivastava R, Burbach B, Shimizu Y. NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J Biol Chem. 2010;285:11100-5 pubmed publisher
    ..In this study, we identify a novel site in ADAP that is critical for association with the TAK1 kinase. ADAP is critical for recruitment of TAK1 and the CBM complex, but not IKK, to protein kinase C-theta...
  28. Oho M, Nakano R, Nakayama R, Sakurai W, Miyamoto A, Masuhiro Y, et al. TIPE2 (Tumor Necrosis Factor ?-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal. J Biol Chem. 2016;291:22650-22660 pubmed
    ..Here, we demonstrate that TIPE2 interacts with TGF-?-activated kinase 1 (TAK1), a crucial regulatory molecule of inflammatory and immune signals, and consequently acts as a powerful negative ..
  29. Li L, Chen Y, Doan J, Murray J, Molkentin J, Liu Q. Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation. 2014;130:2162-72 pubmed publisher
    ..Here, we identified an obligate function for TAK1 (transforming growth factor β-activated kinase 1, gene name Map3k7) in regulating necroptotic myocyte death, ..
  30. Liepelt A, Mossanen J, Denecke B, Heymann F, De Santis R, Tacke F, et al. Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation. RNA. 2014;20:899-911 pubmed publisher
    ..We focused on transforming growth factor-?-activated kinase 1 (TAK1) a central player in TLR4 signaling...
  31. Cui S, Tanabe O, Lim K, Xu H, Zhou X, Lin J, et al. PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol. 2014;34:1956-65 pubmed publisher
    ..Chromatin immunoprecipitation studies revealed that both PGC-1? and -1?, as well as two nuclear receptors, TR2 and TR4, coordinately bind to the various globin gene promoters...
  32. Liu S, Lee Y, Chou S, Uno H, Li G, Brookes P, et al. Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I. Mol Endocrinol. 2011;25:1301-10 pubmed publisher
    ..Here we report that mice lacking testicular nuclear receptor 4 (TR4(-/-)) suffered mitochondrial myopathy, and histological examination of TR4(-/-) soleus muscle revealed abnormal ..
  33. Campbell A, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, et al. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A. 2011;108:18808-13 pubmed publisher
    ..We previously found that nuclear receptors TR2 and TR4 repress expression of the human embryonic ?-globin and fetal ?-globin genes in definitive erythroid cells...
  34. Karim M, Yoshizawa T, Sobuz S, Sato Y, Yamagata K. Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4. Biochem Biophys Res Commun. 2017;490:423-428 pubmed publisher
    ..mice are resistant to high-fat diet-induced fatty liver, and that SIRT7 positively regulates the protein level of TR4, a nuclear receptor involved in lipid metabolism, by inhibiting the CUL4B/DDB1/DCAF1 E3 ubiquitin ligase complex...
  35. Choi H, Kim S, Park S, Chang C, Kim E. TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes. FEBS Lett. 2011;585:2763-7 pubmed publisher
    We show that TR4 facilitates lipid accumulation in 3T3-L1 adipocytes via induction of the FATP1 gene...
  36. Chen H, Liu Y, Li D, Song J, Xia M. PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation. IUBMB Life. 2016;68:145-55 pubmed publisher
    ..Mechanistically, we revealed that TGF-β-activated kinase 1 (TAK1) and its adaptor protein TAK1 binding protein 1 (TAB1) played a dominant role in the regulatory effects of PGC-1β..
  37. Prakhar P, Holla S, Ghorpade D, Gilleron M, Puzo G, Udupa V, et al. Ac2PIM-responsive miR-150 and miR-143 target receptor-interacting protein kinase 2 and transforming growth factor beta-activated kinase 1 to suppress NOD2-induced immunomodulators. J Biol Chem. 2015;290:26576-86 pubmed publisher
    ..expression profiling identified Ac2PIM-responsive miR-150 and miR-143 to target NOD2 signaling adaptors, RIP2 and TAK1, respectively...
  38. Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim K, et al. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes. Blood. 2015;125:1477-87 pubmed publisher
    The orphan nuclear receptors TR2 and TR4 have been shown to play key roles in repressing the embryonic and fetal globin genes in erythroid cells...
  39. Tanabe O, Katsuoka F, Campbell A, Song W, Yamamoto M, Tanimoto K, et al. An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J. 2002;21:3434-42 pubmed
    ..DRED is a 540 kDa complex; sequence determination showed that it contains the nuclear orphan receptors TR2 and TR4. TR2 and TR4 form a heterodimer that binds to the epsilon and gamma promoter DR1 sites...
  40. Guo F, Hutchenreuther J, Carter D, Leask A. TAK1 is required for dermal wound healing and homeostasis. J Invest Dermatol. 2013;133:1646-54 pubmed publisher
    ..In dermal fibroblasts, we show that inhibition of the non-canonical TGF-?-activated kinase 1 (TAK1) selectively reduced the ability of TGF-? to induce expression of a cohort of wound healing genes, such as ..
  41. Du L, Bergsneider M, Mirsadraei L, Young S, Jonker J, Downes M, et al. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A. 2013;110:8555-60 pubmed publisher
    ..Here, we show that testicular orphan nuclear receptor 4 (TR4, nuclear receptor subfamily 2, group C, member 2) is overexpressed in human corticotroph tumors as well as in human ..
  42. Ivshina M, Alexandrov I, Vertii A, Doxsey S, Richter J. CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response. Mol Cell Biol. 2015;35:610-8 pubmed publisher
    ..nuclear localization and IL-6 expression, IκBα and transforming growth factor beta-activated kinase 1 (TAK1), are present at excessively low and high steady-state levels, respectively, in LPS-treated CPEB-depleted ..
  43. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, et al. Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron. 2013;78:312-24 pubmed publisher
    ..Here, we report that loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of many excitatory interneurons in the superficial dorsal ..
  44. Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei H, Hanafusa H, et al. TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus. J Cell Sci. 2016;129:1855-65 pubmed publisher
    ..b>TAK1 (also known as MAP3K7) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family and is ..
  45. Peng X, Huang L, Liu Z. miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages. Biochimie. 2016;127:79-85 pubmed publisher
    ..Several lines of evidence indicate that loss of TR4 leads to reduce lipid accumulation in liver and adipose tissues, etc, and lesional macrophages-derived TR4 can ..
  46. Yumoto K, Thomas P, Lane J, Matsuzaki K, Inagaki M, Ninomiya Tsuji J, et al. TGF-?-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem. 2013;288:13467-80 pubmed publisher
    ..The role of Smad-independent TGF-? signaling in craniofacial development is poorly elucidated...
  47. Yu J, Zhang F, Wang S, Zhang Y, Fan M, Xu Z. TAK1 is activated by TGF-? signaling and controls axonal growth during brain development. J Mol Cell Biol. 2014;6:349-51 pubmed publisher
  48. Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, et al. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013;288:10440-50 pubmed publisher
    ..In this study, we investigated the function of TGF? activated kinase 1 (Tak1), a key regulator of Smad-independent TGF? signaling in palate development...
  49. Hirose T, O Brien D, Jetten A. Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis. Gene. 1995;163:239-42 pubmed
    We have cloned the gene encoding the mouse homologue of the orphan receptor, TAK1, a member of the nuclear receptor superfamily, from a mouse testis cDNA library...
  50. Lin S, Lee S, Lee Y, Miyamoto H, Yang D, Li G, et al. TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. Carcinogenesis. 2014;35:1399-406 pubmed publisher
    Testicular nuclear receptor 4 (TR4), a member of the nuclear receptor superfamily, plays important roles in metabolism, fertility and aging. The linkage of TR4 functions in cancer progression, however, remains unclear...
  51. Sun P, Song S, Jiang S, Li X, Yao Y, Wu Y, et al. Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking-Induced Liver Injury. Molecules. 2016;21: pubmed
    ..SDS inhibited LPS-triggered phosphorylation of LPS-activated kinase 1 (TAK1), p38, c-Jun terminal kinase (JNK), and extracellular signal-regulated kinase (ERK)...
  52. Kim E, Ma W, Lin D, Inui S, Chen Y, Chang C. TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression. Biochem Biophys Res Commun. 2007;361:323-8 pubmed
    ..Here we report that mouse embryonic fibroblast (MEF) cells prepared from TR4-deficient (TR4(-/-)) mice are more susceptible to UV-irradiation mediated apoptosis compared to TR4-Wildtype (TR4(+/..
  53. Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida A, et al. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017;8:359 pubmed publisher
    ..Here, we report that TNF?-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision...