Nr1h2

Summary

Gene Symbol: Nr1h2
Description: nuclear receptor subfamily 1, group H, member 2
Alias: AI194859, LXR, LXRB, LXRBSV, LXRbeta, NER1, OR-1, RIP15, Unr, Unr2, oxysterols receptor LXR-beta, LXR beta, liver X receptor beta, retinoid X receptor-interacting protein No.15, ubiquitously-expressed nuclear receptor 2
Species: mouse
Products:     Nr1h2

Top Publications

  1. Robertson K, Norgård M, Windahl S, Hultenby K, Ohlsson C, Andersson G, et al. Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation. J Bone Miner Res. 2006;21:1276-87 pubmed
    ..However, our studies using the LXRalpha-/-, LXRbeta-/-, and LXRalpha-/-beta-/- mice show that both LXRalpha and beta are also important for bone turnover, mainly by ..
  2. Lee J, Gong H, Khadem S, Lu Y, Gao X, Li S, et al. Androgen deprivation by activating the liver X receptor. Endocrinology. 2008;149:3778-88 pubmed publisher
    ..Genetic or pharmacological activation of the liver X receptor (LXR) in vivo lowered androgenic activity by inducing the hydroxysteroid sulfotransferase 2A1, an enzyme essential for ..
  3. Gabbi C, Kim H, Hultenby K, Bouton D, Toresson G, Warner M, et al. Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc Natl Acad Sci U S A. 2008;105:15052-7 pubmed publisher
    ..In LXRbeta(-/-) mice on a normal diet, there is a reduction in size of perigonadal fat pad and, on high-fat diet there is ..
  4. Qin Y, Dalen K, Gustafsson J, Nebb H. Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochim Biophys Acta. 2009;1791:140-7 pubmed publisher
    ..LXRalpha and LXRbeta play different roles in maintenance of basal expression of Elovl5...
  5. Frenoux J, Vernet P, Volle D, Britan A, Saez F, Kocer A, et al. Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. J Mol Endocrinol. 2004;33:361-75 pubmed
    ..In agreement with the observed caput defect in transgenic animals in which both LXRalpha and LXRbeta isoforms were disrupted, we have shown here that both receptors are expressed in caput and cauda epididymides ..
  6. Robertson K, Schuster G, Steffensen K, Hovatta O, Meaney S, Hultenby K, et al. The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology. 2005;146:2519-30 pubmed
    ..In the absence of LXRbeta, excessive cholesterol accumulated in the Sertoli cells from 2...
  7. Viennois E, Esposito T, Dufour J, Pommier A, Fabre S, Kemeny J, et al. Lxr? regulates the androgen response in prostate epithelium. Endocrinology. 2012;153:3211-23 pubmed publisher
    ..We show that liver X receptor (Lxr)-? knockout mice (lxr?(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted ..
  8. Kim H, Andersson L, Bouton D, Warner M, Gustafsson J. Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice. Proc Natl Acad Sci U S A. 2009;106:558-63 pubmed publisher
    With specific liver X receptor alpha and beta (LXRalpha and LXRbeta) antibodies, we found that LXRalpha is strongly expressed in the luminal and basal cells of prostatic epithelium...
  9. Mouzat K, Prod homme M, Volle D, Sion B, Dechelotte P, Gauthier K, et al. Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus. J Biol Chem. 2007;282:4693-701 pubmed
    ..Here we show that nuclear receptor for oxysterols LXRbeta prevents accumulation of cholesteryl esters in mouse myometrium by controlling expression of genes involved in ..

More Information

Publications82

  1. Xu J, Wagoner G, Douglas J, Drew P. Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity. J Leukoc Biol. 2009;86:401-9 pubmed publisher
    ..Previously, we and others demonstrated that LXR agonists suppressed the activation of primary glial cells and blocked the development of EAE...
  2. Korf H, Vander Beken S, Romano M, Steffensen K, Stijlemans B, Gustafsson J, et al. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice. J Clin Invest. 2009;119:1626-37 pubmed publisher
    ..Furthermore, mice deficient in both LXR isoforms, LXRalpha and LXRbeta (Lxra-/-Lxrb-/- mice), were more susceptible to infection, developing higher bacterial burdens and an increase in ..
  3. Stenson B, Ryden M, Steffensen K, Wahlen K, Pettersson A, Jocken J, et al. Activation of liver X receptor regulates substrate oxidation in white adipocytes. Endocrinology. 2009;150:4104-13 pubmed publisher
    ..of a kinase regulating the cellular fuel switch, pyruvate dehydrogenase kinase 4 (PDK4), is up-regulated by the LXR agonist GW3965 in both in vitro differentiated human primary adipocytes and differentiated murine 3T3-L1 cells...
  4. A Gonzalez N, Bensinger S, Hong C, Beceiro S, Bradley M, Zelcer N, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009;31:245-58 pubmed publisher
    ..We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance...
  5. Kalaany N, Gauthier K, Zavacki A, Mammen P, Kitazume T, Peterson J, et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005;1:231-44 pubmed
    ..Here we show that LXR null mice are defective in hepatic lipid metabolism and are resistant to obesity when challenged with a diet ..
  6. Gerin I, Dolinsky V, Shackman J, Kennedy R, Chiang S, Burant C, et al. LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem. 2005;280:23024-31 pubmed
    ..We demonstrate here that although LXRalpha and LXRbeta are not required for adipocyte development per se, LXRbeta is required for the increase in adipocyte size that ..
  7. Bischoff E, Daige C, Petrowski M, Dedman H, Pattison J, Juliano J, et al. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res. 2010;51:900-6 pubmed publisher
    The liver X receptors LXRalpha and LXRbeta play critical roles in maintaining lipid homeostasis by functioning as transcription factors that regulate genetic networks controlling the transport, catabolism, and excretion of cholesterol...
  8. Laffitte B, Repa J, Joseph S, Wilpitz D, Kast H, Mangelsdorf D, et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001;98:507-12 pubmed
    ..We demonstrate here that the nuclear receptors LXRalpha and LXRbeta and their oxysterol ligands are key regulators of apoE expression in both macrophages and adipose tissue...
  9. Steffensen K, Nilsson M, Schuster G, Stulnig T, Dahlman Wright K, Gustafsson J. Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively. Biochem Biophys Res Commun. 2003;310:589-93 pubmed
    ..In this study we show that LXRalpha and LXRbeta are more expressed in brown adipose tissue and subcutaneous white adipose tissue than visceral (gonadal) adipose ..
  10. Tangirala R, Bischoff E, Joseph S, Wagner B, Walczak R, Laffitte B, et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002;99:11896-901 pubmed
    Recent studies have identified the liver X receptors (LXR alpha and LXR beta) as important regulators of cholesterol metabolism and transport...
  11. Bensinger S, Bradley M, Joseph S, Zelcer N, Janssen E, Hausner M, et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008;134:97-111 pubmed publisher
    ..Ligation of LXR during T cell activation inhibits mitogen-driven expansion, whereas loss of LXRbeta confers a proliferative advantage...
  12. Hong C, Kidani Y, A Gonzalez N, Phung T, Ito A, Rong X, et al. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012;122:337-47 pubmed publisher
    ..Using gain- and loss-of-function models, we found that LXR signaling regulated the efficient clearance of senescent neutrophils by peripheral tissue APCs in a Mer-dependent ..
  13. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, et al. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001;107:565-73 pubmed
    The nuclear oxysterol-receptor paralogues LXRalpha and LXRbeta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar affinities...
  14. Volle D, Mouzat K, Duggavathi R, Siddeek B, Dechelotte P, Sion B, et al. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol. 2007;21:1014-27 pubmed
    Oxysterol nuclear receptors liver X receptor (LXR)alpha and LXRbeta are known to regulate lipid homeostasis in cells exposed to high amounts of cholesterol and/or fatty acids...
  15. Cui G, Qin X, Wu L, Zhang Y, Sheng X, Yu Q, et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest. 2011;121:658-70 pubmed publisher
    ..We report here that ectopic expression of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4+ T cells, while LXR deficiency promotes Th17 differentiation in vitro...
  16. Hong C, Walczak R, Dhamko H, Bradley M, Marathe C, Boyadjian R, et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res. 2011;52:531-9 pubmed publisher
    ..One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects...
  17. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116:607-14 pubmed
    ..Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis ..
  18. Joseph S, Castrillo A, Laffitte B, Mangelsdorf D, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9:213-9 pubmed
    ..Transcriptional profiling of lipopolysaccharide (LPS)-induced macrophages reveals reciprocal LXR-dependent regulation of genes involved in lipid metabolism and the innate immune response...
  19. Cummins C, Volle D, Zhang Y, McDonald J, Sion B, Lefrançois Martinez A, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116:1902-12 pubmed
    ..Here, we show the role of the liver X receptors (LXRalpha and LXRbeta) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes ..
  20. Ouvrier A, Cadet R, Vernet P, Laillet B, Chardigny J, Lobaccaro J, et al. LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner. J Lipid Res. 2009;50:1766-75 pubmed publisher
    ..LXRs), the nuclear receptors for oxysterols, are of major importance in intracellular cholesterol homeostasis, and LXR(-/-)-deficient male mice have already been shown to have reduced fertility at an age of 5 months and complete ..
  21. Patel R, Patel M, Tsai R, Lin V, Bookout A, Zhang Y, et al. LXR? is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest. 2011;121:431-41 pubmed publisher
    ..Here, we show LXR? is required to mediate many of the negative side effects of glucocorticoids...
  22. Joseph S, Bradley M, Castrillo A, Bruhn K, Mak P, Pei L, et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004;119:299-309 pubmed
    ..We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses...
  23. Meng Z, Nie J, Ling J, Sun J, Zhu Y, Gao L, et al. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 2009;52:125-35 pubmed publisher
    ..Adenovirus-based RNA interference was used to knockdown LXRalpha, LXRbeta and p27 in MIN6 cells and mouse islets...
  24. Efanov A, Sewing S, Bokvist K, Gromada J. Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes. 2004;53 Suppl 3:S75-8 pubmed
    ..Culture of pancreatic islets or insulin-secreting MIN6 cells with a LXR specific agonist T0901317 caused an increase in glucose-dependent insulin secretion and islet insulin content...
  25. Valledor A, Hsu L, Ogawa S, Sawka Verhelle D, Karin M, Glass C. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004;101:17813-8 pubmed
    ..In addition, combined activation of LXR and RXR protected macrophages from apoptosis caused by infection with Bacillus anthracis, Escherichia coli, and ..
  26. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100-4 pubmed publisher
    ..Here we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through ..
  27. Repa J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-9 pubmed
    ..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
  28. Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya Kudo M, Matsuzaka T, et al. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Mol Endocrinol. 2003;17:1255-67 pubmed
    ..fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis...
  29. Bradley M, Hong C, Chen M, Joseph S, Wilpitz D, Wang X, et al. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007;117:2337-46 pubmed
    ..The phenotype of these mice suggests that the level of LXR pathway activation in macrophages achieved by LXRbeta and endogenous ligand is unable to maintain homeostasis in the setting of hypercholesterolemia...
  30. Repa J, Liang G, Ou J, Bashmakov Y, Lobaccaro J, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14:2819-30 pubmed
    ..In this report, we describe a novel LXR target, the sterol regulatory element-binding protein-1c gene (SREBP-1c), which encodes a membrane-bound ..
  31. Choe S, Choi A, Lee J, Kim K, Chung J, Park J, et al. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;56:1534-43 pubmed
    Liver X receptor (LXR)alpha and LXRbeta play important roles in fatty acid metabolism and cholesterol homeostasis...
  32. Zitzer H, Wente W, Brenner M, Sewing S, Buschard K, Gromada J, et al. Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Endocrinology. 2006;147:3898-905 pubmed
    Liver X receptors (LXRalpha and LXRbeta) regulate glucose and lipid metabolism. Pancreatic beta-cells and INS-1E insulinoma cells express only the LXRbeta isoform...
  33. Peng D, Hiipakka R, Reardon C, Getz G, Liao S. Differential anti-atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317. Atherosclerosis. 2009;203:59-66 pubmed publisher
    ..In this study, we administered orally the LXR agonist T0901317 to male LDLR-/- mice fed a Western diet...
  34. Wu C, Hussein M, Shrestha E, Leone S, Aiyegbo M, Lambert W, et al. Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. Mol Cell Biol. 2015;35:2024-34 pubmed publisher
    ..promotes macrophage emigration and regression of atherosclerotic plaques in part by liver X receptor (LXR)-mediated induction of the chemokine receptor CCR7...
  35. Guo L, Gao Z, Zhang L, Guo F, Chen Y, Li Y, et al. Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling. Pharm Biol. 2016;54:1312-25 pubmed publisher
    ..18 ± 0.92 versus 10.87 ± 0.97 mmol/mg) contents of the obese C57BL/six mice on a high-fat diet. Sea cucumber may be used for developing antiobesity and antihyperlipidemia drugs. ..
  36. Beyer C, Huang J, Beer J, Zhang Y, Palumbo Zerr K, Zerr P, et al. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Ann Rheum Dis. 2015;74:1317-24 pubmed publisher
    ..We examined both LXR isoforms using LXR?-, LXR?- and LXR-?/?-double-knockout mice...
  37. Oumeddour A, Viennois E, Caira F, Decourbey C, Maqdasy S, Tahraoui A, et al. Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochem Biophys Res Commun. 2014;446:656-62 pubmed publisher
    Liver X receptors LXR? (NR1H3) and LXR? (NR1H2) are transcription factors belonging to the nuclear receptor superfamily, activated by specific oxysterols, oxidized derivatives of cholesterol...
  38. Crisafulli C, Mazzon E, Paterniti I, Galuppo M, Bramanti P, Cuzzocrea S. Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. Respir Res. 2010;11:19 pubmed publisher
    Liver x receptor alpha (LXRalpha) and beta (LXRbeta) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor, estrogen ..
  39. Rébé C, Filomenko R, Raveneau M, Chevriaux A, Ishibashi M, Lagrost L, et al. Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes. PLoS ONE. 2012;7:e48738 pubmed publisher
    Liver X receptor (LXR) ? and LXR ? (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity...
  40. Bindesbøll C, Fan Q, Nørgaard R, MacPherson L, Ruan H, Wu J, et al. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J Lipid Res. 2015;56:771-85 pubmed publisher
    Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding ..
  41. Ishikawa T, Yuhanna I, Umetani J, Lee W, Korach K, Shaul P, et al. LXR?/estrogen receptor-? signaling in lipid rafts preserves endothelial integrity. J Clin Invest. 2013;123:3488-97 pubmed publisher
    Liver X receptors (LXR) are stimulated by cholesterol-derived oxysterols and serve as transcription factors to regulate gene expression in response to alterations in cholesterol...
  42. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology. 2008;134:556-67 pubmed publisher
    Liver X receptor (LXR) is known to promote hepatic lipogenesis by activating the lipogenic transcriptional factor sterol regulatory element-binding protein (Srebp)...
  43. Valbuena Diez A, Blanco F, Oujo B, Langa C, Gonzalez Nuñez M, Llano E, et al. Oxysterol-induced soluble endoglin release and its involvement in hypertension. Circulation. 2012;126:2612-24 pubmed publisher
    ..of oxysterols, we assessed the effect of 22-(R)-hydroxycholesterol, a natural ligand of the liver X receptor (LXR), and the LXR synthetic agonist T0901317...
  44. Gabbi C, Kong X, Suzuki H, Kim H, Gao M, Jia X, et al. Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor ?. Proc Natl Acad Sci U S A. 2012;109:3030-4 pubmed publisher
    The present study demonstrates a key role for the oxysterol receptor liver X receptor ? (LXR?) in the etiology of diabetes insipidus (DI)...
  45. Pommier A, Dufour J, Alves G, Viennois E, de Boussac H, Trousson A, et al. Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. PLoS Genet. 2013;9:e1003483 pubmed publisher
    b>LXR (Liver X Receptors) act as "sensor" proteins that regulate cholesterol uptake, storage, and efflux...
  46. Gold E, Diercks A, Podolsky I, Podyminogin R, Askovich P, Treuting P, et al. 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. Proc Natl Acad Sci U S A. 2014;111:10666-71 pubmed publisher
  47. Wada T, Kang H, Angers M, Gong H, Bhatia S, Khadem S, et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008;73:891-9 pubmed
    ..The mutual suppression between RORalpha and LXR was supported by the in vivo observation that loss of RORalpha increased the expression of selected LXR target ..
  48. Sallam T, Jones M, Gilliland T, Zhang L, Wu X, Eskin A, et al. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016;534:124-8 pubmed publisher
    ..Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates cholesterol ..
  49. Wang Q, Wang S, Shi Y, Yao M, Hou L, Jiang L. Reduction of Liver X Receptor ? expression in primary rat neurons by antisense oligodeoxynucleotides decreases secreted amyloid ? levels. Neurosci Lett. 2014;561:146-50 pubmed publisher
    Ligand-activated Liver X Receptor (LXR) is known to increase cholesterol efflux from cells and reduce the production of amyloid ? (A?) from amyloid-beta precursor protein (APP)...
  50. Marathe C, Bradley M, Hong C, Chao L, Wilpitz D, Salazar J, et al. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow. J Lipid Res. 2009;50:214-24 pubmed publisher
    Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter ..
  51. Steffensen K, Robertson K, Gustafsson J, Andersen C. Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes. Mol Cell Endocrinol. 2006;256:9-16 pubmed
    ..Female mice lacking Lxra, Lxrb or both genes (Lxra(-/-), Lxrb(-/-) and Lxrab(-/-), respectively) conceive less frequently and have significantly ..
  52. He Q, Pu J, Yuan A, Lau W, Gao E, Koch W, et al. Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury. Circ Heart Fail. 2014;7:1032-41 pubmed publisher
    Liver-X-receptors, LXRα (NR1H3) and LXRβ (NR1H2), encode 2 different but highly homologous isoforms of transcription factors belonging to the nuclear receptor superfamily...
  53. Terasaka N, Hiroshima A, Ariga A, Honzumi S, Koieyama T, Inaba T, et al. Liver X receptor agonists inhibit tissue factor expression in macrophages. FEBS J. 2005;272:1546-56 pubmed
    ..Here we demonstrate that activation of liver X receptors (LXRs) LXRalpha and LXRbeta suppresses TF expression...
  54. Kotti T, Ramirez D, Pfeiffer B, Huber K, Russell D. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci U S A. 2006;103:3869-74 pubmed
    ..We conclude that cholesterol turnover in brain activates the mevalonate pathway and that a constant production of geranylgeraniol in a small subset of neurons is required for LTP and learning. ..
  55. Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, et al. Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling. Cardiovasc Res. 2009;84:119-26 pubmed publisher
    ..Several members of nuclear receptor superfamily, including liver X receptors (LXRalpha and LXRbeta), have been shown to suppress inflammatory responses, but little is known about their effects in cardiomyocytes...
  56. Beaven S, MATVEYENKO A, Wroblewski K, Chao L, Wilpitz D, Hsu T, et al. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013;18:106-17 pubmed publisher
    ..We show that LXRs modulate key aspects of the metabolic syndrome in mice. LXR??-deficient-ob/ob (LOKO) mice remain obese but show reduced hepatic steatosis and improved insulin sensitivity ..
  57. Zelcer N, Khanlou N, Clare R, Jiang Q, Reed Geaghan E, Landreth G, et al. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A. 2007;104:10601-6 pubmed
    ..Genetic loss of either Lxralpha or Lxrbeta in APP/PS1 transgenic mice results in increased amyloid plaque load...
  58. Bindesbøll C, Tan S, Bott D, Cho T, Tamblyn L, MacPherson L, et al. TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. Biochem J. 2016;473:899-910 pubmed publisher
    ..poly-ADP-ribose polymerase (TIPARP), mono-ADP-ribosylates and positively regulates liver X receptor α (LXRα) and LXRβ activity. Overexpression of TIPARP enhanced LXR-reporter gene activity...
  59. Mouzat K, Volat F, Baron S, Alves G, Pommier A, Volle D, et al. Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. Endocrinology. 2009;150:3369-75 pubmed publisher
    ..Here we show that liver X receptor (LXR)-alpha and LXR-beta deficient mice present many clinical and biological signs of ovarian hyperstimulation syndrome: ..
  60. Patel M, Wang X, Magomedova L, John R, Rasheed A, Santamaria H, et al. Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice. Diabetologia. 2014;57:435-46 pubmed publisher
    ..streptozotocin (STZ) and maintained for 14 weeks in Lxr?/? (+/+) (Lxr?, also known as Nr1h3; Lxr?, also known as Nr1h2) and Lxr?/? (-/-) mice...
  61. Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, et al. A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPAR?. Biochimie. 2013;95:556-67 pubmed publisher
    ..As expected, T0901317 and fenofibrate induce expression of genes involved LXR-dependent and PPAR?-dependent lipogenic responses...
  62. Köröskényi K, Duró E, Pallai A, Sarang Z, Kloor D, Ucker D, et al. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. J Immunol. 2011;186:7144-55 pubmed publisher
    ..Altogether, our data indicate that adenosine is one of the soluble mediators released by macrophages that mediate engulfment-dependent apoptotic cell suppression of inflammation. ..
  63. Korach Andre M, Archer A, Gabbi C, Barros R, Pedrelli M, Steffensen K, et al. Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice. Am J Physiol Endocrinol Metab. 2011;301:E210-22 pubmed publisher
    ..Recently, LXRs have been proposed as a glucose sensor affecting LXR-dependent gene expression...
  64. Nedumaran B, Kim G, Hong S, Yoon Y, Kim Y, Lee C, et al. Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem. 2010;285:9221-32 pubmed publisher
    ..Overall, this study suggests that DAX-1, a novel corepressor of LXRalpha, functions as a negative regulator of lipogenic enzyme gene expression in liver. ..
  65. Kim G, Park K, Yeom S, Lee K, Kim G, Ko J, et al. Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Mol Endocrinol. 2009;23:966-74 pubmed publisher
    ..Intriguingly, ASC-2 was more highly expressed in macrophages than in the liver and pancreas. To inhibit LXR-specific activity of ASC-2, we used DN2, which contains the C-terminal LXXLL motif of ASC-2 and thereby acts as an ..
  66. Seol W, Choi H, Moore D. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995;9:72-85 pubmed
    ..Of four additional RXR-interacting proteins (RIPs) selected for further study two, RIP14 and RIP15, are previously unidentified orphan members of the nuclear receptor superfamily...
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    The nuclear hormone receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and ..
  68. Komuves L, Schmuth M, Fowler A, Elias P, Hanley K, Man M, et al. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol. 2002;118:25-34 pubmed
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation. ..
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    ..and 27-hydroxycholesterol and that they express their biosynthetic enzymes and receptors (liver X receptors LXR? and LXR?)...
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    ..to infection by intracellular bacteria Listeria monocytogenes and Mycobacterium tuberculosis, we hypothesized that LXR might also influence macrophage responses to the intracellular protozoan parasite Leishmania chagasi/infantum, a ..
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    ..AKR1-B7 (aldo-keto reductase 1-B7) is expressed in LXR target tissues such as intestine, and because of its known role in detoxifying lipid peroxides, we investigated ..
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    ..expressed proteins involved in lipid metabolism was the predicted activation of the liver X receptor (LXR) pathway...
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    ..The GC receptor (GR) and liver X receptors (LXR? and LXR?) regulate overlapping genes involved in gluconeogenesis and inflammation...