Nr0b2

Summary

Gene Symbol: Nr0b2
Description: nuclear receptor subfamily 0, group B, member 2
Alias: SHP, SHP-1, Shp1, nuclear receptor subfamily 0 group B member 2, orphan nuclear receptor SHP, small heterodimer partner
Species: mouse
Products:     Nr0b2

Top Publications

  1. Kim H, Kim J, Kim J, Park S, Seo J, Kim J, et al. Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1. J Biol Chem. 2004;279:28122-31 pubmed
    b>Small heterodimer partner (SHP; NR0B2) is an unusual orphan nuclear receptor that lacks a conventional DNA-binding domain and acts as a modulator of transcriptional activities of a number of nuclear receptors...
  2. Song G, Wang L. MiR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS ONE. 2008;3:e3574 pubmed publisher
  3. Miao J, Xiao Z, Kanamaluru D, Min G, Yau P, Veenstra T, et al. Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev. 2009;23:986-96 pubmed publisher
    b>Small Heterodimer Partner (SHP) inhibits activities of numerous transcription factors involved in diverse biological pathways...
  4. Huang J, Tabbi Anneni I, Gunda V, Wang L. Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1211-21 pubmed publisher
    ..Here, we establish a novel molecular link between Nrf2, nuclear receptor small heterodimer partner (SHP; NROB2), lipogenic genes, and hepatic lipid homeostasis...
  5. Park Y, Qatanani M, Chua S, Larey J, Johnson S, Watanabe M, et al. Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology. 2008;47:1578-86 pubmed publisher
    The orphan nuclear hormone receptor small heterodimer partner (SHP) regulates the expression of several genes involved in bile acid homeostasis in the liver...
  6. Song G, Wang L. Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism. PLoS ONE. 2009;4:e6880 pubmed publisher
    ..Microarray profiling and real-time PCR analysis revealed a marked down-regulation of miR-206 in nuclear receptor SHP(-/-) mice...
  7. Seol W, Choi H, Moore D. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996;272:1336-9 pubmed
    b>SHP is an orphan member of the nuclear hormone receptor superfamily that contains the dimerization and ligand-binding domain found in other family members but lacks the conserved DNA binding domain...
  8. Zhang Y, Andrews G, Wang L. Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP. Nucleic Acids Res. 2012;40:4850-60 pubmed publisher
    ..Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1 (MTF-1)...
  9. Tabbi Anneni I, Cooksey R, Gunda V, Liu S, Mueller A, Song G, et al. Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis. Am J Physiol Endocrinol Metab. 2010;298:E961-70 pubmed publisher
    The orphan nuclear receptor small heterodimer partner (SHP) regulates metabolic pathways involved in hepatic bile acid production and both lipid and glucose homeostasis via the transcriptional repression of other nuclear receptors...

More Information

Publications62

  1. Suh J, Huang J, Park Y, Seong H, Kim D, Shong M, et al. Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation. J Biol Chem. 2006;281:39169-78 pubmed
    Orphan nuclear receptor small heterodimer partner (SHP) is an atypical member of the nuclear receptor superfamily; SHP regulates the nuclear receptor-mediated transcription of target genes but lacks a conventional DNA binding domain...
  2. Lee H, Lee Y, Kim Y, Park S, Lee J, Kwon H, et al. Structure and expression of the orphan nuclear receptor SHP gene. J Biol Chem. 1998;273:14398-402 pubmed
    To determine the organization of the orphan nuclear receptor SHP gene (Seol, W., Choi, H.-S., and Moore, D.D. (1996) Science 272, 1336-1339), genomic clones were isolated from human and mouse genomic libraries...
  3. Park Y, Kim S, Kim J, Anakk S, Lee J, Tseng H, et al. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. 2011;52:2234-44 pubmed publisher
    ..Thus, we reinvestigated the impact of small heterodimer partner (SHP) deletion on diet-induced obesity and insulin resistance using congenic SHP(-/-) mice...
  4. Zhang Y, Xu P, Park K, Choi Y, Moore D, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology. 2008;48:289-98 pubmed publisher
    The small heterodimer partner (SHP; NROB2), a member of the nuclear receptor superfamily, contributes to the biological regulation of several major functions of the liver...
  5. Matsukuma K, Wang L, Bennett M, Osborne T. A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor. J Biol Chem. 2007;282:20164-71 pubmed
    ..We also demonstrate that LRH-1 stimulation of the FAS LXR response is blocked by the addition of small heterodimer partner (SHP) and that FAS mRNA is overexpressed in SHP knock-out animals, providing evidence that FAS is an in ..
  6. Datta S, Wang L, Moore D, Osborne T. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. J Biol Chem. 2006;281:807-12 pubmed
    ..bile acids in the liver is regulated through the bile acid-dependent induction of the negatively acting small heterodimer partner nuclear receptor...
  7. Lee J, Padhye A, Sharma A, Song G, Miao J, Mo Y, et al. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem. 2010;285:12604-11 pubmed publisher
    ..FXR induces expression of small heterodimer partner (SHP), an orphan nuclear receptor and transcriptional corepressor, which in turn results in repression ..
  8. Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science. 2006;312:233-6 pubmed
    ..FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. ..
  9. Potthoff M, Bonéy Montoya J, Choi M, He T, Sunny N, Satapati S, et al. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1? pathway. Cell Metab. 2011;13:729-38 pubmed publisher
    ..Overexpression of PGC-1? blocks the inhibitory effect of FGF15/19 on gluconeogenic gene expression. These results demonstrate that FGF15/19 works subsequent to insulin as a postprandial regulator of hepatic carbohydrate homeostasis. ..
  10. Båvner A, Johansson L, Toresson G, Gustafsson J, Treuter E. A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO Rep. 2002;3:478-84 pubmed
    b>SHP (short heterodimer partner, NROB2) is an atypical orphan member of the mammalian nuclear receptor family that consists only of a putative ligand-binding domain and thus cannot bind DNA...
  11. Miao J, Fang S, Lee J, Comstock C, Knudsen K, Kemper J. Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. Mol Cell Biol. 2009;29:6170-81 pubmed publisher
    ..in maintaining health and is primarily regulated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP)...
  12. Yang C, Yuk J, Kim J, Hwang J, Lee C, Kim J, et al. Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS ONE. 2013;8:e63435 pubmed publisher
    The orphan nuclear receptor, small heterodimer partner (SHP), appears to play a negative regulatory role in innate immune signaling...
  13. Ma K, Saha P, Chan L, Moore D. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006;116:1102-9 pubmed
    ..The absence of this repression in both FXR-/- and small heterodimer partner-null (SHP-/-) mice demonstrated that the previously described FXR-SHP nuclear receptor cascade also ..
  14. Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, et al. Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem. 2002;277:1586-92 pubmed
    b>Small heterodimer partner (SHP, NR0B2) is an atypical orphan nuclear receptor that inhibits transcriptional activation by several other nuclear receptors...
  15. Pan X, Zhang Y, Wang L, Hussain M. Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab. 2010;12:174-86 pubmed publisher
    ..CLOCK knockdown activated MTP promoter and reduced small heterodimer partner (SHP, NROB2). CLOCK upregulated SHP by binding to its E box...
  16. Wang L, Han Y, Kim C, Lee Y, Moore D. Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem. 2003;278:44475-81 pubmed
    The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component of a negative regulatory cascade by which high levels of bile acids repress bile acid biosynthesis...
  17. Goodwin B, Jones S, Price R, Watson M, McKee D, Moore L, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 2000;6:517-26 pubmed
    ..We have used a potent, nonsteroidal FXR ligand to show that FXR induces expression of small heterodimer partner 1 (SHP-1), an atypical member of the nuclear receptor family that lacks a DNA-binding domain...
  18. Kim J, Kim H, Kim K, Park Y, Seong H, Park K, et al. Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding. Mol Endocrinol. 2004;18:2880-94 pubmed
    b>Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor and acts as a coregulator of various nuclear receptors...
  19. Zhang Y, Wang L. Nuclear receptor SHP inhibition of Dnmt1 expression via ERR?. FEBS Lett. 2011;585:1269-75 pubmed publisher
    ..The induction of Dnmt1 by ERR? is repressed by SHP through SHP inhibition of ERR? transactivity, diminishing ERR? recruitment to the Dnmt1 promoter, and altering the ..
  20. Kim D, Lee J. Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner. Proc Natl Acad Sci U S A. 2011;108:12266-70 pubmed publisher
    ..acid (BA) levels under both normal and stressed conditions primarily through up-regulating expression of small heterodimer partner, a critical inhibitor of BA synthesis...
  21. Zhang Y, Wang L. Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4?. PLoS ONE. 2013;8:e68491 pubmed publisher
    The nuclear receptor small heterodimer partner SHP was shown recently to translocate to the mitochondria, interact with Bcl2, and induce apoptosis in liver cancer cells...
  22. Watanabe M, Houten S, Wang L, Moschetta A, Mangelsdorf D, Heyman R, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004;113:1408-18 pubmed
    ..Through the use of mouse mutants for the short heterodimer partner (SHP) and liver X receptor (LXR) alpha and beta, we demonstrate the critical dependence of the reduction of SREBP-1c ..
  23. Hartman H, Lai K, Evans M. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res. 2009;50:193-203 pubmed publisher
    ..is repressed by the sequential activity of two nuclear hormone receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP)...
  24. Song G, Wang L. Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res. 2008;36:5727-35 pubmed publisher
    ..21 miRNAs clustered on chromosome 12, including miR-433 and miR-127, that were co-upregulated in small heterodimer partner (SHP, NR0B2) SHP knockouts (SHP(-/-)) liver...
  25. Huang J, Iqbal J, Saha P, Liu J, Chan L, Hussain M, et al. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 2007;46:147-57 pubmed
    The orphan receptor Small Heterodimer Partner (SHP, NROB2) regulates metabolic pathways, including hepatic bile acid, lipid, and glucose homeostasis...
  26. Yuk J, Shin D, Lee H, Kim J, Kim S, Jin H, et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol. 2011;12:742-51 pubmed publisher
    The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways...
  27. Zhang Y, Bonzo J, Gonzalez F, Wang L. Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. J Biol Chem. 2011;286:29635-43 pubmed publisher
    ..HNF4α activity, as well as its enrichment on the Egr-1 promoter, were markedly repressed by small heterodimer partner (SHP) co-expression. Egr-1 mRNA and protein were transiently induced by HNF4α...
  28. Wang L, Lee Y, Bundman D, Han Y, Thevananther S, Kim C, et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002;2:721-31 pubmed
    The orphan nuclear hormone receptor SHP has been proposed to have a key role in the negative feedback regulation of bile acid production...
  29. Fang S, Miao J, Xiang L, Ponugoti B, Treuter E, Kemper J. Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol. 2007;27:1407-24 pubmed
    b>SHP has been implicated as a pleiotropic regulator of diverse biological functions by its ability to inhibit numerous nuclear receptors...
  30. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel E, et al. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010;30:1341-56 pubmed publisher
    b>Small heterodimer partner (SHP) is an epigenetically regulated nuclear transcriptional repressor that suppresses the development of liver cancer by inhibiting cellular growth...
  31. Kerr T, Saeki S, Schneider M, Schaefer K, Berdy S, Redder T, et al. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell. 2002;2:713-20 pubmed
    The in vivo role of the nuclear receptor SHP in feedback regulation of bile acid synthesis was examined...
  32. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, et al. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005;2:227-38 pubmed
    ..We have found that the orphan nuclear receptor SHP (NR0B2) is a negative regulator of PGC-1alpha expression in brown adipocytes...
  33. Chow E, Magomedova L, Quach H, Patel R, Durk M, Fan J, et al. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 2014;146:1048-59 pubmed publisher
    ..Farnesoid X receptor (Fxr)(-/-), small heterodimer partner (Shp)(-/-), and C57BL/6 (wild-type control) mice were fed normal or Western diets for 3 weeks and were ..
  34. Ohn J, Hwang J, Moon M, Ahn H, Kim H, Koo Y, et al. Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice. PLoS ONE. 2017;12:e0186021 pubmed publisher
    The small heterodimer partner (SHP) regulates fatty acid oxidation and lipogenesis in the liver by regulating peroxisome proliferator-activated receptor (PPAR) ? expression. SHP is also abundantly expressed in the myocardium...
  35. Nishigaki K, Hanson C, Ohashi T, Spadaccini A, Ruscetti S. Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1. J Virol. 2006;80:5678-85 pubmed
    ..The SFFV-transformed cells were shown to express elevated levels of the hematopoietic phosphatase SHP-1, and treatment of the cells with a phosphatase inhibitor restored STAT1 tyrosine phosphorylation...
  36. Kumagai H, Oki T, Tamitsu K, Feng S, Ono M, Nakajima H, et al. Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun. 2003;307:719-29 pubmed
    ..cross-linked, the intracellular domain was tyrosine phosphorylated and capable of recruiting tyrosine phosphatases, SHP-1 and SHP-2 and inositol polyphosphate 5-phosphatase, SHIP...
  37. Iype T, Sankarshanan M, Mauldin I, Mullins D, Lorenz U. The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells. J Immunol. 2010;185:6115-27 pubmed publisher
    ..First, we identify the cytoplasmic tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1) as an endogenous brake and modifier of the suppressive ability of Tregs; consistent with this notion, loss of ..
  38. Martin L, Tremblay J. Nuclear receptors in Leydig cell gene expression and function. Biol Reprod. 2010;83:3-14 pubmed publisher
    ..This review provides an overview of the nuclear receptor family of transcription factors as they relate to Leydig cell gene expression and function. ..
  39. Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford S, Xing C, et al. SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. PLoS Genet. 2017;13:e1006650 pubmed publisher
    ..We demonstrate that activation of SHP (Small Heterodimer Partner), DKK4 (Dickkopf-4), and CADM4 (Cell Adhesion Molecule 4) by SRC-2 suppresses tumorigenesis in vitro and ..
  40. Ballif B, Arnaud L, Arthur W, Guris D, Imamoto A, Cooper J. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004;14:606-10 pubmed
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development. ..
  41. Vega A, Baptissart M, Martinot E, Saru J, Baron S, Schoonjans K, et al. Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP. Expert Opin Ther Targets. 2014;18:1367-76 pubmed publisher
    ..The nuclear receptor small heterodimer partner (SHP) mediates the deleterious effects of neonatal exposure to diethylstilbestrol (DES) on male ..
  42. Lee S, Zhang Y, Tsuchiya H, Smalling R, Jetten A, Wang L. Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2015;61:497-505 pubmed publisher
    ..The Clock gene regulates diurnal plasma triglyceride fluctuation through nuclear receptor small heterodimer partner (Shp; Nr0b2)...
  43. Anakk S, Watanabe M, Ochsner S, McKenna N, Finegold M, Moore D. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest. 2011;121:86-95 pubmed publisher
    ..tightly regulated via a feedback loop operated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP)...
  44. Jeong B, Lee Y, Bae I, Lee C, Shin H, Ha H, et al. The orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation. J Bone Miner Res. 2010;25:262-74 pubmed publisher
    The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) interacts with a diverse array of transcription factors and regulates a variety of cellular events such as cell proliferation, differentiation, and metabolism...
  45. Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore D, et al. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol. 2009;23:137-45 pubmed publisher
    ..CYP7a1 expression was initially suppressed after 70% PH in an farnesoid X receptor/ small heterodimer partner-independent manner; however, both farnesoid X receptor and small heterodimer partner were required to ..
  46. Chen S, Lu W, Yueh M, Rettenmeier E, Liu M, Paszek M, et al. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017;114:E1432-E1440 pubmed publisher
    ..These findings provide a mechanism of NCoR1 in intestinal homeostasis during development and provide a key link to those events that control developmental repression of UGT1A1 and hyperbilirubinemia. ..
  47. Kim Y, Kim Y, Cho Y, Kim D, Ahn S, Lee J, et al. Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models. Diabetologia. 2012;55:1482-94 pubmed publisher
    ..is an anti-diabetic drug used for the treatment of type 2 diabetes, and orphan nuclear receptor small heterodimer partner (SHP, also known as NR0B2), a transcriptional co-repressor, plays an important role in maintaining ..
  48. Phan J, Pesaran T, Davis R, Reue K. The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem. 2002;277:469-77 pubmed
    ..Genetic analysis of serum bile acid levels revealed co-segregation with Diet1, indicating that this locus is likely responsible for both increased bile acid excretion and resistance to hypercholesterolemia in B6By mice...
  49. Oiwa A, Kakizawa T, Miyamoto T, Yamashita K, Jiang W, Takeda T, et al. Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1. Biochem Biophys Res Commun. 2007;353:895-901 pubmed
    b>Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver...
  50. Lai K, Harnish D, Evans M. Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner. J Biol Chem. 2003;278:36418-29 pubmed
    Hormonal status can influence diverse metabolic pathways. Small heterodimer partner (SHP) is an orphan nuclear receptor that can modulate the activity of several transcription factors...
  51. Kim D, Kwon S, Byun S, Xiao Z, Park S, Wu S, et al. Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis. Nat Commun. 2016;7:12179 pubmed publisher
    ..Because of detergent-like toxicity, BA levels must be tightly regulated. An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regulation, but how SHP senses the BA signal for feedback ..
  52. Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
    ..Here, we show that Small Heterodimer Partner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase ..
  53. Jang W, Kim E, Bae I, Lee K, Kim Y, Kim D, et al. Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2. Bone. 2011;48:885-93 pubmed publisher
    ..Metformin-induced mRNA expression of the osteogenic genes and small heterodimer partner (SHP) in MC3T3E1 cells were determined by RT-PCR and real-time PCR...