Gene Symbol: Nqo1
Description: NAD(P)H dehydrogenase, quinone 1
Alias: AV001255, Dia4, Dtd, Nmo-1, Nmo1, Nmor1, Ox-1, Ox1, Qr1, NAD(P)H dehydrogenase [quinone] 1, DT-diaphorase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione oxidoreductase 1, dioxin inducible, NAD(P)H:quinone oxidoreductase 1, azoreductase, diaphorase 4 (NADH/NADPH), menadione reductase, phylloquinone reductase, quinone reductase 1
Species: mouse
Products:     Nqo1

Top Publications

  1. Aleksunes L, Slitt A, Maher J, Dieter M, Knight T, Goedken M, et al. Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones. 2006;11:356-63 pubmed
    ..factor-E2-related factor (Nrf2) induces expression of numerous genes including NAD(P)H:quinone oxidoreductase 1 (Nqo1) during periods of oxidative stress...
  2. Gray J, Eisen T, Cline G, Smith P, Heart E. Plasma membrane electron transport in pancreatic ?-cells is mediated in part by NQO1. Am J Physiol Endocrinol Metab. 2011;301:E113-21 pubmed publisher
    ..Overexpression of cytosolic NAD(P)H-quinone oxidoreductase (NQO1) increased PMET activity in the presence of 10 mM glucose while inhibition of NQO1 by its inhibitor dicoumarol ..
  3. Iskander K, Gaikwad A, Paquet M, Long D, Brayton C, Barrios R, et al. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005;65:2054-8 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic protein that catalyzes metabolic detoxification of quinones and protects cells against redox cycling and oxidative stress...
  4. Asher G, Lotem J, Sachs L, Kahana C, Shaul Y. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc Natl Acad Sci U S A. 2002;99:13125-30 pubmed
    ..We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation...
  5. Hwang J, Kim D, Jo E, Kim Y, Jo Y, Park J, et al. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes. 2009;58:965-74 pubmed publisher
    ..We used beta-lapachone (betaL), a natural substrate of NADH:quinone oxidoreductase 1 (NQO1), to stimulate NADH oxidation...
  6. Ahn K, Sethi G, Jain A, Jaiswal A, Aggarwal B. Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. J Biol Chem. 2006;281:19798-808 pubmed
    The NAD(P)H:quinone oxidoreductase 1 (NQO1) is a phase II enzyme that reduces and detoxifies quinones and their derivatives...
  7. Yamamoto T, Suzuki T, Kobayashi A, Wakabayashi J, Maher J, Motohashi H, et al. Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol. 2008;28:2758-70 pubmed publisher
    ..These results demonstrate critical roles of the cysteine residues in vivo in maintaining Keap1 function, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles. ..
  8. Jyrkkänen H, Kansanen E, Inkala M, Kivelä A, Hurttila H, Heinonen S, et al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res. 2008;103:e1-9 pubmed publisher
    ..mediating the induction of glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H quinone oxidoreductase-1 (NQO1) by oxPAPC in human endothelial cells, whereas the contribution to the induction of heme oxygenase-1 was less ..
  9. Radjendirane V, Joseph P, Lee Y, Kimura S, Klein Szanto A, Gonzalez F, et al. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998;273:7382-9 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress...

More Information


  1. Gussing F, Bohm S. NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps. Eur J Neurosci. 2004;19:2511-8 pubmed
    ..We here show that mature neurons in one defined zone selectively express NADPH:quinone oxidoreductase (NQO1), an enzyme that catalyses reduction of quinones...
  2. Nam S, Hwang J, Kim D, Lu L, Hong J, Zhang P, et al. NQO1-Knockout Mice Are Highly Sensitive to Clostridium Difficile Toxin A-Induced Enteritis. J Microbiol Biotechnol. 2016;26:1446-51 pubmed publisher
    ..We previously showed that NADH:quinone oxidoreductase 1 (NQO1) KO (knockout) mice spontaneously display weak gut inflammation and a marked loss of colonic epithelial tight ..
  3. Joseph P, Long D, Klein Szanto A, Jaiswal A. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Biochem Pharmacol. 2000;60:207-14 pubmed
    b>NQO1-/- mice, along with Chinese hamster ovary (CHO) cells, were used to determine the in vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in cellular protection against quinone cytotoxicity, membrane damage, DNA damage, and ..
  4. Asher G, Lotem J, Tsvetkov P, Reiss V, Sachs L, Shaul Y. P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proc Natl Acad Sci U S A. 2003;100:15065-70 pubmed
    ..The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53. The NQO1 inhibitor dicoumarol induces ubiquitin-independent p53 degradation...
  5. Gang G, Kim Y, Noh J, Kim K, Jung J, Shong M, et al. Protective role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in cisplatin-induced nephrotoxicity. Toxicol Lett. 2013;221:165-75 pubmed publisher
    ..NAD(P)H:quinone oxidoreductase 1 (NQO1) is well known to regulate ROS generation...
  6. Gonzalez F, Kimura S. Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. Mutat Res. 2001;477:79-87 pubmed
    ..Mice lacking expression of microsomal epoxide hydrolase (mEH) and NADPH-quinone oxidoreductase (NQO1) were also made...
  7. Gerhard G, Kaufmann E, Wang X, Erikson K, Abraham J, Grundy M, et al. Genetic differences in hepatic lipid peroxidation potential and iron levels in mice. Mech Ageing Dev. 2002;123:167-76 pubmed
    ..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis. ..
  8. Iskander K, Barrios R, Jaiswal A. Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease. Cancer Res. 2008;68:7915-22 pubmed publisher
    NAD(P)H:quinone oxidoreductase 1 null (NQO1(-/-)) mice exposed to 3 Gy of gamma-radiation showed an increase in neutrophils, bone marrow hypercellularity, and enlarged lymph nodes and spleen...
  9. Kolterud A, Alenius M, Carlsson L, Bohm S. The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity. Development. 2004;131:5319-26 pubmed
    ..do not diversify into subpopulations expressing different OR genes and other region-restricted genes such as Nqo1 and Ncam2...
  10. Dong H, Shertzer H, Genter M, Gonzalez F, Vasiliou V, Jefcoate C, et al. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem Biophys Res Commun. 2013;435:727-32 pubmed publisher
    Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics...
  11. Long D, Waikel R, Wang X, Perlaky L, Roop D, Jaiswal A. NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res. 2000;60:5913-5 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity...
  12. Brewer A, Murray T, Arno M, Zhang M, Anilkumar N, Mann G, et al. Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo. Free Radic Biol Med. 2011;51:205-15 pubmed publisher
    ..These data therefore demonstrate that Nox4 can activate the Nrf2-regulated pathway, and suggest a potential role for Nox4 in the regulation of GSH redox in cardiomyocytes. ..
  13. Sparla F, Tedeschi G, Pupillo P, Trost P. Cloning and heterologous expression of NAD(P)H:quinone reductase of Arabidopsis thaliana, a functional homologue of animal DT-diaphorase. FEBS Lett. 1999;463:382-6 pubmed
    ..Conversely, in spite of the functional homology, sequence similarity between plant NQR and animal DT-diaphorase was limited and essentially confined to the flavin binding site. ..
  14. Cho J, Kam J, Cloutier J. Slits and Robo-2 regulate the coalescence of subsets of olfactory sensory neuron axons within the ventral region of the olfactory bulb. Dev Biol. 2012;371:269-79 pubmed publisher
    ..Taken together, our results demonstrate that Slits and Robo-2 are required for the formation of an accurate glomerular map in the ventral region of the OB. ..
  15. Kitajima M, Kimura A, Suzuki H. Cutting Edge: Nqo1 Regulates Irritant Contact Hypersensitivity against Croton Oil through Maintenance of Dendritic Epidermal T Cells. J Immunol. 2018;200:1555-1559 pubmed publisher
    ..Although Nqo1 is involved in antioxidative reactions and detoxification, its role in ICD remains unknown...
  16. Ingram B, Turbyfill J, Bledsoe P, Jaiswal A, Stafford D. Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice. Biochem J. 2013;456:47-54 pubmed publisher
    b>NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K...
  17. Gharavi N, El Kadi A. Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide. J Pharm Sci. 2007;96:2795-807 pubmed
    ..receptor (AhR)-regulated genes, such as cytochrome P450 1a1 (Cyp1a1) and NADPH: quinone oxidoreductase 1 (Nqo1) gene expression, yet the mechanisms involved remain unknown...
  18. Kwon J, Han E, Bui C, Shin W, Lee J, Lee S, et al. Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep. 2012;13:150-6 pubmed publisher
    ..p62 enhanced basal Nrf2 activity, conferring a higher steady-state expression of NAD(P)H dehydrogenase, quinone 1 (Nqo1) to maintain mitochondrial membrane potential and, thereby, restrict excess oxidant generation...
  19. Kim H, Oh G, Shen A, Lee S, Choe S, Kwon K, et al. Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment. Cell Death Dis. 2014;5:e1292 pubmed publisher
    ..we show that the induction of cellular NAD(+) levels using ?-lapachone (?-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 and SIRT1 activity...
  20. Chen S, Clarke P, Martino P, Deng P, Yeh C, Lee T, et al. Mouse liver NAD(P)H:quinone acceptor oxidoreductase: protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis. Protein Sci. 1994;3:1296-304 pubmed
    ..an amino acid sequence similar to those of the rat and human enzymes, the mouse enzyme has a higher NAD(P)H-menadione reductase activity and is less sensitive to flavones and dicoumarol, 2 known inhibitors of the enzyme...
  21. Shi S, Yoon D, Hodge Bell K, Bebenek I, Whitekus M, Zhang R, et al. The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. Carcinogenesis. 2009;30:1957-61 pubmed publisher
    ..These observations demonstrate that Arnt is required for tumor initiation by B[a]P in this system. ..
  22. Bárta F, Levová K, Frei E, Schmeiser H, Arlt V, Stiborova M. The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study. Mutat Res Genet Toxicol Environ Mutagen. 2014;768:1-7 pubmed publisher
    ..Using Western blotting, we investigated the expression of quinone oxidoreductase (NQO1), the most efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI) in mice and rats...
  23. Yoshida T, Tsuda H. Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance. Biochem Biophys Res Commun. 1995;214:701-8 pubmed
    ..These mutant cell lines seem to be very useful for investigating the functions of DT-diaphorase including the bioactivation and detoxification of quinone species. The generation of a DT-diaphorase-targeted mouse is under investigation. ..
  24. Meyer M, Potts Kant E, Ghio A, Fischer B, Foster W, Voynow J. NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. Am J Physiol Lung Cell Mol Physiol. 2012;303:L181-8 pubmed publisher
    ..reactive oxygen species, and this response is due in part to upregulation of NADPH quinone oxidoreductase 1 (NQO1) activity...
  25. Zhou W, Dowell D, Geraci M, Blackwell T, Collins R, Polosukhin V, et al. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol. 2011;301:L615-22 pubmed publisher
    ..PGI(2) induction of Nqo 1 provides a possible novel mechanism by which this prostanoid protects against bleomycin-induced mortality and identifies a potential therapeutic target for human ALI. ..
  26. Taguchi K, Maher J, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M. Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol Cell Biol. 2010;30:3016-26 pubmed publisher
    ..These results support our contention that the benefits of Nrf2 activation in acute toxicity are hormetic and that constitutive Nrf2 activation beyond a certain threshold is rather disadvantageous to long-term survival. ..
  27. Iskander K, Jaiswal A. Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem Biol Interact. 2005;153-154:147-57 pubmed
    Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress...
  28. Luo L, Chen Y, Wu D, Shou J, Wang S, Ye J, et al. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice. Toxicol Appl Pharmacol. 2015;288:339-48 pubmed publisher
    ..This study was to investigate the histological changes of Nrf2 and its regulated phase II enzymes Nqo1, AKR1B8, and Ho-1 in wild-type (WT) and Nrf2(-/-) mice induced by BHA...
  29. Noll C, Tlili A, Ripoll C, Mallet L, Paul J, Delabar J, et al. Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism. Mol Genet Metab. 2012;105:484-8 pubmed publisher
    ..hydrolase (SAHH) activity, which depends on the activation of NAD(P)H:quinone oxidoreductase-1 (NQO1)...
  30. Long D, Iskander K, Gaikwad A, Arin M, Roop D, Knox R, et al. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002;277:46131-9 pubmed
    ..The NQO2-null mice are a model for NQO2 deficiency in humans and can be used to determine the role of this enzyme in sensitivities to toxicity and carcinogenesis. ..
  31. Zhou G, Randerath K, Donnelly K, Jaiswal A. Effects of NQO1 deficiency on levels of cyclopurines and other oxidative DNA lesions in liver and kidney of young mice. Int J Cancer. 2004;112:877-83 pubmed
    ..We tested the hypothesis that young mice deficient in NAD(P)H:quinone oxidoreductase 1 (NQO1), an antioxidant enzyme catalyzing the detoxification of quinones and their derivatives, show increased formation ..
  32. Kim T, Kim Y, Kim H, Park S, Lee M, Park Y, et al. NQO1 Deficiency Leads Enhanced Autophagy in Cisplatin-Induced Acute Kidney Injury Through the AMPK/TSC2/mTOR Signaling Pathway. Antioxid Redox Signal. 2016;24:867-83 pubmed publisher
    ..quinone oxidoreductase 1 (NQO1) is a highly inducible cytoprotective gene that regulates reactive oxygen species (ROS) generation...
  33. Duggan C, DeMaria S, Baudhuin A, Stafford D, Ngai J. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci. 2008;28:5229-39 pubmed publisher
    ..Therefore, we identified an evolutionarily conserved requirement for Foxg1 in the development of the vertebrate olfactory system. ..
  34. Tabuchi K, Hoshino T, Hirose Y, Hayashi K, Nishimura B, Nakayama M, et al. Age-related hearing loss and expression of antioxidant enzymes in BDF1 mice. Acta Otolaryngol. 2011;131:1020-4 pubmed publisher
    ..In contrast, a decrease in the expression level was not observed regarding NAD(P)H-quinone oxidoreductase 1 (NQO1).
  35. Fisher C, Jackson J, Lickteig A, Augustine L, Cherrington N. Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. Arch Toxicol. 2008;82:959-64 pubmed publisher
    ..and induction of downstream DME targets Cyp1A1, Cyp2B10, Cyp3A11, Cyp4A14 and NAD(P)H:quinone oxidoreductase 1 (Nqo1), respectively...
  36. Adikesavan A, Barrios R, Jaiswal A. In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity. Cancer Res. 2007;67:7966-71 pubmed
    NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)), NQO1(+/-) along with NRH:quinone oxidoreductase 2(-/-) (NQO2(-/-)), and wild-type (WT) mice were exposed to five once weekly doses of mitomycin C...
  37. Alard A, Fabre B, Anesia R, Marboeuf C, Pierre P, Susini C, et al. NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome. Mol Cell Biol. 2010;30:1097-105 pubmed publisher
    ..Here, we show that eIF4GI exists in a complex with NAD(P)H quinone-oxydoreductase 1 (NQO1) in cell extracts...
  38. Ruppert S, Kelsey G, Schedl A, Schmid E, Thies E, Schutz G. Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice. Genes Dev. 1992;6:1430-43 pubmed
    ..Mechanisms by which this metabolic defect might bring about alterations in gene expression characteristic of the alf/hsdr-1 deletion phenotype are discussed. ..
  39. Adamovich Y, Shlomai A, Tsvetkov P, Umansky K, Reuven N, Estall J, et al. The protein level of PGC-1?, a key metabolic regulator, is controlled by NADH-NQO1. Mol Cell Biol. 2013;33:2603-13 pubmed publisher
    ..We further demonstrate that PGC-1? degradation is inhibited by NQO1, a 20S gatekeeper protein. NQO1 binds and protects PGC-1? from degradation in an NADH-dependent manner...
  40. Reiners J, Jones C, Hong N, Myrand S. Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor. Mol Carcinog. 1998;21:135-46 pubmed
    ..Analyses of CYP1A1, CYP1B1, cytosolic aldehyde dehydrogenase class 3, and NAD(P)H:menadione oxidoreductase (NMO1) mRNA content by RT-PCR revealed significant increases in all four mRNAs in the normal tissue adjacent to ..
  41. Choi Y. The cytoprotective effects of ethanol extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK pathway. Gen Physiol Biophys. 2016;35:45-53 pubmed publisher
    ..Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2-mediated HO-1 and inducing NQO-1 via the activation of MAPK signaling pathways. ..
  42. Bongard R, Myers C, Lindemer B, Baumgardt S, Gonzalez F, Merker M. Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung. Am J Physiol Lung Cell Mol Physiol. 2012;302:L949-58 pubmed publisher
    ..reduction on passage through the rat pulmonary circulation was catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) and mitochondrial complex I, but that NQO1 genotype was not a factor in CoQ(1) reduction on passage through the ..
  43. Baker N, English V, Sunkara M, Morris A, Pearson K, Cassis L. Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes. J Nutr Biochem. 2013;24:2168-74 pubmed publisher
    ..were restored by RSV, which resulted in a concentration-dependent increase in NAD(P)H:quinone oxidoreductase 1 (NQO1), the downstream target of Nrf2 signaling...
  44. Faig M, Bianchet M, Talalay P, Chen S, Winski S, Ross D, et al. Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. Proc Natl Acad Sci U S A. 2000;97:3177-82 pubmed
    NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles...
  45. Patrick B, Das A, Jaiswal A. NAD(P)H:quinone oxidoreductase 1 protects bladder epithelium against painful bladder syndrome in mice. Free Radic Biol Med. 2012;53:1886-93 pubmed publisher
    ..Here we demonstrate that NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)) mice developed in our laboratory represent a new animal model of PBS...
  46. Kim Y, Hwang J, Noh J, Gang G, Kim D, Son H, et al. Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. Cardiovasc Res. 2011;91:519-27 pubmed publisher
    ..Lapachone (?L), a well-known substrate of NAD(P)H:quinone oxidoreductase (NQO1), increases the cellular NAD(+)/NADH ratio via the activation of NQO1...
  47. Korashy H, El Kadi A. Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper. Drug Metab Dispos. 2006;34:152-65 pubmed
    ..Hepa 1c1c7 cells the expression of the phase II xenobiotic metabolizing enzymes NAD(P)H:quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase subunit Ya (Gst ya) genes, yet the mechanisms involved remain unknown...
  48. He X, Chen M, Lin G, Ma Q. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer. J Biol Chem. 2006;281:23620-31 pubmed
    ..We analyzed the signaling pathway for induction of detoxification gene NAD(P)H-quinone oxidoreductase (Nqo1) by arsenic...
  49. Gaikwad A, Long D, Stringer J, Jaiswal A. In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue. J Biol Chem. 2001;276:22559-64 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives...
  50. Kummarapurugu A, Fischer B, Zheng S, Milne G, Ghio A, Potts Kant E, et al. NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation. J Biol Chem. 2013;288:4681-91 pubmed publisher
    NADPH:quinone oxidoreductase 1 (NQO1) is recognized as a major susceptibility gene for ozone-induced pulmonary toxicity. In the absence of NQO1 as can occur by genetic mutation, the human airway is protected from harmful effects of ozone...
  51. Kapinya K, Harms U, Harms C, Blei K, Katchanov J, Dirnagl U, et al. Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. J Neurochem. 2003;84:1028-39 pubmed
    A direct involvement of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO1) in neuroprotection has not yet been shown...
  52. Hwang J, Kim Y, Noh J, Gang G, Kim K, Chung H, et al. The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction. Arch Toxicol. 2015;89:2159-66 pubmed publisher
    ..quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone...
  53. Long D, Jaiswal A. Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression. Gene. 2000;252:107-17 pubmed
    ..Northern analysis of eight mouse tissues indicated wide variations in the expression of the NQO2 and NQO1 genes...
  54. Terai K, Dong G, Oh E, Park M, Gu Y, Song C, et al. Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1. Anticancer Drugs. 2009;20:901-9 pubmed publisher
    NAD(P)H:quinone oxidoreductase (NQO1) has been reported to play an important role in cell death caused by beta-lapachone (beta-lap), 3,4-dihydro-22,2-dimethyl-2H-naphthol[1,22b]pyran-5,6-dione...
  55. Stringer J, Gaikwad A, Gonzales B, Long D, Marks L, Jaiswal A. Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. J Comp Neurol. 2004;471:289-97 pubmed
    NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes a reductive detoxification that is thought to protect cells against the adverse effects of quinones and related compounds. NQO1 activity is present in all tissues...
  56. Miller A, Maurer L, Zou D, Firestein S, Greer C. Axon fasciculation in the developing olfactory nerve. Neural Dev. 2010;5:20 pubmed publisher
    ..While regional segregation occurs in the mesenchyme, the final convergence of OR-specific subpopulations does not occur until the axons reach the inner nerve layer of the OB...
  57. Yu L, Zhang F, Hu Z, Ding H, Tang H, Ma Z, et al. Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities. Fitoterapia. 2014;93:115-20 pubmed publisher
    ..The results of electrophilic assay and QR induction activity assay were quite well. New compounds 1 and 2, along with some known prenylated chalcones, displayed certain QR induction activity. ..
  58. Kumaki K, Jensen N, Shire J, Nebert D. Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977;252:157-65 pubmed
    ..These experimental data might be useful in the protein activator hypothesis of the Britten-Davidson model for gene regulation. ..
  59. Kobayashi E, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624 pubmed publisher
    ..This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach. ..
  60. Ruffoli R, Giambelluca M, Soldani P, Grasso L, Gasperi M, Giannessi F. Ultrastructural localization of the NADPH-diaphorase activity in the Leydig cells of aging mice. Anat Embryol (Berl). 2001;203:383-91 pubmed
    ..We conjecture that the impaired steroidogenesis observed in the testis of aging mammals might, at least in part, depend on the increased nitric oxide production in the Leydig cells. ..
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    NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives...
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    ..Therefore, in addition to its role in cancer metabolism, PKM2 plays a role in controlling systemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechanism. ..
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    ..These data support the hypothesis that the outgrowth and coalescence of OSN axons is, at least in part, subject to activity-dependent mechanisms mediated via HCN channels. ..
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    ..Furthermore, these mice show decreased avoidance behavior toward the predator odorant trimethyl-thiazoline. Our results indicate that the pattern of glomerular innervation in the OB is critical for innate behavioral responses in mice. ..
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    ..These results demonstrate that Goofy plays an important role in establishing the acuity of olfactory sensory signaling. ..
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    ..Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis. ..
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    One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1)...
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    ..Here, we showed that NAD(P)H:quinone oxidoreductase 1 (NQO1) was highly expressed in mouse renal tubular epithelial cells...
  70. Petersen D, Gonzalez F, Rapic V, Kozak C, Lee J, Jones J, et al. Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. Proc Natl Acad Sci U S A. 1989;86:6699-703 pubmed
    The NAD(P)H:menadione oxidoreductase gene (Nmo-1) codes for a quinone reductase (also called DT diaphorase; EC believed to play a central role in protection against oxidative stress...
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    ..TCDD, mevinolin markedly increases Cyp1a-1 transcription, CYP1A1 mRNA and protein levels and enzyme activity, and NMO1 mRNA concentrations...
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    ..quinone oxidoreductase 1 (NQO1) is a well-known antioxidant protein that regulates ROS generation...
  73. Hintze K, Katoh Y, Igarashi K, Theil E. Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1. J Biol Chem. 2007;282:34365-71 pubmed
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    ..Our findings reveal that the functions of Nrf2 and the composition of amniotic fluid have coevolved to ensure the formation of a functional barrier...
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    NAD(P)H: quinone oxidoreductase (NQO1) is essential for cell defense against reactive oxidative species, cancer, and metabolic stress...
  76. Nam S, Hwang J, Kim D, Park M, Lee I, Nam H, et al. Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells. BMB Rep. 2014;47:494-9 pubmed
    NADH:quinone oxidoreductase 1 (NQO1) is known to be involved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders...
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    ..We describe here an alternative pathway for ODC degradation that is regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). We show that NQO1 binds and stabilizes ODC...