Npy

Summary

Gene Symbol: Npy
Description: neuropeptide Y
Alias: 0710005A05Rik, pro-neuropeptide Y
Species: mouse
Products:     Npy

Top Publications

  1. Erickson J, Clegg K, Palmiter R. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 1996;381:415-21 pubmed
    Neuropeptide Y (NPY), a 36-amino-acid transmitter distributed throughout the nervous system, is thought to function as a central stimulator of feeding behaviour...
  2. Elefteriou F, Takeda S, Liu X, Armstrong D, Karsenty G. Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology. 2003;144:3842-7 pubmed
    ..Because neuropeptide Y (NPY) is highly expressed in MSG-sensitive neurons we tested whether NPY regulates bone formation...
  3. Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, et al. Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex. 2012;22:680-92 pubmed publisher
    ..Rac1 is necessary for their transition from G1 to S phase, at least in part by regulating cyclin D levels and retinoblastoma protein phosphorylation. ..
  4. Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka Kogo A, Kusaka M, et al. Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002;32:359-69 pubmed
    ..The present report is, to our knowledge, the first to use phenotypic analysis of a knockout mouse to identify a gene associated with an X-linked human brain malformation...
  5. Kuo L, Kitlinska J, Tilan J, Li L, Baker S, Johnson M, et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med. 2007;13:803-11 pubmed
    ..obesity through a peripheral mechanism in the abdominal white adipose tissue that is mediated by neuropeptide Y (NPY)...
  6. Zhou J, Xu Z, Jiang C. Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor. Neurosci Bull. 2008;24:155-9 pubmed
    To examine the effect of neuropeptide Y (NPY) on TGF-beta1 production in RAW264.7 macrophages. Enzyme linked immunosorbent assay (ELISA) was used to detect TGF-beta1 production...
  7. Good D, Porter F, Mahon K, Parlow A, Westphal H, Kirsch I. Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997;15:397-401 pubmed
    ..Our results support a role for Nhlh2 in the onset of puberty and the regulation of body weight metabolism. ..
  8. Baldock P, Lee N, Driessler F, Lin S, Allison S, Stehrer B, et al. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight. PLoS ONE. 2009;4:e8415 pubmed publisher
    ..Mice lacking neuropeptide Y (NPY), a well-known orexigenic factor whose hypothalamic expression is increased in fasting, have significantly ..
  9. Edelsbrunner M, Herzog H, Holzer P. Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner. Behav Brain Res. 2009;203:97-107 pubmed publisher
    Peptide YY (PYY) and neuropeptide Y (NPY) have been proposed to participate in the control of energy homeostasis...

More Information

Publications70

  1. Andrews Z, Liu Z, Walllingford N, Erion D, Borok E, Friedman J, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008;454:846-51 pubmed publisher
    ..behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons)...
  2. Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter A, Guillemot F, et al. Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Dev Biol. 2011;349:406-16 pubmed publisher
    ..fate mapping and loss of function studies in mice demonstrate that Ngn3+ progenitors contribute to subsets of POMC, NPY, TH and SF1 neurons and is required for the specification of these neuronal subtypes in the ventral hypothalamus...
  3. Bannon A, Seda J, Carmouche M, Francis J, Norman M, Karbon B, et al. Behavioral characterization of neuropeptide Y knockout mice. Brain Res. 2000;868:79-87 pubmed
    An extensive behavioral characterization was conducted with mice lacking the gene for neuropeptide Y (NPY) including response to 24 and 48 h fast and challenge with small molecule antagonists of NPY receptors implicated in mediating the ..
  4. Marin O, Anderson S, Rubenstein J. Origin and molecular specification of striatal interneurons. J Neurosci. 2000;20:6063-76 pubmed
    ..1 into adulthood, most of the interneurons expressing somatostatin (SOM), neuropeptide Y (NPY), and neural nitric oxide synthase (NOS) appear to downregulate the expression of NKX2...
  5. Ruohonen S, Pesonen U, Moritz N, Kaipio K, Roytta M, Koulu M, et al. Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons: a novel model of increased adiposity and impaired glucose tolerance. Diabetes. 2008;57:1517-25 pubmed publisher
    A functional polymorphism leucine 7 proline in the human neuropeptide Y (NPY) gene leading to increased NPY release from sympathetic nerves is associated with traits of metabolic syndrome...
  6. Anderson S, Marin O, Horn C, Jennings K, Rubenstein J. Distinct cortical migrations from the medial and lateral ganglionic eminences. Development. 2001;128:353-63 pubmed
    ..In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons. ..
  7. Luque R, Park S, Kineman R. Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone. Endocrinology. 2007;148:300-9 pubmed
    ..A sequential rise in hypothalamic neuropeptide Y (NPY) and CRH mRNA levels preceded the fall in GHRH expression, where fasting-induced changes in CRH and GHRH mRNA ..
  8. Fu L, van den Pol A. GABA excitation in mouse hilar neuropeptide Y neurons. J Physiol. 2007;579:445-64 pubmed
    ..transgenic mouse expressing green fluorescent protein (GFP) in a subset of neurons that colocalized neuropeptide Y (NPY), somatostatin (SST), and GABA for whole-cell, perforated, and cell-attached recording in 240 neurons...
  9. Bagri A, Marin O, Plump A, Mak J, Pleasure S, Rubenstein J, et al. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002;33:233-48 pubmed
  10. Azim E, Jabaudon D, Fame R, Macklis J. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009;12:1238-47 pubmed publisher
    ..These data indicate that SOX6 is a central regulator of both progenitor and cortical interneuron diversity during neocortical development. ..
  11. Morales Medina J, Dumont Y, Quirion R. A possible role of neuropeptide Y in depression and stress. Brain Res. 2010;1314:194-205 pubmed publisher
    Neuropeptide Y (NPY) mediates its physiological effects through at least four receptors known as Y(1), Y(2), Y(4), and Y(5)...
  12. Padilla S, Carmody J, Zeltser L. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med. 2010;16:403-5 pubmed publisher
    ..to gestational influences in mice, we characterized the ontogeny of proopiomelanocortin (POMC) and neuropeptide Y (NPY) cell populations, which exert opposing influences on food intake and body weight...
  13. García López M, Abellan A, Legaz I, Rubenstein J, Puelles L, Medina L. Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008;506:46-74 pubmed
    ..Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala. ..
  14. Stanic D, Mulder J, Watanabe M, Hokfelt T. Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter-related molecules. J Comp Neurol. 2011;519:1219-57 pubmed publisher
    Neuropeptide Y (NPY) is widely expressed in the brain and its biological effects are mediated through a variety of receptors...
  15. Segal Lieberman G, Trombly D, Juthani V, Wang X, Maratos Flier E. NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting. Am J Physiol Endocrinol Metab. 2003;284:E1131-9 pubmed
    Neuropeptide Y (NPY) is an orexigenic (appetite-stimulating) peptide that plays an important role in regulating energy balance...
  16. Erickson J, Hollopeter G, Palmiter R. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 1996;274:1704-7 pubmed
    ..Neuropeptide Y (NPY) is a neuromodulator implicated in the control of energy balance and is overproduced in the hypothalamus of ob/ob ..
  17. Pedrazzini T, Seydoux J, Künstner P, Aubert J, Grouzmann E, Beermann F, et al. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med. 1998;4:722-6 pubmed
    Neuropeptide Y (NPY) is a 36-amino-acid neurotransmitter which is widely distributed throughout the central and peripheral nervous system...
  18. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A. 1998;95:15043-8 pubmed
    Neuropeptide Y (NPY) and the endogenous melanocortin receptor antagonist, agouti gene-related protein (AGRP), coexist in the arcuate nucleus, and both exert orexigenic effects...
  19. Fioramonti X, Contie S, Song Z, Routh V, Lorsignol A, Penicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?. Diabetes. 2007;56:1219-27 pubmed
    ..in mediating glucose sensitivity in glucose-inhibited neurons and the neurotransmitter identity (neuropeptide Y [NPY] or pro-opio melanocortin [POMC]) of glucosensing neurons has remained controversial...
  20. Xu Q, Guo L, Moore H, Waclaw R, Campbell K, Anderson S. Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. Neuron. 2010;65:328-40 pubmed publisher
    ..These results indicate that cortical interneuron diversity, a major determinant of cortical function, is critically influenced by differential levels of SHH signaling within the ventral telencephalon. ..
  21. Jia C, Hegg C. NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium. Neurobiol Dis. 2010;38:405-13 pubmed publisher
    ..In the olfactory epithelium, ATP promotes the synthesis and release of neurotrophic factor NPY in neonates and induces neuroproliferation in neonatal and adult mice...
  22. Real M, Heredia R, Labrador M, Dávila J, Guirado S. Expression of somatostatin and neuropeptide Y in the embryonic, postnatal, and adult mouse amygdalar complex. J Comp Neurol. 2009;513:335-48 pubmed publisher
    ..carried out an immunohistochemical study analyzing spatiotemporal expression patterns for SOM- and neuropeptide Y (NPY)-containing neurons in the embryonic, postnatal, and adult mouse amygdala...
  23. Verma D, Tasan R, Herzog H, Sperk G. NPY controls fear conditioning and fear extinction by combined action on Y? and Y? receptors. Br J Pharmacol. 2012;166:1461-73 pubmed publisher
    Neuropeptide Y (NPY) and its receptors have been implicated in the control of emotional-affective processing, but the mechanism is unclear...
  24. Kanekar S, Jia C, Hegg C. Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. J Neurosci Res. 2009;87:1424-34 pubmed publisher
    ..Thus, we monitored the ATP-induced release of neuropeptide Y (NPY), a neuropeptide that increases neuroproliferation in the olfactory epithelium...
  25. Mercer J, Hoggard N, Williams L, Lawrence C, Hannah L, Morgan P, et al. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 1996;8:733-5 pubmed
    ..There is evidence linking the physiological effects of injected leptin with hypothalamic neuropeptide Y (9, 10) (NPY), which has potent central effects on food intake and energy balance (11), and is also expressed in the arcuate ..
  26. Painsipp E, Herzog H, Sperk G, Holzer P. Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y. Br J Pharmacol. 2011;163:1302-14 pubmed publisher
    Peptide YY (PYY) and neuropeptide Y (NPY) are involved in regulating gut and brain function...
  27. Doyle K, Karl T, Hort Y, Duffy L, Shine J, Herzog H. Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium. J Neurochem. 2008;105:641-52 pubmed
    ..Neuropeptide Y (NPY) is expressed at high levels in the olfactory system, and NPY has been shown to play a role in neuroregeneration of ..
  28. Hansel D, Eipper B, Ronnett G. Neuropeptide Y functions as a neuroproliferative factor. Nature. 2001;410:940-4 pubmed
    Neuropeptide Y (NPY) has a number of functions in mammalian physiology. Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells...
  29. Hahn T, Breininger J, Baskin D, Schwartz M. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci. 1998;1:271-2 pubmed
  30. Qian S, Chen H, Weingarth D, Trumbauer M, Novi D, Guan X, et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol. 2002;22:5027-35 pubmed
    ..normal responses to starvation, diet-induced obesity, and the administration of exogenous leptin or neuropeptide Y (NPY)...
  31. Schwartz M, Baskin D, Bukowski T, Kuijper J, Foster D, Lasser G, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 1996;45:531-5 pubmed
    ..induced by genetic leptin deficiency reduces elevated levels of both blood glucose and hypothalamic neuropeptide Y (NPY) mRNA in ob/ob mice...
  32. McNay D, Pelling M, Claxton S, Guillemot F, Ang S. Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Mol Endocrinol. 2006;20:1623-32 pubmed
    ..expression, positively regulates SF1 expression, and suppresses both tyrosine hydroxylase (TH) and neuropeptide Y (NPY) expression...
  33. Cobos I, Calcagnotto M, Vilaythong A, Thwin M, Noebels J, Baraban S, et al. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005;8:1059-68 pubmed
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss. ..
  34. Gunapala K, Gallardo C, Hsu C, Steele A. Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice. PLoS ONE. 2011;6:e18377 pubmed publisher
    ..Next we tested the orexigenic neuropeptide Y (NPY) and ghrelin and the anorexigenic hormone, leptin, using mouse mutants...
  35. Anitha M, Chandrasekharan B, Salgado J, Grouzmann E, Mwangi S, Sitaraman S, et al. Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y. Gastroenterology. 2006;131:1164-78 pubmed
    Glial-derived neurotrophic factor (GDNF) promotes the survival and proliferation of enteric neurons. Neuropeptide Y (NPY) is an important peptide regulating gastrointestinal motility...
  36. Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, et al. Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012;2:1351-62 pubmed publisher
  37. Naveilhan P, Svensson L, Nystrom S, Ekstrand A, Ernfors P. Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides. 2002;23:1087-91 pubmed
    Neuropeptide Y (NPY) is a 36 amino acid peptide well known for its role in regulating food intake and energy homeostasis...
  38. Patel H, Qi Y, Hawkins E, Hileman S, Elmquist J, Imai Y, et al. Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes. 2006;55:3091-8 pubmed
    Neuropeptide Y (NPY) stimulates feeding and weight gain, but deletion of the NPY gene does not affect food intake and body weight in mice bred on a mixed genetic background...
  39. Karl T, Duffy L, Herzog H. Behavioural profile of a new mouse model for NPY deficiency. Eur J Neurosci. 2008;28:173-80 pubmed publisher
    The abundantly expressed neuropeptide Y (NPY) plays an important role in anxiety and stress reactivity, as exogenous NPY administration reduces anxiety-like behaviour in rodents...
  40. Xu Q, Wonders C, Anderson S. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development. 2005;132:4987-98 pubmed
    ..These results combine in vitro and ex vivo analyses to link embryonic abnormalities in Shh signaling to postnatal alterations in cortical interneuron composition. ..
  41. Batista Brito R, Rossignol E, Hjerling Leffler J, Denaxa M, Wegner M, Lefebvre V, et al. The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron. 2009;63:466-81 pubmed publisher
    ..It is, however, necessary for their normal positioning and maturation. As a consequence, the specific removal of Sox6 from this population results in a severe epileptic encephalopathy. ..
  42. Painsipp E, Herzog H, Holzer P. Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge. J Psychopharmacol. 2010;24:1551-60 pubmed publisher
    ..These findings suggest that neuropeptide Y acting via Y2 and Y4 receptors prevents the development of long-term anxiety- and depression-like behaviour caused by acute immune challenge. ..
  43. Minor R, López M, Younts C, Jones B, Pearson K, Anson R, et al. The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. Aging Cell. 2011;10:483-92 pubmed publisher
    ..We tested CR under appetite suppression using two models: neuropeptide Y (NPY) knockout mice and monosodium glutamate-injected mice...
  44. Zhang L, Nguyen A, Lee I, Yulyaningsih E, Riepler S, Stehrer B, et al. NPY modulates PYY function in the regulation of energy balance and glucose homeostasis. Diabetes Obes Metab. 2012;14:727-36 pubmed publisher
    Both the neuronal-derived neuropeptide Y (NPY) and the gut hormone peptide YY (PYY) have been implicated in the regulation of energy balance and glucose homeostasis...
  45. Minor R, Villarreal J, McGraw M, Percival S, Ingram D, De Cabo R. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res. 2008;189:202-11 pubmed publisher
    A major neuroendocrinological effect of calorie restriction (CR) is induction of neuropeptide Y (NPY) in the arcuate nucleus (ARC)...
  46. Gonçalves G, Li W, Garcia A, Figueiredo M, Bjørbæk C. Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Rep. 2014;7:1093-103 pubmed publisher
    ..blood glucose by leptin is blunted in Lep(ob/ob)/MC4R-null mice, but not in Lep(ob/ob) mice lacking neuropeptide Y (NPY) or gamma-aminobutyric acid (GABA) in AgRP neurons...
  47. Kawakami Y, Yoshida K, Yang J, Suzuki T, Azuma N, Sakai K, et al. Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Neurosci Res. 2009;63:184-93 pubmed publisher
    ..The present integrative study provides in vivo evidence that normal cell cycle progression and subsequent neurogenesis of radial glia cells are severely impaired by serine deficiency. ..
  48. Holm P, Rodriguez F, Kresse A, Canals J, Silos Santiago I, Arenas E. Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development. 2003;130:3535-45 pubmed
    ..In summary, our findings suggest that, unlike NT3 and GDNF, TrkB ligands are required and sufficient to promote the development of central noradrenergic neurons. ..
  49. Lomaga M, Henderson J, Elia A, Robertson J, Noyce R, Yeh W, et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J Neurosci. 2000;20:7384-93 pubmed
    ..Our results demonstrate a novel and prominent role for TRAF6 in the regional control of PCD within the developing CNS. ..
  50. Hu Y, Bloomquist B, Cornfield L, DeCarr L, Flores Riveros J, Friedman L, et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem. 1996;271:26315-9 pubmed
    Neuropeptide Y (NPY) plays important roles in the central control of appetite and energy balance, but the receptor subtype responsible for this function has not been cloned...
  51. Howell O, Silva S, Scharfman H, Sosunov A, Zaben M, Shtaya A, et al. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiol Dis. 2007;26:174-88 pubmed
    We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y(1) receptors (Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. and Gray, W.P...
  52. Lee B, Lee M, Song S, Loi L, Lam D, Yoon J, et al. Specification of neurotransmitter identity by Tal1 in thalamic nuclei. Dev Dyn. 2017;246:749-758 pubmed publisher
    ..Tal1-deficient thalamic neurons lost their GABAergic markers such as Gad1, Npy, and Penk in IGL/vLG. These defects may be associated at least in part with down-regulation of Nkx2...
  53. Imai Y, Patel H, Hawkins E, Doliba N, Matschinsky F, Ahima R. Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice. Endocrinology. 2007;148:5716-23 pubmed
    Neuropeptide Y (NPY), whose role in appetite regulation is well known, is also expressed in pancreatic islets...
  54. Ma T, Zhang Q, Cai Y, You Y, Rubenstein J, Yang Z. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012;22:2120-30 pubmed publisher
    ..In contrast to MGE-derived interneurons, dLGE/dCGE-derived Sp8+ interneurons follow an outside-in layering pattern, preferentially occupying superficial cortical layers. ..
  55. Rose C, Schwegler H, Hanke J, Röhl F, Yilmazer Hanke D. Differential effects of embryo transfer and maternal factors on anxiety-related behavior and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice. Behav Brain Res. 2006;173:163-8 pubmed
    ..of inbred C3H/HeN and DBA/2J mice on the elevated plus maze (EPM), and related to amygdaloid neuropeptide Y (NPY)- and parvalbumin (PARV)-immunoreactive neurons...
  56. Rosmaninho Salgado J, Marques A, Estrada M, Santana M, Cortez V, Grouzmann E, et al. Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-? expression. Peptides. 2012;37:49-54 pubmed publisher
    ..b>NPY immunoneutralization or NPY Y(2) receptor blockage inhibited DPPIV stimulatory effects on lipid accumulation, ..
  57. Homolya L, Watt W, Lazarowski E, Koller B, Boucher R. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. J Biol Chem. 1999;274:26454-60 pubmed
  58. Hollopeter G, Erickson J, Palmiter R. Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice. Int J Obes Relat Metab Disord. 1998;22:506-12 pubmed
    The goal of this study was to ascertain whether neuropeptide Y (NPY) is required in mice for the development of obesity induced by a high-fat diet (HFD), chemical lesions of the hypothalamus caused by monosodium glutamate (MSG) or gold ..
  59. Rohner Jeanrenaud F, Cusin I, Sainsbury A, Zakrzewska K, Jeanrenaud B. The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm Metab Res. 1996;28:642-8 pubmed
    ..Other evidence also suggested that such a loop system was altered in obese animals. ..
  60. Ste Marie L, Luquet S, Cole T, Palmiter R. Modulation of neuropeptide Y expression in adult mice does not affect feeding. Proc Natl Acad Sci U S A. 2005;102:18632-7 pubmed
    Despite numerous experiments showing that administration of neuropeptide Y (NPY) to rodents stimulates feeding and obesity, whereas acute interference with NPY signaling disrupts feeding and promotes weight loss, NPY-null mice have ..
  61. Wan Y, Xue R, Wang Y, Zhang Q, Huang S, Wu W, et al. The effect of neuropeptide Y on brown-like adipocyte's differentiation and activation. Peptides. 2015;63:126-33 pubmed publisher
    Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion...