Gene Symbol: Nprl3
Description: nitrogen permease regulator-like 3
Alias: Aag, CGTHBA, HS-26, HS-40, Mare, Phg, Prox1, m(alpha)RE, GATOR complex protein NPRL3, -14, alpha globin regulatory element containing, alpha-globin regulatory element-containing gene protein, nitrogen permease regulator 3-like protein, proximal locus to the hemoglobin alpha chain complex
Species: mouse
Products:     Nprl3

Top Publications

  1. Anguita E, Sharpe J, Sloane Stanley J, Tufarelli C, Higgs D, Wood W. Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002;100:3450-6 pubmed
    ..These results may indicate differences in the regulation of the alpha-globin clusters in mice and humans or that additional cis-acting elements remain to be characterized in one or both clusters. ..
  2. Gourdon G, Sharpe J, Higgs D, Wood W. The mouse alpha-globin locus regulatory element. Blood. 1995;86:766-75 pubmed
    We have identified and cloned the major alpha globin locus regulatory element in the mouse (m alpha RE)...
  3. Kielman M, Smits R, Hof I, Bernini L. Characterization and comparison of the human and mouse Dist1/alpha-globin complex reveals a tightly packed multiple gene cluster containing differentially expressed transcription units. Genomics. 1996;32:341-51 pubmed
    ..9 kb from the hMPG gene. The mapping results show that the Dist1, MPG, and Prox1 genes, together with the alpha-globin genes and the alpha MRE, form a tightly packed multiple gene cluster that is ..
  4. Flint J, Tufarelli C, Peden J, Clark K, Daniels R, Hardison R, et al. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-82 pubmed
    ..In addition to delimiting the alpha globin chromosomal domain, this study has enabled us to develop a more sensitive and accurate routine for identifying regulatory elements in the human genome. ..
  5. Haque K, Pandey A, Zheng H, Riazuddin S, Sha S, Puligilla C. MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016;36:1347-61 pubmed publisher
    ..These results reveal a new paradigm in the regulation of HC differentiation and provide significant new insights into the mechanism of Fgf signaling governing HC formation. ..
  6. Fu X, Liu D, Tang X, Liu G, Lv X, Li Y, et al. A conserved, extended chromatin opening within alpha-globin locus during development. Exp Cell Res. 2005;309:174-84 pubmed
  7. Kowalczyk M, Hughes J, Babbs C, Sanchez Pulido L, Szumska D, Sharpe J, et al. Nprl3 is required for normal development of the cardiovascular system. Mamm Genome. 2012;23:404-15 pubmed publisher
    ..In-depth sequence analysis shows that C16orf35 (now called NPRL3) is an orthologue of the yeast gene Npr3 (nitrogen permease regulator 3) and, furthermore, is a paralogue of its ..
  8. Zhao Q, Liang X, Mitra S, Gourdon G, Alter B. Cloning and characterization of the mouse alpha globin cluster and a new hypervariable marker. Mamm Genome. 1996;7:749-53 pubmed
    ..The unit sequence of the HVR shares the short core sequence with the HVRs identified in the human alpha-gene cluster. Thus, this HVR may be a valuable evolutionary marker, as well as a useful genetic marker for the mouse. ..
  9. Kowalczyk M, Hughes J, Garrick D, Lynch M, Sharpe J, Sloane Stanley J, et al. Intragenic enhancers act as alternative promoters. Mol Cell. 2012;45:447-58 pubmed publisher
    ..Distinguishing between meRNAs and mRNAs will transform our interpretation of dynamic changes in transcription both at the level of individual genes and of the genome as a whole. ..

More Information


  1. Kaverina N. [Principles of modern drug therapy of ischemic heart disease]. Ter Arkh. 1977;49:22-30 pubmed
  2. Kielman M, Barradeau S, Smits R, Harteveld C, Bernini L. Characterization and localization of the mProx1 gene directly upstream of the mouse alpha-globin gene cluster: identification of a polymorphic direct repeat in the 5'UTR. Mamm Genome. 1996;7:877-80 pubmed
    ..alpha-globin Upstream Flanking Regions (alpha UFR) has identified three nonglobin genes in the order Dist1-MPG-Prox1-alpha-globin...
  3. Loyd M, Okamoto Y, Randall M, Ney P. Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Blood. 2003;102:4223-8 pubmed
    ..Thus, we have demonstrated that AP1/NFE2 binding sites in the murine alpha-globin PRE contribute to long-range alpha-globin gene activation. The proteins that mediate this effect remain to be determined. ..