Gene Symbol: Nppb
Description: natriuretic peptide type B
Alias: AA408272, BNF, BNP, natriuretic peptides B, brain natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor type B, type-B natriuretic factor
Species: mouse
Products:     Nppb

Top Publications

  1. Kuhn M, Völker K, Schwarz K, Carbajo Lozoya J, Flogel U, Jacoby C, et al. The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice. J Clin Invest. 2009;119:2019-30 pubmed publisher
    Cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) modulate blood pressure and volume by activation of the receptor guanylyl cyclase-A (GC-A) and subsequent intracellular cGMP formation...
  2. Mishra S, Hoon M. The cells and circuitry for itch responses in mice. Science. 2013;340:968-71 pubmed publisher
    ..Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb(-/-) mice selectively lose almost all behavioral ..
  3. Tokudome T, Horio T, Kishimoto I, Soeki T, Mori K, Kawano Y, et al. Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides. Circulation. 2005;111:3095-104 pubmed
    ..These results suggest that activation of cardiac GCA by locally secreted natriuretic peptides protects the heart from excessive cardiac remodeling by inhibiting the calcineurin-NFAT pathway. ..
  4. Delgado Olguin P, Huang Y, Li X, Christodoulou D, Seidman C, Seidman J, et al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44:343-7 pubmed publisher
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses. ..
  5. Tamura N, Ogawa Y, Chusho H, Nakamura K, Nakao K, Suda M, et al. Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A. 2000;97:4239-44 pubmed
    ..b>Brain natriuretic peptide (BNP) is a cardiac hormone produced primarily by ventricular myocytes, and its plasma concentrations are ..
  6. Suda M, Ogawa Y, Tanaka K, Tamura N, Yasoda A, Takigawa T, et al. Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc Natl Acad Sci U S A. 1998;95:2337-42 pubmed
    ..peptides organize a family of three structurally related peptides: atrial natriuretic peptide, brain natriuretic peptide (BNP), and C-type natriuretic peptide...
  7. Liu X, Wan L, Huo F, Barry D, Li H, Zhao Z, et al. B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Mol Pain. 2014;10:4 pubmed publisher
    ..NPRA immunostaining is perfectly co-localized with Grp-eGFP in the spinal cord, and a few acute pain behaviors in Nppb-/- mice were tested...
  8. Vilotti S, Marchenkova A, Ntamati N, Nistri A. B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons. PLoS ONE. 2013;8:e81138 pubmed publisher
    ..peptide system in the modulation of nociceptive transmission especially via the B-type natriuretic peptide (BNP) that activates the natriuretic peptide receptor-A (NPR-A) to downregulate sensory neuron excitability...
  9. Cameron V, Aitken G, Ellmers L, Kennedy M, Espiner E. The sites of gene expression of atrial, brain, and C-type natriuretic peptides in mouse fetal development: temporal changes in embryos and placenta. Endocrinology. 1996;137:817-24 pubmed
    Atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) belong to a family of hormones important in blood pressure and sodium homeostasis...

More Information


  1. Roeske C, Martinuk A, Choudhry A, Hendy G, Gollob M, Li Q, et al. Go protein subunit Goα and the secretory process of the natriuretic peptide hormones ANF and BNP. J Mol Endocrinol. 2015;54:277-88 pubmed publisher
    ..showed a 90% decrease in Goα expression and decreased atrial expression and ANF and brain natriuretic peptides (BNP) content. Expression of chromogranin A, a specific atrial granule core constituent, was not affected...
  2. Addisu A, Gower W, Landon C, Dietz J. B-type natriuretic peptide decreases gastric emptying and absorption. Exp Biol Med (Maywood). 2008;233:475-82 pubmed publisher
    ..The objective of this study was to test whether intravenously administered B-type Natriuretic Peptide (BNP) has an effect on gastric emptying and/or absorption in a whole animal mouse model...
  3. Togi K, Yoshida Y, Matsumae H, Nakashima Y, Kita T, Tanaka M. Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development. Biochem Biophys Res Commun. 2006;343:144-51 pubmed
    ..Furthermore, expression of trabecular markers including ANF, BNP, and connexin40 was significantly up-regulated in the ventricles of Hand2 transgenic embryos as well as in H9c2 ..
  4. Levin E, Frank H. Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol. 1991;261:R453-7 pubmed
    ..In these studies, we show that ANP and brain natriuretic peptide significantly (P less than 0...
  5. Goswami S, Thierry Mieg D, Thierry Mieg J, Mishra S, Hoon M, Mannes A, et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. Mol Pain. 2014;10:44 pubmed publisher
    Three neuropeptides, gastrin releasing peptide (GRP), natriuritic precursor peptide B (NPPB), and neuromedin B (NMB) have been proposed to play roles in itch sensation...
  6. Shmilovich H, Ben Shoshan J, Tal R, Afek A, Barshack I, Maysel Auslander S, et al. B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells. Tissue Eng Part A. 2009;15:2741-9 pubmed publisher
    To test the hypothesis that B-type natriuretic peptide (BNP) acts as a potent vasculogenic agent by enhancing the number, proliferation, adhesion, and migration of endothelial progenitor cells (EPCs)...
  7. Petchey L, Risebro C, Vieira J, Roberts T, Bryson J, Greensmith L, et al. Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014;111:9515-20 pubmed publisher
    ..Our study identifies conserved roles for Prox1 between cardiac and skeletal muscle, specifically implicated in slow-twitch fiber-type specification, function, and cardiomyopathic disease. ..
  8. Fischer A, Steidl C, Wagner T, Lang E, Jakob P, Friedl P, et al. Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007;100:856-63 pubmed
    ..Thus, the Hey gene family shows overlap in controlling Notch induced endocardial epithelial to mesenchymal transition, a process critical for valve and septum formation. ..
  9. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999;126:1269-80 pubmed
    ..In situ hybridization studies demonstrated that, among 20 candidate genes examined, expression of ANF, BNP, MLC2V, N-myc, MEF2C, HAND1 and Msx2 was disturbed in the mutant heart...
  10. Shin C, Liu Z, Passier R, Zhang C, Wang D, Harris T, et al. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell. 2002;110:725-35 pubmed
    ..We propose that HOP modulates SRF activity during heart development; its absence results in an imbalance between cardiomyocyte proliferation and differentiation with consequent abnormalities in cardiac morphogenesis. ..
  11. Baker Z, Jett K, Boulet A, Hossain A, Cobine P, Kim B, et al. The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017;26:4617-4628 pubmed publisher
  12. Peng X, Kraus M, Wei H, Shen T, Pariaut R, Alcaraz A, et al. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006;116:217-27 pubmed
    ..Together, these results provide strong evidence for a role of FAK in the regulation of heart hypertrophy in vivo. ..
  13. Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz R, et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009;460:287-91 pubmed publisher
    ..We propose that WHSC1 functions together with developmental transcription factors to prevent the inappropriate transcription that can lead to various pathophysiologies. ..
  14. Marchenkova A, van den Maagdenberg A, Nistri A. Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. Neuroscience. 2016;331:197-205 pubmed publisher
    ..In trigeminal neurons, P2X3Rs are constitutively downregulated by endogenous brain natriuretic peptide (BNP)...
  15. Beiser K, Glaser A, Kleinschmidt K, Scholl I, Röth R, Li L, et al. Identification of novel SHOX target genes in the developing limb using a transgenic mouse model. PLoS ONE. 2014;9:e98543 pubmed publisher
    ..This finding was confirmed in human NHDF and U2OS cells and chicken micromass culture, demonstrating the value of the SHOX-transgenic mouse for the characterization of SHOX-dependent genes and pathways in early limb development. ..
  16. Westendorp B, Major J, Nader M, Salih M, Leenen F, Tuana B. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012;26:2569-79 pubmed publisher
    ..The data highlight an unprecedented role for the strict regulation of the E2F pathway in normal postnatal cardiac function. ..
  17. Park S, Chen W, Durmus N, Bleck B, Reibman J, Riemekasten G, et al. The Effects of Antigen-Specific IgG1 Antibody for the Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in Mice Exposed to Antigen and Fine Particles from Air Pollution. PLoS ONE. 2015;10:e0129910 pubmed publisher
    ..Our studies have identified B cells and antigen specific IgG1 as potential therapeutic targets for pulmonary hypertension associated with immune dysfunction and environmental exposures. ..
  18. Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, et al. Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn. 2008;237:2947-54 pubmed publisher
    ..However, the expression of Bnp was significantly decreased, indicating potential roles of Fgf16 in the heart under pathological conditions...
  19. Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, et al. Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart. FASEB J. 2014;28:1870-9 pubmed publisher
    ..system for monitoring transcriptional activity and identified a novel stress-responsive enhancer of Nppa and Nppb, the most common markers of heart failure. The enhancer is a 650-bp fragment within 50 kb of the Nppa and Nppb loci...
  20. Steinhelper M. Structure, expression, and genomic mapping of the mouse natriuretic peptide type-B gene. Circ Res. 1993;72:984-92 pubmed
    The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones...
  21. Toischer K, Teucher N, Unsöld B, Kuhn M, Kogler H, Hasenfuss G. BNP controls early load-dependent regulation of SERCA through calcineurin. Basic Res Cardiol. 2010;105:795-804 pubmed publisher
    ..expression of sarcoplasmic reticulum calcium-ATPase (SERCA) and increased expression of B-type natriuretic peptide (BNP)...
  22. Liu N, Bezprozvannaya S, Williams A, Qi X, Richardson J, Bassel Duby R, et al. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008;22:3242-54 pubmed publisher
  23. Nguyen A, Xiao B, Neppl R, Kallin E, Li J, Chen T, et al. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011;25:263-74 pubmed publisher
    ..In addition, our study may open new avenues for the diagnosis and treatment of human heart disease. ..
  24. Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, et al. Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development. Endocrinology. 2016;157:358-67 pubmed publisher
    Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and blood vessel dilation...
  25. Sergeeva I, Hooijkaas I, Ruijter J, van der Made I, de Groot N, van de Werken H, et al. Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress. Development. 2016;143:2135-46 pubmed publisher
    The paralogous genes Nppa and Nppb are organized in an evolutionarily conserved cluster and provide a valuable model for studying co-regulation and regulatory landscape organization during heart development and disease...
  26. Qi L, Huang C, Wu X, Tao Y, Yan J, Shi T, et al. Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. J Neurosci. 2017;37:5549-5561 pubmed publisher
    ..They express the natriuretic peptide type B (NPPB), as well as a cohort of receptors and neuropeptides that have been implicated in chronic itch manifestation, ..
  27. Hattori K, Nakamura K, Hisatomi Y, Matsumoto S, Suzuki M, Harvey R, et al. Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. Mol Genet Metab. 2007;91:285-93 pubmed
    ..Our findings support calreticulin being critical for normal heart function and structure. These mice are a useful model for the study of endoplasmic reticulum proteins, such as calreticulin, in various tissues. ..
  28. Lai L, Leone T, Zechner C, Schaeffer P, Kelly S, Flanagan D, et al. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008;22:1948-61 pubmed publisher
    ..We conclude that PGC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT. ..
  29. Dirkx E, Gladka M, Philippen L, Armand A, Kinet V, Leptidis S, et al. Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013;15:1282-93 pubmed publisher
    ..Our results reveal that signalling cascades integrate with microRNAs to induce the expression of the bHLH transcription factor Hand2 in the postnatal mammalian myocardium with impact on embryonic gene programs in heart failure. ..
  30. Xin M, Small E, van Rooij E, Qi X, Richardson J, Srivastava D, et al. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007;104:7975-80 pubmed
    ..These findings reveal a ventricular myocardial cell-autonomous function for Hrt2 in the suppression of atrial cell identity and the maintenance of postnatal cardiac function. ..
  31. Vollmar A, Schulz R. Expression and differential regulation of natriuretic peptides in mouse macrophages. J Clin Invest. 1995;95:2442-50 pubmed
    ..In contrast, the concentration of mRNA coding for brain natriuretic peptide in these cells was reduced by dexamethasone (up to twofold) as well as LPS (two- to fivefold)...
  32. Zhang Y, Sun Y, Ding G, Huang S, Zhang A, Jia Z. Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease. Sci Rep. 2015;5:12480 pubmed publisher
    ..we examined a number of known sodium modulators, including PGE2, ET1, Ang II, natriuretic peptides (ANP, BNP, and CNP), and nitric oxide synthases (iNOS, nNOS, and eNOS)...
  33. van Berlo J, Elrod J, van den Hoogenhof M, York A, Aronow B, Duncan S, et al. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res. 2010;107:1032-40 pubmed publisher
    ..These results indicate that GATA-6 is both necessary and sufficient for regulating the cardiac hypertrophic response and differentiated gene expression, both alone and in coordination with GATA-4. ..
  34. Weidemann A, Klanke B, Wagner M, Volk T, Willam C, Wiesener M, et al. Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction. Biochem J. 2008;409:233-42 pubmed
    b>BNP (brain-type natriuretic peptide) is a cardiac hormone with systemic haemodynamic effects as well as local cytoprotective and antiproliferative properties...
  35. Tanaka M, Yamasaki N, Izumo S. Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol Cell Biol. 2000;20:2874-9 pubmed
    ..3 in the pharynx. Interestingly, in mutant embryos homozygous for Nkx2.6, Nkx2.5 expression extended to the lateral side of the pharynx, suggesting a compensatory function of Nkx2.5 in the mutant pharyngeal pouches. ..
  36. Matkovich S, Edwards J, Grossenheider T, de Guzman Strong C, Dorn G. Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs. Proc Natl Acad Sci U S A. 2014;111:12264-9 pubmed publisher
  37. Pappas C, Mayfield R, Henderson C, JamilPour N, Cover C, Hernandez Z, et al. Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A. 2015;112:13573-8 pubmed publisher
  38. Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-94 pubmed publisher
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction. ..
  39. Qiu Z, Cang Y, Goff S. c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 2010;107:1136-41 pubmed publisher
    ..Genes involved in cardiac stress and remodeling and cell cycle regulation are also up-regulated in the mutant hearts. These findings reveal an essential role for c-Abl in mammalian heart growth and development. ..
  40. Walther T, Klostermann K, Heringer Walther S, Schultheiss H, Tschope C, Stepan H. Fibrosis rather than blood pressure determines cardiac BNP expression in mice. Regul Pept. 2003;116:95-100 pubmed
    ..peptide (NPS) and renin-angiotensin system (RAS), our experiments should clarify whether cardiac brain natriuretic peptide (BNP) is regulated in mice genetically altered for components of the RAS...
  41. Di Somma S, Pittoni V, Raffa S, Magrini L, Gagliano G, Marino R, et al. IL-18 stimulates B-type natriuretic peptide synthesis by cardiomyocytes in vitro and its plasma levels correlate with B-type natriuretic peptide in non-overloaded acute heart failure patients. Eur Heart J Acute Cardiovasc Care. 2017;6:450-461 pubmed publisher
    ..This study provides the first evidence of the ability of IL-18 to induce B-type natriuretic peptide synthesis in vitro and outlines the relationship between the two molecules in acute HF patients with an ongoing inflammatory status. ..
  42. Scott N, Ellmers L, Lainchbury J, Maeda N, Smithies O, Richards A, et al. Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochim Biophys Acta. 2009;1792:1175-84 pubmed publisher
    ..ANP and brain natriuretic peptide (BNP) exert their biological actions through activation of the natriuretic peptide receptor-1 (Npr1)...
  43. Pu W, Ishiwata T, Juraszek A, Ma Q, Izumo S. GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004;275:235-44 pubmed
    ..Surprisingly, expression levels of the putative GATA4 target genes ANF, BNP, MEF2C, Nkx2-5, cyclin D2, and BMP4 were unchanged in mutant hearts, suggesting that GATA4 is not a dose-limiting ..
  44. Ji Y, Kim M, Kim S, Yu D, Shin M, Kim H, et al. Effects of regulator of G protein signaling 19 (RGS19) on heart development and function. J Biol Chem. 2010;285:28627-34 pubmed publisher
    ..RGS19 TG mice showed increased expression levels of brain natriuretic peptide and beta-MHC, which are markers of heart failure, increase of cell proliferation, and electrocardiogram ..
  45. Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson K, et al. TACE is required for fetal murine cardiac development and modeling. Dev Biol. 2003;261:371-80 pubmed
    ..The data suggest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regulatory role during cardiac development and modeling. ..
  46. Komatsu Y, Shibuya H, Takeda N, Ninomiya Tsuji J, Yasui T, Miyado K, et al. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002;119:239-49 pubmed
    ..These results indicate a possibility that TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling. ..
  47. Tamura N, Ogawa Y, Yasoda A, Itoh H, Saito Y, Nakao K. Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes. J Mol Cell Cardiol. 1996;28:1811-5 pubmed
    Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which act as cardiac hormones, are produced mainly by the atrium and ventricle, respectively, and are involved in body fluid homeostasis and blood pressure control...
  48. Li X, Lan Y, Wang Y, Nie M, Lu Y, Zhao E. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway. Mol Med Rep. 2017;15:2574-2582 pubmed publisher
    ..which induces a cascade of atrial natriuretic peptide (ANP) and brain/B‑type natriuretic peptide (BNP) expression and cardiomyocyte apoptosis...
  49. Wang J, Rau C, Avetisyan R, Ren S, Romay M, Stolin G, et al. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 2016;12:e1006038 pubmed publisher
    ..ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls.
  50. Boer P. Activation of the gene for type-b natriuretic factor in mouse stem cell cultures induced for cardiac myogenesis. Biochem Biophys Res Commun. 1994;199:954-61 pubmed
    We assessed the temporal transcriptional activity profiles of the genes for type-B natriuretic factor, BNF, the isoform ANF, and other cardiac muscle proteins in differentiating cultures derived from multipotential mouse cell lines...
  51. Marchenkova A, Vilotti S, Ntamati N, van den Maagdenberg A, Nistri A. Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. Mol Pain. 2016;12: pubmed publisher
    On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A...
  52. Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla F, et al. S100A4 protects the myocardium against ischemic stress. J Mol Cell Cardiol. 2016;100:54-63 pubmed publisher
    ..Increased pro-survival AKT-signaling explained reduced apoptosis in S100A4 overexpressing cells. S100A4 expression protects cardiac myocytes against myocardial ischemia and is required for stabilization of cardiac function after MI. ..
  53. Demerath T, Staffel J, Schreiber A, Valletta D, Schweda F. Natriuretic peptides buffer renin-dependent hypertension. Am J Physiol Renal Physiol. 2014;306:F1489-98 pubmed publisher
    ..system and cardiac natriuretic peptides [atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP)] are opposing control mechanisms for arterial blood pressure...
  54. Bertrand A, Renou L, Papadopoulos A, Beuvin M, Lacene E, Massart C, et al. DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death. Hum Mol Genet. 2012;21:1037-48 pubmed publisher
    ..And importantly, L-CMD patients should be investigated for putative metabolic disorders. ..
  55. Seidman C, Duby A, Choi E, Graham R, Haber E, Homcy C, et al. The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science. 1984;225:324-6 pubmed
    ..Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved. ..
  56. Marchenkova A, Vilotti S, Fabbretti E, Nistri A. Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization. Mol Pain. 2015;11:71 pubmed publisher
    ..this process in mouse TG cultures, we suppressed NPR-A signaling with either siRNA of the endogenous agonist BNP, or the NPR-A blocker anantin...
  57. Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, et al. A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. Am J Pathol. 2014;184:1967-80 pubmed publisher
    ..Taken together, these results demonstrate that AIP1-regulated actin dynamics play essential roles in heart function in mice. ..
  58. Pankow K, Wang Y, Gembardt F, Krause E, Sun X, Krause G, et al. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res. 2007;101:875-82 pubmed
    Natriuretic peptides such as B-type natriuretic peptide (BNP) are important cardioprotective hormones with essential functions in sodium excretion, water balance and blood pressure regulation...
  59. Zhao Z, Ma L. Regulation of axonal development by natriuretic peptide hormones. Proc Natl Acad Sci U S A. 2009;106:18016-21 pubmed publisher
    ..Because their receptors are present in many regions of the embryonic and adult brain, we propose that these hormones have wide influence on the development and function of the nervous system. ..
  60. Raskin A, Hoshijima M, Swanson E, McCulloch A, Omens J. Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle. Mol Cell Biomech. 2009;6:145-59 pubmed
    ..The system was able to measure the induction of hypertrophic markers (BNP, ANP) in tissue after 2 hrs and 5 hrs of stretch...
  61. Yamak A, Temsah R, Maharsy W, Caron S, Paradis P, Aries A, et al. Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts. Am J Physiol Heart Circ Physiol. 2012;303:H1057-66 pubmed publisher
    ..The finding that postnatal upregulation of a cell-cycle gene in GATA4 haplo-insufficient hearts may be protective opens new avenues for maintaining or restoring cardiac function in GATA4-dependent cardiac disease. ..
  62. Ounzain S, Kobayashi S, Peterson R, He A, Motterle A, Samani N, et al. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012;32:1830-43 pubmed publisher
    ..This GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease. ..
  63. Schmidt H, Stonkute A, Jüttner R, Koesling D, Friebe A, Rathjen F. C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009;106:16847-52 pubmed publisher
    ..Functionally, the bifurcation error in CNP mutant mice is maintained at mature stages and results in a reduced input on secondary neurons as detected by patch-clamp recordings. ..
  64. Tanaka M, Schinke M, Liao H, Yamasaki N, Izumo S. Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol Cell Biol. 2001;21:4391-8 pubmed
    ..Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development. ..
  65. Ellmers L, Knowles J, Kim H, Smithies O, Maeda N, Cameron V. Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol. 2002;283:H707-14 pubmed
    Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that regulate blood pressure and volume, and exert their biological actions via the natriuretic peptide receptor-A gene (Npr1)...
  66. Dicicco Bloom E, Lelievre V, Zhou X, Rodriguez W, Tam J, Waschek J. Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system. Dev Biol. 2004;271:161-75 pubmed
    ..We now characterize the patterns of gene expression for the natriuretic peptides [ANP, brain natriuretic peptide (BNP), type-C natriuretic peptide (CNP)] and their receptors (NPR-A, NPR-B, NPR-C) at several early ..
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    Natriuretic peptides, including B-type and C-type natriuretic peptide (BNP and CNP), are powerful regulators of the cardiovascular system; however, their electrophysiological effects in the heart, particularly in the sinoatrial node (SAN)..