Gene Symbol: Npnt
Description: nephronectin
Alias: 1110009H02Rik, AA682063, AI314031, Nctn, POEM, nephronectin, preosteoblast EGF-like repeat protein with MAM domain
Species: mouse
Products:     Npnt

Top Publications

  1. Brandenberger R, Schmidt A, Linton J, Wang D, Backus C, Denda S, et al. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. J Cell Biol. 2001;154:447-58 pubmed
    ..In newborn mouse kidney extracts, alpha8beta1-AP detects a novel ligand of 70-90 kD. This protein, named nephronectin, is an extracellular matrix protein with five EGF-like repeats, a mucin region containing a RGD sequence, and a ..
  2. Sato Y, Uemura T, Morimitsu K, Sato Nishiuchi R, Manabe R, Takagi J, et al. Molecular basis of the recognition of nephronectin by integrin alpha8beta1. J Biol Chem. 2009;284:14524-36 pubmed publisher
    ..Integrin alpha8beta1 bound specifically to nephronectin with an apparent dissociation constant of 0.28 +/- 0...
  3. Lee S, Fang L, Wang C, Kahai S, Deng Z, Yang B. A non-coding transcript of nephronectin promotes osteoblast differentiation by modulating microRNA functions. FEBS Lett. 2011;585:2610-6 pubmed publisher
    ..transcripts and found that expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation dramatically...
  4. Fang L, Kahai S, Yang W, He C, Seth A, Peng C, et al. Transforming growth factor-beta inhibits nephronectin-induced osteoblast differentiation. FEBS Lett. 2010;584:2877-82 pubmed publisher
    ..transforming growth factor beta (TGF-beta) responsive target genes during osteoblast development and found that nephronectin (Npnt) is one such gene that is significantly down-regulated...
  5. Kikkawa Y, Virtanen I, Miner J. Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol. 2003;161:187-96 pubmed
    ..Our results elucidate a mechanism whereby mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the GBM. ..
  6. Linton J, Martin G, Reichardt L. The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development. 2007;134:2501-9 pubmed
    ..Here we present genetic evidence that the extracellular matrix protein nephronectin is an essential ligand that engages alpha8beta1 integrin during early kidney development...
  7. Kahai S, Lee S, Lee D, Yang J, Li M, Wang C, et al. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS ONE. 2009;4:e7535 pubmed publisher
    ..found that one of the miRNAs tested in our system (miR-378, also called miR-378*) plays a role in modulating nephronectin-mediated differentiation in the osteoblastic cell line, MC3T3-E1...
  8. Fujiwara H, Ferreira M, Donati G, MARCIANO D, Linton J, Sato Y, et al. The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011;144:577-89 pubmed publisher
    ..We show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the ..
  9. Boualia S, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, et al. A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013;382:555-66 pubmed publisher
    ..Among the genes directly affected by the core components are the key developmental molecules Nephronectin (Npnt) and Plac8...

More Information


  1. Tsukasaki M, Yamada A, Yoshimura K, Miyazono A, Yamamoto M, Takami M, et al. Nephronectin expression is regulated by SMAD signaling in osteoblast-like MC3T3-E1 cells. Biochem Biophys Res Commun. 2012;425:390-2 pubmed publisher
    b>Nephronectin (Npnt) is an extracellular matrix protein known to be a ligand for the integrin ?8?1. We previously demonstrated that Npnt expression was suppressed by TGF-? through ERK1/2 and JNK in osteoblasts...
  2. Kahai S, Lee S, Seth A, Yang B. Nephronectin promotes osteoblast differentiation via the epidermal growth factor-like repeats. FEBS Lett. 2010;584:233-8 pubmed publisher
    We found that nephronectin was significantly down-regulated by TGF-beta1...
  3. Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, et al. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 2010;107:9240-5 pubmed publisher
    ..Thus, Kif26b is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds. ..
  4. Yang D, McKee K, Chen Z, Mernaugh G, Strickland S, Zent R, et al. Renal collecting system growth and function depend upon embryonic ?1 laminin expression. Development. 2011;138:4535-44 pubmed publisher
  5. Tsukasaki M, Yamada A, Suzuki D, Aizawa R, Miyazono A, Miyamoto Y, et al. Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-?. Biochem Biophys Res Commun. 2011;410:766-70 pubmed publisher
    POEM, also known as nephronectin, is an extracellular matrix protein considered to be a positive regulator of osteoblast differentiation...
  6. Ikehata M, Yamada A, Morimura N, Itose M, Suzawa T, Shirota T, et al. Wnt/?-catenin signaling activates nephronectin expression in osteoblasts. Biochem Biophys Res Commun. 2017;484:231-234 pubmed publisher
    b>Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles as an adhesion molecule in the development and functions of various organs and tissues, such as the kidneys and bone...
  7. Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, et al. Nephronectin Expression Is Up-Regulated by BMP-2. Biol Pharm Bull. 2016;39:1211-5 pubmed publisher
    b>Nephronectin (Npnt), known to be a ligand of integrin ?8?1, plays important roles in the development and function of various tissues, including those of the kidneys, liver, bones, and muscles...
  8. Inagaki F, Tanaka M, Inagaki N, Yagai T, Sato Y, Sekiguchi K, et al. Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells. Biochem Biophys Res Commun. 2013;430:751-6 pubmed publisher
    b>Nephronectin (Npnt) is an extracellular matrix protein known to play a critical role in kidney development; however, its physiological role in the liver remains elusive...
  9. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011;359:163-75 pubmed publisher
    ..As an initial step in this direction we describe a regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development. ..
  10. Kuphal S, Wallner S, Bosserhoff A. Loss of nephronectin promotes tumor progression in malignant melanoma. Cancer Sci. 2008;99:229-33 pubmed publisher
    b>Nephronectin (POEM) was originally identified as a factor involved in tissue morphogenesis. POEM has several characteristics of a matrix protein including an arg-gly-asp binding domain site that is recognized by integrins...
  11. Sato Y, Shimono C, Li S, Nakano I, Norioka N, Sugiura N, et al. Nephronectin binds to heparan sulfate proteoglycans via its MAM domain. Matrix Biol. 2013;32:188-95 pubmed publisher
    b>Nephronectin is a basement membrane protein comprising five N-terminal epidermal growth factor (EGF)-like repeats, a central linker segment containing an Arg-Gly-Asp (RGD) motif and a C-terminal meprin-A5 protein-receptor protein tyrosine ..
  12. Kuek V, Yang Z, Chim S, Zhu S, Xu H, Chow S, et al. NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase. Sci Rep. 2016;6:36210 pubmed publisher
    ..Here, we report that Nephronectin (NPNT), a member of the epidermal growth factor (EGF) repeat superfamily proteins and a homologue of EGFL6, is ..
  13. Morimura N, Tezuka Y, Watanabe N, Yasuda M, Miyatani S, Hozumi N, et al. Molecular cloning of POEM: a novel adhesion molecule that interacts with alpha8beta1 integrin. J Biol Chem. 2001;276:42172-81 pubmed
    ..A novel molecule, POEM (preosteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine ..