Nos2

Summary

Gene Symbol: Nos2
Description: nitric oxide synthase 2, inducible
Alias: MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS, nitric oxide synthase, inducible, NOS type II, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, macrophage NOS, nitric oxide synthase 2, inducible, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: mouse
Products:     Nos2

Top Publications

  1. Bhatt K, Pandey R, Dahiya Y, Sodhi A. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Mol Immunol. 2010;47:861-70 pubmed publisher
    ..This study investigates the signaling pathway involved in inducible nitric oxide synthase (iNOS) expression and nitric oxide release caused by peptidoglycan from Staphylococcus aureus in ..
  2. Hervera A, Negrete R, Leánez S, Martín Campos J, Pol O. The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice. PLoS ONE. 2010;5:e14321 pubmed publisher
    Nitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well ..
  3. Fritz J, Rojas O, Simard N, McCarthy D, Hapfelmeier S, Rubino S, et al. Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature. 2011;481:199-203 pubmed publisher
    ..IgA(+) plasma cells also produce the antimicrobial mediators tumour-necrosis factor-? (TNF-?) and inducible nitric oxide synthase (iNOS), and express many molecules that are commonly associated with monocyte/granulocytic cell types...
  4. Ono K, Suzuki H, Sawada M. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Neurosci Lett. 2010;473:146-50 pubmed publisher
    ..We found that the delayed neural damage was absent in iNOS-deficient mice (iNOS-KO mice)...
  5. Winter S, Winter M, Xavier M, Thiennimitr P, Poon V, Keestra A, et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013;339:708-11 pubmed publisher
    ..Mice deficient in inducible nitric oxide synthase did not support the growth of E...
  6. Lange M, Nakano Y, Traber D, Hamahata A, Esechie A, Jonkam C, et al. Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis. Biochem Biophys Res Commun. 2010;399:286-91 pubmed publisher
    ..different isoforms of NOS, we tested the effects of non-selective NOS inhibition and neuronal NOS (nNOS)- and inducible NOS (iNOS)-gene deficiency on the pulmonary oxidative and nitrosative stress reaction in a murine sepsis model...
  7. Giordano D, Li C, Suthar M, Draves K, Ma D, Gale M, et al. Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses. J Leukoc Biol. 2011;89:443-55 pubmed publisher
    Using NOS2 KO mice, we investigated the hypothesis that NO modulation of BM-DC contributes to the NO-mediated control of Th1 immune responses...
  8. Niedbala W, Alves Filho J, Fukada S, Vieira S, Mitani A, Sonego F, et al. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A. 2011;108:9220-5 pubmed publisher
    ..Furthermore, mice lacking inducible nitric oxide synthase (Nos2(-/-)) developed more severe experimental autoimmune encephalomyelitis than WT mice, with ..
  9. Ponnuswamy P, Ostermeier E, Schröttle A, Chen J, Huang P, Ertl G, et al. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol. 2009;174:2400-10 pubmed publisher
    Genetic and pharmacological inhibition of inducible nitric oxide synthase (iNOS) decreases atherosclerosis development...
  10. Upmacis R, Shen H, Benguigui L, Lamon B, Deeb R, Hajjar K, et al. Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice. Am J Physiol Heart Circ Physiol. 2011;301:H617-24 pubmed publisher
    ..NO) is an important vasoactive molecule produced by three NO synthase (NOS) enzymes: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS)...

Detail Information

Publications90

  1. Bhatt K, Pandey R, Dahiya Y, Sodhi A. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Mol Immunol. 2010;47:861-70 pubmed publisher
    ..This study investigates the signaling pathway involved in inducible nitric oxide synthase (iNOS) expression and nitric oxide release caused by peptidoglycan from Staphylococcus aureus in ..
  2. Hervera A, Negrete R, Leánez S, Martín Campos J, Pol O. The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice. PLoS ONE. 2010;5:e14321 pubmed publisher
    Nitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well ..
  3. Fritz J, Rojas O, Simard N, McCarthy D, Hapfelmeier S, Rubino S, et al. Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature. 2011;481:199-203 pubmed publisher
    ..IgA(+) plasma cells also produce the antimicrobial mediators tumour-necrosis factor-? (TNF-?) and inducible nitric oxide synthase (iNOS), and express many molecules that are commonly associated with monocyte/granulocytic cell types...
  4. Ono K, Suzuki H, Sawada M. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Neurosci Lett. 2010;473:146-50 pubmed publisher
    ..We found that the delayed neural damage was absent in iNOS-deficient mice (iNOS-KO mice)...
  5. Winter S, Winter M, Xavier M, Thiennimitr P, Poon V, Keestra A, et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013;339:708-11 pubmed publisher
    ..Mice deficient in inducible nitric oxide synthase did not support the growth of E...
  6. Lange M, Nakano Y, Traber D, Hamahata A, Esechie A, Jonkam C, et al. Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis. Biochem Biophys Res Commun. 2010;399:286-91 pubmed publisher
    ..different isoforms of NOS, we tested the effects of non-selective NOS inhibition and neuronal NOS (nNOS)- and inducible NOS (iNOS)-gene deficiency on the pulmonary oxidative and nitrosative stress reaction in a murine sepsis model...
  7. Giordano D, Li C, Suthar M, Draves K, Ma D, Gale M, et al. Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses. J Leukoc Biol. 2011;89:443-55 pubmed publisher
    Using NOS2 KO mice, we investigated the hypothesis that NO modulation of BM-DC contributes to the NO-mediated control of Th1 immune responses...
  8. Niedbala W, Alves Filho J, Fukada S, Vieira S, Mitani A, Sonego F, et al. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A. 2011;108:9220-5 pubmed publisher
    ..Furthermore, mice lacking inducible nitric oxide synthase (Nos2(-/-)) developed more severe experimental autoimmune encephalomyelitis than WT mice, with ..
  9. Ponnuswamy P, Ostermeier E, Schröttle A, Chen J, Huang P, Ertl G, et al. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol. 2009;174:2400-10 pubmed publisher
    Genetic and pharmacological inhibition of inducible nitric oxide synthase (iNOS) decreases atherosclerosis development...
  10. Upmacis R, Shen H, Benguigui L, Lamon B, Deeb R, Hajjar K, et al. Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice. Am J Physiol Heart Circ Physiol. 2011;301:H617-24 pubmed publisher
    ..NO) is an important vasoactive molecule produced by three NO synthase (NOS) enzymes: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS)...
  11. Cha H, Kim Y, Kim J, Kim Y, Song I, Min K, et al. Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance. Exp Gerontol. 2010;45:711-8 pubmed publisher
    b>Inducible nitric oxide synthase (iNOS) is involved in obesity-induced insulin resistance...
  12. Bandeira M, Santos C, de Azevedo E, Soares L, Macedo J, Marchi S, et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infect Immun. 2011;79:2936-40 pubmed publisher
    ..PH) in mice unable to produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene (Inos) knockout (KO) on the frequency/severity of interstitial nephritis in vivo...
  13. Chanthaphavong R, Loughran P, Lee T, Scott M, Billiar T. A role for cGMP in inducible nitric-oxide synthase (iNOS)-induced tumor necrosis factor (TNF) ?-converting enzyme (TACE/ADAM17) activation, translocation, and TNF receptor 1 (TNFR1) shedding in hepatocytes. J Biol Chem. 2012;287:35887-98 pubmed publisher
    We and others have previously shown that the inducible nitric-oxide synthase (iNOS) and nitric oxide (NO) are hepatoprotective in a number of circumstances, including endotoxemia...
  14. Yang Z, Wang Z, Doulias P, Wei W, Ischiropoulos H, Locksley R, et al. Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol. 2010;185:6664-9 pubmed publisher
    ..in S-nitrosylation and apoptosis in GSNOR-deficient mice are largely abolished by genetic deletion of inducible NO synthase. Furthermore, the protection of lymphocyte development by GSNOR is apparently intrinsic to hematopoietic ..
  15. Saraswathy S, Nguyen A, Rao N. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2010;51:3680-6 pubmed publisher
    ..Methods. TLR4(-/-), iNOS(-/-), TNF-alpha(-/-), MyD88(-/-), wild-type (WT) control (C57BL/6), and nude mice (B6...
  16. Charbonneau A, Marette A. Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. Diabetes. 2010;59:861-71 pubmed publisher
    The present study was undertaken to assess the contribution of inducible nitric oxide (NO) synthase (iNOS) to lipid-induced insulin resistance in vivo...
  17. Richardson A, Soliven K, Castor M, Barnes P, Libby S, Fang F. The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide. PLoS Pathog. 2009;5:e1000451 pubmed publisher
    ..Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.. Consequently, the level of NO...
  18. Kuboyama K, Tsuda M, Tsutsui M, Toyohara Y, Tozaki Saitoh H, Shimokawa H, et al. Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases. Mol Pain. 2011;7:50 pubmed publisher
    ..pain using mice lacking a single NO synthase (NOS) gene among the three isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS)...
  19. Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel F, et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell. 2011;147:293-305 pubmed publisher
    ..We provide evidence for a causative role of inducible nitric oxide synthase (iNOS) and peroxynitrite in this context. Mice lacking iNOS were protected against emphysema and PH...
  20. Lizano P, Rashed E, Kang H, Dai H, Sui X, Yan L, et al. The valosin-containing protein promotes cardiac survival through the inducible isoform of nitric oxide synthase. Cardiovasc Res. 2013;99:685-93 pubmed publisher
    ..cell survival through activation of the Akt pathway and expression of the inducible nitric oxide (NO) synthase (iNOS), the mediator of ischaemic preconditioning and the most powerful prophylaxis against cardiac cell death...
  21. Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, et al. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005;102:10616-21 pubmed
    ..These results provide evidence that the NOS system plays a critical role in maintaining homeostasis, especially in the kidney...
  22. Nathan C, Xie Q. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994;78:915-8 pubmed
  23. Laubach V, Foley P, Shockey K, Tribble C, Kron I. Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol. 1998;275:H2211-8 pubmed
    ..C57BL/6 wild-type (WT) mice and congenic inducible NO synthase knockout (KO) mice were injected with LPS, and mortality was recorded for 4 days...
  24. Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, et al. Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 2008;117:2211-23 pubmed publisher
    ..because of the nonspecificity of the NOS inhibitors and the compensatory interactions among NOS isoforms (nNOS, iNOS, and eNOS), the ultimate roles of endogenous NO derived from the entire NOS system are still poorly understood...
  25. Predescu D, Predescu S, Shimizu J, Miyawaki Shimizu K, Malik A. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol. 2005;289:L371-81 pubmed
    ..Together, these data demonstrate that constitutive eNOS-derived NO is a crucial determinant of IEJ integrity and thus serves to maintain the low basal permeability of continuous endothelia. ..
  26. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, et al. Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A. 2002;99:9392-7 pubmed
    ..Furthermore, in the UCP2 transfectant, nitric oxide (NO) synthesis, inducible NO synthase (NOS II) protein, NOS II mRNA, and NOS II promoter activity were definitely decreased after LPS ..
  27. Wilcock D, Lewis M, Van Nostrand W, Davis J, Previti M, Gharkholonarehe N, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008;28:1537-45 pubmed publisher
    ..transgenic mouse, which develops amyloid beta (Abeta)-protein deposits only, with a nitric oxide synthase 2 (NOS2) knock-out mouse, which develops no AD-like pathology...
  28. Kim Y, Moon J, Lee K, Park S, Cheong J, Kang H, et al. Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells. Biochem Biophys Res Commun. 2004;314:695-703 pubmed
    ..b>iNOS expression and NO secretion in response to LPS were suppressed by Ca(2+) antagonists (TMB-8, BAPTA/AM, and ..
  29. Leal E, Manivannan A, Hosoya K, Terasaki T, Cunha Vaz J, Ambrósio A, et al. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2007;48:5257-65 pubmed
    ..In this study, the authors aimed to clarify the involvement of constitutive (eNOS, nNOS) and inducible NOS (iNOS) isoforms and the mechanisms underlying NO-mediated leukostasis and BRB breakdown.
  30. Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood. 2007;109:228-34 pubmed
    ..The induction of inducible NO synthase (NOS) was readily detected in MSCs but not T cells, and a specific inhibitor of NOS reversed the ..
  31. Carvalho Filho M, Ueno M, Carvalheira J, Velloso L, Saad M. Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab. 2006;291:E476-82 pubmed
    We have previously demonstrated that the insulin resistance associated with inducible nitric oxide synthase (iNOS) induction in two different models of obesity, diet-induced obesity and the ob/ob mice, is mediated by S-nitrosation of ..
  32. Calvert T, Chicoine L, Liu Y, Nelin L. Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin. Am J Physiol Heart Circ Physiol. 2008;294:H1621-9 pubmed publisher
    ..to low-dose LPS with a fall in blood pressure due to augmented expression of inducible nitric oxide (NO) synthase (iNOS)...
  33. Singh K, Chaturvedi R, Asim M, Barry D, Lewis N, Vitek M, et al. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. J Biol Chem. 2008;283:16752-61 pubmed publisher
    ..We have reported that mice deficient in inducible nitric-oxide (NO) synthase (iNOS) have attenuated C. rodentium-induced colitis...
  34. Lefer D, Jones S, Girod W, Baines A, Grisham M, Cockrell A, et al. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol. 1999;276:H1943-50 pubmed
    ..25 U/ml) superfusion in the mesentery of wild-type, inducible NOS (iNOS)-deficient (-/-), neuronal NOS (nNOS) -/-, and endothelial cell NOS (ecNOS) -/- mice to further our ..
  35. De Sanctis G, MacLean J, Hamada K, Mehta S, Scott J, Jiao A, et al. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999;189:1621-30 pubmed
    ..Although the inducible (NOS2) isoform was significantly upregulated in the lungs of ovalbumin (OVA)-sensitized and -challenged (OVA/OVA) wild-..
  36. Michael S, Mayeux P, Bucci T, Warbritton A, Irwin L, Pumford N, et al. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide. 2001;5:432-41 pubmed
    ..This manuscript examines APAP (300 mg/kg) hepatotoxicity in mice lacking inducible nitric oxide synthase activity (NOS2 null or knockout mice; C57BL/6-Nos2(tm1Lau)) and in the wildtype mice...
  37. Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, et al. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem. 2005;280:14203-11 pubmed
    Chronic inflammation plays an important role in insulin resistance. Inducible nitric-oxide synthase (iNOS), a mediator of inflammation, has been implicated in many human diseases including insulin resistance...
  38. Zingarelli B, Hake P, Yang Z, O Connor M, Denenberg A, Wong H. Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage. FASEB J. 2002;16:327-42 pubmed
    The role of nitric oxide (NO) generated by the inducible NO synthase (iNOS) during myocardial ischemia and reperfusion is not understood...
  39. Perreault M, Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med. 2001;7:1138-43 pubmed
    b>Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in skeletal muscle and fat. It has been proposed that chronic iNOS induction may cause muscle insulin resistance...
  40. Breitbach K, Klocke S, Tschernig T, Van Rooijen N, Baumann U, Steinmetz I. Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice. Infect Immun. 2006;74:6300-9 pubmed
    ..lacking a functional NADPH oxidase were more susceptible to infection, whereas C57BL/6 mice lacking inducible nitric oxide synthase (iNOS) did not show increased susceptibility but were slightly more resistant during the early phase ..
  41. Vitek M, Brown C, Xu Q, Dawson H, Mitsuda N, Colton C. Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. Antioxid Redox Signal. 2006;8:893-901 pubmed
    ..in macrophage function in an animal model, a transgenic mouse was created that contained the entire human NOS2 gene, including the human promoter and all of its exons and introns...
  42. Yogo K, Shimokawa H, Funakoshi H, Kandabashi T, Miyata K, Okamoto S, et al. Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice. Arterioscler Thromb Vasc Biol. 2000;20:E96-E100 pubmed
    ..of the left common carotid artery was performed in control, endothelial NOS (eNOS) knockout (eNOS-KO), and inducible NOS (iNOS) knockout (iNOS-KO) mice...
  43. Marnett L, Wright T, Crews B, Tannenbaum S, Morrow J. Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase. J Biol Chem. 2000;275:13427-30 pubmed
    We investigated the effects of targeted deletion of the inducible NO synthase (iNOS) gene on the formation of prostaglandins in vivo and ex vivo...
  44. Colton C, Vitek M, Wink D, Xu Q, Cantillana V, Previti M, et al. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:12867-72 pubmed
  45. Alam M, Akaike T, Okamoto S, Kubota T, Yoshitake J, Sawa T, et al. Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun. 2002;70:3130-42 pubmed
    ..In this study, we investigated the antimicrobial effect of NO in murine salmonellosis by using inducible NO synthase (iNOS)-deficient mice infected with an avirulent or virulent Salmonella enterica serovar Typhimurium ..
  46. Kitayama J, Faraci F, Gunnett C, Heistad D. Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke. 2006;37:2129-33 pubmed
    During diabetes, expression of inducible nitric oxide synthase (iNOS) plays an important role in the development of endothelial dysfunction in extracranial blood vessels...
  47. Upmacis R, Crabtree M, Deeb R, Shen H, LANE P, Benguigui L, et al. Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2007;293:H2878-87 pubmed
    ..of apolipoprotein E-deficient (ApoE(-/-)) atherosclerotic mice and 2) determine the specific contribution of inducible NOS (iNOS) to these processes...
  48. Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro P, et al. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int. 2001;59:2243-9 pubmed
    ..Recent studies also suggest involvement of nitric oxide (NO), generated by inducible NO synthase (iNOS), in the pathogenesis of endotoxin-induced renal failure...
  49. Shiloh M, MacMicking J, Nicholson S, Brause J, Potter S, Marino M, et al. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 1999;10:29-38 pubmed
    ..of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2)...
  50. Vazquez Torres A, Jones Carson J, Mastroeni P, Ischiropoulos H, Fang F. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J Exp Med. 2000;192:227-36 pubmed
    The contribution of the NADPH phagocyte oxidase (phox) and inducible nitric oxide (NO) synthase (iNOS) to the antimicrobial activity of macrophages for Salmonella typhimurium was studied by using peritoneal phagocytes from C57BL/6, ..
  51. Hertz C, Mansfield J. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol. 1999;192:24-32 pubmed
    ..of inducible NO production in infection, we monitored survival, parasitemia, and Th cell cytokine production in iNOS KO mice...
  52. Bayir H, Kagan V, Borisenko G, Tyurina Y, Janesko K, Vagni V, et al. Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS. J Cereb Blood Flow Metab. 2005;25:673-84 pubmed
    ..Studies in experimental traumatic brain injury (TBI) suggest both deleterious and protective effects of inducible nitric oxide synthase (iNOS)...
  53. Kolodziejski P, Musial A, Koo J, Eissa N. Ubiquitination of inducible nitric oxide synthase is required for its degradation. Proc Natl Acad Sci U S A. 2002;99:12315-20 pubmed
    b>Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators. We have previously shown that iNOS is degraded through the 26S proteasome...
  54. Wei X, Charles I, Smith A, Ure J, Feng G, Huang F, et al. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995;375:408-11 pubmed
    ..It is generated from L-arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated by several immunological stimuli, leading to the production of large quantities of NO ..
  55. Nakamura T, Suzuki H, Wada Y, Kodama T, Doi T. Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-kappaB-dependent signaling pathways through macrophage scavenger receptors. Biochem Biophys Res Commun. 2006;343:286-94 pubmed
    ..acetylated LDL, maleylated bovine serum albumin nor dextran sulfate induces activation of inducible nitric oxide synthase (iNOS) promoter or NO production in RAW264.7 cells...
  56. Shesely E, Gilbert C, Granderson G, Carretero C, Carretero O, Beierwaltes W. Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy. Am J Obstet Gynecol. 2001;185:1198-203 pubmed
    ..This suggests that, at least in the mouse, genetic deficiency of any 1 isoform of nitric oxide synthase does not result in pregnancy-induced hypertension. ..
  57. Michel T, Feron O. Nitric oxide synthases: which, where, how, and why?. J Clin Invest. 1997;100:2146-52 pubmed
  58. DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
    ..NOS inhibitors lack specificity and three NOS isoforms exist: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS)...
  59. Khan I, Matsuura T, Kasper L. Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii. J Immunol. 1998;161:2994-3000 pubmed
    ..gondii is unknown. Mice with a targeted disruption of inducible NO synthase (iNOS) were immunized with an avirulent temperature-sensitive strain of this parasite (ts-4)...
  60. Doherty T, Sher A. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol. 1997;158:4822-31 pubmed
    ..In contrast, knockout mice lacking the genes for the TNF-alpha p55/p75 receptors or inducible nitric oxide synthase not only developed comparable bacterial loads to wild-type animals, they also failed to display the ..
  61. Lin A, Chang C, McCormick C. Molecular cloning and expression of an avian macrophage nitric-oxide synthase cDNA and the analysis of the genomic 5'-flanking region. J Biol Chem. 1996;271:11911-9 pubmed
    ..This is in contrast to the two distinct sites identified in the mouse macrophage NOS promoter. Transcription factor binding sites such as NF-kappaB, PEA1, PEA3, and C/EBP were identified...
  62. Kelleher Z, Matsumoto A, Stamler J, Marshall H. NOS2 regulation of NF-kappaB by S-nitrosylation of p65. J Biol Chem. 2007;282:30667-72 pubmed
    Signal transduction in the NF-kappaB transcription factor pathway is inhibited by inducible nitric oxide synthase (NOS2) activity, although the molecular mechanism(s) are incompletely understood...
  63. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006;203:2691-702 pubmed
    ..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy. ..
  64. Martin L, Chen K, Liu Z. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci. 2005;25:6449-59 pubmed
    ..Fas upregulation was p53 dependent. MNs in mice deficient in neuronal NO synthase (nNOS) and inducible NOS (iNOS) resisted apoptosis...
  65. Moayeri M, Martinez N, Wiggins J, Young H, Leppla S. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun. 2004;72:4439-47 pubmed
    ..We used nine inbred strains and two inducible nitric oxide synthase (iNOS) knockout C57BL/6J strains polymorphic for the LT M phi sensitivity Kif1C locus to analyze the ..
  66. Gunnett C, Heistad D, Faraci F. Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes. Stroke. 2003;34:2970-4 pubmed
    b>Inducible nitric oxide synthase (iNOS) is a mediator of vascular dysfunction during inflammation. The purpose of this study was to test the hypothesis that vascular dysfunction during diabetes is dependent on expression of iNOS...
  67. Kobayashi H, Hataishi R, Mitsufuji H, Tanaka M, Jacobson M, Tomita T, et al. Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cell Mol Biol. 2001;24:390-7 pubmed
    The objective of this study was to determine whether endogenous nitric oxide (NO), specifically the inducible NO synthase isoform (iNOS: NOS II), reduces or amplifies lung injury in mice breathing at a high oxygen tension...
  68. Kim S, Huri D, Snyder S. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005;310:1966-70 pubmed
    Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity...
  69. Yamasaki K, Edington H, McClosky C, Tzeng E, Lizonova A, Kovesdi I, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest. 1998;101:967-71 pubmed
    Most evidence indicates that nitric oxide plays a role in normal wound repair; however, involvement of inducible nitric oxide synthase (iNOS) has not been established...
  70. Isaksson J, Farooque M, Olsson Y. Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord. 2005;43:167-70 pubmed
    ..compression-type spinal cord injury (SCI) in wild-type mice and knockout mice, lacking the inducible nitric oxide synthase (iNOS) gene. To evaluate the role of the nitric oxide generating enzyme iNOS in SCI...
  71. Steudel W, Kirmse M, Weimann J, Ullrich R, Hromi J, Zapol W. Exhaled nitric oxide production by nitric oxide synthase-deficient mice. Am J Respir Crit Care Med. 2000;162:1262-7 pubmed
    ..in airway inflammation have been associated with increased airway expression of nitric oxide synthase 2 (NOS 2), it is uncertain which NOS isoform is responsible for baseline levels of exhaled NO...
  72. Boettger M, Uceyler N, Zelenka M, Schmitt A, Reif A, Chen Y, et al. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur J Pain. 2007;11:810-8 pubmed
    ..injection of complete Freund's adjuvant (CFA) in wild-type (WT) mice and in mice lacking either inducible (iNOS), endothelial (eNOS) or neuronal NOS (nNOS)...
  73. Scanga C, Mohan V, Tanaka K, Alland D, Flynn J, Chan J. The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infect Immun. 2001;69:7711-7 pubmed
    ..function via the production of nitric oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2)...
  74. Liberatore G, Jackson Lewis V, Vukosavic S, Mandir A, Vila M, McAuliffe W, et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med. 1999;5:1403-9 pubmed
    ..a robust gliosis in the substantia nigra pars compacta associated with significant upregulation of inducible nitric oxide synthase (iNOS). These changes preceded or paralleled MPTP-induced dopaminergic neurodegeneration...
  75. Hussain S, Trivers G, Hofseth L, He P, Shaikh I, Mechanic L, et al. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res. 2004;64:6849-53 pubmed
    Inflammation influences the development of cancer. The nitric oxide synthase (NOS2) is induced by inflammatory cytokines, e.g...
  76. Kenyon N, Gohil K, Last J. Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences. Toxicol Appl Pharmacol. 2003;191:2-11 pubmed
    ..aerosol of a different strain of mice, C57BL/6, and compared this response to an otherwise isogenic C57BL strain (iNOS(-/-)) in which the gene for inducible nitric oxide synthetase (iNOS) had been knocked out...
  77. McCafferty D, Miampamba M, Sihota E, Sharkey K, Kubes P. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut. 1999;45:864-73 pubmed
    Studies using inhibitors of nitric oxide synthase (NOS) to date are inconclusive regarding the role of inducible NOS (iNOS) in intestinal inflammation...