Nos1

Summary

Gene Symbol: Nos1
Description: nitric oxide synthase 1, neuronal
Alias: 2310005C01Rik, N-NOS, NC-NOS, NOS, NOS-I, Nos-1, bNOS, nNOS, nitric oxide synthase, brain, NOS type I, constitutive NOS, neuronal NOS, neuronal nitric oxide synthase, peptidyl-cysteine S-nitrosylase NOS1
Species: mouse
Products:     Nos1

Top Publications

  1. Lefer D, Jones S, Girod W, Baines A, Grisham M, Cockrell A, et al. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol. 1999;276:H1943-50 pubmed
    ..25 U/ml) superfusion in the mesentery of wild-type, inducible NOS (iNOS)-deficient (-/-), neuronal NOS (nNOS) -/-, and endothelial cell NOS (ecNOS) -/- mice to further our understanding of NO and leukocyte function...
  2. Boettger M, Uceyler N, Zelenka M, Schmitt A, Reif A, Chen Y, et al. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur J Pain. 2007;11:810-8 pubmed
    ..adjuvant (CFA) in wild-type (WT) mice and in mice lacking either inducible (iNOS), endothelial (eNOS) or neuronal NOS (nNOS)...
  3. Lai Y, Thomas G, Yue Y, Yang H, Li D, Long C, et al. Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy. J Clin Invest. 2009;119:624-35 pubmed publisher
    Sarcolemma-associated neuronal NOS (nNOS) plays a critical role in normal muscle physiology...
  4. Dickson E, Heredia D, McCann C, Hennig G, Smith T. The mechanisms underlying the generation of the colonic migrating motor complex in both wild-type and nNOS knockout mice. Am J Physiol Gastrointest Liver Physiol. 2010;298:G222-32 pubmed publisher
    ..Therefore, our aims were to reexamine the mechanisms underlying the CMMC in the colon of wild-type and neuronal nitric oxide synthase (nNOS)(-/-) mice...
  5. Klamer D, ENGEL J, Svensson L. Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient mice. Eur Neuropsychopharmacol. 2005;15:587-90 pubmed
    ..The present study was conducted to examine the effects of PCP on prepulse inhibition in neuronal NOS (nNOS) deficient mice...
  6. Burkard N, Rokita A, Kaufmann S, Hallhuber M, Wu R, Hu K, et al. Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res. 2007;100:e32-44 pubmed
    The role of the neuronal NO synthase (nNOS or NOS1) enzyme in the control of cardiac function still remains unclear...
  7. Fritzen S, Schmitt A, Köth K, Sommer C, Lesch K, Reif A. Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF. Mol Cell Neurosci. 2007;35:261-71 pubmed
    ..We therefore investigated whether stem cell proliferation or survival is altered in mice lacking neuronal nitric oxide synthase (NOS-I) or both endothelial and neuronal NOS (NOS-I/-III double knockout)...
  8. Kovacs R, Rabanus A, Otahal J, Patzak A, Kardos J, Albus K, et al. Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices. J Neurosci. 2009;29:8565-77 pubmed publisher
    ..hippocampal slice cultures and acute hippocampal-entorhinal cortex slices from wild-type and neuronal NO synthase (nNOS) knock-out mice combining electrophysiological and fluorescence imaging techniques...
  9. DiMagno M, Hao Y, Tsunoda Y, Williams J, Owyang C. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol. 2004;286:G428-36 pubmed
    ..NOS blockade by L-NNA had no effect on carbachol-stimulated amylase secretion in vitro. Thus constitutive NOS isoforms can exert opposite effects on in vivo pancreatic secretion...

More Information

Publications69

  1. Szabadits E, Cserép C, Ludányi A, Katona I, Gracia Llanes J, Freund T, et al. Hippocampal GABAergic synapses possess the molecular machinery for retrograde nitric oxide signaling. J Neurosci. 2007;27:8101-11 pubmed
    ..Here we describe that, in hippocampal pyramidal cells, neuronal nitric oxide synthase (nNOS) is also associated with the postsynaptic active zones of GABAergic symmetrical synapses ..
  2. Zhou L, Li F, Xu H, Luo C, Wu H, Zhu M, et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med. 2010;16:1439-43 pubmed publisher
    ..Excessive stimulation of N-methyl-D-aspartate receptors (NMDARs) and the resulting neuronal nitric oxide synthase (nNOS) activation are crucial for neuronal injury after stroke insult...
  3. Tao F, Tao Y, Zhao C, Dore S, Liaw W, Raja S, et al. Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia. Neuroscience. 2004;128:421-30 pubmed
    The present study investigated the role of neuronal nitric oxide synthase (nNOS) in carrageenan-induced inflammatory pain by combining genomic and pharmacological strategies...
  4. Percival J, Anderson K, Gregorevic P, Chamberlain J, Froehner S. Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice. PLoS ONE. 2008;3:e3387 pubmed publisher
    Skeletal muscle nNOSmu (neuronal nitric oxide synthase mu) localizes to the sarcolemma through interaction with the dystrophin-associated glycoprotein (DAG) complex, where it synthesizes nitric oxide (NO)...
  5. Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, et al. Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 2008;117:2211-23 pubmed publisher
    ..However, because of the nonspecificity of the NOS inhibitors and the compensatory interactions among NOS isoforms (nNOS, iNOS, and eNOS), the ultimate roles of endogenous NO derived from the entire NOS system are still poorly ..
  6. Cheng A, Wang S, Cai J, Rao M, Mattson M. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003;258:319-33 pubmed
    ..neurotrophic factor (BDNF) reduced NPC proliferation and increased the expression of neuronal NO synthase (nNOS) in differentiating neurons...
  7. Burger D, Lu X, Lei M, Xiang F, Hammoud L, Jiang M, et al. Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation. 2009;120:1345-54 pubmed publisher
    b>Neuronal nitric oxide synthase (nNOS) is expressed in cardiomyocytes and plays a role in regulating cardiac function and Ca2+ homeostasis. However, the role of nNOS in cardiac electrophysiology after myocardial infarction (MI) is unclear...
  8. Giove T, Deshpande M, Eldred W. Identification of alternate transcripts of neuronal nitric oxide synthase in the mouse retina. J Neurosci Res. 2009;87:3134-42 pubmed publisher
    ..Previous work shows that neuronal nitric oxide synthase (nNOS) is an important source of NO in the vertebrate retina...
  9. Weitzdoerfer R, Hoeger H, Engidawork E, Engelmann M, Singewald N, Lubec G, et al. Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance. Nitric Oxide. 2004;10:130-40 pubmed
    ..The functional role of nNOS derived NO in cognitive functions, however, is elusive...
  10. Guirado S, Real M, Dávila J. Distinct immunohistochemically defined areas in the medial amygdala in the developing and adult mouse. Brain Res Bull. 2008;75:214-7 pubmed publisher
    ..expression of the neurotransmitter GABA, the vesicular glutamate transporter type 2 (VGLUT2), the neuronal nitric oxide synthase (nNOS), and the calcium-binding proteins calbindin-D28k (CB) and calretinin (CR) in the developing and ..
  11. Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, et al. A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron. 2011;71:995-1013 pubmed publisher
    ..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain. ..
  12. Eu J, Hare J, Hess D, Skaf M, Sun J, Cardenas Navina I, et al. Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. Proc Natl Acad Sci U S A. 2003;100:15229-34 pubmed
    ..We therefore examined, in normal and neuronal NOS (nNOS)-deficient mice, the influence of pO2 on whole-muscle contractility and on myocyte calcium flux and ..
  13. Rivera L, Pontell L, Cho H, Castelucci P, Thacker M, Poole D, et al. Knock out of neuronal nitric oxide synthase exacerbates intestinal ischemia/reperfusion injury in mice. Cell Tissue Res. 2012;349:565-76 pubmed publisher
    ..In this study, we compared the effects of I/R on the intestines of neuronal NOS knockout (nNOS(-/-)) mice and wild-type mice...
  14. Kinugawa S, Huang H, Wang Z, Kaminski P, Wolin M, Hintze T. A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res. 2005;96:355-62 pubmed
    ..A NOS isoform is present in cardiac mitochondria and it is derived from neuronal NOS (nNOS). However, the role of nNOS in the control of MVO2 remains unknown...
  15. Percival J, Anderson K, Huang P, Adams M, Froehner S. Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle. J Clin Invest. 2010;120:816-26 pubmed publisher
    Signaling via the neuronal NOS (nNOS) splice variant nNOSmu is essential for skeletal muscle health and is commonly reduced in neuromuscular disease. nNOSmu is thought to be the predominant source of NO in skeletal muscle...
  16. Dawson D, Lygate C, Zhang M, Hulbert K, Neubauer S, Casadei B. nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction. Circulation. 2005;112:3729-37 pubmed
    The neuronal isoform of nitric oxide synthase (nNOS) has been implicated in the regulation of basal and beta-adrenergic inotropy in normal and chronically infarcted hearts...
  17. Suzuki N, Motohashi N, Uezumi A, Fukada S, Yoshimura T, Itoyama Y, et al. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest. 2007;117:2468-76 pubmed
    ..Among several DGC members, only neuronal NOS (nNOS) quickly dislocated from the sarcolemma to the cytoplasm during tail suspension...
  18. Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, et al. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005;102:10616-21 pubmed
    ..NO is synthesized by three different isoforms of NO synthase (NOS), including neuronal, inducible, and endothelial NOSs...
  19. Zhang G, Kimura S, Murao K, Shimizu J, Matsuyoshi H, Takaki M. Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylation. Cardiovasc Res. 2009;81:389-99 pubmed publisher
    The present study is designed to investigate the role of neuronal nitric oxide synthase (nNOS) in the regulation of vascular mitogen-activated protein kinase (MAPK) activity under basal and angiotensin II (Ang II)-stimulated conditions...
  20. Moens A, Leyton Mange J, Niu X, Yang R, Cingolani O, Arkenbout E, et al. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol. 2009;47:576-85 pubmed publisher
    ..The level of eNOS phosphorylation in beta3(-/-)TAC hearts was diminished, and nNOS and iNOS expression levels were increased...
  21. Khan S, Lee K, Minhas K, Gonzalez D, Raju S, Tejani A, et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A. 2004;101:15944-8 pubmed
    ..producing enzyme, and neuronal nitric oxide synthase (NOS1) coimmunoprecipitate and colocalize in the sarcoplasmic reticulum of cardiac myocytes...
  22. Samengo G, Avik A, Fedor B, Whittaker D, Myung K, Wehling Henricks M, et al. Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia. Aging Cell. 2012;11:1036-45 pubmed publisher
    ..Further, our data show that muscle aging is accompanied by loss of neuronal nitric oxide synthase (nNOS), the primary source of muscle NO, and that expression of a muscle-specific nNOS transgene ..
  23. Packer M, Stasiv Y, Benraiss A, Chmielnicki E, Grinberg A, Westphal H, et al. Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A. 2003;100:9566-71 pubmed
  24. Kolesnikov Y, Chereshnev I, Criesta M, Pan Y, Pasternak G. Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice. Brain Res. 2009;1289:14-21 pubmed publisher
    The role of central and peripheral neuronal nitric oxide synthase (nNOS) splice variants in the development of inflammatory hyperalgesia was investigated using the formalin test...
  25. Jinno S, Kosaka T. Patterns of colocalization of neuronal nitric oxide synthase and somatostatin-like immunoreactivity in the mouse hippocampus: quantitative analysis with optical disector. Neuroscience. 2004;124:797-808 pubmed
    In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons...
  26. Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, et al. Vascular neuronal NO synthase is selectively upregulated by platelet-derived growth factor: involvement of the MEK/ERK pathway. Arterioscler Thromb Vasc Biol. 2005;25:2502-8 pubmed
    ..In this study, we examined the molecular mechanism(s) for vascular neuronal NOS (nNOS) expression...
  27. Bilbo S, Hotchkiss A, Chiavegatto S, Nelson R. Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. J Neuroimmunol. 2003;140:41-8 pubmed
    ..antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and neuronal nitric oxide synthase knockout (nNOS(-/-)) mice at baseline and after 2 h of restraint...
  28. Sartoretto J, Kalwa H, Pluth M, Lippard S, Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci U S A. 2011;108:15792-7 pubmed publisher
    ..Cardiac myocytes contain both the endothelial (eNOS) and neuronal (nNOS) NO synthases, but the differential roles of these NOS isoforms and the interplay of reactive oxygen species and ..
  29. Sears C, Bryant S, Ashley E, Lygate C, Rakovic S, Wallis H, et al. Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling. Circ Res. 2003;92:e52-9 pubmed
    ..Subcellular localization of a constitutive NOS in the proximity of an activating source of Ca2+ suggests that cardiac nNOS-derived NO may regulate ..
  30. Chu Y, Guan Y, Skinner J, Raja S, Johns R, Tao Y. Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain. Pain. 2005;119:113-23 pubmed
    ..The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in ..
  31. Guan Y, Yaster M, Raja S, Tao Y. Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice. Mol Pain. 2007;3:29 pubmed
    b>Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in neuronal tissues and contributes to the spinal central sensitization in inflammatory pain. However, the role of nNOS in neuropathic pain remains unclear...
  32. Saraiva R, Minhas K, Raju S, Barouch L, Pitz E, Schuleri K, et al. Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium. Circulation. 2005;112:3415-22 pubmed
    b>Neuronal nitric oxide synthase (NOS1) plays key cardiac physiological roles, regulating excitation-contraction coupling and exerting an antioxidant effect that maintains tissue NO-redox equilibrium...
  33. Wehling Henricks M, Jordan M, Roos K, Deng B, Tidball J. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Hum Mol Genet. 2005;14:1921-33 pubmed
    ..Dystrophin-deficient mdx mice were produced in which there was myocardial expression of a neuronal nitric oxide synthase (nNOS) transgene...
  34. Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M. Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J Neurol Sci. 2010;294:95-101 pubmed publisher
    Previously, we demonstrated that neuronal nitric oxide synthase (nNOS) is activated and promotes muscle atrophy in skeletal muscle during tail suspension, a model of unloading and denervation...
  35. Chen L, Majde J, Krueger J. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res. 2003;973:214-22 pubmed
    ..in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes...
  36. Wang H, Viatchenko Karpinski S, Sun J, Gyorke I, Benkusky N, Kohr M, et al. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Physiol. 2010;588:2905-17 pubmed publisher
    ..SR) Ca(2+) release channel (ryanodine receptor, RyR2) has been proposed to be an end target of neuronal nitric oxide synthase (NOS1) signalling...
  37. Zhu X, Hua Y, Jiang J, Zhou Q, Luo C, Han X, et al. Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Neuroscience. 2006;141:827-36 pubmed
    b>Neuronal nitric oxide synthase, the major nitric oxide synthase isoform in the mammalian brain, is implicated in some developmental processes, including neuronal survival, precursor proliferation and differentiation...
  38. Ortiz P, Garvin J. Cardiovascular and renal control in NOS-deficient mouse models. Am J Physiol Regul Integr Comp Physiol. 2003;284:R628-38 pubmed
    ..NO is produced by three different NO synthase (NOS) isoforms: endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS)...
  39. Kobayashi Y, Rader E, Crawford R, Iyengar N, Thedens D, Faulkner J, et al. Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature. 2008;456:511-5 pubmed publisher
    ..from a loss in specific force production by muscle, and that sarcolemma-localized signalling by neuronal nitric oxide synthase (nNOS) in skeletal muscle is required to maintain activity after mild exercise...
  40. Wang H, Kohr M, Traynham C, Wheeler D, Janssen P, Ziolo M. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. Am J Physiol Cell Physiol. 2008;294:C1566-75 pubmed publisher
    Studies have shown that neuronal nitric oxide synthase (nNOS, NOS1) knockout mice (NOS1-/-) have increased or decreased contractility, but consistently have found a slowed rate of intracellular Ca2+ ([Ca2+]i) decline and relengthening...
  41. Burkard N, Williams T, Czolbe M, Blömer N, Panther F, Link M, et al. Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia/reperfusion. Circulation. 2010;122:1588-603 pubmed publisher
    We previously demonstrated that conditional overexpression of neuronal nitric oxide synthase (nNOS) inhibited L-type Ca2+ channels and decreased myocardial contractility. However, nNOS has multiple targets within the cardiac myocyte...
  42. Kelley J, Balda M, Anderson K, Itzhak Y. Impairments in fear conditioning in mice lacking the nNOS gene. Learn Mem. 2009;16:371-8 pubmed publisher
    ..In the brain, nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) functions as a retrograde neuronal messenger that facilitates synaptic plasticity, including ..
  43. Thomas G, Shaul P, Yuhanna I, Froehner S, Adams M. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase. Circ Res. 2003;92:554-60 pubmed
    b>Neuronal nitric oxide synthase (nNOS) is abundantly expressed in skeletal muscle where it associates with the dystrophin complex at the sarcolemma by binding to the PDZ domain of alpha-syntrophin...
  44. Chang W, Iannaccone S, Lau K, Masters B, McCabe T, McMillan K, et al. Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc Natl Acad Sci U S A. 1996;93:9142-7 pubmed
    b>Neuronal nitric oxide synthase (nNOS) in fast-twitch skeletal muscle fibers is primarily particulate in contrast to its greater solubility in brain...
  45. Huang Z, Huang P, Panahian N, Dalkara T, Fishman M, Moskowitz M. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-5 pubmed
    ..In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the ..
  46. Crosbie R, Straub V, Yun H, Lee J, Rafael J, Chamberlain J, et al. mdx muscle pathology is independent of nNOS perturbation. Hum Mol Genet. 1998;7:823-9 pubmed
    In skeletal muscle, neuronal nitric oxide synthase (nNOS) is anchored to the sarcolemma via the dystrophin-glycoprotein complex...
  47. Marin O, Anderson S, Rubenstein J. Origin and molecular specification of striatal interneurons. J Neurosci. 2000;20:6063-76 pubmed
    ..most of the interneurons expressing somatostatin (SOM), neuropeptide Y (NPY), and neural nitric oxide synthase (NOS) appear to downregulate the expression of NKX2.1 as they exit the neuroepithelium...
  48. De Sanctis G, MacLean J, Hamada K, Mehta S, Scott J, Jiao A, et al. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999;189:1621-30 pubmed
    ..of NO in an established model of allergic asthma, mice with targeted deletions of the three known isoforms of NOS (NOS1, 2, and 3) were studied...
  49. Anderson J. A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell. 2000;11:1859-74 pubmed
    ..Cell isolation and histology showed that pharmacological inhibition of nitric oxide synthase (NOS) activity prevented the immediate injury-induced myogenic cell release and delayed the hypertrophy of satellite ..
  50. Lau K, Grange R, Isotani E, Sarelius I, Kamm K, Huang P, et al. nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle. Physiol Genomics. 2000;2:21-7 pubmed
    Nitric oxide (NO) from Ca(2+)-dependent neuronal nitric oxide synthase (nNOS) in skeletal muscle fibers may modulate vascular tone by a cGMP-dependent pathway similar to NO derived from NOS in endothelial cells (eNOS)...
  51. Chao D, Silvagno F, Bredt D. Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthase. J Neurochem. 1998;71:784-9 pubmed
    b>Neuronal nitric oxide synthase (nNOS) is a component of the dystrophin complex in skeletal muscle...
  52. Wehling M, Spencer M, Tidball J. A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. J Cell Biol. 2001;155:123-31 pubmed
    Dystrophin-deficient muscles experience large reductions in expression of nitric oxide synthase (NOS), which suggests that NO deficiency may influence the dystrophic pathology...
  53. Ashley E, Sears C, Bryant S, Watkins H, Casadei B. Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes. Circulation. 2002;105:3011-6 pubmed
    ..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-..
  54. Kameya S, Miyagoe Y, Nonaka I, Ikemoto T, Endo M, Hanaoka K, et al. alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration. J Biol Chem. 1999;274:2193-200 pubmed
    ..alpha1-Syntrophin has additionally been shown to associate with neuronal nitric-oxide synthase (nNOS) through PDZ domains in vitro...
  55. Harrison D. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest. 1997;100:2153-7 pubmed
  56. Keilhoff G, Wolf G, Bernstein H. Altered laminar distribution of hippocampal zinc in mutant mice lacking neuronal nitric oxide synthase. A histochemical study. Neurosci Lett. 2001;305:173-6 pubmed
    ..Our data show that life-long withdrawal of neuronal-derived NO has effects on the accumulation of zinc in the hippocampal formation of mice. ..
  57. Son H, Hawkins R, Martin K, Kiebler M, Huang P, Fishman M, et al. Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell. 1996;87:1015-23 pubmed
    ..potentiation (LTP), but LTP is normal in mice with a targeted mutation in the neuronal form of NO synthase (nNOS-)...
  58. Kline D, Yang T, Huang P, Prabhakar N. Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol. 1998;511 ( Pt 1):273-87 pubmed
    1. The role of endogenous nitric oxide (NO) generated by neuronal nitric oxide synthase (NOS-1) in the control of respiration during hypoxia and hypercapnia was assessed using mutant mice deficient in NOS-1. 2...
  59. Crosbie R, Barresi R, Campbell K. Loss of sarcolemma nNOS in sarcoglycan-deficient muscle. FASEB J. 2002;16:1786-91 pubmed
    b>nNOS, anchored to the sarcolemma through its interactions with the dystrophin-glycoprotein complex, is dramatically reduced in dystrophin-deficient mdx mice and Duchenne muscular dystrophy patients...
  60. Nelson R, Demas G, Huang P, Fishman M, Dawson V, Dawson T, et al. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature. 1995;378:383-6 pubmed
    ..Mice with targeted disruption of neuronal NO synthase (nNOS) display grossly normal appearance, locomotor activity, breeding, long-term potentiation and long-term depression...