Gene Symbol: Nore1
Description: Ras association (RalGDS/AF-6) domain family member 5
Alias: 1300019G20Rik, Maxp1, Nore1, Nore1A, Nore1B, Rapl, ras association domain-containing protein 5, Rap1-binding protein, new ras effector 1, novel ras effector 1, regulator for cell adhesion and polarization enriched in lymphoid tissues
Species: mouse
Products:     Nore1

Top Publications

  1. Kanemitsu N, Ebisuno Y, Tanaka T, Otani K, Hayasaka H, Kaisho T, et al. CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood. 2005;106:2613-8 pubmed
    ..the small guanosine triphosphatase (GTPase) Rap1 in B cells, and corroborating this observation, a deficiency of RAPL, the Rap1 effector molecule, caused a significant reduction in shear-resistant B-cell adhesion to intercellular ..
  2. Katagiri K, Imamura M, Kinashi T. Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol. 2006;7:919-28 pubmed
    b>RAPL, a protein that binds the small GTPase Rap1, is required for efficient immune cell trafficking. Here we have identified the kinase Mst1 as a critical effector of RAPL. RAPL regulated the localization and kinase activity of Mst1...
  3. Park J, Kang S, Lee S, Zhang X, Kim M, Beers L, et al. Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010;285:35029-38 pubmed publisher
    Epigenetic silencing of RASSF (Ras association domain family) genes RASSF1 and RASSF5 (also called NORE1) by CpG hypermethylation is found frequently in many cancers...
  4. Zhou D, Medoff B, Chen L, Li L, Zhang X, Praskova M, et al. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008;105:20321-6 pubmed publisher
    ..Mice lacking Mst1 exhibit markedly reduced levels of the Mst1 regulatory protein Nore1B/RAPL in lymphoid cells, whereas Mst2 abundance is unaltered...
  5. Katagiri K, Ohnishi N, Kabashima K, Iyoda T, Takeda N, Shinkai Y, et al. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol. 2004;5:1045-51 pubmed
    ..Here we show that the effector molecule RAPL is indispensable in the integrin-mediated adhesion and migration of lymphocytes and dendritic cells...
  6. Katagiri K, Maeda A, Shimonaka M, Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol. 2003;4:741-8 pubmed
    ..However, the regulatory mechanism involved is unknown. Here, we identify the Rap1 effector, RAPL, as an essential regulator in this activation...
  7. Lee D, Park S, Sung K, Park J, Lee S, Park S, et al. Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 2012;13:163-9 pubmed publisher
    The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear...
  8. Katagiri K, Ueda Y, Tomiyama T, Yasuda K, Toda Y, Ikehara S, et al. Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1. Immunity. 2011;34:24-38 pubmed publisher
    b>RAPL (an alternative spliced form of Rassf5) is a critical Ras-related protein1 (Rap1) effector that regulates lymphocyte adhesion...
  9. Harjes E, Harjes S, Wohlgemuth S, Müller K, Krieger E, Herrmann C, et al. GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1. Structure. 2006;14:881-8 pubmed
    ..Once the C1 domain tumbles freely in solution, a lipid binding interface becomes accessible. Furthermore, we provide evidence of phosphatidylinositol 3-phosphate binding of the free C1 domain. ..

More Information


  1. Choi J, Oh S, Lee D, Oh H, Park J, Lee S, et al. Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice. PLoS ONE. 2009;4:e8011 pubmed publisher
    ..These data support the hypothesis that tolerance to increased levels of intracellular ROS provided by the Mst1-FoxOs signaling pathway is crucial for the maintenance of naïve T cell homeostasis in the periphery. ..
  2. Vavvas D, Li X, Avruch J, Zhang X. Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998;273:5439-42 pubmed
    ..We have identified a novel potential Ras effector or target named Nore1. Nore1 has no significant sequence similarity to known mammalian proteins and lacks an identifiable catalytic ..
  3. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang X, et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002;12:253-65 pubmed
    ..b>NORE1, a noncatalytic polypeptide, binds specifically to Ras-GTP and to several other Ras-like GTPases...
  4. Stieglitz B, Bee C, Schwarz D, Yildiz O, Moshnikova A, Khokhlatchev A, et al. Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J. 2008;27:1995-2005 pubmed publisher
    ..RASSF5, a member of this family, exists in two splice variants known as NORE1A and RAPL. Both of them are involved in distinct cellular pathways triggered by Ras and Rap, respectively...
  5. Bee C, Moshnikova A, Mellor C, Molloy J, Koryakina Y, Stieglitz B, et al. Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. J Biol Chem. 2010;285:16258-66 pubmed publisher
    b>NORE1A is a Ras-binding protein that belongs to a group of tumor suppressors known as the Ras association domain family...
  6. Yao R, Wang Y, You M. Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. Cytogenet Cell Genet. 2001;95:126-8 pubmed
  7. Ortiz Vega S, Khokhlatchev A, Nedwidek M, Zhang X, Dammann R, Pfeifer G, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002;21:1381-90 pubmed
    ..The preferential ability of RASSF1A to heterodimerize with Nore and thereby associate with Ras-like GTPases may be relevant to its putative tumor suppressor function. ..
  8. Ebisuno Y, Katagiri K, Katakai T, Ueda Y, Nemoto T, Inada H, et al. Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood. 2010;115:804-14 pubmed publisher
    The small GTPase Rap1 and its effector RAPL regulate lymphocyte adhesion and motility. However, their precise regulatory roles in the adhesion cascade preceding entry into lymph nodes and during interstitial migration are unclear...
  9. Park S, Lee D, Choi C, Ryu S. Induction of apoptosis by NORE1A in a manner dependent on its nuclear export. Biochem Biophys Res Commun. 2008;368:56-61 pubmed publisher
    ..In this study, we showed that NORE1A was exported actively via its nuclear export signal (NES) in the C-terminus (residues 372-379)...
  10. Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, et al. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity. 2010;32:541-56 pubmed publisher
    ..the "inside-out" pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH domain of RapL. TcR induced Rap1-RapL complex formation and LFA-1 binding failed to occur in Skap1(-/-) primary T cells...
  11. Vos M, Martinez A, Ellis C, Vallecorsa T, Clark G. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. J Biol Chem. 2003;278:21938-43 pubmed
    ..We now show that the Ras effector Nore1, which is structurally related to RASSF1, can also mediate a Ras-dependent apoptosis...
  12. Tommasi S, Dammann R, Jin S, Zhang X, Avruch J, Pfeifer G. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 2002;21:2713-20 pubmed
    ..5 kDa). Both share a RA domain, encoded by exons 3 through 6. NORE1A and NORE1B are expressed in most of the normal tissues analysed but they appear to be down-regulated in several cancer cell ..
  13. Gordon M, El Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, et al. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS ONE. 2013;8:e75483 pubmed publisher
    ..Failure to restrict NFκB resulted in the inflammation-induced DNA damage driven tyrosine phosphorylation of YAP, subsequent p53 accumulation and loss of intestinal epithelial homeostasis. ..
  14. Yang R, Kong E, Jin J, Hergovich A, Püschel A. Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway. J Cell Sci. 2014;127:3463-76 pubmed publisher
    ..Their role in neuronal polarity suggests that Ndr kinases perform a conserved function as regulators of cell polarity. ..
  15. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..These data provide a rich resource for future studies that may better characterize the observed transcriptional changes in gene networks in response to ethanol consumption and wheel running. ..