Nop53

Summary

Gene Symbol: Nop53
Description: NOP53 ribosome biogenesis factor
Alias: 5330430H08Rik, 9430097C02Rik, AU041936, AW536441, Gltscr2, PICT-1, R74911, ribosome biogenesis protein NOP53, glioma tumor suppressor candidate region gene 2, glioma tumor suppressor candidate region gene 2 protein, preS1-binding protein
Species: mouse
Products:     Nop53

Top Publications

  1. Chae T, Allen K, Davisson M, Sweet H, Walsh C. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Mamm Genome. 2002;13:239-44 pubmed
    ..Our physical map and transcript map may be useful for positional cloning of genes in this unusually gene-rich region of the genome. ..
  2. Hong H, Chakravarti A, Takahashi J. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Proc Natl Acad Sci U S A. 2004;101:1748-53 pubmed
    ..The hyh mutant provides a valuable in vivo model to study vesicle/membrane trafficking and provides insight into the potential roles of alpha-SNAP in embryogenesis and brain development. ..
  3. Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell. 2006;17:4888-95 pubmed
    ..Recent study revealed that PICT-1/GLTSCR2 bound to and stabilized PTEN protein in cells, implicating its roles in PTEN-governed PIP(3) signals...
  4. Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011;17:944-51 pubmed publisher
    PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses ..