Nogo 66 receptor

Summary

Gene Symbol: Nogo 66 receptor
Description: reticulon 4 receptor
Alias: NOGOR, NgR, NgR1, reticulon-4 receptor, nogo66 receptor-1
Species: mouse
Products:     Nogo 66 receptor

Top Publications

  1. Steinbach K, McDonald C, Reindl M, Schweigreiter R, Bandtlow C, Martin R. Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis. PLoS ONE. 2011;6:e26341 pubmed publisher
    ..b>NgR1 and NgR2 were identified as interaction partners for the myelin proteins Nogo-A, MAG and OMgp and are probably ..
  2. Mingorance A, Fontana X, Solé M, Burgaya F, Ureña J, Teng F, et al. Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions. Mol Cell Neurosci. 2004;26:34-49 pubmed
    ..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult. ..
  3. Williams G, Wood A, Williams E, Gao Y, Mercado M, Katz A, et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008;283:16641-52 pubmed publisher
    ..In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is mediated by the sialic acid moiety ..
  4. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, et al. Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci. 2009;29:6348-52 pubmed publisher
    ..We hypothesize that BLyS may be a negative regulator for neuronal functions. Here Nogo-66 receptor (NgR) is identified as a high affinity receptor for BLyS, which inhibits dorsal root ganglion outgrowth in culture...
  5. Wills Z, Mandel Brehm C, Mardinly A, McCord A, Giger R, Greenberg M. The nogo receptor family restricts synapse number in the developing hippocampus. Neuron. 2012;73:466-81 pubmed publisher
    ..Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excitatory synapse formation...
  6. Karlén A, Karlsson T, Mattsson A, Lundströmer K, Codeluppi S, Pham T, et al. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A. 2009;106:20476-81 pubmed publisher
    ..We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of ..
  7. Barton W, Liu B, Tzvetkova D, Jeffrey P, Fournier A, Sah D, et al. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 2003;22:3291-302 pubmed
    ..that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR)...
  8. Lee H, Raiker S, Venkatesh K, Geary R, Robak L, Zhang Y, et al. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci. 2008;28:2753-65 pubmed publisher
    ..Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the myelin inhibitors Nogo-A, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte ..
  9. Lauren J, Airaksinen M, Saarma M, Timmusk T. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci. 2003;24:581-94 pubmed
    ..Currently only the Nogo receptor (NgR), in complex with p75(NTR) neurotrophin receptor is known to be involved in this inhibitory signalling in neurons...

More Information

Publications74

  1. Venkatesh K, Chivatakarn O, Sheu S, Giger R. Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol. 2007;177:393-9 pubmed
    Neuronal Nogo66 receptor-1 (NgR1) binds the myelin inhibitors NogoA, OMgp, and myelin-associated glycoprotein (MAG) and has been proposed to function as the ligand-binding component of a receptor complex that also includes Lingo-1, p75(..
  2. Fournier A, GrandPre T, Strittmatter S. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001;409:341-6 pubmed
    ..Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury. ..
  3. Wörter V, Schweigreiter R, Kinzel B, Mueller M, Barske C, Böck G, et al. Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5. PLoS ONE. 2009;4:e5218 pubmed publisher
    ..Two members of the Nogo-receptor (NgR) family, NgR1 and NgR2, have been identified as neuronal binding proteins of MAG...
  4. Nguyen T, Mehta N, Conant K, Kim K, Jones M, Calabresi P, et al. Axonal protective effects of the myelin-associated glycoprotein. J Neurosci. 2009;29:630-7 pubmed publisher
    ..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss. ..
  5. Zheng B, Atwal J, Ho C, Case L, He X, Garcia K, et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005;102:1205-10 pubmed
    ..Neuronal Nogo receptor (NgR) binds to each of the three inhibitors and has been proposed to mediate their inhibitory signals by complexing with ..
  6. Stephany C, Chan L, Parivash S, Dorton H, Piechowicz M, Qiu S, et al. Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. J Neurosci. 2014;34:11631-40 pubmed publisher
    ..plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1)...
  7. Liu B, Fournier A, GrandPre T, Strittmatter S. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002;297:1190-3 pubmed
    ..The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor ..
  8. Fry E, Ho C, David S. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron. 2007;53:649-62 pubmed
    ..Increasing numbers of macrophages in crushed rat sciatic nerves express NgR1 and NgR2 on the cell surface in the first week after injury...
  9. Kim J, Liu B, Park J, Strittmatter S. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004;44:439-51 pubmed
    ..All three of these proteins bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro...
  10. Teng F, Tang B. Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents?. J Neurochem. 2005;94:865-74 pubmed
    IN-1, the monoclonal antibody against the exon 3-encoded N-terminal domain of Nogo-A, and the Nogo-66 receptor (NgR) antagonist NEP1-40 have both shown efficacy in promoting regeneration in animal spinal cord injury models, the latter ..
  11. Theotokis P, Lourbopoulos A, Touloumi O, Lagoudaki R, Kofidou E, Nousiopoulou E, et al. Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuropathol Exp Neurol. 2012;71:907-20 pubmed
    ..The results indicate that Nogo-A and Nogo receptor are actively regulated in EAE lesions; this may indicate a specific time window for localized axonal regeneration in the acute phase of EAE. ..
  12. McDonald C, Steinbach K, Kern F, Schweigreiter R, Martin R, Bandtlow C, et al. Nogo receptor is involved in the adhesion of dendritic cells to myelin. J Neuroinflammation. 2011;8:113 pubmed publisher
    Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors...
  13. Dickendesher T, Baldwin K, Mironova Y, Koriyama Y, Raiker S, Askew K, et al. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012;15:703-12 pubmed publisher
    ..The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition...
  14. McGee A, Yang Y, Fischer Q, Daw N, Strittmatter S. Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science. 2005;309:2222-6 pubmed
    ..We find that mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity...
  15. Wang X, Duffy P, McGee A, Hasan O, Gould G, Tu N, et al. Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011;70:805-21 pubmed publisher
    ..after central nervous system injury, including blockade of myelin-derived inhibitors with soluble Nogo receptor (NgR1, RTN4R) decoy protein...
  16. Wang X, Chun S, Treloar H, Vartanian T, Greer C, Strittmatter S. Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci. 2002;22:5505-15 pubmed
    ..An interaction of Nogo on the oligodendrocyte surface with Nogo-66 Receptor (NgR) on axons has been suggested to play an important role in limiting axonal growth...
  17. Akbik F, Bhagat S, Patel P, Cafferty W, Strittmatter S. Anatomical plasticity of adult brain is titrated by Nogo Receptor 1. Neuron. 2013;77:859-66 pubmed publisher
    ..turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1)...
  18. Raiker S, Lee H, Baldwin K, Duan Y, Shrager P, Giger R. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 2010;30:12432-45 pubmed publisher
    ..Nogo and OMgp complex with the neuronal cell surface receptors Nogo receptor-1 (NgR1) and paired Ig-like receptor-B (PirB) to regulate neuronal morphology...
  19. Cafferty W, Strittmatter S. The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth. J Neurosci. 2006;26:12242-50 pubmed
    The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies...
  20. Yang Y, Harel N, Strittmatter S. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. J Neurosci. 2009;29:13850-9 pubmed publisher
    ..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS. ..
  21. Siegel C, Fink K, Strittmatter S, Cafferty W. Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury. J Neurosci. 2015;35:1443-57 pubmed publisher
  22. Vasudevan S, Schulz J, Zhou C, Cocco M. Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface. Proc Natl Acad Sci U S A. 2010;107:6847-51 pubmed publisher
    ..Moreover, the conformations and relative positions of side chains recognized by the receptor are now defined and provide a foundation for antagonist design. ..
  23. Fang Y, Yan J, Li C, Zhou X, Yao L, Pang T, et al. The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation. J Biol Chem. 2015;290:28901-14 pubmed publisher
    ..Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowth inhibition receptor, is also expressed on microglia and regulates cell adhesion and migration ..
  24. Konopka Anstadt J, Mainou B, Sutherland D, Sekine Y, Strittmatter S, Dermody T. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 2014;15:681-91 pubmed publisher
    ..We demonstrate that reovirus binds Nogo receptor NgR1, a leucine-rich repeat protein expressed in the CNS, to infect neurons...
  25. Hsu R, Woodroffe A, Lai W, Cook M, Mukai J, Dunning J, et al. Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. PLoS ONE. 2007;2:e1234 pubmed
    ..In addition, our results raise interesting issues about evaluating the significance of rare genetic variants in disease and their role in causation. ..
  26. Maynard T, Meechan D, Dudevoir M, Gopalakrishna D, Peters A, Heindel C, et al. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Mol Cell Neurosci. 2008;39:439-51 pubmed publisher
    ..Our results suggest that altered dosage of one, or several 22q11 mitochondrial genes, particularly during early post-natal cortical development, may disrupt neuronal metabolism or synaptic signaling. ..
  27. Tong J, Liu W, Wang X, Han X, Hyrien O, Samadani U, et al. Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice. J Neurotrauma. 2013;30:247-58 pubmed publisher
    ..glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1)...
  28. Wang J, Chan C, Taylor J, Chan S. Localization of Nogo and its receptor in the optic pathway of mouse embryos. J Neurosci Res. 2008;86:1721-33 pubmed publisher
    ..In vitro studies showed that the Nogo receptor (NgR) was expressed on the neurites and growth cones from both the ventral temporal and dorsal nasal quadrant of the ..
  29. Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi Jitsuki A, et al. Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery. Cereb Cortex. 2016;26:427-439 pubmed publisher
    ..Removal of the myelin-inhibiting signaling protein, Nogo receptor (NgR1), restores adult neural plasticity...
  30. Ferraro G, Morrison C, Overall C, Strittmatter S, Fournier A. Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem. 2011;286:31418-24 pubmed publisher
    Nogo-66 receptor 1 (NgR1) is a glycosylphosphatidylinositol-anchored receptor for myelin-associated inhibitors that restricts plasticity and axonal regrowth in the CNS...
  31. Wang X, Hasan O, Arzeno A, Benowitz L, Cafferty W, Strittmatter S. Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Exp Neurol. 2012;237:55-69 pubmed publisher
    ..of either astrocyte-derived chondroitin sulfate proteoglycans (CSPGs) or oligodendrocyte-derived NogoReceptor (NgR1) ligands reduces extrinsic inhibition of axonal growth, though combined blockade of these distinct pathways has not ..
  32. Fink K, Strittmatter S, Cafferty W. Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice. J Neurosci. 2015;35:15403-18 pubmed publisher
    ..Using crym-GFP, we reevaluated the CST in mice lacking nogo receptor 1 (NgR1), a protein implicated in limiting neural repair...
  33. Ng C, Tang B. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. J Neurosci Res. 2002;67:559-65 pubmed
    ..The 66-amino acid extracellular domain of Nogo (Nogo-66) interacts with a high-affinity receptor (NgR), a glycosylphosphatidylinositol (GPI)-linked protein with multiple leucine-rich repeats...
  34. Lee J, Kim M, Li L, Velumian A, Aui P, Fehlings M, et al. Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system. Sci Rep. 2017;7:8958 pubmed publisher
    ..Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, ..
  35. Park J, Gimbel D, GrandPre T, Lee J, Kim J, Li W, et al. Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci. 2006;26:1386-95 pubmed
    ..A Nogo to Nogo-66 receptor (NgR) pathway contributes to determining the ability of adult CNS axons to extend after traumatic injuries...
  36. Fink K, López Giráldez F, Kim I, Strittmatter S, Cafferty W. Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Rep. 2017;18:2687-2701 pubmed publisher
    ..Here, we characterize the in vivo transcriptome of sprouting intact neurons from Ngr1 null mice after partial SCI...
  37. Ramasamy S, Yu F, Hong Yu Y, Srivats H, Dawe G, Ahmed S. NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation. Stem Cells. 2014;32:1636-48 pubmed publisher
    ..In NSCs, NogoR1 functions through Rho whereas PirB uses Shp1/2 signaling pathways to control NSC behavior. Taken together, this work suggests that Nogo signaling is an important pathway for survival of NSCs. ..
  38. Miyazaki K, Nagai M, Ohta Y, Morimoto N, Kurata T, Murakami T, et al. Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice. Neurol Res. 2009;31:316-21 pubmed publisher
    Detailed assessment of Nogo-A and its receptor NgR in the spinal cord of amyotrophic lateral sclerosis (ALS) models or patients has not been reported previously, and we examined the expression and distribution patterns of Nogo-A and NgR ..
  39. Petrinovic M, Duncan C, Bourikas D, Weinman O, Montani L, Schroeter A, et al. Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development. 2010;137:2539-50 pubmed publisher
    ..The same effects are seen with antibodies against the Nogo receptor complex components NgR and Lingo1, or by blocking the downstream effector Rho kinase (ROCK)...
  40. Pernet V, Joly S, Christ F, Dimou L, Schwab M. Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation. J Neurosci. 2008;28:7435-44 pubmed publisher
    ..The common binding protein for Nogo-A and MAG, NgR1, was exclusively upregulated in MAG(-/-) animals, whereas the level of Lingo-1, a coreceptor, remained unchanged...
  41. Wu S, Ying G, Wu Q, Capecchi M. Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet. 2007;39:922-30 pubmed
  42. van Gaalen M, Relo A, Mueller B, Gross G, Mezler M. NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance. Neurosci Lett. 2012;510:58-61 pubmed publisher
    The Nogo-66 receptor (NgR1) is part of a co-receptor complex on neurons that transmits a signal for inhibition of neurite outgrowth...
  43. Harel N, Song K, Tang X, Strittmatter S. Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury. J Neurotrauma. 2010;27:2055-66 pubmed publisher
    ..Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm...
  44. Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, et al. LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand. Mol Cell Neurosci. 2014;61:211-8 pubmed publisher
    ..oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator (BLyS) commonly bind to Nogo receptor-1 (NgR1), leading to enormous restriction of functional recovery after damage to the adult central nervous system...
  45. Palandri A, Salvador V, Wojnacki J, Vivinetto A, Schnaar R, Lopez P. Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015;6:e1876 pubmed publisher
    ..Also, our results highlight the relevance of the nurture/protective effects of myelin on neurons. ..
  46. Lazar N, Singh S, Paton T, Clapcote S, Gondo Y, Fukumura R, et al. Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice. Behav Brain Res. 2011;224:73-9 pubmed publisher
    ..Given the mild effect of the R189H mutation of Rtn4r on behavioural phenotypes relevant to schizophrenia, our results do not support missense mutation of RTN4R as a strong risk factor in the pathogenesis of schizophrenia. ..
  47. Murthy R, Kim J, Sun X, Giger R, Fink D, Mata M. Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1. Mol Brain. 2013;6:30 pubmed publisher
    ..to determine whether neuronal cell surface expression of GABAB-Rs might be regulated by the Nogo receptor 1 (NgR1)...
  48. Yang E, Lin E, Hensch T. Critical period for acoustic preference in mice. Proc Natl Acad Sci U S A. 2012;109 Suppl 2:17213-20 pubmed publisher
    ..exposing adult mice treated acutely with valproic acid or carrying a targeted deletion of the Nogo receptor (NgR(-/-)) unmasked a strong plasticity of preference consistent with a reopening of the critical period as seen in ..
  49. Tong J, Ren Y, Wang X, Dimopoulos V, Kesler H, Liu W, et al. Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury. Neurosurgery. 2014;75:51-60 pubmed publisher
    Neuronal Nogo-66 receptor 1 (NgR1) has attracted attention as a converging point for mediating the effects of myelin-associate inhibitory ligands in the central nervous system, establishing the growth-restrictive environment, and limiting ..
  50. Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, et al. Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A. 2008;105:740-5 pubmed publisher
    The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system...
  51. Mathis C, Schröter A, Thallmair M, Schwab M. Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010;20:2380-90 pubmed publisher
    ..In vitro analysis showed that Nogo-A and its receptor components NgR, Lingo-1, TROY, and p75 are expressed in cells emigrating from embryonic forebrain-derived neurospheres...
  52. Liu G, Ni J, Mao L, Yan M, Pang T, Liao H. Expression of Nogo receptor 1 in microglia during development and following traumatic brain injury. Brain Res. 2015;1627:41-51 pubmed publisher
    As the receptor of myelin associated inhibitory factors Nogo receptor 1 (NgR1) plays an important role in central nervous system (CNS) injury and regeneration...
  53. Budel S, Padukkavidana T, Liu B, Feng Z, Hu F, Johnson S, et al. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008;28:13161-72 pubmed publisher
    ..Neuronal cultures demonstrate that four different schizophrenia-derived NgR1 variants fail to transduce myelin signals into axon inhibition, and function as dominant negatives to disrupt ..
  54. Su Y, Wang F, Teng Y, Zhao S, Cui H, Pan S. Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout mice. Neurosci Lett. 2009;460:223-6 pubmed publisher
    ..glycoprotein (MAG) and Omgp, exert their effects on neuron regeneration through the Nogo receptor (NgR)...
  55. Li S, Strittmatter S. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci. 2003;23:4219-27 pubmed
    ..oligodendrocyte-myelin glycoprotein, and myelin-associated glycoprotein, all bind to an axonal Nogo-66 receptor (NgR) and at least partially account for this lack of CNS repair...
  56. Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, et al. Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS. Sci Rep. 2017;7:12119 pubmed publisher
    ..Thus, the level of LOTUS function titrates axonal regeneration. ..
  57. Litwak S, Payne N, Campanale N, Ozturk E, Lee J, Petratos S, et al. Nogo-receptor 1 deficiency has no influence on immune cell repertoire or function during experimental autoimmune encephalomyelitis. PLoS ONE. 2013;8:e82101 pubmed publisher
    The potential role of Nogo-66 Receptor 1 (NgR1) on immune cell phenotypes and their activation during neuroinflammatory diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), is ..
  58. Frantz M, Kast R, Dorton H, Chapman K, McGee A. Nogo Receptor 1 Limits Ocular Dominance Plasticity but not Turnover of Axonal Boutons in a Model of Amblyopia. Cereb Cortex. 2016;26:1975-85 pubmed publisher
    ..alter the dynamics of intracortical axonal boutons in visual cortex of either adult wild-type (WT) mice or adult NgR1 mutant (ngr1-/-) mice that retain critical period visual plasticity...
  59. Iobbi C, Korte M, Zagrebelsky M. Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics. Cereb Cortex. 2017;27:2779-2792 pubmed publisher
    ..Nogo-66 signals via Nogo Receptor 1 (NgR1) to regulate synaptic function...
  60. Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, et al. Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011;333:769-73 pubmed publisher
    ..We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein...
  61. Kvajo M, McKellar H, Gogos J. Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience. 2012;211:136-64 pubmed publisher
    ..Finally, we discuss emerging mouse models, such as second-generation pathophysiology models based on innovative approaches that are facilitated by the information gathered from the current genetic mouse models. ..
  62. Earls L, Fricke R, Yu J, Berry R, Baldwin L, Zakharenko S. Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia. J Neurosci. 2012;32:14132-44 pubmed publisher
    ..We conclude that miRNA-dependent SERCA2 dysregulation is a pathogenic event in 22q11DS and schizophrenia. ..
  63. Li S, Overman J, Katsman D, Kozlov S, Donnelly C, Twiss J, et al. An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat Neurosci. 2010;13:1496-504 pubmed publisher
    ..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery. ..
  64. Kwon H, Nakaya N, Abu Asab M, Kim H, Tomarev S. Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve. J Neurosci. 2014;34:5539-51 pubmed publisher
    ..Myocilin stimulation of oligodendrocyte differentiation occurs through the NgR1/Lingo-1 receptor complex. Myocilin physically interacts with Lingo-1 and may be considered as a Lingo-1 ligand...
  65. Wang J, Wang L, Zhao H, Chan S. Localization of an axon growth inhibitory molecule Nogo and its receptor in the spinal cord of mouse embryos. Brain Res. 2010;1306:8-17 pubmed publisher
    The localization of an axon growth inhibitory molecule Nogo and its receptor (NgR) was investigated in the mouse spinal cord during prenatal development of the commissural pathway...