Gene Symbol: Nme8
Description: NME/NM23 family member 8
Alias: 1700056P15Rik, Sptrx-2, Txndc3, thioredoxin domain-containing protein 3, spermatid-specific thioredoxin-2, thioredoxin domain containing 3 (spermatozoa)
Species: mouse
Products:     Nme8

Top Publications

  1. Miranda Vizuete A, Tsang K, Yu Y, Jimenez A, Pelto Huikko M, Flickinger C, et al. Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen. J Biol Chem. 2003;278:44874-85 pubmed
  2. Jimenez A, Prieto Alamo M, Fuentes Almagro C, Jurado J, Gustafsson J, Pueyo C, et al. Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins. Biochem Biophys Res Commun. 2005;330:65-74 pubmed
    ..In addition, we show remarkable age-associated variations between the Sptrx mRNA expression patterns. ..
  3. Duriez B, Duquesnoy P, Escudier E, Bridoux A, Escalier D, Rayet I, et al. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Proc Natl Acad Sci U S A. 2007;104:3336-41 pubmed
    ..So far, none of the 18 members of this family has been involved in human pathology. Here we identified TXNDC3, which encodes a thioredoxin-nucleoside diphosphate kinase, as a gene implicated in primary ciliary dyskinesia (..
  4. Smith T, Baker M, Connaughton H, Habenicht U, Aitken R. Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013;65:872-881 pubmed publisher
    ..germ line expresses three unique forms of thioredoxin, known as thioredoxin domain-containing proteins (Txndc2, Txndc3, and Txndc8)...