Nlrp3

Summary

Gene Symbol: Nlrp3
Description: NLR family, pyrin domain containing 3
Alias: AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1, NACHT, LRR and PYD domains-containing protein 3, NACHT/LRR/pyrin domain-containing protein 3, PYRIN-containing APAF1-like protein 1, cold autoinflammatory syndrome 1 protein homolog, cryopyrin, mast cell maturation-associated-inducible protein 1
Species: mouse
Products:     Nlrp3

Top Publications

  1. Hernandez Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, et al. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol. 2012;189:5113-7 pubmed publisher
    Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled activation is associated with inflammatory disorders, suggesting that regulation of the inflammasome is important to prevent detrimental effects...
  2. Sheedy F, Grebe A, Rayner K, Kalantari P, Ramkhelawon B, Carpenter S, et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013;14:812-20 pubmed publisher
    ..crystals and amyloid fibrils, induce production of interleukin 1? (IL-1?) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis, Alzheimer's disease and diabetes...
  3. Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14:454-60 pubmed publisher
    b>NLRP3 forms an inflammasome with its adaptor ASC, and its excessive activation can cause inflammatory diseases. However, little is known about the mechanisms that control assembly of the inflammasome complex...
  4. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
    ..2). Here we show, however, that it crucially relies on the Nlrp3 inflammasome and interleukin-1 receptor signalling...
  5. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39 pubmed publisher
    ..These findings shed light on the regulatory role of ligand-receptor internalization in directing cell fate, which may have an important role in the progress of inflammation following infection and injury. ..
  6. Mulay S, Kulkarni O, Rupanagudi K, Migliorini A, Darisipudi M, Vilaysane A, et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1? secretion. J Clin Invest. 2013;123:236-46 pubmed publisher
    ..We found that CaOx crystals activated murine renal DCs to secrete IL-1? through a pathway that included NLRP3, ASC, and caspase-1...
  7. RAMOS H, Lanteri M, Blahnik G, Negash A, Suthar M, Brassil M, et al. IL-1? signaling promotes CNS-intrinsic immune control of West Nile virus infection. PLoS Pathog. 2012;8:e1003039 pubmed publisher
    ..Here, we identify IL-1? signaling and the NLRP3 inflammasome as key host restriction factors involved in viral control and CNS disease associated with WNV ..
  8. Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
    Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS)...
  9. Aachoui Y, Leaf I, Hagar J, Fontana M, Campos C, Zak D, et al. Caspase-11 protects against bacteria that escape the vacuole. Science. 2013;339:975-8 pubmed publisher
    ..typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways...
  10. Heid M, Keyel P, Kamga C, Shiva S, Watkins S, Salter R. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013;191:5230-8 pubmed publisher
    The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives many inflammatory processes and mediates IL-1 family cytokine release...

Detail Information

Publications80

  1. Hernandez Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, et al. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol. 2012;189:5113-7 pubmed publisher
    Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled activation is associated with inflammatory disorders, suggesting that regulation of the inflammasome is important to prevent detrimental effects...
  2. Sheedy F, Grebe A, Rayner K, Kalantari P, Ramkhelawon B, Carpenter S, et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013;14:812-20 pubmed publisher
    ..crystals and amyloid fibrils, induce production of interleukin 1? (IL-1?) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis, Alzheimer's disease and diabetes...
  3. Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14:454-60 pubmed publisher
    b>NLRP3 forms an inflammasome with its adaptor ASC, and its excessive activation can cause inflammatory diseases. However, little is known about the mechanisms that control assembly of the inflammasome complex...
  4. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
    ..2). Here we show, however, that it crucially relies on the Nlrp3 inflammasome and interleukin-1 receptor signalling...
  5. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39 pubmed publisher
    ..These findings shed light on the regulatory role of ligand-receptor internalization in directing cell fate, which may have an important role in the progress of inflammation following infection and injury. ..
  6. Mulay S, Kulkarni O, Rupanagudi K, Migliorini A, Darisipudi M, Vilaysane A, et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1? secretion. J Clin Invest. 2013;123:236-46 pubmed publisher
    ..We found that CaOx crystals activated murine renal DCs to secrete IL-1? through a pathway that included NLRP3, ASC, and caspase-1...
  7. RAMOS H, Lanteri M, Blahnik G, Negash A, Suthar M, Brassil M, et al. IL-1? signaling promotes CNS-intrinsic immune control of West Nile virus infection. PLoS Pathog. 2012;8:e1003039 pubmed publisher
    ..Here, we identify IL-1? signaling and the NLRP3 inflammasome as key host restriction factors involved in viral control and CNS disease associated with WNV ..
  8. Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
    Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS)...
  9. Aachoui Y, Leaf I, Hagar J, Fontana M, Campos C, Zak D, et al. Caspase-11 protects against bacteria that escape the vacuole. Science. 2013;339:975-8 pubmed publisher
    ..typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways...
  10. Heid M, Keyel P, Kamga C, Shiva S, Watkins S, Salter R. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013;191:5230-8 pubmed publisher
    The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives many inflammatory processes and mediates IL-1 family cytokine release...
  11. Sagulenko V, Thygesen S, Sester D, Idris A, Cridland J, Vajjhala P, et al. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ. 2013;20:1149-60 pubmed publisher
    ..Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ..
  12. Fernandes Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald K, Alnemri E. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013;191:3995-9 pubmed publisher
    Activation of the NLRP3 inflammasome by diverse stimuli requires a priming signal from TLRs and an activation signal from purinergic receptors or pore-forming toxins...
  13. Jacobson L, Lima H, Goldberg M, Gocheva V, Tsiperson V, Sutterwala F, et al. Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. J Biol Chem. 2013;288:7481-91 pubmed publisher
    ..Together our findings suggest that necrotic cell death is a powerful mediator of a Th2-associated immune response...
  14. Shah S, Bohsali A, Ahlbrand S, Srinivasan L, Rathinam V, Vogel S, et al. Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system. J Immunol. 2013;191:3514-8 pubmed publisher
    ..In conclusion, we report a novel immune evasion mechanism of M. tuberculosis that involves the ESX-1-dependent, direct or indirect, suppression of the host cell AIM2 inflammasome activation during infection. ..
  15. Muñoz Planillo R, Kuffa P, Martínez Colón G, Smith B, Rajendiran T, Nunez G. K? efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38:1142-53 pubmed publisher
    The NLRP3 inflammasome is an important component of the innate immune system. However, its mechanism of activation remains largely unknown...
  16. Heneka M, Kummer M, Stutz A, Delekate A, Schwartz S, Vieira Saecker A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013;493:674-8 pubmed publisher
    ..Indeed, amyloid-? activation of the NLRP3 inflammasome in microglia is fundamental for interleukin-1? maturation and subsequent inflammatory events...
  17. Satoh T, Kambe N, Matsue H. NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation. Cell Death Dis. 2013;4:e644 pubmed publisher
    ..Using this system, the expression of NLRP3 mutants in cryopyrin-associated periodic syndrome (CAPS) patients was sufficient for the induction of necrotic cell death without ..
  18. Youm Y, Grant R, McCabe L, Albarado D, Nguyen K, Ravussin A, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18:519-32 pubmed publisher
    ..Here we detail a mechanism by which the Nlrp3 inflammasome controls systemic low-grade age-related "sterile" inflammation in both periphery and brain ..
  19. Case C, Kohler L, Lima J, Strowig T, de Zoete M, Flavell R, et al. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A. 2013;110:1851-6 pubmed publisher
    ..Legionella activation of caspase-11 stimulated activation of caspase-1 through NLRP3 and ASC...
  20. Kayagaki N, Wong M, Stowe I, Ramani S, Gonzalez L, Akashi Takamura S, et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science. 2013;341:1246-9 pubmed publisher
    ..coli LPS. These data unveil a TLR4-independent mechanism for innate immune recognition of LPS. ..
  21. Gonçalves V, Matteucci K, Buzzo C, Miollo B, Ferrante D, Torrecilhas A, et al. NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production. PLoS Negl Trop Dis. 2013;7:e2469 pubmed publisher
    ..Herein, we demonstrate for the first time that T. cruzi infection induces IL-1? production in an NLRP3- and caspase-1-dependent manner...
  22. Lin K, Hu W, Troutman T, Jennings M, Brewer T, Li X, et al. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2014;111:775-80 pubmed publisher
    ..TLRs and a specific NLR, nucleotide binding and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3), simultaneously and discovered that such activation triggers rapid caspase-1 cleavage, leading to secretion of ..
  23. He Y, Franchi L, Nunez G. TLR agonists stimulate Nlrp3-dependent IL-1? production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. J Immunol. 2013;190:334-9 pubmed publisher
    ..activation of the nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain-containing 3 (Nlrp3) inflammasome is thought to require two signals...
  24. Jabaut J, Ather J, Taracanova A, Poynter M, Ckless K. Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1? secretion in association with alterations in cellular redox and energy status. Free Radic Biol Med. 2013;60:233-45 pubmed publisher
    The Nlrp3 inflammasome is activated in response to an array of environmental and endogenous molecules leading to caspase-1-dependent IL-1? processing and secretion by myeloid cells...
  25. McAuley J, Tate M, MacKenzie Kludas C, Pinar A, Zeng W, Stutz A, et al. Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathog. 2013;9:e1003392 pubmed publisher
    ..The NLRP3-inflammasome has been implicated in IAV pathogenesis, but whether IAV virulence proteins can be activators of the ..
  26. Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, et al. Inflammasome-independent NLRP3 augments TGF-? signaling in kidney epithelium. J Immunol. 2013;190:1239-49 pubmed publisher
    ..We recently demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal inflammation, injury, and fibrosis following unilateral ureteric obstruction in mice...
  27. Sandanger Ø, Ranheim T, Vinge L, Bliksøen M, Alfsnes K, Finsen A, et al. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2013;99:164-74 pubmed publisher
    Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory response...
  28. Py B, Kim M, Vakifahmetoglu Norberg H, Yuan J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell. 2013;49:331-8 pubmed publisher
    b>NLRP3 is an important pattern recognition receptor involved in mediating inflammasome activation in response to viral and bacterial infections as well as various proinflammatory stimuli associated with tissue damage or malfunction...
  29. Gomes M, Campos P, Oliveira F, Corsetti P, Bortoluci K, Cunha L, et al. Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. J Immunol. 2013;190:3629-38 pubmed publisher
    ..Therefore, we decided to investigate the function of NLRC4, NLRP3, and AIM2 in sensing Brucella...
  30. Kang T, Yang S, Tóth B, Kovalenko A, Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity. 2013;38:27-40 pubmed publisher
    ..Caspase-8 deficiency in these cells facilitated lipopolysaccharide-induced assembly and function of the NLRP3 inflammasome...
  31. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, et al. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med. 2013;19:1132-40 pubmed publisher
    ..The Nlrp3 inflammasome has been implicated in obesity-induced insulin resistance and beta cell failure...
  32. Lima H, Jacobson L, Goldberg M, Chandran K, Diaz Griffero F, Lisanti M, et al. Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death. Cell Cycle. 2013;12:1868-78 pubmed publisher
    The Nod-like receptor, Nlrp3, has been linked to inflammatory diseases and adjuvant-mediated immune responses...
  33. Li H, Wu S, Mao L, Lei G, Zhang L, Lu A, et al. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome. Protein Cell. 2013;4:529-38 pubmed publisher
    ..induced IL-1? secretion, ASC pyroptosome formation as well as caspase-1 activation were all dependent on NLRP3. Cathepsin B activity, ROS production and K? efflux were required for the inflammasome activation by T...
  34. Shi F, Yang Y, Kouadir M, Fu Y, Yang L, Zhou X, et al. Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol. 2013;260:121-5 pubmed publisher
    ..In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia...
  35. Sokolovska A, Becker C, Ip W, Rathinam V, Brudner M, Paquette N, et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol. 2013;14:543-53 pubmed publisher
    ..Here we report that acidification of phagosomes containing Gram-positive bacteria is regulated by the NLRP3 inflammasome and caspase-1...
  36. Babelova A, Moreth K, Tsalastra Greul W, Zeng Brouwers J, Eickelberg O, Young M, et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem. 2009;284:24035-48 pubmed publisher
    ..Here we show that in macrophages, soluble biglycan induces the NLRP3/ASC inflammasome, activating caspase-1 and releasing mature IL-1beta without the need for additional costimulatory ..
  37. Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, et al. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. J Immunol. 2011;187:4890-9 pubmed publisher
    ..receptors such as nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2), is essentially required for the induction of caspase-1 activation by S...
  38. Sutterwala F, Ogura Y, Szczepanik M, Lara Tejero M, Lichtenberger G, Grant E, et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006;24:317-27 pubmed
    Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and chronic infantile neurologic cutaneous and articular syndrome...
  39. Shenoy A, Wellington D, Kumar P, Kassa H, Booth C, Cresswell P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 2012;336:481-5 pubmed publisher
    ..GBP5 promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents...
  40. Joly S, Ma N, Sadler J, Soll D, CASSEL S, Sutterwala F. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol. 2009;183:3578-81 pubmed publisher
    ..In this study we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the subsequent release of IL-1beta. The ability of C...
  41. Zheng Y, Lilo S, Brodsky I, Zhang Y, Medzhitov R, Marcu K, et al. A Yersinia effector with enhanced inhibitory activity on the NF-?B pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog. 2011;7:e1002026 pubmed publisher
    ..K+ efflux, NLRP3 and ASC were important for secretion of IL-1? in response to Y...
  42. Tsuchiya K, Hara H, Kawamura I, Nomura T, Yamamoto T, Daim S, et al. Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes. J Immunol. 2010;185:1186-95 pubmed publisher
    ..monocytogenes. Secretion of IL-1beta and IL-18 from Nod-like receptor family, pyrin domain containing 3 (NLRP3) and Nod-like receptor family, caspase-activating and recruitment domain containing 4 (NLRC4) knockout macrophages ..
  43. Iyer S, Pulskens W, Sadler J, Butter L, Teske G, Ulland T, et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A. 2009;106:20388-93 pubmed publisher
    ..Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the subsequent release of the proinflammatory cytokine IL-1beta...
  44. Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher
    ..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1. ..
  45. Sutterwala F, Mijares L, Li L, Ogura Y, Kazmierczak B, Flavell R. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med. 2007;204:3235-45 pubmed
    ..This study shows a key role for IPAF and capase-1 in innate immune responses to the pathogen P. aeruginosa, and also demonstrates that virulent ExoU-expressing strains of P. aeruginosa can circumvent this innate immune response. ..
  46. Ichinohe T, Lee H, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med. 2009;206:79-87 pubmed publisher
    ..Although NLRP3 was required for inflammasome activation in certain cell types, CD4 and CD8 T cell responses, as well as mucosal ..
  47. Li H, Willingham S, Ting J, Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol. 2008;181:17-21 pubmed
    ..IL-18, and IL-33 is mediated by the NLR (nucleotide-binding domain leucine-rich repeat-containing) protein NLRP3 and its adaptor ASC, but not by NLRC4...
  48. Hafner Bratkovic I, Bencina M, Fitzgerald K, Golenbock D, Jerala R. NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity. Cell Mol Life Sci. 2012;69:4215-28 pubmed publisher
    ..Microglia and macrophages release IL-1? upon stimulation by PrP fibrils, which depends on the NLRP3 inflammasome...
  49. Zhou R, Yazdi A, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221-5 pubmed publisher
    An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host 'danger', including infection and metabolic dysregulation...
  50. Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, et al. Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci U S A. 2010;107:20459-64 pubmed publisher
    ..show here that the suppressive effect by SEA on TLR signaling is simultaneously coupled to the activation of the Nlrp3 (NLR family, pyrin domain containing 3) inflammasome and thus IL-1? production...
  51. Muñoz Planillo R, Franchi L, Miller L, Nunez G. A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. J Immunol. 2009;183:3942-8 pubmed publisher
    The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood...
  52. Franchi L, Stoolman J, Kanneganti T, Verma A, Ramphal R, Nunez G. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol. 2007;37:3030-9 pubmed
    ..These results provide new insight into the interaction of P. aeruginosa with host macrophages and suggest that distinct regions of flagellin are sensed by Ipaf and TLR5. ..
  53. Kaushik D, Gupta M, Kumawat K, Basu A. NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis. PLoS ONE. 2012;7:e32270 pubmed publisher
    ..enzyme responsible for the maturation of both IL-1? and IL-18 in NACHT, LRR and PYD domains-containing protein-3 (NLRP3) dependent manner...
  54. Bauernfeind F, Bartok E, Rieger A, Franchi L, Nunez G, Hornung V. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol. 2011;187:613-7 pubmed publisher
    A common denominator among the multiple damage-inducing agents that ultimately lead to activation of NLRP3 has not yet been identified...
  55. Kanneganti T, Body Malapel M, Amer A, Park J, Whitfield J, Franchi L, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem. 2006;281:36560-8 pubmed
    ..to caspase-1 activation that is induced by double-stranded RNA (dsRNA) and viral infection that is mediated by Cryopyrin/Nalp3...
  56. Liu Z, Zaki M, Vogel P, Gurung P, Finlay B, Deng W, et al. Role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem. 2012;287:16955-64 pubmed publisher
    ..rodentium has not been characterized. Here, we show that mice lacking the inflammasome components Nlrp3, Nlrc4, and caspase-1 were hypersusceptible to C. rodentium-induced gastrointestinal inflammation...
  57. Seubert A, Calabro S, Santini L, Galli B, Genovese A, Valentini S, et al. Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. Proc Natl Acad Sci U S A. 2011;108:11169-74 pubmed publisher
    ..b>Nlrp3 inflammasome has been previously associated to the activity of alum, another adjuvant broadly used in human ..
  58. Case C, Shin S, Roy C. Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infect Immun. 2009;77:1981-91 pubmed publisher
    ..Activation of caspase-1 in macrophages occurred independently of Nalp3 and proteasome activity, suggesting that a previously uncharacterized mechanism for caspase-1 activation through ..
  59. Masters S, Dunne A, Subramanian S, Hull R, Tannahill G, Sharp F, et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1? in type 2 diabetes. Nat Immunol. 2010;11:897-904 pubmed publisher
    ..polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1?...
  60. Nakamura Y, Kambe N, Saito M, Nishikomori R, Nishikomiri R, Kim Y, et al. Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med. 2009;206:1037-46 pubmed publisher
    Urticarial rash observed in cryopyrin-associated periodic syndrome (CAPS) caused by nucleotide-binding oligomerization domain-leucine-rich repeats containing pyrin domain 3 (NLRP3) mutations is effectively suppressed by anti-interleukin (..
  61. Gasse P, Riteau N, Charron S, Girre S, Fick L, Petrilli V, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med. 2009;179:903-13 pubmed publisher
    ..To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating ..
  62. Stienstra R, Joosten L, Koenen T, van Tits B, van Diepen J, van den Berg S, et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 2010;12:593-605 pubmed publisher
    ..In addition, differentiation of preadipocytes isolated from caspase-1(-/-) or NLRP3(-/-) mice resulted in more metabolically active fat cells...
  63. Nakahira K, Haspel J, Rathinam V, Lee S, Dolinay T, Lam H, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12:222-30 pubmed publisher
    ..Release of mtDNA into the cytosol depended on the NALP3 inflammasome and mitochondrial reactive oxygen species (ROS)...
  64. Shio M, Tiemi Shio M, Eisenbarth S, Savaria M, Vinet A, Bellemare M, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009;5:e1000559 pubmed publisher
    ..we showed that Hz-induced IL-1beta and inflammation are dependent on NOD-like receptor containing pyrin domain 3 (NLRP3), ASC and caspase-1, but not NLRC4 (NLR containing CARD domain)...
  65. Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, et al. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol. 2010;11:912-9 pubmed publisher
  66. Rajan J, Warren S, Miao E, Aderem A. Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett. 2010;584:4627-32 pubmed publisher
    ..We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification...
  67. Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, et al. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med. 2011;17:996-1002 pubmed publisher
  68. McCall S, Sahraei M, Young A, Worley C, Duncan J, Ting J, et al. Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J Bone Miner Res. 2008;23:30-40 pubmed
    ..We showed that murine and human osteoblasts express NLRP3 (previously known as CIAS1, cryopyrin, PYPAF1, or NALP3) but not NLRC4 (IPAF) and showed that the level of expression of this cytosolic receptor is ..
  69. Craven R, Gao X, Allen I, Gris D, Bubeck Wardenburg J, McElvania TeKippe E, et al. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS ONE. 2009;4:e7446 pubmed publisher
    ..the Nucleotide-binding domain and leucine-rich repeat containing gene family, pyrin domain containing 3 protein (NLRP3)-inflammasome, a host inflammatory signaling complex involved in responses to pathogens and endogenous danger ..
  70. Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170-8 pubmed publisher
    ..P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1beta (IL-..
  71. Pan Q, Mathison J, Fearns C, Kravchenko V, da Silva Correia J, Hoffman H, et al. MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol. 2007;82:177-83 pubmed
    ..autoinflammatory syndrome 1 (CIAS1)/NACHT domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NALP3) has been suggested to be sufficient for MDP-dependent release of mature IL-1beta, but the role of Nod2 in this ..
  72. Hsu L, Ali S, McGillivray S, Tseng P, Mariathasan S, Humke E, et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008;105:7803-8 pubmed publisher
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion. ..
  73. Guarda G, Zenger M, Yazdi A, Schroder K, Ferrero I, Menu P, et al. Differential expression of NLRP3 among hematopoietic cells. J Immunol. 2011;186:2529-34 pubmed publisher
    Although the importance of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated, a precise characterization of NLRP3 expression is yet undetermined...
  74. Hirota J, Hirota S, Warner S, Stefanowicz D, Shaheen F, Beck P, et al. The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol. 2012;129:1116-25.e6 pubmed publisher
    ..The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses...
  75. Walter K, Holscher C, Tschopp J, Ehlers S. NALP3 is not necessary for early protection against experimental tuberculosis. Immunobiology. 2010;215:804-11 pubmed publisher
    ..Here, we analyzed the relevance of NALP3, one component of the danger-signaling inflammasome, for (i) Mtb-induced cytokine secretion in vitro and in vivo, (..
  76. Embry C, Franchi L, Nunez G, Mitchell T. Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A. Sci Signal. 2011;4:ra28 pubmed publisher
    ..Defective induction of NLRP3, which depends on MyD88, led to decreased assembly of components of the IL-1?-activating inflammasome required for ..
  77. Lichtnekert J, Kulkarni O, Mulay S, Rupanagudi K, Ryu M, Allam R, et al. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. PLoS ONE. 2011;6:e26778 pubmed publisher
    ..As the NLRP3 inflammasome and caspase-1 were shown to contribute to postischemic and postobstructive tubulointerstitial ..
  78. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11:136-40 pubmed publisher
    The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with several inflammatory diseases, yet little is known about the signaling pathways that lead to its activation...
  79. Allen I, Jania C, Wilson J, Tekeppe E, Hua X, BRICKEY W, et al. Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol. 2012;188:2884-93 pubmed publisher
    The contribution of NLRP3, a member of the nucleotide-binding domain leucine-rich repeat-containing (NLR) family, to the development of allergic airway disease is currently controversial...