Gene Symbol: Nlrc5
Description: NLR family, CARD domain containing 5
Alias: AI451557, AK220210, NOD27, protein NLRC5
Species: mouse
Products:     Nlrc5

Top Publications

  1. Meissner T, Li A, Biswas A, Lee K, Liu Y, Bayir E, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A. 2010;107:13794-9 pubmed publisher
    ..Here, we identify another member of the NLR protein family, NLRC5, as a transcriptional regulator of MHC class I genes...
  2. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, et al. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res. 2012;22:836-47 pubmed publisher
    ..b>NLRC5, the largest member of the NLR family, has recently attracted much attention...
  3. Robbins G, Truax A, Davis B, Zhang L, Brickey W, Ting J. Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem. 2012;287:24294-303 pubmed publisher
    ..Recently, human NLRC5 was found to regulate MHC-I in cell lines; however, a host of conflicting positive and negative functions has been ..
  4. Biswas A, Meissner T, Kawai T, Kobayashi K. Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator. J Immunol. 2012;189:516-20 pubmed publisher
    ..recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5/class I transactivator...
  5. Staehli F, Ludigs K, Heinz L, Seguín Estévez Q, Ferrero I, Braun M, et al. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol. 2012;188:3820-8 pubmed publisher
    ..The function of the family member NLR caspase recruitment domain containing protein 5 (NLRC5) remains a matter of debate, particularly with respect to NF-?B activation, type I IFN, and MHC I expression...
  6. Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, et al. NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections. J Immunol. 2011;186:994-1000 pubmed publisher
    ..b>NLRC5 is a recently identified member of the NLR family that has been implicated in positive and negative regulation of ..
  7. Chen Z, Ding T, Ma C. Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice. Biochem Biophys Res Commun. 2017;493:1143-1150 pubmed publisher
    ..No specific therapeutic strategies are available to attenuate I/R injury. NOD-, LRR-and CARD-containing 5 (NLRC5), a member of the NOD-like protein family, has been suggested to negatively regulate nuclear factor kappa B (NF-?B)..
  8. Tong Y, Cui J, Li Q, Zou J, Wang H, Wang R. Enhanced TLR-induced NF-?B signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 2012;22:822-35 pubmed publisher
    ..b>NLRC5 has recently been identified to be an important regulator of NF-?B, type I interferon (IFN) and inflammasome ..
  9. Ludigs K, Seguín Estévez Q, Lemeille S, Ferrero I, Rota G, Chelbi S, et al. NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module. PLoS Genet. 2015;11:e1005088 pubmed publisher
    ..b>NLRC5, another NLR protein, was recently found to control transcription of MHC class I (MHCI) genes...

More Information


  1. Lupfer C, Stokes K, Kuriakose T, Kanneganti T. Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance. J Virol. 2017;91: pubmed publisher
    ..The NLR family member NLRC5 regulates major histocompatibility complex class I (MHC-I) expression during various types of infections, but its ..
  2. Aachoui Y, Kajiwara Y, Leaf I, Mao D, Ting J, Coers J, et al. Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015;18:320-32 pubmed publisher
    ..thailandensis in vivo, they did not strictly require IFN-γ priming. Thus, caspase-1 provides priming signals upstream of caspase-11 but not caspase-4 during murine defense against a cytosol-invasive bacterium. ..
  3. Xu T, Ni M, Xing Li -, Li X, Meng X, Huang C, et al. NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. Int J Biochem Cell Biol. 2016;70:92-104 pubmed publisher
    ..b>NLRC5, the largest member of the NLR protein family, has recently been identified as a critical regulator of immune ..
  4. Liu X, Wu Y, Yang Y, Li W, Huang C, Meng X, et al. Role of NLRC5 in progression and reversal of hepatic fibrosis. Toxicol Appl Pharmacol. 2016;294:43-53 pubmed publisher
    b>NLRC5, as the largest member of NLRs family, has recently been identified as a critical regulator of immune responses through negatively regulating NF-κB which is associated with the development of hepatic fibrosis...
  5. Ma S, Xie X. NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4/NF-κB. Biomed Pharmacother. 2017;91:755-766 pubmed publisher
    ..The NOD-like protein family member, NLRC5, could interact with IKKα to inhibit IKK complex activation...
  6. Gutte P, Jurt S, Grutter M, Zerbe O. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. Biochemistry. 2014;53:3106-17 pubmed publisher
    ..b>NLRC5 contains an unclassified N-terminal effector domain that has been reported to interact downstream with the tandem ..
  7. Bagri P, Anipindi V, Nguyen P, Vitali D, Stampfli M, Kaushic C. Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination. J Virol. 2017;91: pubmed publisher
    ..This has important implications for developing effective vaccines against HSV-2, as we propose that strategies inducing IL-17A in the genital tract may promote more effective Th1 cell immunity and better overall protection. ..
  8. Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
    b>NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells...
  9. Cui J, Zhu L, Xia X, Wang H, Legras X, Hong J, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell. 2010;141:483-96 pubmed publisher
    ..Here, we show that NLRC5, a member of the highly conserved NOD-like protein family, can inhibit the IKK complex and RIG-I/MDA5 function...
  10. Ji J, Wang R. Molecular cloning of large alternative transcripts based on comparative phylogenetic analysis and exploration of an EST database. Anal Biochem. 2012;424:140-1 pubmed publisher
  11. Benko S, Magalhaes J, Philpott D, Girardin S. NLRC5 limits the activation of inflammatory pathways. J Immunol. 2010;185:1681-91 pubmed publisher
    ..In this study, we present the identification and characterization of NLRC5, a NLR protein whose expression is found predominantly in cells of the myeloid and lymphoid lineages...