Nkx1-2

Summary

Gene Symbol: Nkx1-2
Description: NK1 transcription factor related, locus 2 (Drosophila)
Alias: Nkx-1.1, Nkx-1.2, Sax1, NK1 transcription factor-related protein 2, homeobox protein SAX-1, spinal cord axial homeobox gene 1
Species: mouse

Top Publications

  1. ncbi The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1982-7. 2000
  2. ncbi Expression of the novel murine homeobox gene Sax-1 in the developing nervous system
    F R Schubert
    Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 51:99-114. 1995
  3. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997
  4. ncbi Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
    Y H Kim
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:25875-9. 1998
  5. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
  6. ncbi Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
  7. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
  8. ncbi Laminar organization of the early developing anterior hypothalamus
    Aurore Caqueret
    Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Dev Biol 298:95-106. 2006
  9. ncbi Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008

Scientific Experts

  • Rebecca Lee Yean Wong
  • Aurore Caqueret
  • E Catalani
  • Ruth Simon
  • J S Gaikwad
  • A C Rovescalli
  • M Lucattelli
  • Jacques L Michaud
  • Y H Kim
  • S Fineschi
  • M Dal Monte
  • Francine Boucher
  • C Gangitano
  • L Bosco
  • G Casini
  • P Bagnoli
  • A Gavalas
  • Thomas Lufkin
  • A Cavender
  • R N D'Souza
  • C A Kozak
  • M Nirenberg
  • F R Schubert
  • M Cinquanta
  • J Ferrante
  • M A Conti
  • Y Kim
  • C Y Choi
  • S J Lee
  • F M Rijli
  • P Chambon
  • A Lumsden
  • M Davenne
  • Y Gruenbaum
  • A Fainsod
  • P Gruss

Detail Information

Publications9

  1. ncbi The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1982-7. 2000
    ..Nkx-1.2 mRNA was found in embryos in highest abundance in 10-day embryos; the mRNA levels decrease during further development. Nkx-1.2 mRNA also was found in discrete zones of the embryonic mesencephalon and myelencephalon...
  2. ncbi Expression of the novel murine homeobox gene Sax-1 in the developing nervous system
    F R Schubert
    Abteilung für Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 51:99-114. 1995
    ..0 pc. Ventral shift and finally loss of the signal in the ventral spinal cord was observed in Danforth's short tail homozygotes...
  3. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997
    ..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres...
  4. ncbi Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
    Y H Kim
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:25875-9. 1998
    ..Thus, HIPKs represent a heretofore undescribed family of co-repressors for homeodomain transcription factors...
  5. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
  6. ncbi Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..uncharacterized murine homeobox gene, Sax2, that shows high similarity to the Drosophila S59/slouch and murine Sax1 genes...
  7. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
    ..The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species...
  8. ncbi Laminar organization of the early developing anterior hypothalamus
    Aurore Caqueret
    Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Dev Biol 298:95-106. 2006
    ..We examined the expression pattern of 10 of the identified genes--Cart, Cbln1, Alcam, Unc-13c, Rgs4, Lnx4, Irx3, Sax1, Ldb2 and Neurod6--by in situ hybridization in E12.5 embryos...
  9. ncbi Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...