NKp46

Summary

Gene Symbol: NKp46
Description: natural cytotoxicity triggering receptor 1
Alias: Ly94, NKp46, natural cytotoxicity triggering receptor 1, MAR1 (mouse activating receptor 1), NK-p46, activating receptor 1, lymphocyte antigen 94, mAR-1, mNKp46, natural killer cell p46-related protein
Species: mouse
Products:     NKp46

Top Publications

  1. Arnon T, Achdout H, Lieberman N, Gazit R, Gonen Gross T, Katz G, et al. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. Blood. 2004;103:664-72 pubmed
    ..of viral-infected and tumor cells is mediated in part via the lysis receptor of natural killer (NK) cells, NKp46. The nature, however, of its lysis ligands expressed on target cells is poorly defined...
  2. Guia S, Jaeger B, Piatek S, Mailfert S, Trombik T, Fenis A, et al. Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal. 2011;4:ra21 pubmed publisher
    ..We propose that the confinement of activating receptors at the plasma membrane is pivotal to ensuring the self-tolerance of NK cells. ..
  3. Biassoni R, Pessino A, Bottino C, Pende D, Moretta L, Moretta A. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999;29:1014-20 pubmed
    The NKp46 molecule has been proposed to play the role of triggering receptor in the natural cytotoxicity mediated by human NK cells. In this study we have identified the gene encoding the murine NKp46 homologue that we termed MAR-1...
  4. Satoh Takayama N, Lesjean Pottier S, Vieira P, Sawa S, Eberl G, Vosshenrich C, et al. IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med. 2010;207:273-80 pubmed publisher
    The natural cytotoxicity receptor NKp46 (encoded by Ncr1) was recently shown to identify a subset of noncytotoxic, Rag-independent gut lymphocytes that express the transcription factor Rorc, produce interleukin (IL)-22, and provide ..
  5. Gur C, Enk J, Kassem S, Suissa Y, Magenheim J, Stolovich Rain M, et al. Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46. J Immunol. 2011;187:3096-103 pubmed publisher
    ..We have recently shown that NKp46, a major killer receptor expressed by NK cells, recognizes an unknown ligand expressed by ? cells and that in the ..
  6. Narni Mancinelli E, Chaix J, Fenis A, Kerdiles Y, Yessaad N, Reynders A, et al. Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc Natl Acad Sci U S A. 2011;108:18324-9 pubmed publisher
    b>NKp46 is a cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL-22 and express the transcription factor retinoid-related orphan receptor ..
  7. Satoh Takayama N, Vosshenrich C, Lesjean Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29:958-70 pubmed publisher
    ..In this report, we characterized intestinal lymphocytes expressing the NK cell natural cytotoxicity receptor NKp46. Gut NKp46+ cells were distinguished from classical NK cells by limited IFN-gamma production and absence of ..
  8. Walzer T, Blery M, Chaix J, Fuseri N, Chasson L, Robbins S, et al. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A. 2007;104:3384-9 pubmed
    ..b>NKp46/CD335 is an Ig-like superfamily cell surface receptor involved in human NK cell activation...
  9. Satoh Takayama N, Dumoutier L, Lesjean Pottier S, Ribeiro V, Mandelboim O, Renauld J, et al. The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium. J Immunol. 2009;183:6579-87 pubmed publisher
    Natural cytotoxicity receptors (including NKp30, NKp44, and NKp46 in humans and NKp46 in mice) are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-..

More Information

Publications62

  1. Elboim M, Gazit R, Gur C, Ghadially H, Betser Cohen G, Mandelboim O. Tumor immunoediting by NKp46. J Immunol. 2010;184:5637-44 pubmed publisher
    NK cells interact with a wide variety of hazardous cells including pathogen-infected and tumor cells. NKp46 is a specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands...
  2. Narni Mancinelli E, Jaeger B, Bernat C, Fenis A, Kung S, de Gassart A, et al. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science. 2012;335:344-8 pubmed publisher
    ..and functional analysis revealed a loss-of-function mutation in the Ncr1 gene encoding the activating receptor NKp46. The down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription ..
  3. Gazit R, Gruda R, Elboim M, Arnon T, Katz G, Achdout H, et al. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 2006;7:517-23 pubmed
    ..To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette...
  4. Gur C, Porgador A, Elboim M, Gazit R, Mizrahi S, Stern Ginossar N, et al. The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol. 2010;11:121-8 pubmed publisher
    ..Here we show that the activating receptor NKp46 recognizes mouse and human ligands on pancreatic beta cells...
  5. Chaushu S, Wilensky A, Gur C, Shapira L, Elboim M, Halftek G, et al. Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. PLoS Pathog. 2012;8:e1002601 pubmed publisher
    ..Here, we investigate the role played by the NK killer receptor NKp46 (NCR1 in mice), in the pathogenesis of periodontitis...
  6. Halfteck G, Elboim M, Gur C, Achdout H, Ghadially H, Mandelboim O. Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1. J Immunol. 2009;182:2221-30 pubmed publisher
    ..Whether NK cells and specifically the NK-activating receptor NKp46 (NCR1 in mice) are directly involved in tumor eradication in vivo is still largely unknown...
  7. Ghadially H, Ohana M, Elboim M, Gazit R, Gur C, Nagler A, et al. NK cell receptor NKp46 regulates graft-versus-host disease. Cell Rep. 2014;7:1809-14 pubmed publisher
    ..Here, we demonstrate that in the absence of NKp46, a major killer receptor expressed by human and mouse natural killer (NK) cells, GVHD is greatly exacerbated, ..
  8. Rankin L, Girard Madoux M, Seillet C, Mielke L, Kerdiles Y, Fenis A, et al. Complementarity and redundancy of IL-22-producing innate lymphoid cells. Nat Immunol. 2016;17:179-86 pubmed publisher
    ..Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent ..
  9. Deguine J, Breart B, Lemaitre F, Bousso P. Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions. J Immunol. 2012;189:5493-7 pubmed publisher
    ..Thus, complementary signals mediated by recognition of stress ligands and tumor-specific Abs may contribute to the efficacy of NK cells during mAb therapy. ..
  10. Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
    ..These findings strongly suggest that endogenous T cells with low MHCI expression become NK-cell targets, having thus important implications for T-cell responses in naturally or therapeutically induced inflammatory conditions. ..
  11. Yu J, Mitsui T, Wei M, Mao H, Butchar J, Shah M, et al. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest. 2011;121:1456-70 pubmed publisher
    ..Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic...
  12. Viel S, Marçais A, Guimaraes F, Loftus R, Rabilloud J, Grau M, et al. TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal. 2016;9:ra19 pubmed publisher
    ..Moreover, we propose that boosting the metabolic activity of antitumor lymphocytes could be an effective strategy to promote immune-mediated tumor suppression. ..
  13. Verrier T, Satoh Takayama N, Serafini N, Marie S, Di Santo J, Vosshenrich C. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells. J Immunol. 2016;196:4731-8 pubmed publisher
    ..promotes lymphoid organogenesis and a CCR6(-)T-bet(+) subset that emerges after microbial colonization and harbors NKp46(+) ILC3. We demonstrate that NKp46 expression in the ILC3 subset is highly unstable...
  14. Diab M, Glasner A, Isaacson B, Bar On Y, Drori Y, Yamin R, et al. NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Eur J Immunol. 2017;47:692-703 pubmed publisher
    ..reporter assays and NK-cell cytotoxicity assays performed with human and mouse NK cells, we demonstrated that the NKp46-activating receptor and its mouse orthologue Ncr1, both members of the natural cytotoxicity receptor (NCR) family, ..
  15. Putz E, Mayfosh A, Kos K, Barkauskas D, Nakamura K, Town L, et al. NK cell heparanase controls tumor invasion and immune surveillance. J Clin Invest. 2017;127:2777-2788 pubmed publisher
    ..However, mice lacking heparanase specifically in NK cells (Hpsefl/fl NKp46-iCre mice) were highly tumor prone when challenged with the carcinogen methylcholanthrene (MCA)...
  16. O Sullivan T, Johnson L, Kang H, Sun J. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015;43:331-42 pubmed publisher
    ..Thus, our study reveals the functional importance of mitophagy during the dynamic response of these cytolytic innate lymphocytes. ..
  17. Jang Y, Gerbec Z, Won T, Choi B, Podsiad A, B Moore B, et al. Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection. J Immunol. 2018;200:1982-1987 pubmed publisher
    ..This work sheds light on potential confounding experimental interpretation when this congenic strain is used as a tool for tracking lymphocyte development. ..
  18. Aliahmad P, de la Torre B, Kaye J. Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat Immunol. 2010;11:945-52 pubmed publisher
    ..Thus, many cell lineages of the immune system share a TOX-dependent step for development...
  19. Marcais A, Cherfils Vicini J, Viant C, Degouve S, Viel S, Fenis A, et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol. 2014;15:749-757 pubmed publisher
    ..The mTORC1 inhibitor rapamycin inhibited NK cell cytotoxicity both in mice and humans; this probably contributes to the immunosuppressive activity of this drug in different clinical settings. ..
  20. Satoh Takayama N, Serafini N, Verrier T, Rekiki A, Renauld J, Frankel G, et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity. 2014;41:776-88 pubmed publisher
    ..Intestinal ILC3s expressed CXCR6 and its ablation generated a selective loss of the NKp46(+) ILC3 subset, a depletion of intestinal IL-22, and the inability to control C. rodentium infection...
  21. Cortez V, Ulland T, Cervantes Barragan L, Bando J, Robinette M, Wang Q, et al. SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling. Nat Immunol. 2017;18:995-1003 pubmed publisher
    ..NK cells from a SMAD4-deficient person affected by polyposis were also hyper-responsive to TGF-β. These results identify SMAD4 as a previously unknown regulator that restricts non-canonical TGF-β signaling in NK cells. ..
  22. Elhaik Goldman S, Moshkovits I, Shemesh A, Filiba A, Tsirulsky Y, Vronov E, et al. Natural Killer Receptor 1 Dampens the Development of Allergic Eosinophilic Airway Inflammation. PLoS ONE. 2016;11:e0160779 pubmed publisher
    ..IL-17 and TNF? expression increased only in OVA-immunized NCR1+/+mice. IL-6 mRNA increased only in OVA immunized NCR1gfp/gfp mice. Collectively, it is demonstrated that NCR1 dampens allergic eosinophilic airway inflammation. ..
  23. Freund Brown J, Choa R, Singh B, Robertson T, Ferry G, Viver E, et al. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. J Immunol. 2017;: pubmed publisher
    ..Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes. ..
  24. Sathe P, Delconte R, Souza Fonseca Guimaraes F, Seillet C, Chopin M, Vandenberg C, et al. Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells. Nat Commun. 2014;5:4539 pubmed publisher
    ..These results clearly demonstrate a non-redundant pathway linking IL-15 to Mcl1 in the maintenance of NK cells and innate immune responses in vivo. ..
  25. Vitenshtein A, Charpak Amikam Y, Yamin R, Bauman Y, Isaacson B, Stein N, et al. NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7. Cell Host Microbe. 2016;20:527-534 pubmed publisher
    ..we describe the recognition of an emerging fungal pathogen, Candida glabrata, by the human NK cytotoxic receptor NKp46 and its mouse ortholog, NCR1...
  26. Ghadially H, Horani A, Glasner A, Elboim M, Gazit R, Shoseyov D, et al. NKp46 regulates allergic responses. Eur J Immunol. 2013;43:3006-16 pubmed publisher
    ..namely the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice)...
  27. Elhaik Goldman S, Kafka D, Yossef R, Hadad U, Elkabets M, Vallon Eberhard A, et al. The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk. PLoS ONE. 2011;6:e23472 pubmed publisher
    ..Overall, our results point to the essential contribution of NK-expressed NCR1 in early response to S. pneumoniae infection and to NCR1-mediated interaction of NK and S. pneumoniae infected-macrophages and -DC. ..
  28. Miletić A, Lenartic M, Popovic B, Brizic I, Trsan T, Miklic K, et al. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. Eur J Immunol. 2017;47:1443-1456 pubmed publisher
    b>NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens...
  29. Beuneu H, Deguine J, Breart B, Mandelboim O, Di Santo J, Bousso P. Dynamic behavior of NK cells during activation in lymph nodes. Blood. 2009;114:3227-34 pubmed publisher
    ..That NK cells become activated while remaining motile may constitute an efficient strategy for sampling local concentrations of cytokines around DCs in secondary lymphoid tissues. ..
  30. Eggenhofer E, Sabet Rashedi M, Lantow M, Renner P, Rovira J, Koehl G, et al. RORγt(+) IL-22-producing NKp46(+) cells protect from hepatic ischemia reperfusion injury in mice. J Hepatol. 2016;64:128-34 pubmed publisher
    b>NKp46(+) cells are major effector cells in the pathogenesis of hepatic ischemia reperfusion injury (IRI). Nevertheless, the precise role of unconventional subsets like the IL-22-producing NKp46(+) cells (NK22) remains unknown...
  31. Eisenring M, Vom Berg J, Kristiansen G, Saller E, Becher B. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol. 2010;11:1030-8 pubmed publisher
    ..IL-12 initiated local antitumor immunity by stimulating a subset of NKp46(+) lymphoid tissue-inducer (LTi) cells dependent on the transcription factor ROR?t...
  32. Deguine J, Breart B, Lemaitre F, Di Santo J, Bousso P. Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression. Immunity. 2010;33:632-44 pubmed publisher
    ..Altogether, our results offer mechanistic insight into how NK cells and CTLs can exert cytotoxic activity with remarkably different contact dynamics. ..
  33. Martinet L, Ferrari de Andrade L, Guillerey C, Lee J, Liu J, Souza Fonseca Guimaraes F, et al. DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 2015;11:85-97 pubmed publisher
    ..Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression. ..
  34. Glasner A, Ghadially H, Gur C, Stanietsky N, Tsukerman P, Enk J, et al. Recognition and prevention of tumor metastasis by the NK receptor NKp46/NCR1. J Immunol. 2012;188:2509-15 pubmed publisher
    ..Prominent among these receptors are the natural cytotoxicity receptors (NCRs) (NKp30, NKp44, and NKp46), of which only NKp46 has a mouse ortholog (NCR1)...
  35. Aparicio Domingo P, Romera Hernandez M, Karrich J, Cornelissen F, Papazian N, Lindenbergh Kortleve D, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med. 2015;212:1783-91 pubmed publisher
    ..These data unveil a novel function of ILC3s in limiting tissue damage by preserving tissue-specific stem cells. ..
  36. Viant C, Fenis A, Chicanne G, Payrastre B, Ugolini S, Vivier E. SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells. Nat Commun. 2014;5:5108 pubmed publisher
    ..Mice without SHP-1 in NK cells are unable to reject MHC class I-deficient transplants and to control tumours in vivo. Thus, the inhibitory activity of SHP-1 is needed for setting the threshold of NK cell reactivity. ..
  37. Marcais A, Marotel M, Degouve S, Koenig A, Fauteux Daniel S, Drouillard A, et al. High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors. elife. 2017;6: pubmed publisher
    ..These results demonstrate that mTOR acts as a molecular rheostat of NK cell reactivity controlled by educating receptors and uncover how cytokine stimulation overcomes NK cell education. ..
  38. Garcia Z, Lemaitre F, Van Rooijen N, Albert M, Levy Y, Schwartz O, et al. Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles. Blood. 2012;120:4744-50 pubmed publisher
    ..Our results identify SCS macrophages as primary mediators of NK cell activation in response to lymph-borne viral particles suggesting that they act as early sensors of local infection or delivery of viral-based vaccines. ..
  39. Glasner A, Simic H, Miklić K, Roth Z, Berhani O, Khalaila I, et al. Expression, Function, and Molecular Properties of the Killer Receptor Ncr1-Noé. J Immunol. 2015;195:3959-69 pubmed publisher
    NK cells kill various cells using activating receptors, such as the natural cytotoxicity receptors (NCRs). NKp46 is a major NCR and is the only NCR expressed in mice (denoted Ncr1)...
  40. Ge M, Kokalari B, Flayer C, Killingbeck S, Redai I, MacFarlane A, et al. Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure. J Immunol. 2016;196:553-7 pubmed publisher
    ..Notably, addition of recombinant SP-D to naive mononuclear cells stimulated IFN-γ release in vitro. Because NKp46, a glycosylated membrane receptor, was necessary for dose-dependent SP-D binding to NK cells in vitro and DC ..
  41. Madera S, Rapp M, Firth M, Beilke J, Lanier L, Sun J. Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med. 2016;213:225-33 pubmed publisher
    ..Our study reveals a novel type I IFN-dependent mechanism by which NK cells evade mechanisms of cell death after viral infection. ..
  42. Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, et al. Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1. Immunity. 2014;40:961-73 pubmed publisher
    ..Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack...
  43. Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008;453:1117-21 pubmed publisher
  44. Sheppard S, Triulzi C, Ardolino M, Serna D, Zhang L, Raulet D, et al. Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire. Blood. 2013;121:5025-33 pubmed publisher
    The immunoreceptors NKG2D and NKp46 are known for their capacity to activate natural killer (NK) cell cytotoxicity and secretory responses in the contexts of tumors and infections, yet their roles in NK cell education remain unclear...
  45. O Sullivan T, Geary C, Weizman O, Geiger T, Rapp M, Dorn G, et al. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep. 2016;15:1910-9 pubmed publisher
    ..These findings highlight the essential role for autophagy in ILC development and lymphocyte survival during lymphopenia. ..
  46. Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y, Chen X, et al. Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function. Immunity. 2015;42:457-70 pubmed publisher
    ..Collectively, our data reveal a regulatory pathway by which the negative regulator Foxo1 and the positive regulator Tbx21 play opposing roles in controlling NK cell development and effector functions. ..
  47. Glasner A, Zurunic A, Meningher T, Lenac Rovis T, Tsukerman P, Bar On Y, et al. Elucidating the mechanisms of influenza virus recognition by Ncr1. PLoS ONE. 2012;7:e36837 pubmed publisher
    ..inhibitory and activating receptors; the later include proteins such as the Natural Cytotoxicity Receptors (NCRs: NKp46, NKp44 and NKp30). Among the NCRs, NKp46 is the only receptor that has a mouse orthologue named Ncr1...
  48. Abram C, Roberge G, Hu Y, Lowell C. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods. 2014;408:89-100 pubmed publisher
    ..By focusing on myeloid subsets, we directly compare the relative efficiency and specificity of myeloid deletion in these strains under steady-state conditions. ..
  49. Felker A, Chen Z, Foster W, Croy B. Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice. Placenta. 2013;34:757-64 pubmed publisher
    ..Expression of AHR and NCR1 (ortholog of human NKp46) by gestation day (gd)10.5 mouse uNK cell subsets was measured by quantitative real-time RT-PCR...
  50. Song C, Lee J, Gilfillan S, Robinette M, Newberry R, Stappenbeck T, et al. Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med. 2015;212:1869-82 pubmed publisher
    Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 and include lymphoid tissue-inducer (LTi)-like and NKp46(+) subsets...
  51. Narni Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane A, et al. Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017;2: pubmed publisher
    ..The nature of some of these ligands remains unclear, limiting our understanding of ILC biology. We focused on NKp46, which is highly conserved in mammals and expressed by all mature NK cells and subsets of ILC1 and ILC3...
  52. Jaeger B, Donadieu J, Cognet C, Bernat C, Ordoñez Rueda D, Barlogis V, et al. Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med. 2012;209:565-80 pubmed publisher
    ..These findings reveal novel types of cooperation between cells of the innate immune system and prompt examination of NK cell functional deficiency in patients suffering from neutropenia-associated diseases. ..
  53. Bessoles S, Angelov G, Back J, Leclercq G, Vivier E, Held W. Education of murine NK cells requires both cis and trans recognition of MHC class I molecules. J Immunol. 2013;191:5044-51 pubmed publisher
    ..These data suggest that two separate functions of MHC-I receptors are needed to adapt NK cells to self-MHC-I. ..