Gene Symbol: Nkd1
Description: naked cuticle 1
Alias: 2810434J10Rik, 9030215G15Rik, Nkd, protein naked cuticle homolog 1, mNkd, mNkd1, naked cuticle 1 homolog, naked-1
Species: mouse
Products:     Nkd1

Top Publications

  1. Creyghton M, Roël G, Eichhorn P, Hijmans E, Maurer I, Destree O, et al. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 2005;19:376-86 pubmed
    ..Moreover, PR72 is required during early embryonic development to regulate cell morphogenetic movements during body axis formation. ..
  2. van de Ven C, Bialecka M, Neijts R, Young T, Rowland J, Stringer E, et al. Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development. 2011;138:3451-62 pubmed publisher
    ..They shed a new light on the etiology of the caudal dysplasia or caudal regression range of human congenital defects. ..
  3. Muñoz Espín D, Canamero M, Maraver A, Gomez Lopez G, Contreras J, Murillo Cuesta S, et al. Programmed cell senescence during mammalian embryonic development. Cell. 2013;155:1104-18 pubmed publisher
    ..We conclude that the role of developmentally programmed senescence is to promote tissue remodeling and propose that this is the evolutionary origin of damage-induced senescence. ..
  4. Yan D, Wallingford J, Sun T, Nelson A, Sakanaka C, Reinhard C, et al. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001;98:3802-7 pubmed
    ..2000) Nature (London) 403, 789--795]. Here we have cloned a cDNA encoding a mammalian homolog of Drosophila Nkd, mNkd, and demonstrated that mNkd interacts directly with Dishevelled...
  5. Ishikawa A, Kitajima S, Takahashi Y, Kokubo H, Kanno J, Inoue T, et al. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev. 2004;121:1443-53 pubmed
    ..In a screen for novel genes involved in somitogenesis, we identified a gene encoding a Wnt antagonist, Nkd1, which is transcribed in an oscillatory manner, and may represent a new member of the molecular clock constituents...
  6. Zhang T, Hoffman B, Ruiz de Algara T, Helgason C. SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expr Patterns. 2006;6:310-24 pubmed
    ..These studies provide the first evidence that Wnt pathway members are expressed in the developing prostate. Functional analyses are now required to establish the biological significance of this observation. ..
  7. Wharton K, Zimmermann G, Rousset R, Scott M. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001;234:93-106 pubmed
    ..Here we describe two mouse and human proteins, Nkd1 and Nkd2, related to fly Nkd...
  8. Poobalasingam T, Yates L, Walker S, Pereira M, Gross N, Ali A, et al. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017;10:409-423 pubmed publisher
    ..Our data reveal an important novel role for the PCP pathway in adult lung homeostasis and repair and shed new light on the genetic factors which may modify destructive lung diseases such as emphysema. ..
  9. Kim W, Matsui T, Yamao M, Ishibashi M, Tamada K, Takumi T, et al. The period of the somite segmentation clock is sensitive to Notch activity. Mol Biol Cell. 2011;22:3541-9 pubmed publisher
    ..Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs. ..

More Information


  1. Nakamura T, Saito D, Kawasumi A, Shinohara K, Asai Y, Takaoka K, et al. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nat Commun. 2012;3:1322 pubmed publisher
    ..Mathematical modelling and experimental data suggest that these feedback loops behave as a bistable switch that can amplify in a noise-resistant manner a small bias conferred by fluid flow. ..
  2. Li Q, Ishikawa T, Miyoshi H, Oshima M, Taketo M. A targeted mutation of Nkd1 impairs mouse spermatogenesis. J Biol Chem. 2005;280:2831-9 pubmed
    b>Nkd1 is an antagonist of the canonical Wnt/beta-catenin signaling pathway. The EF-hand motif of Nkd1 is required for its inhibitory function...
  3. Nakaya M, Biris K, Tsukiyama T, Jaime S, Rawls J, Yamaguchi T. Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development. 2005;132:5425-36 pubmed
    ..Thus, Wnt3a links the segmentation clock and AP axis elongation with key left-determining events, suggesting that Wnt3a is an integral component of the trunk organizer. ..
  4. Zhang S, Cagatay T, Amanai M, Zhang M, Kline J, Castrillon D, et al. Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol. 2007;27:4454-64 pubmed
    ..Mice and humans have two nkd homologs, nkd1 and nkd2, whose encoded proteins can bind Dsh homologs (the Dvl proteins) and inhibit Wnt signaling...
  5. O Brien K, Alberich Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, et al. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010;137:2147-56 pubmed publisher
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells. ..
  6. Pan X, Karner C, Carroll T. Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells. Development. 2017;144:4173-4182 pubmed publisher