Gene Symbol: NK1.1
Description: killer cell lectin-like receptor subfamily B member 1C
Alias: AI462337, CD161, Klrb1b, Ly-59, Ly55c, Ly59, NK-RP1, NK1.1, NKR-P1.9, NKRP1, NKRP140, Nk-1, Nk-1.2, Nk1, Nk1.2, Nkrp1b, Nkrp1c, ly-55c, killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, NKR-P1 40, NKR-P1B, killer cell lectin-like receptor subfamily A member 1C, lymphocyte antigen 55 complex, locus C, lymphocyte antigen 55c, lymphocyte antigen 59, natural killer cell receptor protein NKR-P1C, natural killer cell receptor-P1, natural killer cell surface protein P1-40, natural killer cell-associated antigen 1
Species: mouse
Products:     NK1.1

Top Publications

  1. Poulton L, Smyth M, Hawke C, Silveira P, Shepherd D, Naidenko O, et al. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol. 2001;13:887-96 pubmed
    ..Here, we have generated a congenic line of NOD mice (NOD.b-Nkrp1(b)) which express the allelic NK1.1 marker, enabling the direct study of NK and NKT cells in NOD mice...
  2. Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T. Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol. 2003;224:98-105 pubmed
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo. ..
  3. Carlyle J, Martin A, Mehra A, Attisano L, Tsui F, Zúñiga Pflücker J. Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. J Immunol. 1999;162:5917-23 pubmed
    The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag...
  4. Brown M, Fulmek S, Matsumoto K, Cho R, Lyons P, Levy E, et al. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics. 1997;42:16-25 pubmed
    ..Herein we show that Nkrp1 genes are clustered in a region flanked by A2m and Cd69 genes and that most Ly49 genes are clustered in a distal ..
  5. Plougastel B, Matsumoto K, Dubbelde C, Yokoyama W. Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Immunogenetics. 2001;53:592-8 pubmed
    The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells. This family includes the gene for NKR-P1C (NK1...
  6. Ljutic B, Carlyle J, Filipp D, Nakagawa R, Julius M, Zuniga Pflucker J. Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors. J Immunol. 2005;174:4789-96 pubmed
    The NK cell receptor protein 1 (NKR-P1) (CD161) molecules represent a family of type II transmembrane C-type lectin-like receptors expressed predominantly by NK cells. Despite sharing a common NK1...
  7. Tian W, Nunez R, Cheng S, Ding Y, Tumang J, Lyddane C, et al. C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Cell Immunol. 2005;234:39-53 pubmed
    ..Our studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo. ..
  8. Blasius A, Barchet W, Cella M, Colonna M. Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J Exp Med. 2007;204:2561-8 pubmed
    Lymphoid organs contain a B220(+)CD11c(+)NK1.1(+) cell population that was recently characterized as a novel dendritic cell (DC) subset that functionally overlaps with natural killer (NK) cells and plasmacytoid DCs (PDCs)...
  9. Aust J, Gays F, Mickiewicz K, Buchanan E, Brooks C. The expression and function of the NKRP1 receptor family in C57BL/6 mice. J Immunol. 2009;183:106-16 pubmed publisher
    ..NKRP1A, D, and F expression could not be detected on NKT cells, all of which express NKRP1C, and although some activated T cells expressed NKRP1C and perhaps low levels of NKRP1A, no significant expression ..

More Information


  1. Carlyle J, Jamieson A, Gasser S, Clingan C, Arase H, Raulet D. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004;101:3527-32 pubmed
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells. ..
  2. Ryan J, Turck J, Niemi E, Yokoyama W, Seaman W. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol. 1992;149:1631-5 pubmed
    In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1...
  3. Yokoyama W, Ryan J, Hunter J, Smith H, Stark M, Seaman W. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991;147:3229-36 pubmed
    ..We have termed this genetic region the NK complex. ..
  4. Chen P, Belanger S, Aguilar O, Zhang Q, St Laurent A, Rahim M, et al. Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor-ligand interactions despite significant allelic polymorphism. Immunogenetics. 2011;63:627-40 pubmed publisher
    ..g., Nkrp1b,c)...
  5. Carlyle J, Mesci A, Ljutic B, Belanger S, Tai L, Rousselle E, et al. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006;176:7511-24 pubmed
    ..In fact, significant divergence is confined to the Nkrp1b and Nkrp1c genes...
  6. Ho E, Heusel J, Brown M, Matsumoto K, Scalzo A, Yokoyama W. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc Natl Acad Sci U S A. 1998;95:6320-5 pubmed
    ..Thus, these data indicate the expanding complexity of the NK complex and the corresponding repertoire of C-type lectin-like receptors on murine NK cells. ..
  7. Mathew P, Garni Wagner B, Land K, Takashima A, Stoneman E, Bennett M, et al. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993;151:5328-37 pubmed
    ..The 2B4 gene has been mapped to mouse chromosome 1 by analysis of 2B4 expression in recombinant inbred mouse strains. ..
  8. Giorda R, Weisberg E, Ip T, Trucco M. Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1. J Immunol. 1992;149:1957-63 pubmed
    ..NKR-P1 expression appears to coincide with that of the NK1.1 Ag. This observation further supports the hypothesis that the NK1.1 Ag is encoded by one of the NKR-P1 genes...
  9. Mendiratta S, Martin W, Hong S, Boesteanu A, Joyce S, van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997;6:469-77 pubmed
    ..T cells, termed natural T (NT) cells, that coexpress the T cell receptor (TCR) and the natural killer cell receptor NK1.1...
  10. Scalzo A, Fitzgerald N, Wallace C, Gibbons A, Smart Y, Burton R, et al. The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol. 1992;149:581-9 pubmed
    ..In contrast, in vivo depletion of NK cells by injection of the anti-NK1.1 mAb PK136 abrogated restricted splenic virus replication in C57BL/6J----BALB...
  11. Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim K, et al. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009;206:2987-3000 pubmed publisher
    ..Thus, GATA-3 is required for the cell-autonomous development of the earliest characterized thymic T cell progenitors. ..
  12. Marie J, Liggitt D, Rudensky A. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity. 2006;25:441-54 pubmed
    ..Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity. ..
  13. Kawamura T, Koka R, Ma A, Kumar V. Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction. J Immunol. 2003;171:5085-90 pubmed
    ..These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells...
  14. Kolenko P, Rozbeský D, Vanek O, Kopecký V, Hofbauerová K, Novak P, et al. Molecular architecture of mouse activating NKR-P1 receptors. J Struct Biol. 2011;175:434-41 pubmed publisher
    ..A functional dimeric form of the receptor is suggested, with the loop, evolutionarily conserved within this family, proposed to participate in interactions with ligands. ..
  15. Depatie C, Chalifour A, Pare C, Lee S, Vidal S, Lemieux S. Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets. Int Immunol. 1999;11:1541-51 pubmed
    ..Whether residual NK cells, post-depletion, belong to a particular subset expressing another Ly49 receptor, or a molecule encoded by a yet to be identified gene of the NKC, is discussed. ..
  16. Beutner U, Launois P, Ohteki T, Louis J, MacDonald H. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997;27:928-34 pubmed
    ..cell-related surface markers such as interleukin-2 receptor beta (IL-2R beta; CD122) and the polymorphic antigen NK1.1...
  17. Aliahmad P, de la Torre B, Kaye J. Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat Immunol. 2010;11:945-52 pubmed publisher
    ..Thus, many cell lineages of the immune system share a TOX-dependent step for development...
  18. Haas J, González F, Schmitz S, Chennupati V, Föhse L, Kremmer E, et al. CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol. 2009;39:3488-97 pubmed publisher
    ..T cells of the adult thymus are segregated into two lineages by the mutually exclusive expression of CCR6 and NK1.1. Only CCR6+ gammadelta T cells produced IL-17A, while NK1...
  19. Taherzadeh Z, Vanbavel E, de Vos J, Matlung H, Van Montfrans G, Brewster L, et al. Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex. Am J Physiol Heart Circ Physiol. 2010;298:H1273-82 pubmed publisher
    ..Cellular colocalization of CD11b with NK1.1 indicated the recruitment of NK cells in C57BL/6 mice. Congenic BALB...
  20. Kung S, Su R, Shannon J, Miller R. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. J Immunol. 1999;162:5876-87 pubmed
    ..Therefore, the mouse NKR-P1 gene family, like the Ly49 family, includes both activation and inhibitory receptors. ..
  21. Doisne J, Soulard V, Becourt C, Amniai L, Henrot P, Havenar Daughton C, et al. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol. 2011;186:662-6 pubmed publisher
    We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor ?t(+) NK1.1(-) invariant NKT (iNKT) cells produce IL-17A independently of IL-6...
  22. Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, et al. Involvement of NK 1.1-positive ??T cells in interleukin-18 plus interleukin-2-induced interstitial lung disease. Am J Respir Cell Mol Biol. 2011;45:659-66 pubmed publisher
    ..An accumulation of NK1.1(+) ??T cells similar to NK cells was evident in the lungs. The T Cell Receptor (TCR) V? and V? repertoires of NK1...
  23. Asjo B, Kiessling R, Klein G, Povey S. Genetic variation in antibody response and natural killer cell activity against a Moloney virus-induced lymphoma (YAC). Eur J Immunol. 1977;7:554-8 pubmed
    ..There was no relationship between the segregation of natural killer cell activity and antibody response in a [(A X C57BL) X A] backcross population. ..
  24. Emoto M, Yoshizawa I, Emoto Y, Takahashi Y, Hurwitz R, Miamoto M, et al. Reversible NK1.1 surface expression on invariant liver natural killer T cells during Listeria monocytogenes infection. Microbes Infect. 2007;9:1511-20 pubmed
    ..Despite their name, the iNKT cells represent a heterogeneous population, which can be divided on the basis of NK1.1 surface expression. Here we show that NK1...
  25. Tamada K, Harada M, Ito O, Takenoyama M, Mori T, Matsuzaki G, et al. The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumour-infiltrating lymphocytes: a possible role of transforming growth factor-beta. Immunology. 1996;89:627-35 pubmed
    ..TGF-beta could be an autocrine growth factor for NKL1.1+ T cells and thereby induce non-cytolytic NK1.1+ T cells in the long-term culture of TIL.
  26. Koizumi S, Wakita D, Sato T, Mitamura R, Izumo T, Shibata H, et al. Essential role of Toll-like receptors for dendritic cell and NK1.1(+) cell-dependent activation of type 1 immunity by Lactobacillus pentosus strain S-PT84. Immunol Lett. 2008;120:14-9 pubmed publisher
    ..We further revealed that NK1.1 positive NK cells and NKT cells are responsible cells for producing IFN-gamma after stimulation with S-PT84 in ..
  27. Burton R, Winn H. Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum. J Immunol. 1981;126:1985-9 pubmed
    ..2, and the corresponding antibodies as anti-NK-1.2. However, the possibility that CE anti-CBA serum detects a new system of NK-specific antigen has not been excluded. ..
  28. Qian X, Hu C, Han S, Lin Z, Xiao W, Ding Y, et al. NK1.1- CD4+ NKG2D+ T cells suppress DSS-induced colitis in mice through production of TGF-?. J Cell Mol Med. 2017;21:1431-1444 pubmed publisher
    ..Here, murine CD4+ NKG2D+ T cells were further classified into NK1.1- CD4+ NKG2D+ and NK1...
  29. Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
    ..Collectively, our results indicate that an excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes. ..
  30. Ruiz A, Soudja S, Deceneux C, Lauvau G, Marie J. NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response. Nat Commun. 2014;5:5150 pubmed publisher
    ..Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1...
  31. Muniz L, Pacer M, Lira S, Furtado G. A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures. J Immunol. 2011;187:828-34 pubmed publisher
    ..Taken together, these data suggest a critical role for CD11c(+) DCs in the induction of lymphangiogenesis in tertiary lymphoid structures...
  32. Jordan M, Fletcher J, Pellicci D, Baxter A. Slamf1, the NKT cell control gene Nkt1. J Immunol. 2007;178:1618-27 pubmed
    ..In this study, we report the production and characterization of a NOD.Nkrp1(b)...
  33. Zhang Q, Rahim M, Allan D, Tu M, Belanger S, Abou Samra E, et al. Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance. PLoS ONE. 2012;7:e50561 pubmed publisher
    ..Nkrp1 evolutionary rate. Focused allelic polymorphisms were found within the Nkrp1b/d (Klrb1b), Nkrp1c (Klrb1c), and Clr-c (Clec2f) genes, suggestive of possible immune selection...
  34. Pollack S, Emmons S. NK-2.1: an NK-associated antigen detected with NZB anti-BALB/c serum. J Immunol. 1982;129:2277-81 pubmed
  35. Klein G, Karre K, Klein G, Kiessling R. The genetic regulation of NK-activity: studies on congenic mice with B10 or AKR background. J Immunogenet. 1980;7:401-7 pubmed
  36. Myrick C, DiGuisto R, DeWolfe J, Bowen E, Kappler J, Marrack P, et al. Linkage analysis of variations in CD4:CD8 T cell subsets between C57BL/6 and DBA/2. Genes Immun. 2002;3:144-50 pubmed
    ..43) with increases in CD4 T cells among T cell precursors in the thymus. All of these QTLs were affected by epistatic interactions, indicating that additional modifiers in the B6 and DBA/2 genomes modulate this phenotype. ..
  37. Depatie C, Muise E, Lepage P, Gros P, Vidal S. High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 1997;39:154-63 pubmed
    ..with Cmv1 in 1967 meioses analyzed; the proximal limit of the Cmv1 domain was defined by 8 crossovers between Nkrp1/ D6Mit61/135/257/289/338 and Cmv1/Ly49A/D6Mit370, and the distal limit was defined by 5 crossovers between Cmv1/..
  38. Matsumoto K, Nakajima T, Sakai H, Kato S, Sagara A, Arakawa K, et al. Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. Dig Dis Sci. 2013;58:3440-51 pubmed publisher
    ..to investigate peripheral alterations due to the 5-FU-induced mucositis of neuronal and non-neuronal 5-HT3 and NK1 receptor expression by immunohistochemical analysis. 5-FU was administered by i.p. injection to C57BL/6 mice...
  39. Delano M, Brownstein D. Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype. J Virol. 1995;69:5875-7 pubmed
    ..Spleen virus titers were significantly augmented in B6 (NK1.1+) mice depleted of asialo GM1+ or NK1.1+ cells, whereas spleen virus titers were unaffected in D2 (NK1...
  40. Glimcher L, Shen F, Cantor H. Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med. 1977;145:1-9 pubmed
    ..e., (C3H X BALB/c)F1 alphaCE spleen cells). This antiserum, provisionally termed 'anti-NK', defines a new subclass of lymphocytes which may play a central role in the immunosurveillance against tumors. ..
  41. Aguilar O, Berry R, Rahim M, Reichel J, Popovic B, Tanaka M, et al. A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell. 2017;169:58-71.e14 pubmed publisher
    ..Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1...
  42. Gan Y, Liu Q, Wu W, Yin J, Bai X, Shen R, et al. Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proc Natl Acad Sci U S A. 2014;111:2704-9 pubmed publisher
    ..Therefore, NK cells catalyzed neuronal death in the ischemic brain. ..
  43. Aguilar O, Mesci A, Ma J, Chen P, Kirkham C, Hundrieser J, et al. Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection. J Innate Immun. 2015;7:584-600 pubmed publisher
    ..Together, these data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies. ..
  44. Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, et al. Activation of CD1d-independent NK1.1+ T cells in the large intestine by Lactobacilli. Immunol Lett. 2006;102:74-8 pubmed
    Among digestive organs, the liver and the large intestine are abundant in T cells expressing NK1.1. NK1.1+ T cells in the liver are mostly CD1d-dependent whereas those in the large intestine are CD1d-independent...
  45. Engel I, Zhao M, Kappes D, Taniuchi I, Kronenberg M. The transcription factor Th-POK negatively regulates Th17 differentiation in V?14i NKT cells. Blood. 2012;120:4524-32 pubmed publisher
    ..Our data suggest that NKT17-cell differentiation is intrinsically regulated by Th-POK activity, with only low levels of Th-POK permissive for the differentiation of NKT17 cells. ..
  46. Hamerman J, Ogasawara K, Lanier L. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol. 2004;172:2001-5 pubmed
    ..RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection. ..
  47. Scalzo A, Lyons P, Fitzgerald N, Forbes C, Yokoyama W, Shellam G. Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1. Genomics. 1995;27:435-41 pubmed
    ..Thus, the close linkage of Cmv1 to the Ly49 and musNKR-P1 multigene families suggests that it may represent an NK cell recognition structure encoded in the NKC region. ..
  48. Ashkar A, Reid S, Verdu E, Zhang K, Coombes B. Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues. Infect Immun. 2009;77:214-22 pubmed publisher
    ..Interleukin-15 (IL-15) directs the development, maturation, and function of a population of cells positive for NK1.1, such as natural killer (NK) cells, which are critical components of the innate immune defense against several ..
  49. Liu Q, Sanai N, Jin W, La Cava A, Van Kaer L, Shi F. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 2016;19:243-52 pubmed publisher
    ..Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation. These findings reveal that reciprocal interactions between NSCs and NK cells regulate neurorepair. ..
  50. Idris A, Iizuka K, Smith H, Scalzo A, Yokoyama W. Genetic control of natural killing and in vivo tumor elimination by the Chok locus. J Exp Med. 1998;188:2243-56 pubmed
    ..Furthermore, CHO killing did not correlate with expression of NK1.1 or 2B4 activation molecules...
  51. Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, et al. Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood. 2006;107:4317-25 pubmed
  52. Sentman C, Hackett J, Moore T, Tutt M, Bennett M, Kumar V. Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen. Hybridoma. 1989;8:605-14 pubmed
    ..We have isolated pure populations of C57BL/6 (H-2b) NK cells using the IgG2b monoclonal antibody PK136 (anti-NK1.1). These NK1...
  53. Giorda R, Trucco M. Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells. J Immunol. 1991;147:1701-8 pubmed
    ..They also share a sequence that could be the binding site of the P56lck tyrosine kinase. These observations are consistent with the signaling function hypothesized for these proteins. ..
  54. Iizuka K, Scalzo A, Xian H, Yokoyama W. Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol. 2008;180:3260-7 pubmed
    ..These data suggest that the NK cell self-tolerance process dynamically modulates the NK cell alloreactivity in vivo. ..
  55. Turchinovich G, Hayday A. Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity. 2011;35:59-68 pubmed publisher
  56. Stenstrom M, Sköld M, Andersson A, Cardell S. Natural killer T-cell populations in C57BL/6 and NK1.1 congenic BALB.NK mice-a novel thymic subset defined in BALB.NK mice. Immunology. 2005;114:336-45 pubmed
    ..NKT cells have mostly been studied in one single mouse strain, C57BL/6 (B6), because of the absence of NK1.1 in other common mouse strains, and the lack of other reliable surface markers for CD1d-restricted cells...
  57. Ljutic B, Carlyle J, Zuniga Pflucker J. Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C. J Biol Chem. 2003;278:31909-17 pubmed
    Mouse NKR-P1C (NK1.1) is a homodimeric type II transmembrane protein expressed on natural killer (NK) cells, NKT cells, and on CD117+ progenitor thymocytes capable of giving rise to cells of the T and NK lineages...
  58. Dhiman R, Periasamy S, Barnes P, Jaiswal A, Paidipally P, Barnes A, et al. NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis. J Immunol. 2012;189:897-905 pubmed publisher
    ..BCG vaccination enhanced the number of IFN-?-producing and IL-22-producing NK cells. Depletion of NK1.1(+) cells at the time of BCG vaccination increased the number of immunosuppressive Tregs (CD4(+)CD25(hi), 95% ..
  59. Yokoyama W. Natural killer cell receptors specific for major histocompatibility complex class I molecules. Proc Natl Acad Sci U S A. 1995;92:3081-5 pubmed
  60. Serizawa I, Koezuka Y, Amao H, Saito T, Takahashi K. Functional natural killer T cells in experimental mouse strains, including NK1.1- strains. Exp Anim. 2000;49:171-80 pubmed
    ..fully identified and little attention has been paid to the roles of NKT cells in immunological experiments in which NK1.1- strains were used...
  61. Grobarova V, Benson V, Rozbeský D, Novak P, Cerny J. Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides. Immunol Lett. 2013;156:110-7 pubmed publisher
    ..Our results indicate possible indirect involvement of NK cells in GN8P mediated immune responses. ..
  62. Kim P, Pai S, Brigl M, Besra G, Gumperz J, Ho I. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006;177:6650-9 pubmed
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent. ..
  63. Koike J, Wakao H, Ishizuka Y, Sato T, Hamaoki M, Seino K, et al. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. J Exp Med. 2004;199:137-44 pubmed
    ..NKG2I is a novel activating receptor mediating recognition and rejection of allogeneic target cells. ..
  64. Arase K, Saijo K, Watanabe H, Konno A, Arase H, Saito T. Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene. Proc Natl Acad Sci U S A. 1999;96:9264-8 pubmed
  65. Kim S, Lalani S, Parekh V, Vincent T, Wu L, Van Kaer L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest. 2008;118:2301-15 pubmed publisher
    ..These findings may have important implications for the development of iNKT cell-based therapies. ..