Gene Symbol: Ngfr
Description: nerve growth factor receptor (TNFR superfamily, member 16)
Alias: LNGFR, Tnfrsf16, p75, p75NGFR, p75NTR, tumor necrosis factor receptor superfamily member 16, NGF receptor, low affinity neurotrophin receptor p75NTR, low-affinity nerve growth factor receptor, p75 neurotrophin receptor
Species: mouse
Products:     Ngfr

Top Publications

  1. Lim Y, McLaughlin T, Sung T, Santiago A, Lee K, O Leary D. p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron. 2008;59:746-58 pubmed publisher
    ..We show that the p75 neurotrophin receptor (NTR) serves this role in retinal axons...
  2. Bentley C, Lee K. p75 is important for axon growth and schwann cell migration during development. J Neurosci. 2000;20:7706-15 pubmed
    Mice lacking the low-affinity neurotrophin receptor p75 have multiple peripheral neural deficits. Here we examined the developmental nature of these deficiencies...
  3. Korade Z, Mi Z, Portugal C, Schor N. Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain. Neurobiol Aging. 2007;28:1522-31 pubmed
    ..Since adult hippocampal and cholinergic neurons express p75 neurotrophin receptors (p75NTR) we hypothesized that p75NTR regulates expression of cholesterogenic enzymes...
  4. Sørensen B, Tandrup T, Koltzenburg M, Jakobsen J. No further loss of dorsal root ganglion cells after axotomy in p75 neurotrophin receptor knockout mice. J Comp Neurol. 2003;459:242-50 pubmed
    The role of the p75 neurotrophin receptor for neuronal survival after nerve crush was studied in L5 dorsal root ganglia (DRG) of knockout mice and controls with assumption-free stereological methods...
  5. Catts V, Al Menhali N, Burne T, Colditz M, Coulson E. The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. Eur J Neurosci. 2008;28:883-92 pubmed publisher
    ..Here we show that mice lacking the p75 neurotrophin receptor (p75(NTR-/-)) have 25% fewer neuroblasts and 50% fewer newborn neurons in the dentate gyrus, coincident ..
  6. Pirvola U, Ylikoski J, Trokovic R, Hebert J, McConnell S, Partanen J. FGFR1 is required for the development of the auditory sensory epithelium. Neuron. 2002;35:671-80 pubmed
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium. ..
  7. Park K, Grosso C, Aubert I, Kaplan D, Miller F. p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Nat Neurosci. 2010;13:559-66 pubmed publisher
    ..Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism...
  8. Gammill L, Gonzalez C, Gu C, Bronner Fraser M. Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling. Development. 2006;133:99-106 pubmed
    ..Interestingly, neural crest cells still condense into segmentally arranged dorsal root ganglia in Npn2 nulls, suggesting that segmental neural crest migration and segmentation of the peripheral nervous system are separable processes. ..
  9. Lebrun Julien F, Bertrand M, De Backer O, Stellwagen D, Morales C, Di Polo A, et al. ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A. 2010;107:3817-22 pubmed publisher
    Neurotrophin binding to the p75 neurotrophin receptor (p75(NTR)) activates neuronal apoptosis following adult central nervous system injury, but the underlying cellular mechanisms remain poorly defined...

More Information


  1. Jacques B, Montcouquiol M, Layman E, Lewandoski M, Kelley M. Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development. 2007;134:3021-9 pubmed
    ..These results suggest that PCs might exist in a transient state of differentiation that makes them potential targets for regenerative therapies. ..
  2. Deinhardt K, Kim T, Spellman D, Mains R, Eipper B, Neubert T, et al. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011;4:ra82 pubmed publisher
    ..This retraction was initiated by an interaction between the p75 neurotrophin receptor (p75NTR) and the sortilin family member SorCS2 (sortilin-related VPS10 domain-containing receptor 2)...
  3. Barrett G, Reid C, Tsafoulis C, Zhu W, Williams D, Paolini A, et al. Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice. Hippocampus. 2010;20:145-52 pubmed publisher
    ..reports have described increases in the size and number of cholinergic neurons in the basal forebrain in p75 neurotrophin receptor (p75(NTR)) knockout mice...
  4. Ben Zvi A, Ben Gigi L, Klein H, Behar O. Modulation of semaphorin3A activity by p75 neurotrophin receptor influences peripheral axon patterning. J Neurosci. 2007;27:13000-11 pubmed
    The p75 neurotrophin receptor (p75(NTR)) interacts with multiple ligands and coreceptors. It is thought to mediate myelin growth inhibition as part of the Nogo receptor complex, in addition to its other roles...
  5. Srinivasan B, Wang Z, Brun Zinkernagel A, Collier R, Black R, Frank S, et al. Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain. Mol Cell Neurosci. 2007;36:449-61 pubmed
    The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis factor receptor superfamily that paradoxically mediates neuronal survival and differentiation or apoptotic cell death...
  6. Kenchappa R, Zampieri N, Chao M, Barker P, Teng H, Hempstead B, et al. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 2006;50:219-32 pubmed
    The p75 neurotrophin receptor regulates neuronal survival, promoting it in some contexts yet activating apoptosis in others. The mechanism by which the receptor elicits these differential effects is poorly understood...
  7. Syroid D, Maycox P, Soilu Hanninen M, Petratos S, Bucci T, Burrola P, et al. Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. J Neurosci. 2000;20:5741-7 pubmed
    Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established...
  8. Harada T, Harada C, Nakayama N, Okuyama S, Yoshida K, Kohsaka S, et al. Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron. 2000;26:533-41 pubmed
    ..a novel pathway of light-induced photoreceptor apoptosis involving the low-affinity neurotrophin receptor p75 (p75NTR)...
  9. Dubreuil C, Winton M, McKerracher L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system. J Cell Biol. 2003;162:233-43 pubmed
    ..Next, we examined the role of the p75 neurotrophin receptor (p75NTR) in Rho signaling...
  10. Sachs B, Baillie G, McCall J, Passino M, Schachtrup C, Wallace D, et al. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol. 2007;177:1119-32 pubmed
    ..Here, we report that the p75 neurotrophin receptor (p75(NTR)), a TNF receptor superfamily member up-regulated after tissue injury, blocks fibrinolysis by ..
  11. Masoudi R, Ioannou M, Coughlin M, Pagadala P, Neet K, Clewes O, et al. Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. J Biol Chem. 2009;284:18424-33 pubmed publisher
    ..The ratio of tropomyosin-related kinase A to p75 neurotrophin receptor is low in unprimed PC12 cells compared with primed PC12 cells and sympathetic neurons, altering the ..
  12. Capsoni S, Tiveron C, Vignone D, Amato G, Cattaneo A. Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci U S A. 2010;107:12299-304 pubmed publisher proNGF and prevents binding of mature NGF to the tropomyosin-related kinase A (TrkA) receptor and to p75 neurotrophin receptor (p75NTR), we postulated that neurodegeneration in AD11 mice is provoked by an imbalance of proNGF/NGF ..
  13. Schwarz Q, Maden C, Vieira J, Ruhrberg C. Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc Natl Acad Sci U S A. 2009;106:6164-9 pubmed publisher
    ..We conclude that NRP1 signaling coordinates pathway choice with NCC fate and therefore confines neuronal differentiation to appropriate locations. ..
  14. Yamamoto N, Chang W, Kelley M. Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol. 2011;353:367-79 pubmed publisher
    ..These results suggest important roles for Rbpj and notch signaling in multiple aspects of inner ear development including prosensory cell maturation, cellular differentiation and survival. ..
  15. Zheng B, Atwal J, Ho C, Case L, He X, Garcia K, et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005;102:1205-10 pubmed mediate their inhibitory signals by complexing with a signal-transducing coreceptor, the neurotrophin receptor p75(NTR)...
  16. Langevin C, Jaaro H, Bressanelli S, Fainzilber M, Tuffereau C. Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor. J Biol Chem. 2002;277:37655-62 pubmed a trimeric and surface-exposed viral coat protein that has been shown to interact with the murine p75 neurotrophin receptor. We have investigated binding of RVG to p75 and describe several features that distinguish the p75-RVG ..
  17. Deppmann C, Mihalas S, Sharma N, Lonze B, Niebur E, Ginty D. A model for neuronal competition during development. Science. 2008;320:369-73 pubmed publisher
    ..NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling ..
  18. Sotthibundhu A, Sykes A, Fox B, Underwood C, Thangnipon W, Coulson E. Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci. 2008;28:3941-6 pubmed publisher
    ..Abeta is a ligand for the p75 neurotrophin receptor (p75(NTR)), which is best known for mediating neuronal death and has been consistently linked to the ..
  19. Lorentz C, Woodward W, Tharp K, Habecker B. Altered norepinephrine content and ventricular function in p75NTR-/- mice after myocardial infarction. Auton Neurosci. 2011;164:13-9 pubmed publisher
    ..Nerve growth factor modulates sympathetic transmission through activation of TrkA and p75NTR. Nerve growth factor plays an important role in post-infarct sympathetic remodeling...
  20. von Schack D, Casademunt E, Schweigreiter R, Meyer M, Bibel M, Dechant G. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001;4:977-8 pubmed
  21. Okamura Y, Saga Y. Notch signaling is required for the maintenance of enteric neural crest progenitors. Development. 2008;135:3555-65 pubmed publisher
  22. Raiker S, Lee H, Baldwin K, Duan Y, Shrager P, Giger R. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 2010;30:12432-45 pubmed publisher
    ..OMgp inhibits LTP in part through PirB but independently of p75. This suggests that NgR1 and PirB participate in ligand-dependent inhibition of synaptic plasticity...
  23. Song X, Zhong J, Wang X, Zhou X. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci. 2004;24:542-6 pubmed
    The neurotrophin receptor p75NTR is the coreceptor for Nogo receptor, mediating growth cone collapse in vitro by MAG, myelin oligodendrocyte glycoprotein (Omgp), and Nogo...
  24. Habecker B, Bilimoria P, Linick C, Gritman K, Lorentz C, Woodward W, et al. Regulation of cardiac innervation and function via the p75 neurotrophin receptor. Auton Neurosci. 2008;140:40-8 pubmed publisher
    ..We investigated whether the p75 neurotrophin receptor plays a developmental role in cardiac innervation by analyzing sympathetic and parasympathetic fibers in ..
  25. Gehler S, Gallo G, Veien E, Letourneau P. p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity. J Neurosci. 2004;24:4363-72 pubmed
    ..We investigated the role of the p75 neurotrophin receptor (p75NTR) in mediating neurotrophin-induced increases in filopodial length...
  26. Fujita Y, Endo S, Takai T, Yamashita T. Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 2011;30:1389-401 pubmed publisher
    ..Our results thus identify a new molecular target to enhance regeneration of the injured CNS. ..
  27. Passino M, Adams R, Sikorski S, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science. 2007;315:1853-6 pubmed
    ..We show that the neurotrophin receptor p75NTR, a tumor necrosis factor receptor superfamily member expressed in HSCs after fibrotic and cirrhotic liver injury ..
  28. Mueller K, Jacques B, Kelley M. Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci. 2002;22:9368-77 pubmed
    ..Moreover, the position of the pillar cells appears to be determined by the activation of FGFR3 in a subset of the progenitor cells that initially express this receptor. ..
  29. Song X, Zhang F, Zhou F, Zhong J, Zhou X. Deletion of p75NTR impairs regeneration of peripheral nerves in mice. Life Sci. 2009;84:61-8 pubmed publisher
    After peripheral nerve injury, p75NTR was upregulated in Schwann cells of the Wallerian degenerative nerves and in motor neurons but down-regulated in the injured sensory neurons...
  30. Schwarz Q, Maden C, Davidson K, Ruhrberg C. Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development. 2009;136:1785-9 pubmed publisher
    ..By contrast, the combined loss of both guidance pathways leads to ectopic invasion of the intersomitic furrows and posterior sclerotome halves, disrupting metameric NCC streaming and DRG segmentation. ..
  31. Freyer L, Aggarwal V, Morrow B. Dual embryonic origin of the mammalian otic vesicle forming the inner ear. Development. 2011;138:5403-14 pubmed publisher
    ..This study defines a dual cellular origin of the inner ear from sensory placode ectoderm and NECs, and changes the current paradigm of inner ear neurosensory development. ..
  32. Barraud P, Seferiadis A, Tyson L, Zwart M, Szabo Rogers H, Ruhrberg C, et al. Neural crest origin of olfactory ensheathing glia. Proc Natl Acad Sci U S A. 2010;107:21040-5 pubmed publisher
  33. Copray J, Jaarsma D, Küst B, Bruggeman R, Mantingh I, Brouwer N, et al. Expression of the low affinity neurotrophin receptor p75 in spinal motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis. Neuroscience. 2003;116:685-94 pubmed
    ..Aberrant neurotrophin signalling via the low affinity neurotrophin receptor p75 has been suggested to be involved in the motoneuron death by the activation of apoptotic pathways...
  34. Maden C, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C. NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev Biol. 2012;369:277-85 pubmed publisher
    ..We further show that abnormal sympathetic development in mice lacking NRP1 in the sympathetic lineage has functional consequences, as it causes sinus bradycardia, similar to mice lacking SEMA3A. ..
  35. Tuffereau C, Schmidt K, Langevin C, Lafay F, Dechant G, Koltzenburg M. The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection. J Virol. 2007;81:13622-30 pubmed
    ..The neurotrophin receptor (p75(NTR)), through its cysteine-rich domain 1, is a specific receptor for RVG and neutralizes virus infectivity, but ..
  36. Krimm R. Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:1294-302 pubmed
    ..normally function via the tyrosine kinase receptor, trkB, they also bind to the pan-neurotrophin receptor, p75. The goal of the present study was to determine whether the p75 receptor is required for the development or ..
  37. Roffers Agarwal J, Gammill L. Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation. Development. 2009;136:1879-88 pubmed publisher
    ..These data show that Nrp2 and Nrp1 work together to produce segmentation of sensory and motor nerves, and that dorsal peripheral nervous system metamerism is generated in a stepwise, Nrp-dependent process. ..
  38. Stenqvist A, Agerman K, Marmigere F, Minichiello L, Ernfors P. Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo. EMBO Rep. 2005;6:973-8 pubmed
    ..TrkB and TrkC receptors are thus not functionally redundant for NT 3, even when coexpressed in neurons of the cochleovestibular system. ..
  39. Benson M, Romero M, Lush M, Lu Q, Henkemeyer M, Parada L. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A. 2005;102:10694-9 pubmed
    ..All three myelin components transduce their inhibitory signals through the same Nogo receptor/p75 neurotrophin receptor/LINGO-1 (NgR1/p75/LINGO-1) complex...
  40. Kuruvilla R, Zweifel L, Glebova N, Lonze B, Valdez G, Ye H, et al. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell. 2004;118:243-55 pubmed
    ..Interestingly, final target-derived NGF promotes expression of the p75 neurotrophin receptor, in turn causing a reduction in the sensitivity of axons to intermediate target-derived NT-3...
  41. Beattie M, Harrington A, Lee R, Kim J, Boyce S, Longo F, et al. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 2002;36:375-86 pubmed
    The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its role after injury has remained unclear...
  42. Sharma N, Deppmann C, Harrington A, St Hillaire C, Chen Z, Lee F, et al. Long-distance control of synapse assembly by target-derived NGF. Neuron. 2010;67:422-34 pubmed publisher
    ..Furthermore, the p75 neurotrophin receptor restricts PSD formation, suggesting an important role for antagonistic NGF-TrkA and p75 signaling ..
  43. Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, et al. The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res. 2008;86:3566-74 pubmed publisher
    ..Here we report that the administration of neutralizing antibody to the neurotrophin receptor p75 (p75(NTR)) blocks hyperalgesia, which develops with complete Freund's adjuvant (CFA)-induced inflammation or with ..
  44. Yamashita T, Higuchi H, Tohyama M. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol. 2002;157:565-70 pubmed
    ..Here we show that the neurotrophin receptor p75 (p75(NTR)) is the signal transducing element for MAG...
  45. Huh S, Jones J, Warchol M, Ornitz D. Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 2012;10:e1001231 pubmed publisher
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans. ..
  46. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching. ..
  47. Forni P, Taylor Burds C, Melvin V, Williams T, Williams T, Wray S. Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells. J Neurosci. 2011;31:6915-27 pubmed publisher
    ..Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies...
  48. Hayashi T, Cunningham D, Bermingham McDonogh O. Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007;236:525-33 pubmed
    ..Thus, in addition to controlling the fate decision between pillar cells and Deiters' cells, we find that Fgfr3 also regulates the width of the sensory epithelium...
  49. Xu Z, Sun Y, Li H, Lim Y, Zhong J, Zhou X. Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. Eur J Neurosci. 2011;33:1376-84 pubmed publisher
    ..We demonstrate that proBDNF and its receptors p75 neurotrophin receptor (p75NTR) and sortilin are highly expressed in the cerebella as determined by immunohistochemistry and ..
  50. Tomita K, Kubo T, Matsuda K, Fujiwara T, Yano K, Winograd J, et al. The neurotrophin receptor p75NTR in Schwann cells is implicated in remyelination and motor recovery after peripheral nerve injury. Glia. 2007;55:1199-208 pubmed
    The function of the p75(NTR) neurotrophin receptor (p75(NTR)) in nervous system regeneration is still controversial...
  51. Lebrun Julien F, Morquette B, Douillette A, Saragovi H, Di Polo A. Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells. Mol Cell Neurosci. 2009;40:410-20 pubmed publisher
    ..In the adult retina, nerve growth factor (NGF) binds to TrkA (expressed by neurons) and p75(NTR) (expressed by Müller glia), but fails to promote the survival of axotomized retinal ganglion cells (RGCs)...
  52. Charalampopoulos I, Vicario A, Pediaditakis I, Gravanis A, Simi A, Ibanez C. Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor. Cell Rep. 2012;2:1563-70 pubmed publisher
    ..The p75 neurotrophin receptor (p75(NTR)), also known as TNFRSF16, is a key regulator of trophic and injury responses in the nervous ..
  53. Taylor M, Yeager K, Morrison S. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development. 2007;134:2435-47 pubmed
    ..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors. ..
  54. Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging. Biochem J. 2005;391:59-67 pubmed
    ..that two members of the neurotrophin receptor superfamily, TrkA (tyrosine kinase receptor A) and p75NTR (p75 neurotrophin receptor), differentially regulate the processing of APP (amyloid precursor protein): TrkA reduces, whereas ..
  55. Cosgaya J, Chan J, Shooter E. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science. 2002;298:1245-8 pubmed
    Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75NTR. Neurotrophins are key mediators of peripheral nervous system myelination...
  56. Huang E, Liu W, Fritzsch B, Bianchi L, Reichardt L, Xiang M. Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development. 2001;128:2421-32 pubmed
    ..Thus, Brn3a must control additional downstream genes that are required for axon pathfinding. ..
  57. Kraemer R. Reduced apoptosis and increased lesion development in the flow-restricted carotid artery of p75(NTR)-null mutant mice. Circ Res. 2002;91:494-500 pubmed
    ..In recent studies, we have identified the neurotrophin receptor, p75(NTR), as a mediator of apoptosis of neointimal smooth muscle cells...
  58. Mantela J, Jiang Z, Ylikoski J, Fritzsch B, Zacksenhaus E, Pirvola U. The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development. 2005;132:2377-88 pubmed
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia. ..
  59. Fritzsch B, Dillard M, Lavado A, Harvey N, Jahan I. Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS ONE. 2010;5:e9377 pubmed publisher
    ..These results identify a dual role of Prox1 during inner ear development; growth of the canal cristae and fiber guidance of Type II fibers along supporting cells in the cochlea. ..
  60. Jansen P, Giehl K, Nyengaard J, Teng K, Lioubinski O, Sjoegaard S, et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci. 2007;10:1449-57 pubmed
    ..although mature neurotrophins promote neuronal survival by binding to tropomyosin receptor kinases and p75 neurotrophin receptor (p75(NTR)), pro-neurotrophins induce apoptosis in cultured neurons by engaging sortilin and p75(NTR) in ..
  61. Woods C, Montcouquiol M, Kelley M. Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci. 2004;7:1310-8 pubmed
    ..These results show that Math1 functions in the developing cochlea to initiate both inductive and inhibitory signals that regulate the overall formation of the sensory epithelia. ..
  62. Andrieu D, Watrin F, Niinobe M, Yoshikawa K, Muscatelli F, Fernandez P. Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression. Gene Expr Patterns. 2003;3:761-5 pubmed
    ..Recently, Necdin and other MAGE proteins were found to interact in vitro with the intracellular domain of the p75NTR neurotrophin receptor, but this interaction has not been validated in vivo...
  63. Waimey K, Huang P, Chen M, Cheng H. Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008;315:448-58 pubmed publisher
    ..They function cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons. ..
  64. Woo N, Teng H, Siao C, Chiaruttini C, Pang P, Milner T, et al. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci. 2005;8:1069-77 pubmed
    Pro- and mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75 neurotrophin receptor (p75(NTR)) and TrkB. Mature BDNF facilitates hippocampal synaptic potentiation through TrkB...
  65. Volosin M, Song W, Almeida R, Kaplan D, Hempstead B, Friedman W. Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. J Neurosci. 2006;26:7756-66 pubmed
    Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via p75NTR even in cells expressing survival-promoting Trk ..
  66. Schwarz Q, Vieira J, Howard B, Eickholt B, Ruhrberg C. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development. 2008;135:1605-13 pubmed publisher
    ..We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections. ..
  67. Nykjaer A, Willnow T, Petersen C. p75NTR--live or let die. Curr Opin Neurobiol. 2005;15:49-57 pubmed
    ..The trophic signals are relayed to the cells via binding to Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, the p75 neurotrophin receptor also ensures rapid and appropriate apoptosis of neonatal ..
  68. Wang K, Kim J, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002;420:74-8 pubmed
    ..Here, we demonstrate that p75, a transmembrane protein known to be a receptor for the neurotrophin family of growth factors, specifically ..
  69. Singh K, Park K, Hong E, Kramer B, Greenberg M, Kaplan D, et al. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008;11:649-58 pubmed publisher
    ..secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning...
  70. Sonnenberg Riethmacher E, Miehe M, Stolt C, Goerich D, Wegner M, Riethmacher D. Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. Mech Dev. 2001;109:253-65 pubmed
    ..5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism. ..
  71. Sun Y, Lim Y, Li F, Liu S, Lu J, Haberberger R, et al. ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS ONE. 2012;7:e35883 pubmed publisher
    ..outgrowth in murine dorsal root ganglion (DRG) neurons and cortical neurons by activating RhoA via the p75 neurotrophin receptor (p75NTR)...
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