Ngf

Summary

Gene Symbol: Ngf
Description: nerve growth factor
Alias: Ngfb, beta-NGF, beta-nerve growth factor, nerve growth factor, beta
Species: mouse
Products:     Ngf

Top Publications

  1. Francis N, Farinas I, Brennan C, Rivas Plata K, Backus C, Reichardt L, et al. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors. Dev Biol. 1999;210:411-27 pubmed
    ..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor. ..
  2. Li H, Li Z, Qin L, Liu S, Lau L, Han J, et al. The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett. 2006;580:1723-8 pubmed
    ..To elucidate the effects of neurotrophins, we treated day 5 neurons with NT-3, BDNF or NGF for 48 h...
  3. Micera A, Lambiase A, Stampachiacchiere B, Sgrulletta R, Normando E, Bonini S, et al. Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva. Mol Vis. 2007;13:981-7 pubmed
    To evaluate the role of nerve growth factor (NGF) in remodeling processes of vernal keratoconjunctivitis (VKC). VKC is a chronic inflammatory disorder of the conjunctiva and is characterized by marked tissue remodeling...
  4. Deppmann C, Mihalas S, Sharma N, Lonze B, Niebur E, Ginty D. A model for neuronal competition during development. Science. 2008;320:369-73 pubmed publisher
    ..Target-derived nerve growth factor (NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA-mediated signals...
  5. Potts P, Singh S, Knezek M, Thompson C, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol. 2003;163:789-99 pubmed
    ..These data identify a critical function of endogenous XIAP in regulating apoptosis in mammalian cells. ..
  6. McDonald N, Lapatto R, Murray Rust J, Gunning J, Wlodawer A, Blundell T. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 1991;354:411-4 pubmed
    Nerve growth factor (NGF) is a member of an expanding family of neurotrophic factors (including brain-derived neurotrophic factor and the neurotrophins) that control the development and survival of certain neuronal populations both in ..
  7. Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng K, et al. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J Mol Biol. 2010;396:967-84 pubmed publisher
    Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form...
  8. Muller M, Triaca V, Besusso D, Costanzi M, Horn J, Koudelka J, et al. Loss of NGF-TrkA signaling from the CNS is not sufficient to induce cognitive impairments in young adult or intermediate-aged mice. J Neurosci. 2012;32:14885-98 pubmed publisher
    ..An ongoing discussion is whether signaling of nerve growth factor (NGF) through its high-affinity receptor TrkA contributes to attention behavior and/or learning and memory, based on its ..
  9. Harrington A, St Hillaire C, Zweifel L, Glebova N, Philippidou P, Halegoua S, et al. Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell. 2011;146:421-34 pubmed publisher
    The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuronal survival...

More Information

Publications96

  1. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    b>NGF controls survival, differentiation, and target innervation of both peptidergic and nonpeptidergic DRG sensory neurons...
  2. Pagadala P, Dvorak L, Neet K. Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization. Proc Natl Acad Sci U S A. 2006;103:17939-43 pubmed
    ..The proNGF molecule is processed by proteases at three dibasic sites found in the pro domain to form mature NGF (termed herein as sites 1, 2, and 3 from the proNGF N terminus)...
  3. Holland D, Cousens L, Meng W, Matthews B. Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. J Mol Biol. 1994;239:385-400 pubmed
    Murine beta-nerve growth factor (beta NGF) is a 118 amino acid residue polypeptide which, as a functional dimer, plays an important role in the survival and development of certain neuronal populations...
  4. Crowley C, Spencer S, Nishimura M, Chen K, Pitts Meek S, Armanini M, et al. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell. 1994;76:1001-11 pubmed
    ..recombination was utilized to generate mice with a deletion in the coding sequence of the nerve growth factor (NGF) gene...
  5. Patel T, Jackman A, Rice F, Kucera J, Snider W. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron. 2000;25:345-57 pubmed
    ..the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA...
  6. Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, et al. The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res. 2008;86:3566-74 pubmed publisher
    ..arises through the actions of inflammatory mediators, and one of the key molecules is nerve growth factor (NGF)...
  7. Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, Van Linthout S, et al. Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res. 2010;106:1275-84 pubmed publisher
    Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF potential for cardiac repair has never been investigated...
  8. Glebova N, Ginty D. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci. 2004;24:743-51 pubmed
    The neurotrophin nerve growth factor (NGF) plays a crucial role in the development of the sympathetic nervous system...
  9. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..Moreover, axonal projection defects in mice harboring a null mutation in Linx resemble those in mice lacking Ngf, TrkA, and Ret...
  10. Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, Tomita Y, et al. Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts. Circulation. 2006;114:2351-63 pubmed
    ..The present study focused on the roles of nerve growth factor (NGF) in the regulation of the cardiac sensory nervous system and analyzed the mechanism of silent myocardial ischemia ..
  11. Harrison S, Davis B, Nishimura M, Albers K, Jones M, Phillips H. Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF. Brain Res Mol Brain Res. 2004;122:116-25 pubmed
    Mice lacking a functional NGF gene (ngf-/- mice) have less than one third of the normal complement of sensory neurons, few sympathetic postganglionic neurons and die shortly after birth...
  12. Abram M, Wegmann M, Fokuhl V, Sonar S, Luger E, Kerzel S, et al. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol. 2009;182:4705-12 pubmed publisher
    ..In vitro, the nerve growth factor (NGF) and neurotrophin-3 (NT3) led to a dose-dependent increase in viability of isolated pulmonary plasma cells due to ..
  13. Masoudi R, Ioannou M, Coughlin M, Pagadala P, Neet K, Clewes O, et al. Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. J Biol Chem. 2009;284:18424-33 pubmed publisher
    Nerve growth factor (NGF) is produced as a precursor called pro-nerve growth factor (proNGF), which is secreted by many tissues and is the predominant form of NGF in the central nervous system...
  14. Jiang Y, Chen G, Zheng Y, Lu L, Wu C, Zhang Y, et al. TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-kappa B pathways. Mol Immunol. 2008;45:1557-66 pubmed
    ..Nerve growth factor (NGF) and its receptors are found to be widely expressed in the immune system and regulate both innate and adaptive ..
  15. Harper S, Davies A. NGF mRNA expression in developing cutaneous epithelium related to innervation density. Development. 1990;110:515-9 pubmed
    To determine if the initial level of NGF mRNA in developing cutaneous epithelium is correlated with its final innervation density, we measured the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic ..
  16. Addo L, Tanaka H, Yamamoto M, Toki Y, Ito S, Ikuta K, et al. Hepatic nerve growth factor induced by iron overload triggers defenestration in liver sinusoidal endothelial cells. Biochim Biophys Acta. 2015;1852:175-83 pubmed publisher
    ..In this study, we found a novel link between LSEC defenestration and hepatic nerve growth factor (NGF) in iron-overloaded mice...
  17. Feng L, Xie X, Ding Q, Luo X, He J, Fan F, et al. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007;104:14348-53 pubmed
    ..RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation...
  18. Guo T, Mandai K, Condie B, Wickramasinghe S, Capecchi M, Ginty D. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci. 2011;14:31-6 pubmed publisher
    ..Although nerve growth factor (NGF) controls survival, maturation and axonal projections of nociceptors of different vertebrates, whether the NGF ..
  19. Dorfman H, Bailey A, St Louis M, Zadina J, Ribeiro da Silva A. Postnatal development of ectopic sensory fibers containing endomorphin-2 in the white matter of the spinal cord of a transgenic mouse expressing nerve growth factor in oligodendrocytes. Neuroscience. 2005;134:1205-16 pubmed
  20. O CONNOR R, Tessier Lavigne M. Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons. Neuron. 1999;24:165-78 pubmed
  21. Salehi A, Roux P, Kubu C, Zeindler C, Bhakar A, Tannis L, et al. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron. 2000;27:279-88 pubmed
    ..NRAGE binds p75NTR in vitro and in vivo, and NRAGE associates with the plasma membrane when NGF is bound to p75NTR...
  22. Zheng L, Zhang Y, Han J, Sun Z, Zhou S, Zhao W, et al. Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor. J Diabetes Complications. 2015;29:323-8 pubmed publisher
    Nerve growth factor (NGF), a member of the neurotrophin family, plays an essential role in diabetic neuropathy and ischemic heart disease...
  23. Geetha T, Zheng C, Unroe B, Sycheva M, KLUESS H, Babu J. Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival. Biochem Biophys Res Commun. 2012;421:286-90 pubmed publisher
    Specific binding of nerve growth factor (NGF) to p75 neurotrophin receptor (p75(NTR)) leads to p75(NTR) polyubiquitination and its subsequent interaction with TRAF6 resulting in neuronal cell survival...
  24. Yamashita N, Joshi R, Zhang S, Zhang Z, Kuruvilla R. Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. Dev Cell. 2017;42:626-639.e5 pubmed publisher
    ..Here, we report that retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, and we define the molecular ..
  25. Chou H, Chien C, Lu K. The distribution of PGP9. 5, BDNF and NGF in the vallate papilla of adult and developing mice. Anat Embryol (Berl). 2001;204:161-9 pubmed
    ..5 (PGP 9.5), and against nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). PGP 9...
  26. Bhalerao J, Tylzanowski P, Filie J, Kozak C, Merregaert J. Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage. J Biol Chem. 1995;270:16385-94 pubmed
    ..Alternative splicing may serve as a mechanism for generating functional diversity in the Ecm1 gene. ..
  27. Heumann R, Hengerer B, Brown M, Perry H. Molecular mechanisms leading to lesion-induced increases in nerve growth factor synthesis. Ann N Y Acad Sci. 1991;633:581-2 pubmed
  28. Hingtgen C, Roy S, Clapp D. Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene. Neuroscience. 2006;137:637-45 pubmed
  29. Mehta H, Woo S, Neet K. Comparison of nerve growth factor receptor binding models using heterodimeric muteins. J Neurosci Res. 2012;90:2259-71 pubmed publisher
    Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons...
  30. Katoh Semba R, Semba R, Kato H, Ueno M, Arakawa Y, Kato K. Regulation by androgen of levels of the beta subunit of nerve growth factor and its mRNA in selected regions of the mouse brain. J Neurochem. 1994;62:2141-7 pubmed
    Our previous studies showed that the concentration of the beta subunit of nerve growth factor (beta-NGF) in nervous tissues is higher in male than in female mice...
  31. Holmberg K, Shi T, Albers K, Davis B, Hokfelt T. Effect of peripheral nerve lesion and lumbar sympathectomy on peptide regulation in dorsal root ganglia in the NGF-overexpressing mouse. Exp Neurol. 2001;167:290-303 pubmed
    ..It is strongly upregulated after peripheral nerve lesions, and it has been proposed that nerve growth factor (NGF) plays a role in this regulation...
  32. O Neill R, Tokoro T, Kozak C, Brady R. Comparison of the chromosomal localization of murine and human glucocerebrosidase genes and of the deduced amino acid sequences. Proc Natl Acad Sci U S A. 1989;86:5049-53 pubmed
    ..Comparison of linkage relationships in the human and murine genome indicates that these closely linked mouse genes are also syntenic on human chromosome 1 but in positions that span the centromere. ..
  33. Van Kanegan M, Strack S. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol. 2009;29:662-74 pubmed publisher
    Nerve growth factor (NGF) is critical for the differentiation and maintenance of neurons in the peripheral and central nervous system...
  34. White F, Silos Santiago I, Molliver D, Nishimura M, Phillips H, Barbacid M, et al. Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. J Neurosci. 1996;16:4662-72 pubmed
    Determinations of dorsal root ganglion (DRG) neuron loss in nerve growth factor (NGF) and neurotrophin-3 (NT-3) null mutant mice have supported the concept that neurons can switch neurotrophin dependence by revealing that many neurons ..
  35. Kerr B, Garcia Rudaz C, Dorfman M, Paredes A, Ojeda S. NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. Reproduction. 2009;138:131-40 pubmed publisher
    ..Here, we show that primordial follicle formation is decreased in the absence of nerve growth factor (NGF) or its receptor NTRK1, and in the absence of NTRK2, the receptor for neurotrophin-4 (NTF4) and brain-derived ..
  36. Bax B, Blundell T, Murray Rust J, McDonald N. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure. 1997;5:1275-85 pubmed
    Nerve growth factor (NGF) is a neurotrophic factor that promotes the differentiation and survival of certain populations of neurons in the central and peripheral nervous systems...
  37. Wang Z, McDowell T, Wang P, Alvarez R, Gomez T, Bjorling D. Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons. Neuroscience. 2014;277:679-89 pubmed publisher
    ..Exposure to nerve growth factor (NGF) rapidly increases TRPV1 activity (sensitization)...
  38. Vieira K, de Almeida e Silva Lima Zollner A, Malaguti C, Vilella C, de Lima Zollner R. Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice. Cytokine. 2008;42:92-104 pubmed publisher
    ..pancreas beta cells are regulated by a variety of hormones and growth factors, including the nerve growth factor (NGF)...
  39. Shim J, Hamamura K, Chen A, Wan Q, Na S, Yokota H. Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes. J Musculoskelet Neuronal Interact. 2013;13:372-9 pubmed
    ..gentle loads applied to the knee on mRNA expression of nerve growth factor, particularly, the active beta subunit (NGF?) in cartilage and chondrocyte...
  40. Zhang L, Schmidt R, Yan Q, Snider W. NGF and NT-3 have differing effects on the growth of dorsal root axons in developing mammalian spinal cord. J Neurosci. 1994;14:5187-201 pubmed
    ..These effects of NGF are highly selective...
  41. Martin J, Miano J, Hustad C, Copeland N, Jenkins N, Olson E. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol Cell Biol. 1994;14:1647-56 pubmed
    ..The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes. ..
  42. Payne C, Gallagher S, Foreman O, Dannenberg J, Depinho R, Braun R. Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010;28:1424-34 pubmed publisher
    ..We conclude that the epigenome of Sertoli cells influences the establishment of a niche for germline stem cells as well as for tumor initiating cells. ..
  43. Bodmer D, Levine Wilkinson S, Richmond A, Hirsh S, Kuruvilla R. Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. J Neurosci. 2009;29:7569-81 pubmed publisher
    Nerve growth factor (NGF) is a potent survival and axon growth factor for neuronal populations in the peripheral nervous system...
  44. Schnegelsberg B, Sun T, Cain G, Bhattacharya A, Nunn P, Ford A, et al. Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function. Am J Physiol Regul Integr Comp Physiol. 2010;298:R534-47 pubmed publisher
    b>NGF has been suggested to play a role in urinary bladder dysfunction by mediating inflammation, as well as morphological and functional changes, in sensory and sympathetic neurons innervating the urinary bladder...
  45. Middleton G, Davies A. Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development. 2001;128:4715-28 pubmed
    ..To further examine this assertion in vivo, we have studied two populations of NGF-dependent neurones during the period of naturally occurring neuronal death in mice that lack BAX, NGF or the NGF ..
  46. Sobkowicz H, August B, Slapnick S. Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture. Int J Dev Neurosci. 2002;20:537-54 pubmed
    ..in organotypic culture to brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and nerve growth factor (NGF), and also to gamma aminobutyric acid (GABA), for up to 8 days...
  47. Caetano A, Shiue Y, Lyons L, O Brien S, Laughlin T, Bowling A, et al. A comparative gene map of the horse (Equus caballus). Genome Res. 1999;9:1239-49 pubmed
    ..The equine type I markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps. ..
  48. Paoletti F, Malerba F, Ercole B, Lamba D, Cattaneo A. A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. Biochim Biophys Acta. 2015;1854:187-97 pubmed publisher
    b>NGF is the prototype member of the neurotrophin family of proteins that promote the survival and growth of selected neurons in the central and peripheral nervous systems. As for all neurotrophins, NGF is translated as a pre-pro-protein...
  49. Tomlinson R, Li Z, Zhang Q, Goh B, Li Z, Thorek D, et al. NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone. Cell Rep. 2016;16:2723-2735 pubmed publisher
    ..Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse ..
  50. Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nat Med. 2007;13:604-12 pubmed
    ..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control. ..
  51. Barker J, Wu Z, Hunter D, Dey R. Ozone exposure initiates a sequential signaling cascade in airways involving interleukin-1beta release, nerve growth factor secretion, and substance P upregulation. J Toxicol Environ Health A. 2015;78:397-407 pubmed publisher
    Previous studies demonstrated that interleukin-1β (IL-1β) and nerve growth factor (NGF) increase synthesis of substance P (SP) in airway neurons both after ozone (O3) exposure and by direct application...
  52. Venkatesan C, Chrzaszcz M, Choi N, Wainwright M. Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation. 2010;7:32 pubmed publisher
  53. von Büdingen H, Mei F, Greenfield A, Jahn S, Shen Y, Reid H, et al. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015;210:891-8 pubmed
    ..In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-..
  54. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, et al. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004;113:876-84 pubmed
    The cardiac sympathetic nerve plays an important role in regulating cardiac function, and nerve growth factor (NGF) contributes to its development and maintenance...
  55. Tsai M, Lin Y, Sun C, Huang S, Lee P, Kao Y. Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress. PLoS ONE. 2014;9:e112113 pubmed publisher
    The role of nerve growth factor (NGF) in liver injury induced by bile duct ligation (BDL) remains elusive...
  56. Elliott J, MacLellan A, Saini J, Chan J, Scott S, Kawaja M. Transgenic mice expressing nerve growth factor in smooth muscle cells. Neuroreport. 2009;20:223-7 pubmed
    Ectopic expression of nerve growth factor (NGF) in transgenic mice leads to site-specific sympathetic sprouting. Smooth muscle cells in the intestines, urinary bladder, and arteries have been shown to express NGF...
  57. Kumar A, Dai X, Kozak C, Mims M, Gotto A, Ballantyne C. Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form. J Immunol. 1994;153:4088-98 pubmed
    ..Thus, expression of VCAM-1 is restricted and controlled at the level of transcription and by alternative splicing. ..
  58. Suo D, Park J, Harrington A, Zweifel L, Mihalas S, Deppmann C. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014;17:36-45 pubmed publisher
    ..Here we report that in mouse sympathetic neurons, the target-derived nerve growth factor (NGF)-tropomyosin-related kinase type 1 (TrkA, also called Ntrk1) signaling endosome, on arrival at the cell body, ..
  59. Yamamoto T, Yamakuni T, Okabe N, Amano T. Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1. Neurochem Int. 1992;21:251-8 pubmed
    ..methods, Northern blot analysis using a 50 nucleotides probe to the conserved region of the nerve growth factor (NGF) gene, and enzyme immunoassay using a monoclonal biotinylated rat anti-NGF IgG-avidin conjugated peroxidase system, ..
  60. GOBEL V, Lipkowitz S, Kozak C, Kirsch I. NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell Growth Differ. 1992;3:143-8 pubmed
  61. Kim E, Hong Y, Go S, Lee B, Jung S. Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease. Exp Mol Med. 2006;38:348-56 pubmed
    ..These results suggest that a reduction in neurotrophic factors could be involved in neuronal loss in Gaucher disease. ..
  62. Zhang X, Huang J, McNaughton P. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 2005;24:4211-23 pubmed
    ..sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and ..
  63. Shao H, Pandey A, O Shea K, Seldin M, Dixit V. Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J Biol Chem. 1995;270:5636-41 pubmed
    ..Finally, the gene for B61 was localized to a specific position on mouse chromosome 3 by interspecific back-cross analysis. ..
  64. Mucenski M, Taylor B, Copeland N, Jenkins N. Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res. 1988;2:219-33 pubmed
    ..Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic cell hybrid analysis, were also determined...
  65. Yamaguchi Y, Yonemura S, Takada S. Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006;133:4737-48 pubmed
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. ..
  66. Ullrich A, Gray A, Berman C, Dull T. Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 1983;303:821-5 pubmed
    Nerve growth factor (NGF) is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurones (see refs 1-3 for review)...
  67. Spencer M, Shao H, Tucker H, Andres D. Nerve growth factor-dependent activation of the small GTPase Rin. J Biol Chem. 2002;277:17605-15 pubmed
    ..In this study, we show that stimulation of PC6 cells with either epidermal growth factor or nerve growth factor (NGF) results in rapid activation of Rin...
  68. Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L. Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem. 2003;278:4778-85 pubmed
    ..Thus, this set of data indicated that GPCR-elicited GTP loading of Rap1 was not sufficient to stimulate efficiently ERK in PC12 cells and required the permissive co-stimulation of PKA, PKC, or Ras. ..
  69. Soria Castro I, Krzyzanowska A, Pelaéz M, Regadera J, Ferrer G, Montoliu L, et al. Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation. J Biol Chem. 2010;285:33805-15 pubmed publisher
    ..Moreover, Cot/tpl2 deficiency dramatically decreased the production of the hypernociceptive ligand NGF at the inflammatory site during the course of inflammation...
  70. Clegg D. Characterization of a beta-nerve growth factor expression vector for mammalian cells. Gene. 1993;130:291-6 pubmed
    A mammalian expression vector that directs expression of murine beta-nerve growth factor (beta-NGF) from a murine sarcoma virus long terminal repeat (LTR) promoter element was constructed and characterized...
  71. Takano S, Uchida K, Miyagi M, Inoue G, Fujimaki H, Aikawa J, et al. Nerve Growth Factor Regulation by TNF-? and IL-1? in Synovial Macrophages and Fibroblasts in Osteoarthritic Mice. J Immunol Res. 2016;2016:5706359 pubmed publisher
    To investigate the role of macrophages as a regulator and producer of nerve growth factor (NGF) in the synovial tissue (ST) of osteoarthritis (OA) joints, the gene expression profiles of several inflammatory cytokines in the ST, ..
  72. Houtz J, Borden P, Ceasrine A, Minichiello L, Kuruvilla R. Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. Dev Cell. 2016;39:329-345 pubmed publisher
    ..Nerve growth factor (NGF), a classical trophic factor for nerve cells, is expressed in pancreatic vasculature while its TrkA receptor is ..
  73. Luukko K, Kettunen P. Coordination of tooth morphogenesis and neuronal development through tissue interactions: lessons from mouse models. Exp Cell Res. 2014;325:72-7 pubmed publisher
    ..Therefore, tissue interactions mediated by conserved signal families may constitute key mechanism for the integration of tooth organogenesis and development of its peripheral nerve supply. ..
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    ..These data further strengthen the concept that neurotrophin signaling is an important element in controlling the rate of hair follicle morphogenesis, yet also highlight the complexity of this signaling system. ..
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    ..In this study, we examined the antileishmanial effect of nerve growth factor (NGF) using a murine infection model...
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    Addition of nerve growth factor (NGF) to PC12 cells promotes neuronal differentiation while inhibiting cell proliferation...
  78. Nakanishi T, Takahashi K, Aoki C, Nishikawa K, Hattori T, Taniguchi S. Expression of nerve growth factor family neurotrophins in a mouse osteoblastic cell line. Biochem Biophys Res Commun. 1994;198:891-7 pubmed
    ..from newborn mouse calvaria, the mRNAs encoding three representative neurotrophins, namely, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), were proved in estimation by the polymerase ..
  79. Forgie A, Kuehnel F, Wyatt S, Davies A. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. Eur J Neurosci. 2000;12:670-6 pubmed
    ..the classic example of a population of peripheral nervous system neurons that do not require nerve growth factor (NGF) for survival during development but are dependent on other neurotrophins...
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    The development of crural Pacinian corpuscles was explored in neonatal mutant mice lacking nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) or neurotrophin-4 (NT4), or their cognate Trk receptors...
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    ..Nerve growth factor (NGF), a homodimeric polypeptide, plays an important role in the nervous system by supporting the survival and growth of ..
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    The gamma-subunit of mouse 7S nerve growth factor (gamma-NGF) is a member of a family of closely related serine proteases that includes kallikreins and tamases...
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    ..These results demonstrate that the CB-1/Fim-3 and Evi-1 loci constitute a large genomic region in which viral integrations activate the transcription of a new potential myeloid transforming gene. ..
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    ..the survival of sympathetic neurons and the majority of sensory neurons depends on a supply of nerve growth factor (NGF) from tissues they innervate...
  85. Hassankhani A, Steinhelper M, Soonpaa M, Katz E, Taylor D, Andrade Rozental A, et al. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev Biol. 1995;169:309-21 pubmed
    Nerve growth factor (NGF) supports the survival of developing sympathetic and a subpopulation of sensory neurons. In the adult it participates in maintenance of the neurotransmitter phenotype of responsive neurons...
  86. Avdoshina V, Becker J, CAMPBELL L, Parsadanian M, Mhyre T, Tessarollo L, et al. Neurotrophins modulate the expression of chemokine receptors in the brain. J Neurovirol. 2011;17:58-62 pubmed publisher
    ..This new evidence suggests that the neurotrophins may be an adjunct therapy to reduce HIV-mediated neuronal injury evoked by chemokine receptor activation. ..
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