Ngb

Summary

Gene Symbol: Ngb
Description: neuroglobin
Alias: neuroglobin
Species: mouse
Products:     Ngb

Top Publications

  1. Wei X, Yu Z, Cho K, Chen H, Malik M, Chen X, et al. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol. 2011;179:2788-97 pubmed publisher
    b>Neuroglobin (NGB), a newly discovered member of the globin superfamily, may regulate neuronal survival under hypoxia or oxidative stress...
  2. Khan A, Sun Y, Jin K, Mao X, Chen S, Ellerby L, et al. A neuroglobin-overexpressing transgenic mouse. Gene. 2007;398:172-6 pubmed
    b>Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults...
  3. Chen X, Qin L, Zhang C, Yang L, Gao Z, Liu S, et al. Presence of neuroglobin in cultured astrocytes. Glia. 2005;50:182-6 pubmed
    b>Neuroglobin (Ngb), a recently discovered intracellular respiratory globin in neurons, may play a crucial role in oxygen homeostasis in the brain...
  4. Khan A, Mao X, Banwait S, DerMardirossian C, Bokoch G, Jin K, et al. Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J. 2008;22:1737-47 pubmed publisher
    The signal transduction pathways involved in neuronal death are not well understood. Neuroglobin (Ngb), a recently discovered vertebrate globin expressed predominantly in the brain, shows increased expression in neurons in response to ..
  5. Fordel E, Thijs L, Moens L, Dewilde S. Neuroglobin and cytoglobin expression in mice. Evidence for a correlation with reactive oxygen species scavenging. FEBS J. 2007;274:1312-7 pubmed
    Although essentially unknown, several functions are hypothesized for neuroglobin and cytoglobin, two new members of the globin family...
  6. Hundahl C, Stoltenberg M, Fago A, Weber R, DeWilde S, Fordel E, et al. Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues. Neuropathol Appl Neurobiol. 2005;31:610-7 pubmed
    Nerve cells are highly susceptible to ischemic and hypoxic injuries. The neuroglobin (Ngb), found in vertebrate nerve cells, has been suggested to protect nerve cells from ischemic episodes by a yet unknown mechanism...
  7. Brunori M, Giuffrè A, Nienhaus K, Nienhaus G, Scandurra F, Vallone B. Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Proc Natl Acad Sci U S A. 2005;102:8483-8 pubmed
    b>Neuroglobin (Ngb) is a globin expressed in the nervous system of humans and other organisms that is involved in the protection of the brain from ischemic damage...
  8. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature. 2000;407:520-3 pubmed
    ..This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr)..
  9. Khan A, Wang Y, Sun Y, Mao X, Xie L, Miles E, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006;103:17944-8 pubmed
    b>Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or ischemic neuronal injury...

More Information

Publications67

  1. Hundahl C, Fahrenkrug J, Luuk H, Hay Schmidt A, Hannibal J. Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase. Biochem Biophys Res Commun. 2012;425:100-6 pubmed publisher
    b>Neuroglobin (Ngb), a neuronal specific oxygen binding heme-globin, reported to be expressed at high levels in most layers of the murine retina...
  2. Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y, et al. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008;39:1869-74 pubmed publisher
    Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood...
  3. Mammen P, Shelton J, Ye Q, Kanatous S, McGrath A, Richardson J, et al. Cytoglobin is a stress-responsive hemoprotein expressed in the developing and adult brain. J Histochem Cytochem. 2006;54:1349-61 pubmed
    ..In the adult mouse, Cygb is expressed in distinct regions of the brain as compared with neuroglobin (Ngb), another globin protein, and these regions are responsive to oxidative stress (i.e...
  4. Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans J, Moens L. A globin in the nucleus!. J Biol Chem. 2003;278:30417-20 pubmed
    Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues...
  5. Liu N, Yu Z, Xiang S, Zhao S, Tjarnlund Wolf A, Xing C, et al. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J. 2012;443:153-64 pubmed publisher
    Ngb (neuroglobin) has been identified as a novel endogenous neuroprotectant. However, little is known about the regulatory mechanisms of Ngb expression, especially under conditions of hypoxia...
  6. Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber R. Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. J Biol Chem. 2004;279:44417-26 pubmed
    Two new globin proteins have recently been discovered in vertebrates, neuroglobin in neurons and cytoglobin in all tissues, both showing heme hexacoordination by the distal His(E7) in the absence of gaseous ligands...
  7. Liu J, Yu Z, Guo S, Lee S, Xing C, Zhang C, et al. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009;87:164-70 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered tissue globin with a high affinity for oxygen that is widely and specifically expressed in neurons of vertebrate central and peripheral nervous systems...
  8. Khan A, Mao X, Banwait S, Jin K, Greenberg D. Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci U S A. 2007;104:19114-9 pubmed
    b>Neuroglobin (Ngb), a vertebrate globin expressed primarily in neurons, is induced by and protects against neuronal hypoxia and cerebral ischemia...
  9. Hundahl C, Allen G, Hannibal J, Kjaer K, Rehfeld J, Dewilde S, et al. Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain. Brain Res. 2010;1331:58-73 pubmed publisher
    The present study aimed at characterizing the anatomical and subcellular localization of cytoglobin (Cygb) and neuroglobin (Ngb) in the mouse brain by use of in situ hybridisation, immunohistochemistry and immunoelectron microscopy...
  10. Schmidt M, Giessl A, Laufs T, Hankeln T, Wolfrum U, Burmester T. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J Biol Chem. 2003;278:1932-5 pubmed
    ..Here we show that neuroglobin, a neuron-specific respiratory protein distantly related to hemoglobin and myoglobin, is present at high ..
  11. Hundahl C, Luuk H, Ilmjärv S, Falktoft B, Raida Z, Vikesaa J, et al. Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. PLoS ONE. 2011;6:e28160 pubmed publisher
    b>Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain...
  12. Awenius C, Hankeln T, Burmester T. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem Biophys Res Commun. 2001;287:418-21 pubmed
    b>Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and man. Here we show that neuroglobin is also present in the teleost fish...
  13. Van Doorslaer S, Dewilde S, Kiger L, Nistor S, Goovaerts E, Marden M, et al. Nitric oxide binding properties of neuroglobin. A characterization by EPR and flash photolysis. J Biol Chem. 2003;278:4919-25 pubmed
    b>Neuroglobin is a recently discovered member of the globin superfamily...
  14. Steenhard B, Isom K, Stroganova L, St John P, Zelenchuk A, Freeburg P, et al. Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen {alpha}1{alpha}2{alpha}1(IV), expression of neuroglobin, and proteinuria. Am J Pathol. 2010;177:84-96 pubmed publisher
    ..In addition, the brain oxygen-binding protein, Neuroglobin, was induced in mutant podocytes...
  15. Sugitani K, Koriyama Y, Sera M, Arai K, Ogai K, Wakasugi K. A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury. Biochem Biophys Res Commun. 2017;493:1254-1259 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules. Mammalian Ngb plays a crucial role in neuroprotection under conditions of oxidative stress...
  16. Yin G, Li Y, Li J, Li J, Du W, Wei Q, et al. Solution 1H NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin. Biophys Chem. 2008;136:115-23 pubmed publisher
    ..out to investigate the molecular and electronic structures of the active site in H64Q/V68F double mutant mouse neuroglobin in the cyanomet form...
  17. Kriegl J, Bhattacharyya A, Nienhaus K, Deng P, Minkow O, Nienhaus G. Ligand binding and protein dynamics in neuroglobin. Proc Natl Acad Sci U S A. 2002;99:7992-7 pubmed
    b>Neuroglobin (Ngb) is a recently discovered protein in vertebrate brain tissue that belongs to the globin family of proteins...
  18. Sun Y, Jin K, Mao X, Xie L, Peel A, Childs J, et al. Effect of aging on neuroglobin expression in rodent brain. Neurobiol Aging. 2005;26:275-8 pubmed
    b>Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo...
  19. Fabrizius A, Andre D, Laufs T, Bicker A, Reuss S, Porto E, et al. Critical re-evaluation of neuroglobin expression reveals conserved patterns among mammals. Neuroscience. 2016;337:339-354 pubmed publisher
    b>Neuroglobin (Ngb) is a respiratory protein that is almost exclusively expressed in the vertebrate nervous system. Despite many years of research, the exact function and even the expression sites of Ngb are still a matter of debate...
  20. Jin K, Mao X, Xie L, Greenberg D. Interactions between vascular endothelial growth factor and neuroglobin. Neurosci Lett. 2012;519:47-50 pubmed publisher
    Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown...
  21. Xu J, Yin G, Huang F, Wang B, Du W. Molecular dynamics simulation of a carboxy murine neuroglobin mutated on the proximal side: heme displacement and concomitant rearrangement in loop regions. J Mol Model. 2010;16:759-70 pubmed publisher
    b>Neuroglobin, a member of vertebrate globin family, is distributed primarily in the brain and retina...
  22. Wystub S, Laufs T, Schmidt M, Burmester T, Maas U, Saaler Reinhardt S, et al. Localization of neuroglobin protein in the mouse brain. Neurosci Lett. 2003;346:114-6 pubmed
    b>Neuroglobin is a recently discovered vertebrate oxygen-binding respiratory protein...
  23. Yu Z, Xu J, Liu N, Wang Y, Li X, Pallast S, et al. Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons. Neuroscience. 2012;218:235-42 pubmed publisher
    b>Neuroglobin (Ngb) is a new member of the globin family and a novel endogenous neuroprotective molecule, but its neuroprotective mechanisms remain largely undefined...
  24. Nienhaus K, Kriegl J, Nienhaus G. Structural dynamics in the active site of murine neuroglobin and its effects on ligand binding. J Biol Chem. 2004;279:22944-52 pubmed
    We have examined the effects of active site residues on ligand binding to the heme iron of mouse neuroglobin using steady-state and time-resolved visible spectroscopy...
  25. Raida Z, Hundahl C, Nyengaard J, Hay Schmidt A. Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size. PLoS ONE. 2013;8:e76565 pubmed publisher
    Stroke is a major cause of death and severe disability, but effective treatments are limited. Neuroglobin, a neuronal heme-globin, has been advocated as a novel pharmacological target in combating stroke and neurodegenerative disorders ..
  26. Taylor J, Kelley B, Gregory E, Berman N. Neuroglobin overexpression improves sensorimotor outcomes in a mouse model of traumatic brain injury. Neurosci Lett. 2014;577:125-9 pubmed publisher
    ..One potential neuroprotective mechanism is to increase oxygen binding proteins such as neuroglobin. Neuroglobin has a high affinity for oxygen, is an effective free radical scavenger, and is neuroprotective ..
  27. Cai B, Li W, Mao X, Winters A, Ryou M, Liu R, et al. Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism. Mol Neurobiol. 2016;53:1254-65 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered globin with preferential localization to neurons...
  28. Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S. A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina. Adv Exp Med Biol. 2016;854:671-5 pubmed publisher
    b>Neuroglobin (Ngb) is a new member of the family of heme proteins and is specifically expressed in neurons of the central and peripheral nervous systems in all vertebrates...
  29. Reuss S, Saaler Reinhardt S, Weich B, Wystub S, Reuss M, Burmester T, et al. Expression analysis of neuroglobin mRNA in rodent tissues. Neuroscience. 2002;115:645-56 pubmed
    b>Neuroglobin is a respiratory protein which was reported to be preferentially expressed in the vertebrate brain. Here we present the first detailed analysis of the expression of neuroglobin in mouse and rat tissues...
  30. Vinck E, Van Doorslaer S, DeWilde S, Mitrikas G, Schweiger A, Moens L. Analyzing heme proteins using EPR techniques: the heme-pocket structure of ferric mouse neuroglobin. J Biol Inorg Chem. 2006;11:467-75 pubmed
    ..Frozen solutions of ferric mouse neuroglobin (mNgb) are analyzed by means of electron spin echo envelope modulation and pulsed electron-nuclear double ..
  31. Arcovito A, Ardiccioni C, Cianci M, D Angelo P, Vallone B, Della Longa S. Polarized X-ray absorption near-edge structure spectroscopy of neuroglobin and myoglobin single crystals. J Phys Chem B. 2010;114:13223-31 pubmed publisher
    Polarized Fe K-edge X-ray absorption near-edge structure (XANES) spectra of murine carbonmonoxy-neuroglobin (NgbCO) single crystals have been collected and compared with a number of derivatives of sperm whale myoglobin (Mb), that is, the ..
  32. DellaValle B, Hempel C, Kurtzhals J, Penkowa M. In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis. Glia. 2010;58:1220-7 pubmed publisher
    b>Neuroglobin (Ngb) is proposed to be a neuron-specific, hypoxia-responsive, neuroprotective protein. However, results are conflicting concerning both Ngb's physiological and pathological significance...
  33. Nienhaus K, Lutz S, Meuwly M, Nienhaus G. Structural identification of spectroscopic substates in neuroglobin. Chemphyschem. 2010;11:119-29 pubmed publisher
    The structural origins of infrared absorptions of photodissociated CO in murine neuroglobin (Ngb) are determined by combining Fourier transform infrared (FTIR) spectroscopy and molecular dynamics (MD) simulations...
  34. Yu Z, Zhang Y, Liu N, Yuan J, Lin L, ZhuGe Q, et al. Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons. Mol Neurobiol. 2016;53:3249-3257 pubmed publisher
    b>Neuroglobin (Ngb) is a tissue globin specifically expressed in brain neurons...
  35. Chan A, Saraswathy S, Rehak M, Ueki M, Rao N. Neuroglobin protection in retinal ischemia. Invest Ophthalmol Vis Sci. 2012;53:704-11 pubmed publisher
    b>Neuroglobin (Ngb) is a vertebrate globin that is predominantly expressed in the retina and brain...
  36. Shao G, Gong K, Li J, Xu X, Gao C, Zeng X, et al. Antihypoxic effects of neuroglobin in hypoxia-preconditioned mice and SH-SY5Y cells. Neurosignals. 2009;17:196-202 pubmed publisher
    This work aims at investigating the neuroprotective effects of neuroglobin (Ngb) in vivo and in vitro...
  37. Gysemans C, Waer M, Valckx D, Laureys J, Mihkalsky D, Bouillon R, et al. Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts. Diabetes. 2000;49:1992-7 pubmed
    ..These data suggest that early islet xenograft failure is more common in spontaneously diabetic NOD mice and could be due to a nonspecific inflammatory reaction locally in the grafts. ..
  38. Laufs T, Wystub S, Reuss S, Burmester T, Saaler Reinhardt S, Hankeln T. Neuron-specific expression of neuroglobin in mammals. Neurosci Lett. 2004;362:83-6 pubmed
    b>Neuroglobin, a vertebrate oxygen-binding protein, is expressed in many regions of the adult brain...
  39. Schmidt M, Laufs T, Reuss S, Hankeln T, Burmester T. Divergent distribution of cytoglobin and neuroglobin in the murine eye. Neurosci Lett. 2005;374:207-11 pubmed
    b>Neuroglobin (Ngb) and cytoglobin (Cygb) are two vertebrate globins with yet poorly defined functions...
  40. Ye S, Zhou X, Lai X, Zheng L, Chen X. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin. 2009;30:913-8 pubmed publisher
    To explore the protective role and mechanism of endogenous neuroglobin (Ngb) in neuronal cells under oxidative stress...
  41. Fago A, Mathews A, Moens L, Dewilde S, Brittain T. The reaction of neuroglobin with potential redox protein partners cytochrome b5 and cytochrome c. FEBS Lett. 2006;580:4884-8 pubmed
    Previously identified, potentially neuroprotective reactions of neuroglobin require the existence of yet unknown redox partners...
  42. Vallone B, Nienhaus K, Brunori M, Nienhaus G. The structure of murine neuroglobin: Novel pathways for ligand migration and binding. Proteins. 2004;56:85-92 pubmed
    b>Neuroglobin, a recently discovered globin predominantly expressed in neuronal tissue of vertebrates, binds small, gaseous ligands at the sixth coordination position of the heme iron...
  43. Liu N, Yu Z, Li Y, Yuan J, Zhang J, Xiang S, et al. Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells. Neurosci Lett. 2013;534:333-7 pubmed publisher
    b>Neuroglobin (Ngb) has been demonstrated to be a novel neuroprotective protein that protects against hypoxia/ischemia and oxidative stress-induced injury in the nervous system...
  44. Hümmler N, Schneider C, Giessl A, Bauer R, Walkinshaw G, Gassmann M, et al. Acute hypoxia modifies regulation of neuroglobin in the neonatal mouse brain. Exp Neurol. 2012;236:112-21 pubmed publisher
    Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant...
  45. De Marinis E, Ascenzi P, Pellegrini M, Galluzzo P, Bulzomi P, Arevalo M, et al. 17?-estradiol--a new modulator of neuroglobin levels in neurons: role in neuroprotection against H?O?-induced toxicity. Neurosignals. 2010;18:223-35 pubmed publisher
    Although discovered in 2000, neuroglobin (Ngb) functions are still uncertain. A contribution to the role played by Ngb in neurons could certainly derive from the identification of Ngb endogenous modulators...
  46. Anselmi M, Brunori M, Vallone B, Di Nola A. Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water. Biophys J. 2007;93:434-41 pubmed
    ..Unexpectedly a few years ago a new member was discovered and called neuroglobin (Ngb), being predominantly expressed in the brain...
  47. Gorgun F, Zhuo M, Singh S, Englander E. Neuroglobin mitigates mitochondrial impairments induced by acute inhalation of combustion smoke in the mouse brain. Inhal Toxicol. 2014;26:361-9 pubmed publisher
    ..We previously showed that overexpressed neuroglobin (Ngb), neuron specific globin protein, attenuates the formation of smoke inhalation-induced oxidative DNA ..
  48. Yu Z, Liu N, Wang Y, Li X, Wang X. Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Neuroscience. 2012;200:99-105 pubmed publisher
    b>Neuroglobin (Ngb) is a globin protein that is highly and specifically expressed in brain neurons...
  49. Vallone B, Nienhaus K, Matthes A, Brunori M, Nienhaus G. The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity. Proc Natl Acad Sci U S A. 2004;101:17351-6 pubmed
    b>Neuroglobin (Ngb), a globular heme protein expressed in the brain of vertebrates, binds oxygen reversibly, with an affinity comparable to myoglobin (Mb). Despite low sequence identity, the overall 3D fold of Ngb and Mb is very similar...
  50. Reuss S, Banica O, Elgurt M, Mitz S, Disque Kaiser U, Riemann R, et al. Neuroglobin Expression in the Mammalian Auditory System. Mol Neurobiol. 2016;53:1461-1477 pubmed publisher
    ..b>Neuroglobin (Ngb) is a neuron-specific hemoprotein of the globin family, which is suggested to be involved in oxidative ..
  51. Hundahl C, Fahrenkrug J, Hay Schmidt A, Georg B, Faltoft B, Hannibal J. Circadian behaviour in neuroglobin deficient mice. PLoS ONE. 2012;7:e34462 pubmed publisher
    b>Neuroglobin (Ngb), a neuron-specific oxygen-binding globin with an unknown function, has been proposed to play a key role in neuronal survival. We have previously shown Ngb to be highly expressed in the rat suprachiasmatic nucleus (SCN)...
  52. Teh A, Saito J, Baharuddin A, Tuckerman J, Newhouse J, Kanbe M, et al. Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin. FEBS Lett. 2011;585:3250-8 pubmed publisher
    ..Bacterial HGbI's unique resistance to the sort of extreme acidity that would extract heme from any other hemoglobin makes it an ideal candidate for comparative structure-function studies of the expanding globin superfamily. ..
  53. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen M, et al. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012;13:67 pubmed publisher
    Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries...
  54. Giuffrè A, Moschetti T, Vallone B, Brunori M. Neuroglobin: enzymatic reduction and oxygen affinity. Biochem Biophys Res Commun. 2008;367:893-8 pubmed publisher
    b>Neuroglobin (Ngb) is a hexacoordinate globin expressed in the nervous system of vertebrates, involved in neuroprotection...
  55. Li L, Liu Q, Xiong X, Liu J, Lai X, Cheng C, et al. Neuroglobin promotes neurite outgrowth via differential binding to PTEN and Akt. Mol Neurobiol. 2014;49:149-62 pubmed publisher
    b>Neuroglobin, the third mammalian globin with a hexa-coordinated heme, exists predominantly in neurons of the brain. Neuroglobin plays an important role in neuronal death upon ischemia and oxidative stress...
  56. Couture M, Burmester T, Hankeln T, Rousseau D. The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket. J Biol Chem. 2001;276:36377-82 pubmed
    b>Neuroglobin (Ngb) is a newly discovered oxygen-binding heme protein that is primarily expressed in the brain of humans and other vertebrates...
  57. Azarov I, Wang L, Rose J, Xu Q, Huang X, Belanger A, et al. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016;8:368ra173 pubmed
    ..potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues...
  58. Van Acker Z, Luyckx E, Van Leuven W, Geuens E, De Deyn P, Van Dam D, et al. Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels. FEBS Lett. 2017;591:1321-1332 pubmed publisher
    Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD...