Nfatc3

Summary

Gene Symbol: Nfatc3
Description: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Alias: C80703, D8Ertd281e, NFAT4, NFATx, nuclear factor of activated T-cells, cytoplasmic 3, NF-AT4, NF-ATc3, T-cell transcription factor NFAT4
Species: mouse
Products:     Nfatc3

Top Publications

  1. Canté Barrett K, Winslow M, Crabtree G. Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007;179:103-10 pubmed
    ..In this study, we address the requirement for NFATc3 in T cell development by generating NFATc3 conditional knockout mice...
  2. Oukka M, Ho I, de la Brousse F, Hoey T, Grusby M, Glimcher L. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998;9:295-304 pubmed
    ..Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes...
  3. Rengarajan J, Tang B, Glimcher L. NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nat Immunol. 2002;3:48-54 pubmed
    ..We found that naïve T(H) precursors that are doubly deficient in NFATc2 and NFATc3 intrinsically differentiate into TH(2)-secreting cells, even in the absence of interleukin 4 (IL-4) production...
  4. Bushdid P, Osinska H, Waclaw R, Molkentin J, Yutzey K. NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res. 2003;92:1305-13 pubmed
    ..In this report, the function of NFATc3 and NFATc4 in embryonic heart development was examined in mice with targeted disruption of both nfatc3 and nfatc4 ..
  5. Neilson J, Winslow M, Hur E, Crabtree G. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004;20:255-66 pubmed
  6. Awla D, Zetterqvist A, Abdulla A, Camello C, Berglund L, Spégel P, et al. NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice. Gastroenterology. 2012;143:1352-1360.e7 pubmed publisher
    ..infusion of taurocholate into the pancreatic ducts of wild-type, NFAT luciferase reporter (NFAT-luc), and NFATc3-deficient mice...
  7. Bierer R, Nitta C, Friedman J, Codianni S, de Frutos S, Dominguez Bautista J, et al. NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2011;301:L872-80 pubmed publisher
    ..The Ca(2+)-dependent transcription factor, nuclear factor of activated T cells isoform c3 (NFATc3), has been implicated in chronic hypoxia-induced pulmonary arterial remodeling in adult mice...
  8. Masuda E, Naito Y, Tokumitsu H, Campbell D, Saito F, Hannum C, et al. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol Cell Biol. 1995;15:2697-706 pubmed
    ..The novel molecule, designated NFATx, exhibits in its middle a region very similar to the Rel homology domain in NFATc and NFATp...
  9. Graef I, Wang F, Charron F, Chen L, Neilson J, Tessier Lavigne M, et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003;113:657-70 pubmed
    ..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development. ..

More Information

Publications86

  1. Wilkins B, De Windt L, Bueno O, Braz J, Glascock B, Kimball T, et al. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol. 2002;22:7603-13 pubmed
    ..Accordingly, mice with targeted disruptions in NFATc3 and NFATc4 genes were characterized...
  2. Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006;441:595-600 pubmed
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease. ..
  3. Pierre K, Jones C, Pierce J, Nicoud I, Earl T, Chari R. NFAT4 deficiency results in incomplete liver regeneration following partial hepatectomy. J Surg Res. 2009;154:226-33 pubmed publisher
    ..Eight-week old NFAT4 knockout (KO) mice and their wild type counterparts (Balb-c) underwent two-thirds partial hepatectomy...
  4. Ranger A, Oukka M, Rengarajan J, Glimcher L. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity. 1998;9:627-35 pubmed
    ..Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling coupled with ..
  5. Pan S, Koyano Nakagawa N, Tsuruta L, Amasaki Y, Yokota T, Mori S, et al. Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc. Biochem Biophys Res Commun. 1997;240:314-23 pubmed
    ..In the mouse embryo, mNFATc transcript was strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart suggesting that mNFATc may have a role both in embryogenesis and in mature T cells. ..
  6. Lawrence M, Naziruddin B, Levy M, Jackson A, McGlynn K. Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells. J Biol Chem. 2011;286:1025-36 pubmed publisher
    ..Thus, by these mechanisms, pancreatic ? cells themselves may contribute to islet inflammation and their own immunological destruction in the pathogenesis of diabetes. ..
  7. Debnath I, Roundy K, Weis J, Weis J. Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes. J Immunol. 2007;178:7139-50 pubmed
    ..binding of YY1, NF-kappaB-p52, Pax5, and Oct-1 proteins to CD21 sequences in B cells but no specific binding of NFATc3 or Pax5 in T cells...
  8. Pouillon V, Hascakova Bartova R, Pajak B, Adam E, Bex F, Dewaste V, et al. Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development. Nat Immunol. 2003;4:1136-43 pubmed
    ..These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development. ..
  9. Nystoriak M, Nieves Cintrón M, Nygren P, Hinke S, Nichols C, Chen C, et al. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014;114:607-15 pubmed publisher
    ..that AKAP150 is an important determinant of BKCa channel remodeling, CaN/nuclear factor of activated T-cells c3 (NFATc3) activation, and resistance artery constriction in hyperglycemic animals on high-fat diet...
  10. Gómez Sintes R, Lucas J. NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest. 2010;120:2432-45 pubmed publisher
    ..We found that GSK-3 inhibition increased translocation of nuclear factor of activated T cells c3/4 (NFATc3/4) transcription factors to the nucleus, leading to increased Fas ligand (FasL) levels and Fas activation...
  11. de Frutos S, Nitta C, Caldwell E, Friedman J, Gonzalez Bosc L. Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. Am J Physiol Lung Cell Mol Physiol. 2009;297:L475-86 pubmed publisher
    ..Since the transcription factor NFATc3 is required for the upregulation of the smooth muscle hypertrophic/differentiation marker alpha-actin in pulmonary ..
  12. Daou N, Lecolle S, Lefebvre S, Della Gaspera B, Charbonnier F, Chanoine C, et al. A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013;140:4914-25 pubmed publisher
    ..and chromatin immunoprecipitation assays, we identified NFATc2 bound to the neonatal Mhc gene, whereas NFATc1 and NFATc3 would preferentially bind the embryonic Mhc gene...
  13. Ranjan R, Deng J, Chung S, Lee Y, Park G, Xiao L, et al. The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6:754-64 pubmed publisher
    ..Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in macrophages stimulated with lipopolysaccharide...
  14. van Rooij E, Doevendans P, de Theije C, Babiker F, Molkentin J, De Windt L. Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J Biol Chem. 2002;277:48617-26 pubmed
    ..These results indicate that multiple NFAT isoforms are expressed in cardiomyocytes where they function as necessary transducers of calcineurin in facilitating cardiomyocyte hypertrophy. ..
  15. Hatem Vaquero M, Griera M, Giermakowska W, Luengo A, Calleros L, Gonzalez Bosc L, et al. Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochim Biophys Acta Gene Regul Mech. 2017;1860:922-935 pubmed publisher
    ..In the present work, we used in vivo and in vitro approaches to examine ILK participation in NFATc3/AP-1-mediated increases in AQP2 gene expression...
  16. Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
    ..is specific for iTreg development, because frequency of nTreg remained unaltered in mice lacking NFAT1, NFAT2, or NFAT4 alone or in combination...
  17. Rodriguez Galan M, Bream J, Farr A, Young H. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol. 2005;174:2796-804 pubmed
  18. Luo J, Sun L, Lin X, Liu G, Yu J, Parisiadou L, et al. A calcineurin- and NFAT-dependent pathway is involved in ?-synuclein-induced degeneration of midbrain dopaminergic neurons. Hum Mol Genet. 2014;23:6567-74 pubmed publisher
    ..Furthermore, overexpression of ?-syn A53T mutation significantly increased the CN-dependent nuclear import of NFATc3 in the mDA neurons of transgenic mice...
  19. Zeini M, Hang C, Lehrer Graiwer J, Dao T, Zhou B, Chang C. Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development. 2009;136:3335-45 pubmed publisher
  20. de Frutos S, Duling L, Alò D, Berry T, Jackson Weaver O, Walker M, et al. NFATc3 is required for intermittent hypoxia-induced hypertension. Am J Physiol Heart Circ Physiol. 2008;294:H2382-90 pubmed publisher
    ..Therefore, we hypothesized that NFATc3 is activated by H-IH and is required for H-IH-induced hypertension...
  21. Tsika R, Schramm C, Simmer G, Fitzsimons D, Moss R, Ji J. Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J Biol Chem. 2008;283:36154-67 pubmed publisher
    ..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression. ..
  22. Kao S, Wu H, Xie J, Chang C, Ranish J, Graef I, et al. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009;323:651-4 pubmed publisher
    ..initiates an increase in cytoplasmic Ca2+, which activates calcineurin and the downstream transcription factors NFATc3 and c4...
  23. Wang K, Zhang D, Long B, An T, Zhang J, Zhou L, et al. NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1. Cell Death Dis. 2015;6:e2007 pubmed publisher
    ..Here we report that NFAT4, miR-324-5p and mitochondrial fission regulator 1 (Mtfr1) function in one signaling axis that regulates ..
  24. Hebinck A, Dalski A, Engel H, Mattei M, Hawken R, Schwinger E, et al. Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains. Cytogenet Cell Genet. 2000;90:68-70 pubmed
    ..1 subband, the localization of the murine gene at chromosome 8D, and the identification and mapping of the porcine counterpart to chromosome 6p1.4. ..
  25. Zetterqvist A, Blanco F, Öhman J, Kotova O, Berglund L, de Frutos Garcia S, et al. Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice. J Diabetes Res. 2015;2015:428473 pubmed publisher
    ..Acute hyperglycemia induced by an IP-GTT (intraperitoneal glucose tolerance test) resulted in increased NFATc3 nuclear accumulation and NFAT-dependent transcriptional activity in retinal vessels of NFAT-luciferase reporter ..
  26. Ya J, Schilham M, de Boer P, Moorman A, Clevers H, Lamers W. Sox4-deficiency syndrome in mice is an animal model for common trunk. Circ Res. 1998;83:986-94 pubmed
  27. de Frutos S, Caldwell E, Nitta C, Kanagy N, Wang J, Wang W, et al. NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. Am J Physiol Heart Circ Physiol. 2010;299:H356-63 pubmed publisher
    ..Furthermore, intermittent hypoxia (IH) in mice increases nuclear factor of activated T cells isoform 3 (NFATc3) transcriptional activity in aorta and mesenteric arteries, whereas the calcineurin/NFAT inhibitor cyclosporin A ..
  28. Nilsson Berglund L, Zetterqvist A, Nilsson Ohman J, Sigvardsson M, Gonzalez Bosc L, Smith M, et al. Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia. Arterioscler Thromb Vasc Biol. 2010;30:218-24 pubmed publisher
    ..An intraperitoneal glucose-tolerance test in mice increased NFATc3 nuclear accumulation in vascular smooth muscle...
  29. Kurabayashi N, Sanada K. Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013;27:2708-21 pubmed publisher
    ..In sum, our findings suggest that dosage of DYRK1A and DSCR1 is critical for proper neurogenesis through NFATc and provide a potential mechanism to explain the neurodevelopmental defects in DS. ..
  30. Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, et al. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016;22:506-15 pubmed publisher
    ..These findings highlight an epithelial cell-intrinsic pathway that integrates signals derived from the commensal microbiota to promote intestinal tumor development. ..
  31. Amberg G, Rossow C, Navedo M, Santana L. NFATc3 regulates Kv2.1 expression in arterial smooth muscle. J Biol Chem. 2004;279:47326-34 pubmed
    ..Consistent with our hypothesis, we found that calcineurin and NFATc3 are obligatory components of the signaling cascade mediating reduced IKv by Ang II...
  32. Hullmann J, Grisanti L, Makarewich C, Gao E, Gold J, Chuprun J, et al. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res. 2014;115:976-85 pubmed publisher
    ..Furthermore, the loss of NFATc3 expression in the heart protected GRK5 overexpressing transgenic mice from the exaggerated hypertrophy and early ..
  33. Yissachar N, Sharar Fischler T, Cohen A, Reich Zeliger S, Russ D, Shifrut E, et al. Dynamic response diversity of NFAT isoforms in individual living cells. Mol Cell. 2013;49:322-30 pubmed publisher
    ..show, using imaging of individual living mammalian cells, that the closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation...
  34. Nariyama M, Shimizu K, Uematsu T, Maeda T. Identification of chromosomes associated with dental caries susceptibility using quantitative trait locus analysis in mice. Caries Res. 2004;38:79-84 pubmed
    ..These results suggest that major gene(s) responsible for dental caries susceptibility or resistance are located in one or more of these regions. ..
  35. Neria F, Del Carmen Serrano Pérez M, Velasco P, Urso K, Tranque P, Cano E. NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells. Glia. 2013;61:1052-66 pubmed publisher
    ..Astrocyte Mmp3 expression was induced by overexpression of a constitutively active form of NFATc3, whereas other MMPs and tissue inhibitor of metalloproteinases (TIMP) were unaffected...
  36. Oba M, Tsuchiaka S, Omatsu T, Katayama Y, Otomaru K, Hirata T, et al. A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system. Biochem Biophys Res Commun. 2018;495:1871-1877 pubmed publisher
    ..Our data showed usefulness of SureSelect target enrichment system for comprehensive analysis of genomic information of various viruses in field samples. ..
  37. Samanta D, Palmetshofer A, Marinkovic D, Wirth T, Serfling E, Nitschke L. B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice. J Immunol. 2005;174:4797-802 pubmed
    ..These observations suggest that the strongly elevated Th2 cytokine milieu in NFATc2/c3-deficient mice leads to a hyperactivation of mature, follicular B cells, whereas MZ B cells are less responsive to these signals. ..
  38. Alfieri C, Evans Anderson H, Yutzey K. Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle. Am J Physiol Cell Physiol. 2007;292:C1887-94 pubmed
    ..in developing skeletal muscle, and its embryonic expression is significantly reduced in embryos lacking both NFATc3 and NFATc4...
  39. Chang C, Neilson J, Bayle J, Gestwicki J, Kuo A, Stankunas K, et al. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004;118:649-63 pubmed
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis. ..
  40. Gomez M, Bosc L, Stevenson A, Wilkerson M, Hill Eubanks D, Nelson M. Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1. J Biol Chem. 2003;278:46847-53 pubmed
    ..depolarization and mediated by voltage-dependent Ca2+ channels, does not result in nuclear localization of the NFATc3 isoform in smooth muscle. However, vasoconstrictors (e.g...
  41. de Frutos S, Diaz J, Nitta C, Sherpa M, Bosc L. Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. Am J Physiol Cell Physiol. 2011;301:C441-50 pubmed publisher
    ..hypoxia (CH) activates the Ca(2+)-dependent transcription factor nuclear factor of activated T cells isoform c3 (NFATc3) in mouse pulmonary arteries. However, the mechanism of this response has not been explored...
  42. Lee H, Chouinard L, Bonin M, Michel R. NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice. Mol Carcinog. 2005;44:219-22 pubmed
    ..Here we report that two out of three NFATc3-/- and two in four NFATc3 +/- female mice developed aggressive mammary adenocarcinoma by 12...
  43. Crabtree G. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999;96:611-4 pubmed
  44. Bueno O, Brandt E, Rothenberg M, Molkentin J. Defective T cell development and function in calcineurin A beta -deficient mice. Proc Natl Acad Sci U S A. 2002;99:9398-403 pubmed
    ..suggested by the observation that CnA beta(-/-) T cells are defective in stimulation-induced NFATc1, NFATc2, and NFATc3 activation...
  45. Gomez M, Stevenson A, Bonev A, Hill Eubanks D, Nelson M. Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle. J Biol Chem. 2002;277:37756-64 pubmed
    ..We have previously shown that nuclear accumulation of NFATc3 is induced in ileal smooth muscle by platelet-derived growth factor in a manner that depends on Ca(2+) influx ..
  46. Chen J, Amasaki Y, Kamogawa Y, Nagoya M, Arai N, Arai K, et al. Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells. J Immunol. 2003;170:3109-17 pubmed
    ..For example, CD4(+) T cells isolated from NFATx-disrupted mice do not show any modulation in cytokine gene expression, perhaps because other family members ..
  47. Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, et al. NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J Exp Med. 2005;201:181-7 pubmed
  48. Nieves Cintrón M, Hirenallur Shanthappa D, Nygren P, Hinke S, Dell Acqua M, Langeberg L, et al. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016;28:733-40 pubmed publisher
    The Ca(2+)-responsive phosphatase calcineurin/protein phosphatase 2B dephosphorylates the transcription factor NFATc3. In the myocardium activation of NFATc3 down-regulates the expression of voltage-gated K(+) (Kv) channels after ..
  49. Concepcion A, Vaeth M, Wagner L, Eckstein M, Hecht L, Yang J, et al. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016;126:4303-4318 pubmed publisher
    ..Our findings demonstrate that Ca2+ influx via store-operated CRAC channels is essential for CaCC activation, chloride secretion, and sweat production in humans and mice. ..
  50. Layne J, Werner M, Hill Eubanks D, Nelson M. NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. Am J Physiol Cell Physiol. 2008;295:C611-23 pubmed publisher
    ..Ca(2+)-sensitive potassium (BK) channels and voltage-gated K(+) (K(V)) channels may be regulatory targets of NFATc3 in urinary bladder smooth muscle (UBSM)...
  51. Rossow C, Dilly K, Santana L. Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart. Circ Res. 2006;98:1306-13 pubmed
    ..Here, we tested the hypothesis that differential [Ca2+]i and calcineurin/NFATc3 signaling in EPI and ENDO cells contributes to the gradient of Ito function in the mouse left ventricle...
  52. Ramiro Diaz J, Giermakowska W, Weaver J, Jernigan N, Gonzalez Bosc L. Mechanisms of NFATc3 activation by increased superoxide and reduced hydrogen peroxide in pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2014;307:C928-38 pubmed publisher
    ..in O2(·-) and H2O2 is associated with elevated activity of nuclear factor of activated T cells isoform c3 (NFATc3) in pulmonary arterial smooth muscle cells (PASMC)...
  53. Ma J, Sasai M, Ohshima J, Lee Y, Bando H, Takeda K, et al. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. J Exp Med. 2014;211:2013-32 pubmed publisher
    ..granule protein GRA6 regulates activation of the host transcription factor nuclear factor of activated T cells 4 (NFAT4). GRA6 overexpression robustly and selectively activated NFAT4 via calcium modulating ligand (CAMLG)...
  54. Gonzalez Bosc L, Wilkerson M, Bradley K, Eckman D, Hill Eubanks D, Nelson M. Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase. J Biol Chem. 2004;279:10702-9 pubmed
    ..that elevation of calcium by membrane depolarization fails to induce an increase in nuclear localization of the NFATc3 isoform...
  55. de Frutos S, Spangler R, Alò D, Bosc L. NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. J Biol Chem. 2007;282:15081-9 pubmed
    ..b>NFATc3 (nuclear factor of activated T cells isoform c3), which is aCa(2+)-dependent transcription factor, has been ..
  56. Ho S, Thomas D, Timmerman L, Li X, Francke U, Crabtree G. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995;270:19898-907 pubmed
    ..roles of antigen receptor signaling throughout T cell development, we have identified a new NFATc family member, NFATc3, that is expressed at highest levels in the thymus...
  57. Hudson M, Woodworth Hobbs M, Zheng B, Rahnert J, Blount M, Gooch J, et al. miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export. Am J Physiol Cell Physiol. 2014;306:C551-8 pubmed publisher
    ..It also was reported to be regulated by cytoplasmic nuclear factor of activated T cells 3 (NFATc3) in cardiomyocytes...
  58. Dave V, Childs T, Whitsett J. Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem. 2004;279:34578-88 pubmed
    ..Calcineurin and NFATc3 proteins were detected in the embryonic and adult mouse lung epithelium, and the mRNA expression profiles of the ..
  59. Oliveira R, Ferreira J, Gomes E, Paixão N, Rolim N, Medeiros A, et al. Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. J Physiol. 2009;587:3899-910 pubmed publisher
    ..While nuclear calcineurin B, NFATc3 and GATA-4 translocation were significantly increased in alpha(2A)/alpha(2C)ARKO mice, no changes were observed in ..
  60. Kulkarni R, Greenberg J, Akeson A. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009;126:350-65 pubmed publisher
    ..In reporter assays, NFATc1 activated lymphatic specific gene promoters. These results demonstrate the role of calcineurin-NFAT pathway in lymphangiogenesis and suggest that NFATc1 is the principle NFAT involved. ..
  61. Deng K, Wang A, Ji Y, Zhang X, Fang J, Zhang Y, et al. Suppressor of IKK? is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016;7:11432 pubmed publisher
  62. Dave V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, et al. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest. 2006;116:2597-609 pubmed
    ..Nuclear factor of activated T cells (Nfat) calcineurin-dependent 3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, ..
  63. Rengarajan J, Mittelstadt P, Mages H, Gerth A, Kroczek R, Ashwell J, et al. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity. 2000;12:293-300 pubmed
    ..critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in mice lacking both NFATp and NFAT4 (DKO)...
  64. Tomita M, Reinhold M, Molkentin J, Naski M. Calcineurin and NFAT4 induce chondrogenesis. J Biol Chem. 2002;277:42214-8 pubmed
    ..The calcineurin substrate, NFAT4, also induced chondrogenesis and chondrocyte gene expression...
  65. Klein M, Klein Hessling S, Palmetshofer A, Serfling E, Tertilt C, Bopp T, et al. Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines. J Immunol. 2006;177:6667-74 pubmed
    ..NFATc2 are part of a MC-specific signaling network that regulates the expression of TNF-alpha and IL-13, whereas NFATc3 is dispensable...
  66. Nieves Cintrón M, Amberg G, Nichols C, Molkentin J, Santana L. Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. J Biol Chem. 2007;282:3231-40 pubmed
    ..Here, we tested the hypothesis that activation of the calcineurin/NFATc3 signaling pathway down-regulates beta1 expression during angiotensin II-induced hypertension...
  67. Wu H, Kao S, Barrientos T, Baldwin S, Olson E, Crabtree G, et al. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J Biol Chem. 2007;282:30673-9 pubmed
    ..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation. ..
  68. Binder A, Grammer J, Herndon M, Stanton J, Nilson J. GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT. Mol Endocrinol. 2012;26:873-86 pubmed publisher
    ..Additionally, although small interfering RNA specific for Nfat4 only marginally reduced GnRH regulation of Jun, Fos, and Atf3 mRNA accumulation, activity of an activator protein-..
  69. Ramakrishna S, Kim I, Petrovic V, Malin D, Wang I, Kalin T, et al. Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor. Dev Dyn. 2007;236:1000-13 pubmed
    ..defects in Foxm1 -/- hearts were associated with a reduced expression of Cdk1-activator Cdc25B phosphatase and NFATc3 transcription factor, and with abnormal nuclear accumulation of the Cdk-inhibitor p21(Cip1) protein...
  70. Kegley K, Gephart J, Warren G, Pavlath G. Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult. Dev Biol. 2001;232:115-26 pubmed
    ..The purpose of this study was to determine the role of the NFATC3 isoform in skeletal muscle development...
  71. Long C, Butler S, Fesi J, Frank C, Canning D, Zderic S. Genetic or pharmacologic disruption of the calcineurin-nuclear factor of activated T-cells axis prevents social stress-induced voiding dysfunction in a murine model. J Pediatr Urol. 2014;10:598-604 pubmed publisher
    ..b>NFATc3, NFATc4 knockout (KO) and wild-type (WT) mice were studied...
  72. Burn S, Webb A, Berry R, Davies J, Ferrer Vaquer A, Hadjantonakis A, et al. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol. 2011;352:288-98 pubmed publisher
    ..Activated in T cells) transcription factor gene family are expressed throughout murine kidney morphogenesis and NFATc3 is localised to the developing nephrons...
  73. Willingham A, Orth A, Batalov S, Peters E, Wen B, Aza Blanc P, et al. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science. 2005;309:1570-3 pubmed
  74. Phuong T, Yun Y, Kim S, Kang T. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. 2013;430:722-8 pubmed publisher
    ..Transient increase of NFATc3 expression was observed in the initial phase of differentiation, and the increased activity of NFATc3 isoform was ..
  75. Liu J, Koyano Nakagawa N, Amasaki Y, Saito Ohara F, Ikeuchi T, Imai S, et al. Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization. Mol Biol Cell. 1997;8:157-70 pubmed
    ..We report here cDNA cloning and chromosomal localization of a murine homologue of human NFATx, designated as mNFATx1, and its splicing variants mNFATx2 and m delta NFATx...
  76. Stasik I, Rapak A, Zioło E, Strzadała L. The mitochondrial localization of RelB and NFATx in immature T cells. Cell Mol Biol Lett. 2008;13:493-501 pubmed publisher
    ..Certain transcription factors have also been found on mitochondria. Here, the localization of RelB and NFATx in the mitochondrial fractions of normal thymocytes and thymic lymphoma cells is shown for the first time...
  77. Li G, Zhang X, Li R, Wang Y, Wang Y, Han K, et al. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. J Biol Chem. 2008;283:32660-8 pubmed publisher
    ..In accord with this, CHP2-transfected cells showed increased nuclear presence of NFATc3 (nuclear factor of activated T cells) and enhanced NFAT activity...