NFATc2

Summary

Gene Symbol: NFATc2
Description: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Alias: AI607462, NF-ATc2, NF-ATp, NFAT1, NFAT1-D, Nfatp, nuclear factor of activated T-cells, cytoplasmic 2, NFAT pre-existing subunit, T-cell transcription factor NFAT1
Species: mouse
Products:     NFATc2

Top Publications

  1. Matsuo K, Galson D, Zhao C, Peng L, Laplace C, Wang K, et al. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem. 2004;279:26475-80 pubmed
    ..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation. ..
  2. Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem. 2004;279:28257-65 pubmed
    ..Here we demonstrate that the sumoylation of NFAT1 defines a novel mechanism of the nuclear anchorage and transcriptional activation downstream from the known ..
  3. Bourajjaj M, Armand A, da Costa Martins P, Weijts B, van der Nagel R, Heeneman S, et al. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008;283:22295-303 pubmed publisher
    ..Here we reveal that nfatc2 transcripts outnumber those from other nfat genes in the unstimulated heart by severalfold...
  4. Peng S, Gerth A, Ranger A, Glimcher L. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity. 2001;14:13-20 pubmed
    ..To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both...
  5. Rengarajan J, Tang B, Glimcher L. NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nat Immunol. 2002;3:48-54 pubmed
    ..We found that naïve T(H) precursors that are doubly deficient in NFATc2 and NFATc3 intrinsically differentiate into TH(2)-secreting cells, even in the absence of interleukin 4 (IL-4) ..
  6. Hodge M, Chun H, Rengarajan J, Alt A, Lieberson R, Glimcher L. NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science. 1996;274:1903-5 pubmed
    ..The identification of NIP45 advances our understanding of gene activation of cytokines, critical mediators of the immune response. ..
  7. Abe B, Shin D, Mocholí E, Macian F. NFAT1 supports tumor-induced anergy of CD4(+) T cells. Cancer Res. 2012;72:4642-51 pubmed publisher
    ..b>NFAT1 deficiency blunted the induction of anergy in tumor antigen-specific CD4+ T cells, enhancing antitumor responses...
  8. Ranger A, Gerstenfeld L, Wang J, Kon T, Bae H, Gravallese E, et al. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med. 2000;191:9-22 pubmed
    ..Here, we report that NFATp regulates chondrogenesis in the adult animal...
  9. Caetano M, Vieira de Abreu A, Teixeira L, Werneck M, Barcinski M, Viola J. NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression. FASEB J. 2002;16:1940-2 pubmed
    ..As previously demonstrated, NFATC2-/- mice consistently showed a marked increase in lymphocyte proliferation...

More Information

Publications70

  1. Weigmann B, Lehr H, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, et al. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med. 2008;205:2099-110 pubmed publisher
    ..In this study, we have identified a crucial regulatory role of the transcription factor NFATc2 in T cell-dependent experimental colitis...
  2. Ghosh S, Koralov S, Stevanovic I, Sundrud M, Sasaki Y, Rajewsky K, et al. Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010;107:15169-74 pubmed publisher
    ..We engineered a hyperactivable version of NFAT1 with increased affinity for calcineurin and decreased affinity for casein kinase 1...
  3. Werneck M, Vieira de Abreu A, Chammas R, Viola J. NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis. Cancer Immunol Immunother. 2011;60:537-46 pubmed publisher
    ..NFAT proteins can modulate cellular transformation intrinsically, and NFAT-deficient (NFAT1-/-) mice are indeed more susceptible to transformation than wild-type counterparts...
  4. Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, et al. NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J Exp Med. 2005;201:181-7 pubmed
    The phenotype of NFATc2(-/-) c3(-/-) (double knockout [DKO]) mice implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena...
  5. Xanthoudakis S, Viola J, Shaw K, Luo C, Wallace J, Bozza P, et al. An enhanced immune response in mice lacking the transcription factor NFAT1. Science. 1996;272:892-5 pubmed
    ..The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene...
  6. Carvalho L, Teixeira L, Carrossini N, Caldeira A, Ansel K, Rao A, et al. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle. 2007;6:1789-95 pubmed
    ..Previous studies have shown that NFAT1-deficient mice display lymphocyte hyperproliferation, shortened cell cycle duration, and cyclin overexpression...
  7. Gerth A, Lin L, Neurath M, Glimcher L, Peng S. An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Gastroenterology. 2004;126:1115-21 pubmed
    ..Such findings indicate a novel, interleukin-10-independent role for nuclear factor of activated T cells in the regulation of innate immunity and in intestinal immune tolerance. ..
  8. Viola J, Kiani A, Bozza P, Rao A. Regulation of allergic inflammation and eosinophil recruitment in mice lacking the transcription factor NFAT1: role of interleukin-4 (IL-4) and IL-5. Blood. 1998;91:2223-30 pubmed
    ..The NFAT protein NFAT1 (NFATp) is expressed and functional in T cells, B cells, mast cells, and natural killer cells...
  9. Crabtree G. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999;96:611-4 pubmed
  10. Mehta D, Wurster A, Weinmann A, Grusby M. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A. 2005;102:2016-21 pubmed
    ..that the proximal promoter of IL-21 controls its Th-cell-subset-specific expression through the action of NFATc2 and T-bet...
  11. Erb K, Twardzik T, Palmetshofer A, Wohlleben G, Tatsch U, Serfling E. Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infection. Infect Immun. 2003;71:6641-7 pubmed
    Infection of nuclear factor of activated T-cell transcription factor c2 (NFATc2)-deficient mice with the helminth Nippostrongylus brasiliensis led to a distinct increase in interleukin-4 (IL-4) and IL-5 protein synthesis by lymph node and ..
  12. Li X, Ho S, Luna J, Giacalone J, Thomas D, Timmerman L, et al. Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68:185-91 pubmed
    ..as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  13. Agarwal S, Avni O, Rao A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity. 2000;12:643-52 pubmed
    ..The antigen-inducible transcription factor NFAT1 binds the IL-4 enhancer and the IL-4 promoter only in stimulated Th2 cells; conversely, NFAT1 binds to the ..
  14. McCaffrey P, Luo C, Kerppola T, Jain J, Badalian T, Ho A, et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993;262:750-4 pubmed
    ..The DNA-binding specificity of NFAT is conferred by NFATp, a phosphoprotein that is a target for the immunosuppressive compounds cyclosporin A and FK506...
  15. Aramburu J, Garcia Cozar F, Raghavan A, Okamura H, Rao A, Hogan P. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol Cell. 1998;1:627-37 pubmed
    ..a single residue in this sequence impairs the calcineurin-mediated dephosphorylation and nuclear translocation of NFAT1. Peptides spanning the region inhibit the ability of calcineurin to bind to and dephosphorylate NFAT proteins, ..
  16. Jain J, Burgeon E, Badalian T, Hogan P, Rao A. A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem. 1995;270:4138-45 pubmed
    The cyclosporin-sensitive factor NFATp cooperates with Fos and Jun family proteins to regulate transcription of the interleukin 2 gene in activated T cells...
  17. Rengarajan J, Mittelstadt P, Mages H, Gerth A, Kroczek R, Ashwell J, et al. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity. 2000;12:293-300 pubmed
    The critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in mice lacking both NFATp and NFAT4 (DKO)...
  18. Hodge M, Ranger A, Charles de la Brousse F, Hoey T, Grusby M, Glimcher L. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 1996;4:397-405 pubmed
    ..These data suggest that NF-ATp may be involved in cell growth, and that it is important for the balanced transcription of the IL-4 gene during the course of an immune response. ..
  19. Schuh K, Kneitz B, Heyer J, Bommhardt U, Jankevics E, Berberich Siebelt F, et al. Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur J Immunol. 1998;28:2456-66 pubmed
    ..This might indicate defects in other types of programmed cell death which are controlled by the activity of NF-ATp. ..
  20. Ho S, Thomas D, Timmerman L, Li X, Francke U, Crabtree G. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995;270:19898-907 pubmed
    ..Given the preferential expression of NFATc3 in the thymus, NFATc family members may regulate distinct subsets of genes during T cell development. ..
  21. Plyte S, Boncristiano M, Fattori E, Galvagni F, Paccani S, Majolini M, et al. Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain. J Biol Chem. 2001;276:14350-8 pubmed
    ..Here we report the identification, cDNA cloning, and functional characterization of a new isoform of NFAT1 highly expressed in mouse brain...
  22. Oukka M, Ho I, de la Brousse F, Hoey T, Grusby M, Glimcher L. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998;9:295-304 pubmed
    ..Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes...
  23. Kiani A, García Cozar F, Habermann I, Laforsch S, Aebischer T, Ehninger G, et al. Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood. 2001;98:1480-8 pubmed
    ..Here it is shown that the transcription factor NFAT1 (NFATc2) is a major regulator of IFN-gamma production in vivo...
  24. Baksh S, Widlund H, Frazer Abel A, Du J, Fosmire S, Fisher D, et al. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002;10:1071-81 pubmed
    ..Ectopic expression of NFATc2 inhibited the basal activity of the human CDK4 promoter...
  25. Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
    ..This is specific for iTreg development, because frequency of nTreg remained unaltered in mice lacking NFAT1, NFAT2, or NFAT4 alone or in combination...
  26. Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, et al. NFAT and Osterix cooperatively regulate bone formation. Nat Med. 2005;11:880-5 pubmed
    ..In fact, bone formation is inhibited in Nfatc1- and Nfatc2-deficient cells as well as in FK506-treated osteoblasts...
  27. Luo C, Burgeon E, Carew J, McCaffrey P, Badalian T, Lane W, et al. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol. 1996;16:3955-66 pubmed
    ..We have identified two new isoforms of the transcription factor NFAT1 (previously termed NFATp) that are the predominant isoforms expressed in murine and human T cells...
  28. Zhou B, Cron R, Wu B, Genin A, Wang Z, Liu S, et al. Regulation of the murine Nfatc1 gene by NFATc2. J Biol Chem. 2002;277:10704-11 pubmed
    NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system...
  29. Ho A, Jain J, Rao A, Hogan P. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J Biol Chem. 1994;269:28181-6 pubmed
    The transcription factor NFATp, which has a central role in cytokine gene induction in T cells, was previously thought to be expressed only in T cells and other immune cells...
  30. Berland R, Wortis H. Normal B-1a cell development requires B cell-intrinsic NFATc1 activity. Proc Natl Acad Sci U S A. 2003;100:13459-64 pubmed
    ..Here we show that the B-1a compartment is normal in mice lacking NFATc2 but essentially absent in mice lacking NFATc1. Loss of NFATc1 affects both peritoneal and splenic B-1a cells...
  31. Robbs B, Cruz A, Werneck M, Mognol G, Viola J. Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol. 2008;28:7168-81 pubmed publisher
    ..Here, we demonstrate that two constitutively active forms of NFAT proteins (CA-NFAT1 and CA-NFAT2 short isoform) induce distinct phenotypes in NIH 3T3 cells...
  32. Teixeira L, Fonseca B, Vieira de Abreu A, Barboza B, Robbs B, Bozza P, et al. IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation. J Immunol. 2005;175:5931-9 pubmed
    ..In this study, we evaluated the involvement of NFAT1 in the regulation of IFN-gamma gene expression in murine CD8+ T cells and its relevance during Th differentiation...
  33. Aliprantis A, Ueki Y, Sulyanto R, Park A, Sigrist K, Sharma S, et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008;118:3775-89 pubmed publisher
    ..Taken together, our study demonstrates that NFATc1 is required for remodeling of the growing and adult skeleton and suggests that NFATc1 may be an effective therapeutic target for osteoporosis associated with inflammatory states...
  34. Okamura H, Aramburu J, Garcia Rodriguez C, Viola J, Raghavan A, Tahiliani M, et al. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell. 2000;6:539-50 pubmed
    ..We show by mass spectrometry that NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are ..
  35. Vihma H, Pruunsild P, Timmusk T. Alternative splicing and expression of human and mouse NFAT genes. Genomics. 2008;92:279-91 pubmed publisher
    Four members of the nuclear factor of activated T cells (NFAT) family (NFATC1, NFATC2, NFATC3, and NFATC4) are Ca(2+)-regulated transcription factors that regulate several processes in vertebrates, including the development and function ..
  36. Tsytsykova A, Goldfeld A. Nuclear factor of activated T cells transcription factor NFATp controls superantigen-induced lethal shock. J Exp Med. 2000;192:581-6 pubmed
    ..Here, we show that nuclear factor of activated T cells transcription factor, NFATp, controls susceptibility to superantigen-induced lethal shock in mice through its activation of TNF-alpha gene ..
  37. Asai M, Iwasaki Y, Yoshida M, Mutsuga Nakayama N, Arima H, Ito M, et al. Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro. Mol Endocrinol. 2004;18:3011-9 pubmed
    ..GHRH, NFAT1, NFAT4, and related genes were endogenously expressed in Gsh+/+ cells and the rat arcuate nucleus, where NFAT1 and ..
  38. Pan S, Koyano Nakagawa N, Tsuruta L, Amasaki Y, Yokota T, Mori S, et al. Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc. Biochem Biophys Res Commun. 1997;240:314-23 pubmed
    ..In the mouse embryo, mNFATc transcript was strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart suggesting that mNFATc may have a role both in embryogenesis and in mature T cells. ..
  39. Okamura H, Garcia Rodriguez C, Martinson H, Qin J, Virshup D, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol. 2004;24:4184-95 pubmed
    In resting cells, the NFAT1 transcription factor is kept inactive in the cytoplasm by phosphorylation on multiple serine residues...
  40. Ranger A, Oukka M, Rengarajan J, Glimcher L. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity. 1998;9:627-35 pubmed
    ..Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling ..
  41. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med. 2005;202:1261-9 pubmed
    NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system...
  42. Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006;441:595-600 pubmed
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease. ..
  43. Gerlach K, Daniel C, Lehr H, Nikolaev A, Gerlach T, Atreya R, et al. Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis. Cancer Res. 2012;72:4340-50 pubmed publisher
    NFAT transcription factors control T-cell activation and function. Specifically, the transcription factor NFATc2 affects the regulation of cell differentiation and growth and plays a critical role in the development of colonic ..
  44. Graef I, Wang F, Charron F, Chen L, Neilson J, Tessier Lavigne M, et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003;113:657-70 pubmed
    ..In vitro, sensory and commissural neurons lacking calcineurin function or NFATc2, c3, and c4 are unable to respond to neurotrophins or netrin-1 with efficient axonal outgrowth...
  45. Kiani A, Viola J, Lichtman A, Rao A. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity. 1997;7:849-60 pubmed
    ..Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiting T helper 2 responses...
  46. Gonzalez Bosc L, Layne J, Nelson M, Hill Eubanks D. Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer. J Biol Chem. 2005;280:26113-20 pubmed
    ..These data provide the first evidence that NFAT and SRF may interact to cooperatively regulate SMC-specific gene expression and support a role for NFAT in the phenotypic maintenance of smooth muscle. ..
  47. Nicholson C, Lambert J, Chow C, Lefer D, Calvert J. Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion. J Mol Cell Cardiol. 2013;64:1-10 pubmed publisher
    ..Additionally, these results suggest that the modest infarct sparing effects of VE are the result of a decrease in the hearts ability to reduce nitrite to nitric oxide during MI/R. ..
  48. Vázquez Cedeira M, Lazo P. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. J Biol Chem. 2012;287:42739-50 pubmed publisher
    ..Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene...
  49. Barlic J, McDermott D, Merrell M, Gonzales J, Via L, Murphy P. Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms. J Biol Chem. 2004;279:48520-34 pubmed
    ..Furthermore, chromatin immunoprecipitation revealed that IL-15 promoted specific recruitment of NFAT1 but not NFAT2 to the CX3CR1 promoter, whereas IL-2 had the converse effect...
  50. Valdor R, Schreiber V, Saenz L, Martinez T, Munoz Suano A, Dominguez Villar M, et al. Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells. Mol Immunol. 2008;45:1863-71 pubmed
    ..Here, we provide evidence for a novel post-translational modification that regulates NFAT. Indeed, NFATc1 and NFATc2 are poly(ADP-ribosyl)ated by poly-ADP-ribose polymerase-1 (PARP-1)...
  51. Mowen K, Schurter B, Fathman J, David M, Glimcher L. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004;15:559-71 pubmed
    ..Covalent modification of NIP45 by arginine methylation is an important mechanism of regulating the expression of NFAT-dependent cytokine genes. ..
  52. Gafter Gvili A, Sredni B, Gal R, Gafter U, Kalechman Y. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes. Am J Physiol Cell Physiol. 2003;284:C1593-603 pubmed
    ..is associated with hair keratinocyte differentiation in vivo, affecting nuclear factor of activated T cells (NFAT1) activity in these cells...
  53. Brogdon J, Leitenberg D, Bottomly K. The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol. 2002;168:3825-32 pubmed
    ..Furthermore, the strength of the TCR signal differentially affects the balance of NFATp and NFATc DNA binding activity, thereby regulating IL-4 transcription...
  54. Okamoto M, Van Stry M, Chung L, Koyanagi M, Sun X, Suzuki Y, et al. Mina, an Il4 repressor, controls T helper type 2 bias. Nat Immunol. 2009;10:872-9 pubmed publisher
    ..Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias. ..
  55. Srinivasan M, Frauwirth K. Reciprocal NFAT1 and NFAT2 nuclear localization in CD8+ anergic T cells is regulated by suboptimal calcium signaling. J Immunol. 2007;179:3734-41 pubmed
    ..This correlated with a block in nuclear localization of NFAT1 in anergic cells...
  56. Klein M, Klein Hessling S, Palmetshofer A, Serfling E, Tertilt C, Bopp T, et al. Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines. J Immunol. 2006;177:6667-74 pubmed
    ..In this study, we demonstrate that the transcription factors NFATc1 and NFATc2 are part of a MC-specific signaling network that regulates the expression of TNF-alpha and IL-13, whereas NFATc3 ..
  57. Crist S, Elzey B, Ahmann M, Ratliff T. Early growth response-1 (EGR-1) and nuclear factor of activated T cells (NFAT) cooperate to mediate CD40L expression in megakaryocytes and platelets. J Biol Chem. 2013;288:33985-96 pubmed publisher
    ..The present study identifies NFATc2 as a key transcriptional modulator of CD40L expression in megakaryocytes and inflammatory activity of platelets...
  58. Greenblatt M, Ritter S, Wright J, Tsang K, Hu D, Glimcher L, et al. NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A. 2013;110:19914-9 pubmed publisher
    ..Here, we demonstrate that cartilage-specific ablation of Nuclear factor of activated T cells c1 (Nfatc1) in Nfatc2(-/-) mice leads to early onset, aggressive OA affecting multiple joints...
  59. Burn S, Webb A, Berry R, Davies J, Ferrer Vaquer A, Hadjantonakis A, et al. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol. 2011;352:288-98 pubmed publisher
    ..We propose that the non-canonical Calcium/NFAT Wnt signalling pathway plays an important role in early mammalian renal development and is required for complete MET during nephrogenesis, potentially acting downstream of Wnt4. ..
  60. Garrett Sinha L, Eberspaecher H, Seldin M, de Crombrugghe B. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem. 1996;271:31384-90 pubmed
    ..The chromosomal location of the gene was mapped using mouse interspecific backcrosses and was shown to localize to mouse chromosome 4 and to cosegregate with the thioredoxin gene. ..
  61. Dietz L, Frommer F, Vogel A, Vaeth M, Serfling E, Waisman A, et al. NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms. Eur J Immunol. 2015;45:1377-89 pubmed publisher
    ..Here, we demonstrate an essential role for NFAT in disease induction, as the combined lack of NFAT1 (NFATc2) and NFAT2 (NFATc1) completely protected mice...