Gene Symbol: Nfatc1
Description: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Alias: 2210017P03Rik, AI449492, AV076380, NF-ATc, NFAT2, NFATc, Nfatcb, nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFAT transcription complex cytosolic component, transcription factor NF-ATc
Species: mouse
Products:     Nfatc1

Top Publications

  1. Li X, Ho S, Luna J, Giacalone J, Thomas D, Timmerman L, et al. Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995;68:185-91 pubmed
    ..capable of functioning as the pre-existing (p) and cytosolic (c) component of the NFAT transcription complex, NFATc of human and NFATp of murine origin (Northrop et al., 1994; McCaffrey et al., 1993b)...
  2. Oukka M, Ho I, de la Brousse F, Hoey T, Grusby M, Glimcher L. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998;9:295-304 pubmed
    ..Here we report that NFAT4, in contrast to NFATp and NFATc, is preferentially expressed in DP thymocytes...
  3. Sherman M, Powell D, Weiss D, Brown M. NF-ATc isoforms are differentially expressed and regulated in murine T and mast cells. J Immunol. 1999;162:2820-8 pubmed
    ..These results demonstrate another level of regulation within the NF-AT family that can contribute to cell type-specific gene expression. ..
  4. Nayak A, Glöckner Pagel J, Vaeth M, Schumann J, Buttmann M, Bopp T, et al. Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. J Biol Chem. 2009;284:10935-46 pubmed publisher
    ..In peripheral T-cells NFATc1 and -c2 are predominantly expressed...
  5. Ishida N, Hayashi K, Hoshijima M, Ogawa T, Koga S, Miyatake Y, et al. Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J Biol Chem. 2002;277:41147-56 pubmed
    ..Among a group of 106 early inducible genes (within 2-5 h after RANKL stimulation), four genes including NFAT2 were identified as genes whose enhanced expressions were fairly correlated with an efficient induction of matured ..
  6. Kawamura T, Ono K, Morimoto T, Akao M, Iwai Kanai E, Wada H, et al. Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Circ Res. 2004;94:1492-9 pubmed
    ..We show here that p300 markedly potentiates the binding of NFATc1 to the bcl-2 NFAT element by interacting with NFATc1 in an E1A-dependent manner...
  7. Peng S, Gerth A, Ranger A, Glimcher L. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity. 2001;14:13-20 pubmed
    ..To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both...
  8. Zanotti S, Smerdel Ramoya A, Canalis E. Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem. 2011;286:4576-88 pubmed publisher
    ..b>NFATc1 was induced in Rosa(Notch) osteoblastic cells by transducing an adenoviral vector expressing constitutively active ..
  9. Gitler A, Zhu Y, Ismat F, Lu M, Yamauchi Y, Parada L, et al. Nf1 has an essential role in endothelial cells. Nat Genet. 2003;33:75-9 pubmed
    ..level of ras signaling in Nf1(-/-) endothelial cells and greater nuclear localization of the transcription factor Nfatc1. Inactivation of Nf1 in the neural crest does not cause cardiac defects but results in tumors of neural-crest ..

More Information


  1. Ranger A, Hodge M, Gravallese E, Oukka M, Davidson L, Alt F, et al. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998;8:125-34 pubmed
    ..Our data demonstrate that NF-ATc is essential for the optimal generation and function of mature T and B lineage cells, with an especially profound effect on IL-4-driven responses. ..
  2. Sato K, Suematsu A, Nakashima T, Takemoto Kimura S, Aoki K, Morishita Y, et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006;12:1410-6 pubmed
    ..reduced CREB phosphorylation and downregulated the expression of c-Fos, which is required for the induction of NFATc1 (the master transcription factor for osteoclastogenesis) that is activated by receptor activator of NF-kappaB ..
  3. Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon A, et al. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008;135:3611-22 pubmed publisher
    ..These results provide new insight into the signaling molecules downstream of FGF receptor tyrosine kinases in cardiac progenitors. ..
  4. Klein Hessling S, Bopp T, Jha M, Schmidt A, Miyatake S, Schmitt E, et al. Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter. J Biol Chem. 2008;283:31030-7 pubmed publisher
    ..protein-protein interactions involving the C-terminal Zn(2+)-finger of GATA-3 and the C-terminal region of the NFATc1 DNA binding domain...
  5. Lange A, Molkentin J, Yutzey K. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol. 2004;266:346-60 pubmed
    ..DSCR1(e4)/lacZ expression in the developing valve endocardium colocalizes with NFATc1 and, endocardial DSCR1(e4)/lacZ, is notably reduced or absent in NFATc1(-/-) embryos...
  6. Yoshida H, Nishina H, Takimoto H, Marengere L, Wakeham A, Bouchard D, et al. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 1998;8:115-24 pubmed
    ..These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response. ..
  7. Chen Y, Ishii M, Sucov H, Maxson R. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75 pubmed publisher
    ..null mutant AV cushions, we found decreased Bmp2/4 and Notch1 signaling as well as reduced expression of Has2, NFATc1 and Notch1, demonstrating impaired endocardial activation and EMT...
  8. Yeo H, Beck L, McDonald J, Zayzafoon M. Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation. Bone. 2007;40:1502-16 pubmed
    ..of varying concentrations of CsA on bone formation and osteoblast differentiation and elucidate the role of NFATc1 in this response. We show that low concentrations of CsA (<1 microM in vitro and 35...
  9. Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain A, et al. Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012;151:1083-96 pubmed publisher
    ..This information may help develop better cell therapies for coronary artery disease...
  10. Lange A, Yutzey K. NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K. Dev Biol. 2006;292:407-17 pubmed
    b>NFATc1 is necessary for remodeling endocardial cushions into mature heart valve leaflets and is also an essential effector of receptor activator of NFkappaB ligand (RANKL) signaling required for transcriptional activation of bone matrix ..
  11. Hock M, Vaeth M, Rudolf R, Patra A, Pham D, Muhammad K, et al. NFATc1 induction in peripheral T and B lymphocytes. J Immunol. 2013;190:2345-53 pubmed publisher
    ..We have reported previously that the short isoform NFATc1/?A whose generation is induced by immune receptor stimulation supports the proliferation and inhibits the ..
  12. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002;3:889-901 pubmed
    ..We show here that RANKL selectively induces NFATc1 expression via these two pathways...
  13. Matsumoto M, Kogawa M, Wada S, Takayanagi H, Tsujimoto M, Katayama S, et al. Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J Biol Chem. 2004;279:45969-79 pubmed
    ..constructs of the cathepsin K gene promoter indicates that limited sets of the transcription factors such as NFATc1, PU...
  14. Zaslavsky A, Chou S, Schadler K, Lieberman A, Pimkin M, Kim Y, et al. The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood. 2013;121:3205-15 pubmed publisher
    ..b>NFATc1 and c2 isoforms are expressed in megakaryocytes...
  15. Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
    ..This is specific for iTreg development, because frequency of nTreg remained unaltered in mice lacking NFAT1, NFAT2, or NFAT4 alone or in combination...
  16. Puri S, Magenheimer B, Maser R, Ryan E, Zien C, Walker D, et al. Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway. J Biol Chem. 2004;279:55455-64 pubmed
  17. Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, et al. NFAT and Osterix cooperatively regulate bone formation. Nat Med. 2005;11:880-5 pubmed
    ..Among NFAT proteins, NFATc1 is crucial for the differentiation of bone-resorbing osteoclasts...
  18. Bhattacharyya S, Deb J, Patra A, Thuy Pham D, Chen W, Vaeth M, et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med. 2011;208:823-39 pubmed publisher
    By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B cells upon B cell ..
  19. Vihma H, Pruunsild P, Timmusk T. Alternative splicing and expression of human and mouse NFAT genes. Genomics. 2008;92:279-91 pubmed publisher
    Four members of the nuclear factor of activated T cells (NFAT) family (NFATC1, NFATC2, NFATC3, and NFATC4) are Ca(2+)-regulated transcription factors that regulate several processes in vertebrates, including the development and function ..
  20. Pan S, Koyano Nakagawa N, Tsuruta L, Amasaki Y, Yokota T, Mori S, et al. Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc. Biochem Biophys Res Commun. 1997;240:314-23 pubmed
    ..Here we describe cloning and characterization of full-length cDNA encoding murine (m) NFATc which predicts that the protein has all the conserved structural motifs of NFAT family members, including the rel ..
  21. Patra A, Avots A, Zahedi R, Schüler T, Sickmann A, Bommhardt U, et al. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol. 2013;14:127-35 pubmed publisher
    ..Here we found that IL-7-Jak3 signals activated the transcription factor NFATc1 in DN thymocytes by phosphorylating Tyr371 in the regulatory region of NFATc1...
  22. Zhou B, Cron R, Wu B, Genin A, Wang Z, Liu S, et al. Regulation of the murine Nfatc1 gene by NFATc2. J Biol Chem. 2002;277:10704-11 pubmed
    NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system...
  23. Greenblatt M, Aliprantis A, Hu B, Glimcher L. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med. 2010;207:923-31 pubmed publisher
  24. Meissner J, Umeda P, Chang K, Gros G, Scheibe R. Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway. J Cell Physiol. 2007;211:138-48 pubmed
    ..Transient transfection assays demonstrated that the calcineurin/NFATc1 signaling pathway is essential for MyHCbeta promoter activation during transformation of C2C12 myotubes but is not ..
  25. Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006;441:595-600 pubmed
    ..lie within the critical region of human chromosome 21 and act synergistically to prevent nuclear occupancy of NFATc transcription factors, which are regulators of vertebrate development...
  26. Aliprantis A, Ueki Y, Sulyanto R, Park A, Sigrist K, Sharma S, et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008;118:3775-89 pubmed publisher
    ..disease, we generated a conditional knockout of the transcription factor nuclear factor of activated T cells c1 (Nfatc1)...
  27. Yamashita T, Yao Z, Li F, Zhang Q, Badell I, Schwarz E, et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007;282:18245-53 pubmed
    ..Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors...
  28. Wu B, Wang Y, Lui W, Langworthy M, Tompkins K, Hatzopoulos A, et al. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res. 2011;109:183-92 pubmed publisher
    ..b>Nfatc1 (nuclear factor of activated T cells, cytoplasmic 1) is highly expressed in valve endocardial cells and is ..
  29. Wilkins B, De Windt L, Bueno O, Braz J, Glascock B, Kimball T, et al. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol. 2002;22:7603-13 pubmed
    ..NFATc3-null mice also demonstrated attenuated pressure overload- and angiotensin II-induced cardiac hypertrophy. These results provide genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo. ..
  30. Wang Y, Jarad G, Tripathi P, Pan M, Cunningham J, Martin D, et al. Activation of NFAT signaling in podocytes causes glomerulosclerosis. J Am Soc Nephrol. 2010;21:1657-66 pubmed publisher
    ..Here, we generated mice that allow conditional induction of NFATc1. Mice with NFAT activation in nascent podocytes in utero developed proteinuria and glomerulosclerosis postnatally, ..
  31. Ranger A, Grusby M, Hodge M, Gravallese E, de la Brousse F, Hoey T, et al. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998;392:186-90 pubmed
    ..Our results indicate that NF-ATc may play a critical role in signal-transduction processes required for normal cardiac valve formation. ..
  32. Kim K, Kim J, Lee J, Jin H, Lee S, Fisher D, et al. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem. 2005;280:35209-16 pubmed
    ..During osteoclast differentiation, NFATc1 is further activated via calcium signaling when costimulatory receptors expressed on osteoclast precursors, such ..
  33. Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich Siebelt F, Gattenloehner S, et al. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A. 2011;108:2480-5 pubmed publisher
    ..High levels of ICER suppressed the induction of nuclear factor of activated T cell c1 (Nfatc1) gene in T cells whose inducible Nfatc1 P1 promoter bears two highly conserved cAMP-responsive elements to which ..
  34. Canté Barrett K, Winslow M, Crabtree G. Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007;179:103-10 pubmed
    ..Expression of a nuclear (and constitutively active) NFATc1 even at subphysiological levels can rescue the transition of double-negative to double-positive thymocytes in RAG-..
  35. Kim K, Lee S, Ha Kim J, Choi Y, Kim N. NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol. 2008;22:176-85 pubmed
    b>NFATc1 has been characterized as a master regulator of nuclear factor kappaB ligand-induced osteoclast differentiation...
  36. Xu L, Yan J, Wang B, Liu P, Gong J, Wang C. [Effect of the costimulatory molecules OX40-OX40 ligand interaction on the expression of NFATc1 in leukocytes of apolipoprotein E-deficient mice]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39:526-30 pubmed
    To investigate the effect of OX40/OX40L interaction on the nuclear factor of activated T cells c1 (NFATc1) in ApoE-/- mice...
  37. Neilson J, Winslow M, Hur E, Crabtree G. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004;20:255-66 pubmed
  38. Ho S, Thomas D, Timmerman L, Li X, Francke U, Crabtree G. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995;270:19898-907 pubmed
    ..the NFAT transcription complex as a result of the calcium-dependent nuclear translocation of cytosolic subunits, NFATc, and the Ras/protein kinase C-dependent induction of a nuclear subunit, NFATn...
  39. Choo M, Yeo H, Zayzafoon M. NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone. 2009;45:579-89 pubmed publisher
    ..To investigate the mechanism by which NFATc1 regulates osteoblast differentiation, we established an osteoblast cell line that overexpresses a constitutively ..
  40. Chakkalakal J, Harrison M, Carbonetto S, Chin E, Michel R, Jasmin B. Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. Hum Mol Genet. 2004;13:379-88 pubmed
    ..Muscles from mdx/CnA* displayed increased nuclear localization of NFATc1 and a fiber type shift towards a slower phenotype...
  41. Horsley V, Aliprantis A, Polak L, Glimcher L, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008;132:299-310 pubmed publisher
    ..How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP ..
  42. Kim R, Robertson E, Solloway M. Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. Dev Biol. 2001;235:449-66 pubmed
    ..5 and 15.5 dpc due to cardiac insufficiency. These data provide the first genetic evidence that BMPs are involved in the formation of the cardiac cushions. ..
  43. Zhou B, Wu B, Tompkins K, Boyer K, Grindley J, Baldwin H. Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development. 2005;132:1137-46 pubmed
    b>Nfatc1 is an endocardial transcription factor required for development of cardiac valves...
  44. Yi T, Tan K, Cho S, Wang Y, Luo J, Zhang W, et al. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J Biol Chem. 2010;285:17811-20 pubmed publisher
    ..Using chromatin immunoprecipitation and luciferase assays, we demonstrate that Gpr54 regulates NFAT2- and Sp1-mediated Bmp7 transcription...
  45. Berland R, Wortis H. Normal B-1a cell development requires B cell-intrinsic NFATc1 activity. Proc Natl Acad Sci U S A. 2003;100:13459-64 pubmed
    ..Here we show that the B-1a compartment is normal in mice lacking NFATc2 but essentially absent in mice lacking NFATc1. Loss of NFATc1 affects both peritoneal and splenic B-1a cells...
  46. Chang C, Neilson J, Bayle J, Gestwicki J, Kuo A, Stankunas K, et al. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004;118:649-63 pubmed
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis. ..
  47. Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H. Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. J Biol Chem. 2005;280:32905-13 pubmed
    ..signals required for RANKL-mediated activation of calcium signaling, which leads to the activation of NFATc1. However, it remains unknown whether the expression of immunoreceptors are under the control of NFATc1...
  48. Akiyama H, Chaboissier M, Behringer R, Rowitch D, Schedl A, Epstein J, et al. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004;101:6502-7 pubmed
    ..In Sox9-null mutants, endocardial cushions are markedly hypoplastic. In these mutants, Nfatc1 is ectopically expressed and no longer restricted to endothelial cells...
  49. Hock M, Brown M. Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. J Biol Chem. 2003;278:26695-703 pubmed
    ..both conventional and novel protein kinase C (PKC) family members regulate endogenous mast cell NFAT activity, and NFAT2 TA. Overexpression of dominant active PKC (which has been implicated in immune receptor signaling) induces NFAT2...
  50. Ma L, Lu M, Schwartz R, Martin J. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 2005;132:5601-11 pubmed
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis. ..
  51. Nurieva R, Chuvpilo S, Wieder E, Elkon K, Locksley R, Serfling E, et al. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol. 2007;179:1096-103 pubmed
    T cell activation and differentiation is accompanied and mediated by transcriptional reprogramming. The NFATc1 transcription factor is strongly induced upon T cell activation and controls numerous genes involved in the T cell effector ..
  52. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med. 2005;202:1261-9 pubmed
    b>NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system...
  53. Kamel Mohamed S, Sugiyama E, Shinoda K, Hounoki H, Taki H, Maruyama M, et al. Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: a possible mechanism for downregulation of osteoclastogenesis. Biochem Biophys Res Commun. 2005;329:839-45 pubmed
    ..Recently NFATc1, a transcription factor, has been shown to play critical roles in osteoclastogenesis...
  54. Winslow M, Pan M, Starbuck M, Gallo E, Deng L, Karsenty G, et al. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006;10:771-82 pubmed
    ..Here, we show that mice expressing a constitutively nuclear NFATc1 variant (NFATc1(nuc)) in osteoblasts develop high bone mass...
  55. de la Pompa J, Timmerman L, Takimoto H, Yoshida H, Elia A, Samper E, et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature. 1998;392:182-6 pubmed
  56. Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha M, et al. Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity. 2002;16:881-95 pubmed
    ..In these cells, the short isoform A of NFATc1 is induced to high levels due to the autoregulation of the NFATc1 promoter P1 by NFATs...
  57. Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, Abe M, et al. Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription. J Cell Biol. 2002;156:983-91 pubmed
    ..Using immunoprecipitation Western blotting, we showed that NFATc1 interacted with GATA-6. Consistent with this, NFATc1 further potentiated GATA-6-activated Sm-MHC transcription...