Neu1

Summary

Gene Symbol: Neu1
Description: neuraminidase 1
Alias: AA407268, AA407316, Aglp, Apl, Bat-7, Bat7, Map-2, Neu, Neu-1, sialidase-1, G9 sialidase, HLA-B-associated transcript 7, N-acetyl-alpha-neuraminidase 1, lysosomal sialidase
Species: mouse
Products:     Neu1

Top Publications

  1. Arabkhari M, Bunda S, Wang Y, Wang A, Pshezhetsky A, Hinek A. Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin. Glycobiology. 2010;20:603-16 pubmed publisher
    We recently established that the subunit of cell surface-residing elastin receptor, neuraminidase-1 (Neu1), can desialylate adjacent insulin-like growth factor 1 receptors (IGF-1R) of arterial smooth muscle cells, thereby quenching their ..
  2. Zanoteli E, van de Vlekkert D, Bonten E, Hu H, Mann L, Gomero E, et al. Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue. Biochim Biophys Acta. 2010;1802:659-72 pubmed publisher
    Neuraminidase 1 (NEU1) regulates the catabolism of sialoglycoconjugates in lysosomes...
  3. Seyrantepe V, Iannello A, Liang F, Kanshin E, Jayanth P, Samarani S, et al. Regulation of phagocytosis in macrophages by neuraminidase 1. J Biol Chem. 2010;285:206-15 pubmed publisher
    ..of monocytes into macrophages and dendritic cells is accompanied by induction of cell-surface neuraminidase 1 (Neu1) and cathepsin A (CathA), the latter forming a complex with and activating Neu1...
  4. Amith S, Jayanth P, Franchuk S, Siddiqui S, Seyrantepe V, Gee K, et al. Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase. Glycoconj J. 2009;26:1197-212 pubmed publisher
    ..Here, we show a membrane controlling mechanism that is initiated by ligand binding to TLR-2, -3 and-4 to induce Neu1 sialidase activity within minutes in live primary bone marrow (BM) macrophage cells and macrophage and dendritic ..
  5. Yogalingam G, Bonten E, van de Vlekkert D, Hu H, Moshiach S, Connell S, et al. Neuraminidase 1 is a negative regulator of lysosomal exocytosis. Dev Cell. 2008;15:74-86 pubmed publisher
    ..Here we show that neuraminidase NEU1 negatively regulates lysosomal exocytosis in hematopoietic cells by processing the sialic acids on the lysosomal ..
  6. De Geest N, Bonten E, Mann L, de Sousa Hitzler J, Hahn C, D AZZO A. Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice. Hum Mol Genet. 2002;11:1455-64 pubmed
    ..Mice nullizygous at the Neu1 locus develop clinical abnormalities reminiscent of early-onset sialidosis in children, including severe ..
  7. Abdulkhalek S, Amith S, Franchuk S, Jayanth P, Guo M, Finlay T, et al. Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. J Biol Chem. 2011;286:36532-49 pubmed publisher
    ..sialidase-controlling mechanism that depends on ligand binding to its TLR to induce mammalian neuraminidase-1 (Neu1) activity, to influence receptor desialylation, and subsequently to induce TLR receptor activation and the ..
  8. Pshezhetsky A, Hinek A. Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors. Glycoconj J. 2011;28:441-52 pubmed publisher
    ..The current review summarizes emerging data demonstrating that neuraminidase 1 (NEU1), well known for its lysosomal catabolic function, can be also targeted to the cell surface and assume the ..
  9. Bonten E, Wang D, Toy J, Mann L, Mignardot A, Yogalingam G, et al. Targeting macrophages with baculovirus-produced lysosomal enzymes: implications for enzyme replacement therapy of the glycoprotein storage disorder galactosialidosis. FASEB J. 2004;18:971-3 pubmed
    ..we demonstrate that three baculovirus-expressed enzymes, protective protein/cathepsin A (PPCA), neuraminidase (Neu1), and beta-glucosidase, were readily taken up and restored lysosomal function in enzyme-deficient mouse macrophages...

More Information

Publications65

  1. Landolfi N, Leone J, Womack J, Cook R. Activation of T lymphocytes results in an increase in H-2-encoded neuraminidase. Immunogenetics. 1985;22:159-67 pubmed
    ..from a panel of inbred mouse strains indicated that cells from mice of the H-2v haplotype, which possess the Neu-1a allele and are deficient in liver neuraminidase, exhibited a level of activity which was significantly lower ..
  2. Neves J, Rizzato V, Fappi A, Garcia M, Chadi G, van de Vlekkert D, et al. Neuraminidase-1 mediates skeletal muscle regeneration. Biochim Biophys Acta. 2015;1852:1755-64 pubmed publisher
    Neuraminidase-1 (NEU1) is the sialidase responsible for the catabolism of sialoglycoconjugates in lysosomes...
  3. Wang D, Zaitsev S, Taylor G, D AZZO A, Bonten E. Protective protein/cathepsin A rescues N-glycosylation defects in neuraminidase-1. Biochim Biophys Acta. 2009;1790:275-82 pubmed publisher
    Neuraminidase-1 (NEU1) catabolizes the hydrolysis of sialic acids from sialo-glycoconjugates. NEU1 depends on its interaction with the protective protein/cathepsin A (PPCA) for lysosomal compartmentalization and catalytic activation...
  4. Kijimoto Ochiai S, Koda T, Suwama T, Matsukawa H, Fujii M, Tomobe K, et al. Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells "Neu-medullocyte" in the murine thymus. Glycoconj J. 2008;25:787-96 pubmed publisher
    ..the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver...
  5. Menezes J, Luskin M. Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon. J Neurosci. 1994;14:5399-416 pubmed
    ..Although the fate of the TuJ1-positive cells that reside in the proliferative zones remains unclear, their tangentially aligned orientation and their distribution suggest that they migrate independent of radial glial fibers. ..
  6. Carrillo M, Milner C, Ball S, Snoek M, Campbell R. Cloning and characterization of a sialidase from the murine histocompatibility-2 complex: low levels of mRNA and a single amino acid mutation are responsible for reduced sialidase activity in mice carrying the Neu1a allele. Glycobiology. 1997;7:975-86 pubmed
    The Neu1 locus, in the S region of the murine histocompatibility-2 complex, regulates the sialic acid content of several liver lysosomal enzymes...
  7. Lalley P, Shows T. Lysosomal Acid phosphatase deficiency: liver specific variant in the mouse. Genetics. 1977;87:305-17 pubmed
    ..studies indicated that this deficiency variant segregated as an autosomal codominant gene which has been designated Apl to symbolize the acid phosphatase liver phenotype...
  8. Snoek M, Jansen M, Olavesen M, Campbell R, Teuscher C, van Vugt H. Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus. Genomics. 1993;15:350-6 pubmed
    ..Heat shock proteins play an important role in a large number of physiological processes and it is tempting to speculate that Hsc70t, which exhibits testis-specific expression, may be identical to Orch-1...
  9. Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane. ..
  10. Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T. Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. J Biol Chem. 2009;284:21157-64 pubmed publisher
    ..These results suggest that mouse Neu4 plays an important regulatory role in neurite formation, possibly through desialylation of glycoproteins. ..
  11. Chorney M, Shen F, Michaelson J, Boyse E. Monoclonal antibody to an alloantigenic determinant on beta2-microglobulin (beta 2M) of the mouse. Immunogenetics. 1982;16:91-3 pubmed
  12. Dridi L, Seyrantepe V, Fougerat A, Pan X, Bonneil E, Thibault P, et al. Positive regulation of insulin signaling by neuraminidase 1. Diabetes. 2013;62:2338-46 pubmed publisher
    ..We now report that mammalian neuraminidase 1 (Neu1), in addition to its catabolic function in lysosomes, is transported to the cell surface where it is involved in ..
  13. Wu X, Steigelman K, Bonten E, Hu H, He W, Ren T, et al. Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells contribute to hearing loss in neuraminidase 1-deficient mice. Biochim Biophys Acta. 2010;1802:259-68 pubmed publisher
    The neuraminidase-1 (Neu1) knockout mouse model is a phenocopy of the lysosomal storage disease (LSD) sialidosis, characterized by multisystemic and neuropathic symptoms, including hearing loss...
  14. Kakani S, Yardeni T, Poling J, Ciccone C, Niethamer T, Klootwijk E, et al. The Gne M712T mouse as a model for human glomerulopathy. Am J Pathol. 2012;180:1431-40 pubmed publisher
    ..Moreover, the partial restoration of glomerular architecture in ManNAc-treated mice highlights ManNAc as a potential treatment for humans affected with disorders of glomerular hyposialylation. ..
  15. Wang S, Lewcock J, Feinstein P, Mombaerts P, Reed R. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development. 2004;131:1377-88 pubmed
    ..We suggest that a decreased dose of O/E protein may alter expression of O/E target genes and underlie the ORN projection defect. ..
  16. Potier M, Lu Shun Yan D, Womack J. Neuraminidase deficiency in the mouse. FEBS Lett. 1979;108:345-8 pubmed
  17. Guo Y, Xie D, Yang X. [Morphological and functional alterations of ear in lysosomal neuraminidase gene deficient mouse]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:824-9 pubmed
    ..Neul homozygous (Neul -/-) mice at 3 weeks, 2 and 4 months of age, and their wildtype littermates (Neu1 +/+) were examined for auditory thresholds through auditory brainstem responses (ABR) to click, 8, 16, and 32 kHz ..
  18. Yang A, Gyulay G, Mitchell M, White E, Trigatti B, Igdoura S. Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice. J Lipid Res. 2012;53:2573-85 pubmed publisher
    ..To address the impact of sialidase (neu1) activity on lipoprotein metabolism, we have generated a mouse model with a hypomorphic neu1 allele (B6...
  19. Natori Y, Nasui M, Kihara Negishi F. Neu1 sialidase interacts with perilipin 1 on lipid droplets and inhibits lipolysis in 3T3-L1 adipocytes. Genes Cells. 2017;22:485-492 pubmed publisher
    ..Increased plasma FFA levels in obesity are associated with several clinical conditions. We previously found that Neu1 activity is aberrant in the epididymal fat and liver of obese and diabetic mice...
  20. Harper J, Mould A, Andrews R, Bikoff E, Robertson E. The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Proc Natl Acad Sci U S A. 2011;108:10585-90 pubmed publisher
    ..In contrast, those required for processing maternal milk were markedly reduced. Thus, we conclude Blimp1 governs the developmental switch responsible for postnatal intestinal maturation. ..
  21. Vandeberg J, Bittner G, Meyer G, Kunz H, Gill T. Linkage of neuraminidase and alpha-mannosidase to the major histocompatibility complex in the rat. J Immunogenet. 1981;8:239-42 pubmed
  22. Gasser D, Sternberg N, Pierce J, Goldner Sauve A, Feng H, Haq A, et al. P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci. Immunogenetics. 1994;39:48-55 pubmed
    ..1 and BAT6 (valyl-tRNA synthetase). This refines the location of the Cps-1 locus to a 45 kb region contained in the H2-124 P1 insert...
  23. Pan X, De Aragão C, Velasco Martin J, Priestman D, Wu H, Takahashi K, et al. Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides. FASEB J. 2017;31:3467-3483 pubmed publisher
    ..Wu, H. Y., Takahashi, K., Yamaguchi, K., Sturiale, L., Garozzo, D., Platt, F. M., Lamarche-Vane, N., Morales, C. R., Miyagi, T., Pshezhetsky, A. V. Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides. ..
  24. Katoh S, Maeda S, Fukuoka H, Wada T, Moriya S, Mori A, et al. A crucial role of sialidase Neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model. Clin Exp Immunol. 2010;161:233-41 pubmed publisher
    ..Splenic CD4+ T cell binding of HA was examined with flow cytometry. Expression of sialidases (Neu1, Neu2, Neu3 and Neu4) in spleen cells was evaluated by quantitative real-time reverse transcription-polymerase ..
  25. Abdulkhalek S, Szewczuk M. Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses. Cell Signal. 2013;25:2093-105 pubmed publisher
    ..G-protein coupled receptor (GPCR) signaling platform to potentiate a novel mammalian neuraminidase-1 (Neu1) and matrix metalloproteinase-9 (MMP-9) cross-talk in alliance with neuromedin B GPCR, all of which form a ..
  26. Hirotsune S, Takahara T, Sasaki N, Hirose K, Yoshiki A, Ohashi T, et al. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nat Genet. 1995;10:77-83 pubmed
    ..Our findings offer an explanation for how the reeler mutant phenotype causes a disturbance of the complex architecture of the neuronal network. ..
  27. Pereira V, Queiroz M, D Almeida V. Differential expression of microRNAs from miR-17 family in the cerebellum of mucopolysaccharidosis type I mice. Gene. 2016;595:207-211 pubmed publisher
    ..Reduction of Neu1 expression has been previously observed in the cerebellum of MPS I mice; to be active, neuraminidase 1 forms the ..
  28. Samollow P, Vandeberg J, Ford A, Douglas T, David C. Electrophoretic analysis of liver neuraminidase-1 variation in mice and additional evidence concerning the location of NEU-1. J Immunogenet. 1986;13:29-39 pubmed
    Neuraminidase-1 (NEU-1) is one of two neuraminidase isozymes which can be detected electrophoretically in mouse liver extracts...
  29. Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, et al. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-? secretion via deregulated lysosomal exocytosis. Nat Commun. 2013;4:2734 pubmed publisher
    ..Here we show that deficiency of the lysosomal sialidase NEU1 leads to the spontaneous occurrence of an AD-like amyloidogenic process in mice...
  30. Hildebrand C, Gonzalez F, Kozak C, Nebert D. Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochem Biophys Res Commun. 1985;130:396-406 pubmed
  31. Veracini L, Simon V, Richard V, Schraven B, Horejsi V, Roche S, et al. The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. J Cell Biol. 2008;182:603-14 pubmed publisher
    ..cell surface and, thus, displaces PDGFR from caveolae, a process that requires the ganglioside-specific sialidase Neu-3...
  32. Ze Y, Hu R, Wang X, Sang X, Ze X, Li B, et al. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. J Biomed Mater Res A. 2014;102:470-8 pubmed publisher
    ..Ddit4, Cyp2e1, and Krev interaction trapped protein 1 (Krit1) expressions and great decreases in DA receptor D2, Neu1, Fc receptor-like molecules, and Dhcr7 expressions following long-term exposure to TiO2 NPs resulted in neurogenic ..
  33. Kurtz A, Zimmer A, Schnutgen F, Bruning G, Spener F, Muller T. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development. 1994;120:2637-49 pubmed
  34. Womack J, Eicher E. Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse chromosome 17. Mol Gen Genet. 1977;155:315-7 pubmed
    b>Apl, a gene involved in the processing of lysosomal acid phosphatase in mouse liver, has been mapped on Chromosome 17. The gene order and map distances in per cent recombination of the loci studied are T (20.6 +/- 3.4) Pgk-2 (7.4 +/- 2...
  35. Ma F, Wu D, Deng L, Secrest P, Zhao J, Varki N, et al. Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem. 2012;287:38073-9 pubmed publisher
    ..We report the presence of two sialidases (neuraminidases Neu1 and Neu3) on mammalian sperm. These are themselves shed from sperm during capacitation...
  36. Dizik M, Elliott R. A second gene affecting the sialylation of lysosomal alpha-mannosidase in mouse liver. Biochem Genet. 1978;16:247-60 pubmed
    ..In contrast, at the Map-1 locus, the more negatively charged phenotype is dominant. The electrophoretic pattern of development of the liver enzyme from SM/JCv mice is described. ..
  37. Womack J, David C. Mouse gene for neuraminidase activity (Neu-1) maps to the D end of H-2. Immunogenetics. 1982;16:177-80 pubmed
  38. Natori Y, Ohkura N, Nasui M, Atsumi G, Kihara Negishi F. Acidic sialidase activity is aberrant in obese and diabetic mice. Biol Pharm Bull. 2013;36:1027-31 pubmed
    Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions...
  39. Figueroa F, Klein D, Tewarson S, Klein J. Evidence for placing the Neu-1 locus within the mouse H-2 complex. J Immunol. 1982;129:2089-93 pubmed
    ..Since all six and no other lines carry the rare Neu-1a allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus...
  40. Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
    ..TLR4 activation triggers Neu1 translocation to cell surface to disrupt TLR4:Siglec-E interaction...
  41. Bonten E, Yogalingam G, Hu H, Gomero E, van de Vlekkert D, D AZZO A. Chaperone-mediated gene therapy with recombinant AAV-PPCA in a new mouse model of type I sialidosis. Biochim Biophys Acta. 2013;1832:1784-92 pubmed publisher
    ..lysosomal storage disease sialidosis is caused by a primary deficiency of the sialidase N-acetyl-?-neuraminidase-1 (NEU1)...
  42. Igdoura S, Gafuik C, Mertineit C, Saberi F, Pshezhetsky A, Potier M, et al. Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts. Hum Mol Genet. 1998;7:115-21 pubmed
    b>Lysosomal sialidase occurs in a multienzyme complex that also contains beta-galactosidase and cathepsin A. We previously cloned the human lysosomal sialidase cDNA and characterized mutations in human sialidosis patients...
  43. Peters J, Swallow D, Andrews S, Evans L. A gene (Neu-1) on chromosome 17 of the mouse affects acid alpha-glucosidase and codes for neuraminidase. Genet Res. 1981;38:47-55 pubmed
  44. Klein D, Klein J. Polymorphism of the Apl (Neu-1) locus in the mouse. Immunogenetics. 1982;16:181-4 pubmed
  45. Gayral S, Garnotel R, Castaing Berthou A, Blaise S, Fougerat A, Berge E, et al. Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3K? pathway. Cardiovasc Res. 2014;102:118-27 pubmed publisher
    ..Altogether, this work identifies EP as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3K? signalling pathway as a key mediator of this function in vitro and in vivo. ..
  46. Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger P, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest. 2008;118:2190-9 pubmed publisher
    ..We conclude that beclin 1 deficiency disrupts neuronal autophagy, modulates APP metabolism, and promotes neurodegeneration in mice and that increasing beclin 1 levels may have therapeutic potential in AD. ..
  47. Starcher B, D AZZO A, Keller P, Rao G, Nadarajah D, Hinek A. Neuraminidase-1 is required for the normal assembly of elastic fibers. Am J Physiol Lung Cell Mol Physiol. 2008;295:L637-47 pubmed publisher
    ..Here, we describe in vivo histopathological effects of neuraminidase-1 (Neu1) deficiency on elastin assembly in the lungs and aorta of mice...
  48. Porteus M, Bulfone A, Liu J, Puelles L, Lo L, Rubenstein J. DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain. J Neurosci. 1994;14:6370-83 pubmed
  49. Ogawa M, Miyata T, Nakajima K, Yagyu K, Seike M, Ikenaka K, et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron. 1995;14:899-912 pubmed
    ..These findings revealed that the selective expression of a distinct molecule on Cajal-Retzius neurons is critical for the normal lamination of cortical neurons in the mammalian neocortex. ..
  50. Rottier R, Bonten E, d Azzo A. A point mutation in the neu-1 locus causes the neuraminidase defect in the SM/J mouse. Hum Mol Genet. 1998;7:313-21 pubmed
    ..This defect was linked to a single gene, neu-1 , on chromosome 17, which was mapped by linkage analysis to the H-2 locus...
  51. Aldrich C, Rodgers J, Rich R. Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm. Immunogenetics. 1988;28:334-44 pubmed
    ..Mechanisms of Qdm function may include either a novel protein modification system or an unprecedented case of antigen recognition restricted by a nonclassical major histocompatibility complex molecule. ..
  52. Turner S, Miller C, Wettstein P, Hasenkrug K, Stimpfling J, Carlson G. Meiotic recombination within the H-2K-H-2D interval: characterization of a panel of congenic mice, including 12 new strains, using DNA markers. Immunogenetics. 1993;38:332-40 pubmed
    ..extended the analysis of the crossover sites in these mice using DNA markers for Ab, Aa, Eb, Ea, Cyp21-ps, D17Tu3, Bat7, and Bat5...
  53. Champigny M, Mitchell M, Fox Robichaud A, Trigatti B, Igdoura S. A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency. Mol Genet Metab. 2009;97:43-52 pubmed publisher
    ..Our findings support a significant role for lysosomal sialidase in inflammation and highlight the significance of repressor-recruitment in genetic disease.
  54. Womack J, Yan D, Potier M. Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases. Science. 1981;212:63-5 pubmed
    ..This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and ..
  55. Suzuki K, Sorimachi H. A novel aspect of calpain activation. FEBS Lett. 1998;433:1-4 pubmed
    ..A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed. ..
  56. Li J, van der Wal D, Zhu G, Xu M, Yougbare I, Ma L, et al. Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun. 2015;6:7737 pubmed publisher
    ..These findings shed light on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP. ..