Nes

Summary

Gene Symbol: Nes
Description: nestin
Alias: AA166324, C78523, ESTM46, Ifaprc2, Marc2, RC2, nestin, intermediate filament protein, intermediate filament-associated protein RC2
Species: mouse

Top Publications

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
  2. ncbi Nestin expression--a property of multi-lineage progenitor cells?
    C Wiese
    In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
    Cell Mol Life Sci 61:2510-22. 2004
  3. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
  4. doi Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
    Jessica L MacDonald
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:2256-67. 2008
  5. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
  6. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
  7. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
  8. ncbi AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia
    M Diers-Fenger
    Department of Neurobiology, University of Heidelberg, Heidelberg, Germany
    Glia 34:213-28. 2001
  9. ncbi Nestin enhancer requirements for expression in normal and injured adult CNS
    Clas B Johansson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 69:784-94. 2002
  10. pmc Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development
    Konstantinos Zarbalis
    Department of Neurology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:14002-7. 2007

Detail Information

Publications153 found, 100 shown here

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  2. ncbi Nestin expression--a property of multi-lineage progenitor cells?
    C Wiese
    In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
    Cell Mol Life Sci 61:2510-22. 2004
    ..In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells...
  3. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  4. doi Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
    Jessica L MacDonald
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:2256-67. 2008
    ..These results identify key developmental stages of HDAC expression and suggest transitions of neural development that may utilize HDAC1 and/or HDAC2...
  5. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
    ..Thus, Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development...
  6. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Consistent with a neural developmental role for the CSF-1R, ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brain size, an expanded neural progenitor pool and elevated cellular ..
  7. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  8. ncbi AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia
    M Diers-Fenger
    Department of Neurobiology, University of Heidelberg, Heidelberg, Germany
    Glia 34:213-28. 2001
    ..In the embryonic spinal cord, cells staining with AN2 antibodies were found closely apposed to radial glial cells, suggesting that glial precursors, like neurons, may use radial glia as scaffolds for migration...
  9. ncbi Nestin enhancer requirements for expression in normal and injured adult CNS
    Clas B Johansson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 69:784-94. 2002
    The nestin gene is expressed in many CNS stem/progenitor cells, both in the embryo and the adult, and nestin is used commonly as a marker for these cells...
  10. pmc Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development
    Konstantinos Zarbalis
    Department of Neurology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:14002-7. 2007
    ..Furthermore, we provide evidence that defects in meningeal differentiation can lead to severe cortical dysplasia...
  11. doi Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus
    Atsushi Enomoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuron 63:774-87. 2009
    ..These findings identify girdin as an intrinsic factor in postnatal development of the DG and provide insights into the critical role of the DISC1/girdin interaction in postnatal neurogenesis in the DG...
  12. pmc Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Biol 8:. 2010
    ..Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells...
  13. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling...
  14. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  15. pmc Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division
    Jessica Yingling
    Departments of Pediatrics and Medicine, Center for Human Genetics and Genomics, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92098 0627, USA
    Cell 132:474-86. 2008
    ..Thus, control of symmetric division, essential for neuroepithelial stem cell proliferation, is mediated through spindle orientation determined via LIS1/NDEL1/dynein-mediated cortical microtubule capture...
  16. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ....
  17. pmc Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1
    Carrie A Ambler
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Development 137:3569-79. 2010
    ..We conclude that jagged 1 is a key mediator of non-cell autonomous Notch signalling in skin...
  18. ncbi Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system
    J Dahlstrand
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Brain Res Dev Brain Res 84:109-29. 1995
    b>Nestin is a recently discovered intermediate filament (IF) gene...
  19. ncbi Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex
    E S Anton
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8001, USA
    Neuron 22:277-89. 1999
    ..These results suggest that alpha3beta1 and alpha(v) integrins regulate distinct aspects of neuronal migration and neuron-glial interactions during corticogenesis...
  20. ncbi Adult Apaf-1-deficient mice exhibit male infertility
    N Honarpour
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Dev Biol 218:248-58. 2000
    ..These findings strongly suggest that alternative apoptotic pathways work in conjunction with and parallel to Apaf-1 and can modify its effect on programmed cell death...
  21. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
  22. ncbi Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    J Histochem Cytochem 55:1075-88. 2007
    ..a number of markers that identify migratory or postmigratory neural crest cells, namely, TuJ1, neurofilament 160, nestin, P75NTR, and Sox10. Moreover, we examined the expression of E-cadherin, an epithelial cell marker...
  23. doi SSAO/VAP-1 protein expression during mouse embryonic development
    Tony Valente
    Departament de Bioquimica i Biologia Molecular, Institut de Neurociencies, Facultat de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
    Dev Dyn 237:2585-93. 2008
    ..Altogether, this suggests that SSAO/VAP-1 enzyme could be involved in the differentiation processes that take place during embryonic development, concretely in tissue vascularisation...
  24. ncbi Pax-2 expression defines a subset of GABAergic interneurons and their precursors in the developing murine cerebellum
    S M Maricich
    Alzheimer Research Laboratory, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Neurobiol 41:281-94. 1999
    ..Finally, our data support the hypothesis that the basket and stellate cells arise from neuronally restricted, migratory precursors located in the early postnatal cerebellar white matter...
  25. ncbi Radial glia serve as neuronal progenitors in all regions of the central nervous system
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 41:881-90. 2004
    ..Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia...
  26. pmc Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
    S Yamamoto
    Division of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 102:15983-8. 2005
    ..However, mutant NSPCs were able to self-renew, demonstrating that Shp2-binding sites on FRS2alpha play an important role in NSPC proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation...
  27. ncbi Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50. 2007
    ..Recombinant Dkk-1 applied to EBs behaved like RA in inducing the expression of the neural markers nestin and distal-less homeobox gene (Dlx-2)...
  28. doi Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells
    Mia Niklasson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Exp Cell Res 316:2779-89. 2010
    ..Transgenic mice were generated with PDGF-B under control of a minimal nestin enhancer element, which is specific for embryonic expression and will not drive adult expression in mice...
  29. ncbi Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    M Ishibashi
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Genes Dev 9:3136-48. 1995
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
  30. ncbi Intermediate filament protein partnership in astrocytes
    C Eliasson
    Department of Medical Biochemistry, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Biol Chem 274:23996-4006. 1999
    ..Here we have addressed the role of specific intermediate filament protein partnerships in the formation of intermediate filaments in astrocytes...
  31. pmc Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
    Yoshinobu Sugitani
    Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
    Genes Dev 16:1760-5. 2002
    ..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development...
  32. ncbi Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
    Petur H Petersen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 419:929-34. 2002
    ..Our findings show that a shared molecular mechanism, with mouse Numb and Nbl as key components, governs the self-renewal of all neural progenitor cells, regardless of their lineage or regional identities...
  33. ncbi Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Japan
    Exp Neurol 182:103-12. 2003
    ..1-deficient mice, the abnormal crossing of ascending DA axons observed may be attributed to the elimination of these chemorepulsive signals in the medial part of the mutant hypothalamus...
  34. ncbi Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    ..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
  35. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  36. pmc Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation
    Amaya Miquelajauregui
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 104:12919-24. 2007
    ..Sip1 is therefore essential to the development of the hippocampus and dentate gyrus, and is able to modulate Wnt signaling in these regions...
  37. pmc Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage
    Nicole Arbour
    Department of Biochemistry, Microbiology, and Immunology, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 28:6068-78. 2008
    ..Together, our results are the first to demonstrate the requirement of Mcl-1, an anti-apoptotic Bcl-2 family protein, for cortical neurogenesis and the survival of neurons after DNA damage...
  38. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..As in wild-type mice, immature nestin-positive glia, which encompass all types of radial glia, populate the hippocampus in Nfib-deficient mice at ..
  39. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  40. doi Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
    Rebecca Favaro
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Nat Neurosci 12:1248-56. 2009
    ..Their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells. Thus, NSCs control their status, at least partly, through Sox2-dependent autocrine mechanisms...
  41. ncbi CNS stem cells express a new class of intermediate filament protein
    U Lendahl
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02142
    Cell 60:585-95. 1990
    ..amino acid sequence of the nestin gene product shows that nestin defines a distinct sixth class of intermediate filament protein. These observations extend a model in which transitions in intermediate filament gene expression ..
  42. ncbi Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres
    M A Gates
    Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    J Comp Neurol 361:249-66. 1995
    ..a chondroitin sulfate proteoglycan termed dermatan sulfate-dependent proteoglycan-1 (DSD-1-PG)], stem-cell marker (nestin), and proliferation-specific marker [bromodeoxyuridine (BrdU)]...
  43. ncbi Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice
    T Miyata
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Comp Neurol 372:215-28. 1996
    ..The spatiotemporal expressions of the CR-50 antigen in the cerebellum are consistent with the possibility that this antigen is involved in cell-cell interactions related to the histogenetic assembly of Purkinje cells...
  44. ncbi The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse
    K Fröjdman
    Turku Centre for Biotechnology, University of Turku, Finland
    Differentiation 61:243-9. 1997
    b>Nestin is an intermediate filament (IF) protein (IFP) which occurs during early developmental stages and during regenerative processes in muscle and neuronal cells...
  45. pmc Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development
    M Berk
    Department of Cancer Biology, Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Genes Dev 11:2029-39. 1997
    ..b>Nestin is an intermediate filament expressed in highly proliferative neuroepithelial stem cells and in myogenic ..
  46. pmc Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene
    P J Yaworsky
    Molecular Neuroscience Program, Samuel C Johnson Medical Research Center, Scottsdale, Arizona, 85259, USA
    Dev Biol 205:309-21. 1999
    ..each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene...
  47. ncbi Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation
    H Toresson
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 126:1317-26. 1999
    ..These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation...
  48. pmc Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
    T Ohtsuka
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, USA
    EMBO J 18:2196-207. 1999
    ..These results demonstrate that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation...
  49. ncbi Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice
    L Carlsson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, SE 901 87, Sweden
    Exp Cell Res 251:213-23. 1999
    ..We have investigated whether and how neuromuscular and myotendinous junctions are affected and whether nestin compensates for the lack of desmin in the knock-out (K/O) mice...
  50. ncbi Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1
    S Horton
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell Neurosci 14:355-69. 1999
    ..Taken together, an essential role for MASH1 in the coordination of events required for correct cell-type specification and timing of differentiation during neural development in ventral forebrain regions is demonstrated...
  51. ncbi Presenilin-1 regulates neuronal differentiation during neurogenesis
    M Handler
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 127:2593-606. 2000
    ..1997, Nature 387, 288-292). These results provide direct evidence that PS1 controls neuronal differentiation in association with the downregulation of Notch signalling during neurogenesis...
  52. ncbi Tbr1 regulates differentiation of the preplate and layer 6
    R F Hevner
    Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 29:353-66. 2001
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
  53. ncbi Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
    D Graus-Porta
    Friedrich Miescher Institute, Maulbeerstr 66, 4058, Basel, Switzerland
    Neuron 31:367-79. 2001
    ..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases...
  54. ncbi A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNS
    J Andrae
    Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Mech Dev 107:181-5. 2001
    ..The results indicate that GFAP activity is regulated in a region-specific manner during central nervous system (CNS) development and that the gene is turned on in different cell types independently...
  55. ncbi Mouse nestin cDNA cloning and protein expression in the cytoskeleton of transfected cells
    J Yang
    Institute of Biochemstry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, PR China
    Biochim Biophys Acta 1520:251-4. 2001
    Complementary DNA (cDNA) corresponding to mouse nestin intermediate filament protein, a specific marker for neural stem cells, was isolated and characterized...
  56. ncbi The adhesion molecule TAG-1 mediates the migration of cortical interneurons from the ganglionic eminence along the corticofugal fiber system
    M Denaxa
    Department of Basic Science, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, PO Box 1527, 711 10 Heraklion, Greece
    Development 128:4635-44. 2001
    ..These observations reveal a mechanism by which the adhesion molecule TAG-1, known to be involved in axonal pathfinding, also takes part in neuronal migration...
  57. ncbi The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum
    P Chapouton
    Max Planck Institute for Neurobiology, Am Klopferspitz 18a, D 82152 Planegg Martinsried, Germany
    Development 128:5149-59. 2001
    ..Taken together, these results show that distinct cues located in the cortico-striatal boundary restrict cells in the dorsal and ventral telencephalon...
  58. ncbi The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
    N Dahmane
    Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5201-12. 2001
    ..SHH-GLI signaling thus modulates normal dorsal brain growth by controlling precursor proliferation, an evolutionarily important and plastic process that is deregulated in brain tumors...
  59. ncbi Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment
    William A Gomes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 255:164-77. 2003
    ..Therefore, BMPs are likely important mediators of astrocyte development in vivo...
  60. ncbi Decrease in expression of alpha 5 beta 1 integrin during neuronal differentiation of cortical progenitor cells
    Naoko Yoshida
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Exp Cell Res 287:262-71. 2003
    ..and FACS analysis of cells in which GFP expression was driven by regulatory (promoter) regions of the nestin gene (nestin-GFP(+))...
  61. pmc Nestin expression in hair follicle sheath progenitor cells
    Lingna Li
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Proc Natl Acad Sci U S A 100:9958-61. 2003
    The intermediate filament protein, nestin, marks progenitor cells of the CNS. Such CNS stem cells are selectively labeled by placing GFP under the control of the nestin regulatory sequences...
  62. ncbi Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm
    Scott E Williams
    Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Neuron 39:919-35. 2003
    ..EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2...
  63. ncbi The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate
    Teresa H Chae
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Department of Neurology and Program in Neuroscience, Harvard Medical School, HIM 816, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Genet 36:264-70. 2004
    ..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells...
  64. ncbi Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain
    Akinori Tokunaga
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 90:142-54. 2004
    ..Taken together, the present method has enabled us to determine the timing, gradients, and boundaries of the activation of Notch signaling...
  65. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..Radial sprout elongation correlated with tip cell filopodia extensions along nestin-positive radial glial processes, but in the SVZ, the tip cell filopodia also extended perpendicular to the glial ..
  66. ncbi Mitotic spindle regulation by Nde1 controls cerebral cortical size
    Yuanyi Feng
    Department of Neurology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 44:279-93. 2004
    ..In vitro analysis demonstrated that Nde1 is essential for centrosome duplication and mitotic spindle assembly. Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex...
  67. ncbi Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Development 131:5539-50. 2004
    ..Our data also indicate that embryonic neural stem cells change their characters over time in the following order: Hes-independent neuroepithelial cells, transitory Hes-dependent neuroepithelial cells and Hes-dependent radial glial cells...
  68. ncbi BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage
    Yassemi Koutmani
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 115 21, Greece
    Eur J Neurosci 20:2509-23. 2004
    ..Our data show an interesting correlation between BM88 expression and the progression of progenitor cells towards neuronal differentiation during the neurogenic interval...
  69. ncbi Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons
    Mary Wines-Samuelson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 277:332-46. 2005
    ..These findings show a cell-autonomous role for PS1 in cortical lamination and radial glial development, and a non-cell-autonomous role for PS1 in CR neuron survival...
  70. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ....
  71. ncbi Id4 is required for the correct timing of neural differentiation
    Lynn Bedford
    Institute of Genetics, Queen s Medical Centre, School of Biology, The University of Nottingham, UK
    Dev Biol 280:386-95. 2005
    ..Together, these in vivo and in vitro data suggest a crucial role for Id4 in regulating NPC proliferation and differentiation...
  72. pmc Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly
    Agnieszka Niewmierzycka
    Department of Pathology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:7022-31. 2005
    ..This study demonstrates a critical role for Ilk in cortical lamination and suggests that Ilk-associated pathways are involved in the pathogenesis of cobblestone lissencephalies...
  73. ncbi Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    Samantha Cicero
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:9658-68. 2005
    ..absent in Cdk5(-/-) cells that have migrated to the cortical plate while these same cells continue to express nestin. Similarly, in vitro, Map-2-positive cells are rare in cultures from E16 Cdk5(-/-) embryos...
  74. ncbi Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain
    Shannon W Mendes
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:882-92. 2006
    ..Our results support a significant role for ephrins and Eph receptors in CC development and may provide insight to possible mechanisms involved in axon midline crossing and human disorder...
  75. ncbi The unique 473HD-Chondroitinsulfate epitope is expressed by radial glia and involved in neural precursor cell proliferation
    Alexander von Holst
    Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Neurosci 26:4082-94. 2006
    ....
  76. ncbi Expression pattern of BM88 in the developing nervous system of the chick and mouse embryo
    Panagiotis K Politis
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vas Sofias Avenue, Athens 11521, Greece
    Gene Expr Patterns 7:165-77. 2007
    ..BM88 is also widely expressed in the mouse embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons.
  77. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  78. ncbi Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system
    Rosalind S E Carney
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 26:11562-74. 2006
    ..We further demonstrate that the generation of the LCS is dependent on the homeodomain-containing gene Gsh2, revealing a novel requirement for Gsh2 in telencephalic development...
  79. ncbi Involvement of the myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation
    Ana Mingorance-Le Meur
    Department of Cell Biology, Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Institute for Research in Biomedicine, University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, 08028 Barcelona, Spain
    Cereb Cortex 17:2375-86. 2007
    ..On the basis of these observations, we propose that Nogo proteins, particularly Nogo-A, are involved in multiple processes during cortical development...
  80. ncbi Regulation of the intermediate filament protein nestin at rodent neuromuscular junctions by innervation and activity
    Hyuno Kang
    Section of Neurobiology, Institute of Neuroscience, University of Texas, Austin, Texas 78712, USA
    J Neurosci 27:5948-57. 2007
    The intermediate filament nestin is localized postsynaptically at rodent neuromuscular junctions...
  81. ncbi Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors
    Mladen Roko Rasin
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nat Neurosci 10:819-27. 2007
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex...
  82. pmc Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors
    Carolyn N Wrobel
    Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Ward 3 190, Chicago, IL 60611, USA
    Dev Biol 309:285-97. 2007
    ..An increased fraction of transgenic cortical cells express the progenitor markers Nestin and LewisX, confirming a relative expansion of this population...
  83. doi Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina
    A Horvat-Bröcker
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, Universitaetsstr 150, 44780 Bochum, Germany
    Neuroscience 152:618-45. 2008
    ..Our results suggest distinct roles of RPTPs in cell proliferation and establishing phenotypes of different retinal cells during retinogenesis as well as later in the maintenance of mature retina...
  84. pmc MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
    Karpagam Srinivasan
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 135:1781-90. 2008
    ..Our results suggest that MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex...
  85. doi C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment
    Anne K Voss
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Development 135:2139-49. 2008
    ..In C3G-deficient cells, Rap1 GTP loading in response to reelin stimulation is reduced. In conclusion, the Ras family regulator C3G is essential for two aspects of cortex development, namely radial glial attachment and neuronal migration...
  86. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  87. pmc Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice
    Kevin A Burns
    Division of Developmental Biology, Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Glia 57:1115-29. 2009
    ..We previously generated Nestin-CreER mice to fate-map the progeny of radial glial cells (RG), a source of astrocytes and oligodendrocytes in the ..
  88. pmc Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development
    Zhigang Jin
    Laboratory of Molecular Cell Biology and State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 284:8160-73. 2009
    b>Nestin is a molecular marker for neural progenitor cells. Rat and human nestin genes possess a central nervous system-specific enhancer within their second introns...
  89. pmc The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors
    Jens C Schwamborn
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell 136:913-25. 2009
    ..TRIM32 is the mouse ortholog of Drosophila Brat and Mei-P26 and might be part of a protein family that regulates the balance between differentiation and proliferation in stem cell lineages...
  90. doi The radial glia antibody RC2 recognizes a protein encoded by Nestin
    Donghyun Park
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, 929E, 57th, W503B, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 382:588-92. 2009
    ..Here, we present evidences clearly demonstrating that Nestin encodes the RC2 antigen...
  91. pmc Regulation of radial glial survival by signals from the meninges
    Randor Radakovits
    The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
    J Neurosci 29:7694-705. 2009
    ..Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size...
  92. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  93. pmc Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis
    Xuecai Ge
    Picower Institute for Learning and Memory, Department of Brain and Cognitive, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 46, Room 4235A, Cambridge, MA 02139, USA
    Neuron 65:191-203. 2010
    ..These results underscore the importance of centrosomal assembly in neurogenesis and provide potential insights into the etiology of brain developmental diseases related to the centrosome dysfunction...
  94. pmc TGF-beta signaling specifies axons during brain development
    Jason J Yi
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 142:144-57. 2010
    ..These results define an extrinsic cue for neuronal polarity in vivo that patterns neural circuits in the developing brain...
  95. doi Nestin is required for the proper self-renewal of neural stem cells
    Donghyun Park
    Department of Human Genetics, University of Chicago, Howard Hughes Medical Institute, Chicago, Illinois, USA
    Stem Cells 28:2162-71. 2010
    The intermediate filament protein, nestin, is a widely employed marker of multipotent neural stem cells (NSCs)...
  96. pmc Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain
    Jakob S Satz
    Howard Hughes Medical Institute, and Department of Molecular Physiology, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 30:14560-72. 2010
    ..Differences in dystroglycan glycosylation in distinct cell types of the CNS may contribute to the diversity of dystroglycan function in the CNS, as well as to the broad clinical spectrum of type II lissencephalies...
  97. doi FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development
    Roya Saffary
    Department of Neurosurgery, Boston Medical Center, Boston, MA 02118, USA
    J Neurosci 31:1427-39. 2011
    ..Our data suggest that FMRP suppresses the transition from RGCs to IPCs during neocortical development by an actin-dependent mechanism...
  98. pmc Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development
    Joong Sun Kim
    Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Vet Sci 12:1-6. 2011
    Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development...
  99. pmc VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm
    Lynda Erskine
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Neuron 70:951-65. 2011
    ..These findings have identified a permissive midline signal for axons at the chiasm midline and provide in vivo evidence that VEGF-A is an essential axon guidance cue...
  100. pmc G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
    Rong Luo
    Division of Newborn Medicine, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:12925-30. 2011
    ..Thus, collagen III regulates the proper lamination of the cerebral cortex by acting as the major ligand of GPR56 in the developing brain...
  101. pmc Dystroglycan organizes axon guidance cue localization and axonal pathfinding
    Kevin M Wright
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 76:931-44. 2012
    ..These findings establish a novel role for glycosylated dystroglycan as a key determinant of axon guidance cue distribution and function in the mammalian nervous system...

Research Grants8

  1. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  2. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  3. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ....
  4. Cell migration and differentiation in the olfactory bulb
    Adam Puche; Fiscal Year: 2004
    ..Understand the mechanisms of SVZ progenitor migration through the olfactory bulb and cues governing phenotype selection have important implications for the use of these cells as clinical therapy. ..
  5. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
    ....
  6. ROLE OF HLX IN MOUSE GASTROINTESTINAL/LIVER DEVELOPMENT
    Michael Bates; Fiscal Year: 2004
    ..This program will allow additional training in molecular and cellular techniques, development of supervisory skills, and further instruction in the responsible conduct of research. ..
  7. Hix in Enteric Mesenchymal and Neuronal Development
    Michael Bates; Fiscal Year: 2005
    ..abstract_text> ..
  8. Adult pancreatic progenitor cells as target of early oncogenic events
    CATHERINE CARRIERE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..