Gene Symbol: Nell1
Description: NEL-like 1
Alias: B230343H07Rik, l7R6, protein kinase C-binding protein NELL1, NEL-like protein 1
Species: mouse
Products:     Nell1

Top Publications

  1. Aghaloo T, Cowan C, Chou Y, Zhang X, Lee H, Miao S, et al. Nell-1-induced bone regeneration in calvarial defects. Am J Pathol. 2006;169:903-15 pubmed
    ..Insights into Nell-1-regulated osteogenesis coupled with its ability to stimulate bone regeneration revealed a potential therapeutic role and an alternative to the currently accepted techniques for bone regeneration. ..
  2. Zhang X, Cowan C, Jiang X, Soo C, Miao S, Carpenter D, et al. Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development. Lab Invest. 2006;86:633-44 pubmed
    ..NELL-1: used when describing the human gene; NELL-1: used when describing the human protein; Nell-1: used when describing the rodent gene; Nell-1: used when describing the rodent protein. ..
  3. Hasebe A, Nakamura Y, Tashima H, Takahashi K, Iijima M, Yoshimoto N, et al. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin ?3?1. FEBS Lett. 2012;586:2500-6 pubmed publisher
    b>NELL1 is a secretory osteogenic protein containing several structural motifs that suggest that it functions as an extracellular matrix component...
  4. Shen J, James A, Chung J, Lee K, Zhang J, Ho S, et al. NELL-1 promotes cell adhesion and differentiation via Integrin?1. J Cell Biochem. 2012;113:3620-8 pubmed publisher
    ..Our results identify for the first time a cell surface target of NELL-1, Integrin?1, and elucidate new functions of NELL-1 in promoting cell adherence and osteogenic differentiation. ..
  5. Pang S, Shen J, Liu Y, Chen F, Zheng Z, James A, et al. Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1. Stem Cells. 2015;33:904-15 pubmed publisher
    ..In vivo, NELL-1570 induced significant calvarial defect regeneration accompanied by increased cell proliferation. Thus, NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration. ..
  6. Rinchik E, Carpenter D, Johnson D. Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15. Proc Natl Acad Sci U S A. 2002;99:844-9 pubmed
  7. Zhang X, Ting K, Bessette C, Culiat C, Sung S, Lee H, et al. Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice. J Bone Miner Res. 2011;26:777-91 pubmed publisher
  8. Chen W, Zhang X, Siu R, Chen F, Shen J, Zara J, et al. Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells. J Bone Miner Res. 2011;26:1230-41 pubmed publisher
    ..Nell-1, Runx2, and Nfatc2 in vivo, their presence and distribution were visualized in femurs of wild-type and Nell1-deficient mice at both neonatal and various developmental stages using immunohistochemistry...
  9. James A, Pan A, Chiang M, Zara J, Zhang X, Ting K, et al. A new function of Nell-1 protein in repressing adipogenic differentiation. Biochem Biophys Res Commun. 2011;411:126-31 pubmed publisher
    ..These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog dependent mechanism. ..

More Information


  1. Nakamura R, Nakamoto C, Obama H, Durward E, Nakamoto M. Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions. J Biol Chem. 2012;287:3282-91 pubmed publisher
    ..In vivo, Nel and related Nell1 are expressed in several regions of the mouse central nervous system with partly overlapping patterns...
  2. Zhang X, Ting K, Pathmanathan D, Ko T, Chen W, Chen F, et al. Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency. J Craniofac Surg. 2012;23:61-6 pubmed publisher
    ..In summary, Nell-1 is required for normal craniofacial membranous and endochondral skeletal development...
  3. Tang R, Wang Q, Du J, Yang P, Wang X. Expression and localization of Nell-1 during murine molar development. J Mol Histol. 2013;44:175-81 pubmed publisher
  4. Nakamura Y, Hasebe A, Takahashi K, Iijima M, Yoshimoto N, Maturana A, et al. Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading. J Biol Chem. 2014;289:9781-94 pubmed publisher
    b>NELL1 is a large oligomeric secretory glycoprotein that functions as an osteoinductive factor...
  5. James A, Shen J, Zhang X, Asatrian G, Goyal R, Kwak J, et al. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015;6:7362 pubmed publisher
    ..Altogether, these findings suggest that NELL-1 deficiency plays a role in osteoporosis and demonstrate the potential utility of NELL-1 as a combination anabolic/antiosteoclastic therapeutic for bone loss. ..
  6. Jaworski A, Tom I, Tong R, Gildea H, Koch A, Gonzalez L, et al. Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science. 2015;350:961-5 pubmed publisher
  7. Li C, Jiang J, Zheng Z, Lee K, Zhou Y, Chen E, et al. Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation. Am J Pathol. 2017;187:963-972 pubmed publisher
    ..Nell-1 is a key functional mediator of chondrogenesis, thus opening up new possibilities for the application of Nell-1 in cartilage regeneration. ..