Gene Symbol: Nectin4
Description: nectin cell adhesion molecule 4
Alias: 1200017F15Rik, Prr4, Pvrl4, nectin-4, ig superfamily receptor LNIR, nectin 4, poliovirus receptor-related 4, poliovirus receptor-related protein 4
Reymond N, Fabre S, Lecocq E, Adelaide J, Dubreuil P, Lopez M. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem. 2001;276:43205-15 pubmed
..We identify a new member of the nectin family named nectin4. Peptide sequences of human and murine nectin4 share 92% identity, and as for other members, the ectodomain is ..
Brancati F, Fortugno P, Bottillo I, Lopez M, Josselin E, Boudghene Stambouli O, et al
. Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. Am J Hum Genet. 2010;87:265-73 pubmed publisher
..By candidate gene analysis, we identified a homozygous mutation in the PVRL4 gene that not only evoked an amino acid change but also led to exon skipping...
Yoshida T, Miyoshi J, Takai Y, Thesleff I. Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth. Dev Dyn. 2010;239:2558-69 pubmed publisher
..These results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation. ..
Mollo M, Antonini D, Mitchell K, Fortugno P, Costanzo A, Dixon J, et al
. p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis. Exp Dermatol. 2015;24:114-9 pubmed publisher
..As mutations in the Pvrl1 and Pvrl4 genes encoding for nectins cause genetic disorders with phenotypes similar to p63-related syndromes, we ..
Noyce R, Bondre D, Ha M, Lin L, Sisson G, Tsao M, et al
. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog. 2011;7:e1002240 pubmed publisher
..Of these, only the human tumor cell marker PVRL4 (Nectin 4) rendered cells amenable to measles virus infections...
Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, et al
. s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin. Genes Cells. 2014;19:853-63 pubmed publisher
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, et al
. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. J Biol Chem. 2016;291:5817-31 pubmed publisher
..Thus, a novel nectin-mediated cell adhesion apparatus regulates the prolactin receptor signaling for mammary gland development. ..
Maruoka M, Kedashiro S, Ueda Y, Mizutani K, Takai Y. Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. J Biol Chem. 2017;292:6895-6909 pubmed publisher
..These results indicate that nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway. ..
Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al
. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13:e1006828 pubmed publisher