Gene Symbol: Ndor1
Description: NADPH dependent diflavin oxidoreductase 1
Alias: 4930447P04Rik, NR1, Ndor, Tg(UBC-cre/ERT2)1Ejb, Ubc-cre, NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ESR1)1Ejb
Species: mouse
Products:     Ndor1

Top Publications

  1. Ruzankina Y, Pinzon Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007;1:113-26 pubmed publisher
    ..In aggregate, these studies suggest that reduced regenerative capacity in adults via deletion of a developmentally essential DDR gene is sufficient to cause the premature appearance of age-related phenotypes. ..
  2. Price N, Gomes A, Ling A, Duarte F, Martin Montalvo A, North B, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15:675-90 pubmed publisher
    ..Together these data indicate that SIRT1 plays an essential role in the ability of moderate doses of resveratrol to stimulate AMPK and improve mitochondrial function both in vitro and in vivo. ..
  3. Ding L, Saunders T, Enikolopov G, Morrison S. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481:457-62 pubmed publisher
    ..Most HSCs were lost when Scf was deleted from both endothelial and Lepr-expressing perivascular cells. Thus, HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance. ..
  4. Lamming D, Ye L, Katajisto P, Goncalves M, Saitoh M, Stevens D, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012;335:1638-43 pubmed publisher
    ..Thus, mTORC2 disruption is an important mediator of the effects of rapamycin in vivo. ..
  5. Chen Y, Yan J, Keeshan K, Tubbs A, Wang H, Silva A, et al. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A. 2006;103:1018-23 pubmed
    ..These studies uncover an important role for menin in both normal hematopoiesis and myeloid transformation and provide a mechanistic understanding of menin's function in these processes that may be used for therapy. ..
  6. Sonnenberg G, Mangan P, Bezman N, Sekiguchi D, Luning Prak E, Erikson J, et al. Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood. 2010;115:2186-95 pubmed publisher
    ..Thus, the abnormal effector T-cell phenotype still occurs in the presence of preserved central and peripheral tolerance, suggesting that diminished T-cell receptor signaling can promote skewed T-cell responses. ..
  7. Reamy A, Wolfgang M. Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. J Neurochem. 2011;118:388-98 pubmed publisher
    ..These data show that CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet. ..
  8. Xu R, Sen N, Paul B, Snowman A, Rao F, Vandiver M, et al. Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal. 2013;6:ra22 pubmed publisher
    ..These results suggest that IPMK acts as a transcriptional coactivator for p53 and that it is an integral part of the p53 transcriptional complex facilitating cell death. ..
  9. Covarrubias A, Aksoylar H, Yu J, Snyder N, WORTH A, Iyer S, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. elife. 2016;5: pubmed publisher
    ..We propose that Akt-mTORC1 signaling calibrates metabolic state to energetically demanding aspects of M2 activation, which may define a new role for metabolism in supporting macrophage activation. ..

More Information

Publications104 found, 100 shown here

  1. Tang Y, Wallace M, Sanchez Gurmaches J, Hsiao W, Li H, Lee P, et al. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016;7:11365 pubmed publisher
    ..These data suggest mTORC2 functions in WAT as part of an extra-hepatic nutrient-sensing mechanism to control glucose homeostasis. ..
  2. Fang V, Chaluvadi V, Ramos Perez W, Mendoza A, Baeyens A, Rivera R, et al. Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-? response. Nat Immunol. 2017;18:15-25 pubmed publisher
    ..Our findings elucidate the spatial cues for NK cell organization and reveal a previously unknown role for S1P in positioning cells within the medulla. ..
  3. Sun X, Wang S, Wei Y, Luo X, Jia Y, Li L, et al. Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. Cancer Cell. 2017;32:574-589.e6 pubmed publisher
    ..In summary, ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer. ..
  4. Rahman A, Zhang R, Blosser C, Hou B, DeFranco A, Maltzman J, et al. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011;117:3123-30 pubmed publisher
    ..Our findings clarify the importance of MyD88 during distinct phases of the antiviral T-cell response and establish differential dependence on MyD88 signaling as a novel characteristic that distinguishes naive from memory CD8 T cells. ..
  5. Chang J, Burkett P, Borges C, Kuchroo V, Turka L, Chang C. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013;110:2270-5 pubmed publisher
    ..Taken together, our results demonstrate that MyD88 has a dual function in Th17 cells by delivering IL-1 signaling during the early differentiation stage and integrating IL-23 signaling to the mTOR complex to expand committed Th17 cells. ..
  6. Hwang W, Salinas R, Siu J, Kelley K, Delgado R, Paredes M, et al. Distinct and separable roles for EZH2 in neurogenic astroglia. elife. 2014;3:e02439 pubmed publisher
    ..DOI: http://dx.doi.org/10.7554/eLife.02439.001. ..
  7. Pestal K, Funk C, Snyder J, Price N, Treuting P, Stetson D. Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development. Immunity. 2015;43:933-44 pubmed publisher
    ..Our findings delineate genetically separable roles for both ADAR1 isoforms in vivo, with implications for the human diseases caused by ADAR mutations. ..
  8. Sztainberg Y, Chen H, Swann J, Hao S, Tang B, Wu Z, et al. Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Nature. 2015;528:123-6 pubmed publisher
  9. Jacobs S, Michalek R, Rathmell J. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol. 2010;184:3461-9 pubmed publisher
  10. Kobayashi H, Gilbert V, Liu Q, Kapitsinou P, Unger T, Rha J, et al. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol. 2012;188:5106-15 pubmed publisher
    ..Collectively, we provide experimental evidence that hypoxia and/or myeloid cell-specific HIF activation attenuates renal inflammation associated with chronic kidney injury. ..
  11. Popmihajlov Z, Xu D, Morgan H, Milligan Z, Smith K. Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. Front Immunol. 2012;3:102 pubmed publisher
  12. Ma M, Tian X, Igarashi P, Pazour G, Somlo S. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet. 2013;45:1004-12 pubmed publisher
    ..These data establish the existence of a new pathway defined by polycystin-dependent inhibition and cilia-dependent activation that promotes rapid cyst growth. ..
  13. Gomes A, Price N, Ling A, Moslehi J, Montgomery M, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155:1624-38 pubmed publisher
    ..Thus, a pseudohypoxic state that disrupts PGC-1?/?-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible. ..
  14. Lamming D, Mihaylova M, Katajisto P, Baar E, Yilmaz O, Hutchins A, et al. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 2014;13:911-7 pubmed publisher
    ..Our results suggest that inhibition of mTORC2 signaling is detrimental to males, which may explain in part why interventions that decrease mTOR signaling show greater efficacy in females. ..
  15. Bui H, Enis D, Robciuc M, Nurmi H, Cohen J, Chen M, et al. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. J Clin Invest. 2016;126:2167-80 pubmed publisher
  16. Drosten M, Simón Carrasco L, Hernández Porras I, Lechuga C, Blasco M, Jacob H, et al. H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences. Cancer Res. 2017;77:707-718 pubmed publisher
    ..Cancer Res; 77(3); 707-18. ©2016 AACR. ..
  17. Piñeiro Hermida S, López I, Alfaro Arnedo E, Torrens R, Iñiguez M, Alvarez Erviti L, et al. IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model. Sci Rep. 2017;7:4290 pubmed publisher
    ..These findings identify IGF1R as an important player in murine acute lung inflammation, suggesting that targeting IGF1R may counteract the inflammatory component of many lung diseases. ..
  18. Madera S, Geary C, Lau C, Pikovskaya O, Reiner S, Sun J. Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. J Immunol. 2018;200:1977-1981 pubmed publisher
    ..These findings uncover a nonredundant and stage-specific influence of T-box transcription factors in the antiviral NK cell response. ..
  19. Ganuza M, Saiz Ladera C, Canamero M, Gomez G, Schneider R, Blasco M, et al. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012;31:2498-510 pubmed publisher
    ..This process, a physiological attempt to maintain tissue homeostasis, led to the attrition of adult stem cell pools and to the appearance of age-related phenotypes, including telomere shortening and early death. ..
  20. Sun W, Wagnon J, Mahaffey C, Briese M, Ule J, Frankel W. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice. J Physiol. 2013;591:241-55 pubmed publisher
    ..6 protein at the AIS in both null and heterozygous neurons. Together these results suggest that activation of Na(v)1.6 plays a crucial role in seizure generation in this complex model of neurological disease. ..
  21. Souza C, Davidson D, Rhee I, Gratton J, Davis E, Veillette A. The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability. J Biol Chem. 2012;287:43180-90 pubmed publisher
    ..This function explains at least in part the essential role of PTP-PEST in embryonic development and viability. ..
  22. Schmidt A, Lu W, Sindhava V, Huang Y, Burkhardt J, Yang E, et al. Regulatory T cells require TCR signaling for their suppressive function. J Immunol. 2015;194:4362-70 pubmed publisher
    ..Together, these data suggest that TCR-mediated PLCγ activation, but not integrin activation, is required for Tregs to inhibit Tconv proliferation. ..
  23. Reddy O, Cates J, Gellert L, Crist H, Yang Z, Yamashita H, et al. Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer. Am J Pathol. 2015;185:1385-95 pubmed publisher
    ..Analysis of human tumor specimens confirmed a significant relationship between loss of FOXA1 and increased cytokeratin 14 expression. ..
  24. Sanchez Gurmaches J, Tang Y, Jespersen N, Wallace M, Martinez Calejman C, Gujja S, et al. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2018;27:195-209.e6 pubmed publisher
    ..These data provide insight into adipocyte DNL regulation and function and illustrate the metabolic flexibility of thermogenesis. ..
  25. Quintana A, Kruse S, Kapur R, Sanz E, Palmiter R. Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome. Proc Natl Acad Sci U S A. 2010;107:10996-1001 pubmed publisher
    ..These data suggest that dysfunctional complex I in specific brain regions results in progressive glial activation that promotes neuronal death that ultimately results in mortality. ..
  26. Bauler T, Kamiya N, Lapinski P, Langewisch E, Mishina Y, Wilkinson J, et al. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. Dis Model Mech. 2011;4:228-39 pubmed publisher
  27. Sawamukai N, Satake A, Schmidt A, Lamborn I, Ojha P, Tanaka Y, et al. Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD. Blood. 2012;119:5575-83 pubmed publisher
    ..These data illustrate the complex makeup of the donor-derived FoxP3(+) Treg pool in allogeneic recipients and their potential role in protection against GVHD. ..
  28. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne J, et al. Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Mol Genet Metab. 2013;110:222-30 pubmed publisher
  29. Lenti E, Farinello D, Yokoyama K, Penkov D, Castagnaro L, Lavorgna G, et al. Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development. J Clin Invest. 2016;126:2452-64 pubmed publisher
    ..Together, these findings establish TLX1 as a critical regulator of RA metabolism and provide mechanistic insights into the molecular determinants of human congenital asplenia. ..
  30. Brandt M, Grazioso T, Fawal M, Tummala K, Torres Ruiz R, Rodriguez Perales S, et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018;27:118-135.e8 pubmed publisher
    ..Our work reveals mTORC1 oncogenic and tumor-suppressive roles in intestinal epithelium and avenues to optimized and personalized therapeutic regimens for CRC. ..
  31. Maillard I, Chen Y, Friedman A, Yang Y, Tubbs A, Shestova O, et al. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood. 2009;113:1661-9 pubmed publisher
  32. Ruzankina Y, Schoppy D, Asare A, CLARK C, Vonderheide R, Brown E. Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet. 2009;41:1144-9 pubmed publisher
    ..Together, our results indicate that the combined loss of Atr and Trp53 in adult mice leads to the accumulation of highly damaged cells, which, consequently, impose a barrier to regeneration from undamaged progenitors. ..
  33. Gilad O, Nabet B, Ragland R, Schoppy D, Smith K, Durham A, et al. Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res. 2010;70:9693-702 pubmed publisher
    ..These results highlight the importance of the ATR pathway both as a barrier to malignant progression and as a potential target for cancer treatment. ..
  34. Mionnet C, Sanos S, Mondor I, Jorquera A, Laugier J, Germain R, et al. High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. Blood. 2011;118:6115-22 pubmed publisher
  35. Küper C, Beck F, Neuhofer W. Generation of a conditional knockout allele for the NFAT5 gene in mice. Front Physiol. 2014;5:507 pubmed publisher
  36. Tan Q, Brunetti L, Rousseaux M, Lu H, Wan Y, Revelli J, et al. Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A. 2018;115:E1511-E1519 pubmed publisher
    ..Moreover, we show that mouse models lacking CIC in the hematopoietic system are robust models for studying the role of RAS signaling as well as NOTCH1 and MYC transcriptional programs in T-ALL. ..
  37. Jones T, Jones P. A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy. PLoS ONE. 2018;13:e0192657 pubmed publisher
    ..Overall, the FLExDUX4 line of mice is quite versatile and will allow new investigations into mechanisms of DUX4-mediated pathophysiology as well as much-needed pre-clinical testing of DUX4-targeted FSHD interventions in vivo. ..
  38. Gruber M, Hu C, Johnson R, Brown E, Keith B, Simon M. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007;104:2301-6 pubmed
  39. Jung H, Hsiung B, Pestal K, Procyk E, Raulet D. RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J Exp Med. 2012;209:2409-22 pubmed publisher
    ..These findings suggest that cellular proliferation, as occurs in cancer cells but also other pathological conditions, is a key signal tied to immune reactions mediated by NKG2D-bearing lymphocytes. ..
  40. Soleimanpour S, Gupta A, Bakay M, Ferrari A, Groff D, Fadista J, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014;157:1577-90 pubmed publisher
    ..This pathway could be targeted for prevention and control of diabetes and may extend to the pathogenesis of other Clec16a- and Parkin-associated diseases. ..
  41. Gage P, Kuang C, Zacharias A. The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea. Dev Dyn. 2014;243:1391-400 pubmed publisher
    ..However, they are unlikely to play a role in specifying cell fate within the corneal ectoderm. Together, these data provide important insights into the mechanisms regulating cornea development. ..
  42. Schoppy D, Ragland R, Gilad O, Shastri N, Peters A, Murga M, et al. Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest. 2012;122:241-52 pubmed publisher
  43. Young N, Kamireddy A, Van Nostrand J, Eichner L, Shokhirev M, Dayn Y, et al. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016;30:535-52 pubmed publisher
    ..Collectively, these results uncover the AMPK pathway as a novel regulator of cell fate determination during differentiation. ..
  44. Lapinski P, Lubeck B, Chen D, Doosti A, Zawieja S, Davis M, et al. RASA1 regulates the function of lymphatic vessel valves in mice. J Clin Invest. 2017;127:2569-2585 pubmed publisher
    ..Thus, RASA1 catalytic activity is essential for the function and development of LV valves. These data provide a partial explanation for LV leakage defects and potentially other LV abnormalities observed in CM-AVM. ..
  45. Das R, Bassiri H, Guan P, Wiener S, Banerjee P, Zhong M, et al. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 2013;121:3386-95 pubmed publisher
    ..Collectively, these studies highlight a novel and essential role for SAP during iNKT cell cytotoxicity and formation of a functional IS. ..
  46. Gibson D, Pi L, Sriram S, Mao C, Petersen B, Scott E, et al. Conditional knockout of CTGF affects corneal wound healing. Invest Ophthalmol Vis Sci. 2014;55:2062-70 pubmed publisher
    ..Connective tissue growth factor is expressed in the naïve cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds...
  47. Royo H, Prosser H, Ruzankina Y, Mahadevaiah S, Cloutier J, Baumann M, et al. ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing. Genes Dev. 2013;27:1484-94 pubmed publisher
    ..Our work identifies a role for ATR in the epigenetic regulation of gene expression and presents a new technique for ablating gene function in the germline. ..
  48. Akbay E, Moslehi J, Christensen C, Saha S, Tchaicha J, Ramkissoon S, et al. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev. 2014;28:479-90 pubmed publisher
    ..Together, these findings indicate that inhibitors of mutant IDH2 may be beneficial in the treatment of D2HGA and suggest that 2HG produced by IDH mutant tumors has the potential to provoke a paraneoplastic condition. ..
  49. Hu X, Das B, Hou H, He W, Yan R. BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exp Med. 2018;215:927-940 pubmed publisher
  50. Nakada D, Saunders T, Morrison S. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature. 2010;468:653-8 pubmed publisher
    ..Lkb1 is therefore required for HSC maintenance through AMPK-dependent and AMPK-independent mechanisms, revealing differences in metabolic and cell-cycle regulation between HSCs and some other haematopoietic progenitors. ..
  51. Corbo Rodgers E, Staub E, Zou T, Smith A, Kambayashi T, Maltzman J. Oral ivermectin as an unexpected initiator of CreT2-mediated deletion in T cells. Nat Immunol. 2012;13:197-8 pubmed publisher
  52. Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, et al. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013;121:3228-36 pubmed publisher
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  53. Mercken E, Mitchell S, Martin Montalvo A, Minor R, Almeida M, Gomes A, et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014;13:787-96 pubmed publisher
    ..These results demonstrate it is possible to design a small molecule that can slow aging and delay multiple age-related diseases in mammals, supporting the therapeutic potential of SIRT1 activators in humans. ..
  54. Jantsch J, Schatz V, Friedrich D, Schröder A, Kopp C, Siegert I, et al. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab. 2015;21:493-501 pubmed publisher
    ..We suggest that the hypertonic microenvironment could serve as a barrier to infection. ..
  55. Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, et al. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. elife. 2016;5: pubmed publisher
    ..Together, our results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII. ..
  56. Shinoda G, Shyh Chang N, Soysa T, Zhu H, Seligson M, Shah S, et al. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013;31:1563-73 pubmed publisher
    ..Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. ..
  57. Li Y, Choi P, Casey S, Felsher D. Activation of Cre recombinase alone can induce complete tumor regression. PLoS ONE. 2014;9:e107589 pubmed publisher
    ..Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53-/- mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors. ..
  58. Kim H, Choi W, Sorscher N, Park H, Tronche F, Palmiter R, et al. Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiol Aging. 2015;36:2617-27 pubmed publisher
    ..These findings suggest the existence of alternative mechanisms of dopaminergic neuron death independent of mitochondrial complex I inhibition. ..
  59. Cho S, Raybuck A, Stengel K, Wei M, Beck T, Volanakis E, et al. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature. 2016;537:234-238 pubmed publisher
    ..We propose that the restriction of oxygen in lymphoid organs, which can be altered in pathophysiological states, modulates humoral immunity. ..
  60. Piñeiro Hermida S, Gregory J, López I, Torrens R, Ruíz Martínez C, Adner M, et al. Attenuated airway hyperresponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice. Allergy. 2017;72:1317-1326 pubmed publisher
    ..Thus, our study identifies IGF1R as a potential therapeutic target, not only for asthma but also for hypersecretory airway diseases. ..
  61. Lapinski P, Bauler T, Brown E, Hughes E, Saunders T, King P. Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis. 2007;45:762-7 pubmed
    ..The conditional rasa1 mouse will be useful for the analysis of the role of RasGAP in mature cell types. ..
  62. Gao Y, Sartori D, Li C, Yu Q, Kushner J, Simon M, et al. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol. 2012;32:5129-39 pubmed publisher
    ..This work demonstrates that contrary to expectations, PERK is required for secretory homeostasis and ? cell survival in adult mice...
  63. Yang P, Zhang Y, Pang J, Zhang S, Yu Q, He L, et al. Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities. Am J Pathol. 2013;183:617-25 pubmed publisher
    ..These data are important not only for understanding the exact role that Jak2 plays in endothelial homeostasis, but also for assessing Jak2-based therapeutic strategies in a variety of clinical settings. ..
  64. Biel T, Lee S, Flores Toro J, Dean J, Go K, Lee M, et al. Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner. Cell Death Differ. 2016;23:279-90 pubmed publisher
    ..Thus, our results demonstrate that the loss of SIRT1 causes a sequential chain of defective autophagy, mitochondrial dysfunction, and hepatocyte death after I/R. ..
  65. Jacome A, Gutierrez Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez Acebes S, et al. NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 2015;34:2604-19 pubmed publisher
    ..Our work reveals that SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate segregation; functions of the SMC5/6 complex that are necessary to prevent cancer and aging in mice. ..
  66. Lum J, Bui T, Gruber M, Gordan J, DeBerardinis R, Covello K, et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 2007;21:1037-49 pubmed
    ..Together, these data suggest that HIF-1alpha contributes to the regulation of growth factor-stimulated glucose metabolism even in the absence of hypoxia...
  67. Sha H, Sun S, Francisco A, Ehrhardt N, Xue Z, Liu L, et al. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014;20:458-70 pubmed publisher
    ..The Sel1L-mediated control of LPL secretion is also seen in other LPL-expressing cell types including cardiac myocytes and macrophages. Thus, our study reports a role of Sel1L in LPL secretion and systemic lipid metabolism...
  68. Yin Q, Shen J, Wan X, Liu Q, Zhou Y, Zhang Y. Impaired sperm maturation in conditional Lcn6 knockout mice. Biol Reprod. 2017;: pubmed publisher
    ..01). These results demonstrate an important function of LCN6 in preventing calcium overload and premature acrosome reaction of sperm and suggest a potential risk factor of LCN6 deficiency for sperm maturation...
  69. Wu G, Corbo E, Schmidt M, Smith Garvin J, Riese M, Jordan M, et al. Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol. 2011;41:2064-73 pubmed publisher
  70. Zacharias A, Gage P. Canonical Wnt/?-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn. 2010;239:3215-25 pubmed publisher
    ..Other key transcription factors in the neural crest, including Foxc1, do not require intact canonical Wnt signaling. ..
  71. Wagnon J, Mahaffey C, Sun W, Yang Y, Chao H, Frankel W. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Genes Brain Behav. 2011;10:765-77 pubmed publisher
    ..We posit that altered excitatory neurotransmission resulting from Celf4 deficiency underlies the complex seizure disorder in Celf4 mutant mice. ..
  72. Sellars M, Huh J, Day K, Issuree P, Galan C, Gobeil S, et al. Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol. 2015;16:746-54 pubmed publisher
    ..Our findings suggest that stage-specific methylation and demethylation events in Cd4 regulate its heritable expression in response to the distinct signals that dictate lineage 'choice' during T cell development. ..
  73. Majmundar A, Lee D, Skuli N, Mesquita R, Kim M, Yodh A, et al. HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo. Development. 2015;142:2405-12 pubmed publisher
    ..Our data provide the first evidence that HIF1? regulates skeletal myogenesis in vivo and establish a novel link between HIF and Wnt signaling in this context. ..
  74. Meng L, Ohman Gault L, Ma L, Krimm R. Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds. Eneuro. 2015;2: pubmed publisher
    ..Taste buds were confirmed as the source of BDNF regulating innervation. We conclude that BDNF expressed in taste receptor cells is required to maintain normal levels of innervation in adulthood. ..
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