Gene Symbol: Ndn
Description: necdin
Alias: AI528698, Peg6, necdin
Species: mouse
Products:     Ndn

Top Publications

  1. Lee S, Kozlov S, Hernandez L, Chamberlain S, Brannan C, Stewart C, et al. Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype. Hum Mol Genet. 2000;9:1813-9 pubmed
    ..Affected individuals exhibit neonatal hypotonia, developmental delay and childhood-onset obesity. Necdin, a protein implicated in the terminal differentiation of neurons, is the only PWS candidate gene to reduce ..
  2. Maruyama K, Usami M, Aizawa T, Yoshikawa K. A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun. 1991;178:291-6 pubmed
    ..This novel mRNA encoding the nuclear protein, termed necdin, may represent a useful marker for the differentiation and development of brain cells.
  3. Takazaki R, Nishimura I, Yoshikawa K. Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons. Exp Cell Res. 2002;277:220-32 pubmed
    b>Necdin is expressed predominantly in postmitotic neurons and serves as a growth suppressor that is functionally similar to the retinoblastoma tumor suppressor protein...
  4. Hayashi Y, Matsuyama K, Takagi K, Sugiura H, Yoshikawa K. Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons. Biochem Biophys Res Commun. 1995;213:317-24 pubmed
    b>Necdin is a 325 amino acid residue protein localized to the nuclei of postmitotic neurons, which withdraw permanently from the cell cycle...
  5. Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, et al. Necdin protects embryonic motoneurons from programmed cell death. PLoS ONE. 2011;6:e23764 pubmed publisher
    b>NECDIN belongs to the type II Melanoma Associated Antigen Gene Expression gene family and is located in the Prader-Willi Syndrome (PWS) critical region. Necdin-deficient mice develop symptoms of PWS, including a sensory and motor deficit...
  6. Pagliardini S, Ren J, Wevrick R, Greer J. Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol. 2005;167:175-91 pubmed
    b>Necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome (PWS)...
  7. Lee S, Walker C, Karten B, Kuny S, Tennese A, O Neill M, et al. Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Hum Mol Genet. 2005;14:627-37 pubmed
    b>Necdin and Magel2 are related proteins inactivated in Prader-Willi syndrome (PWS), a sporadic chromosomal deletion disorder...
  8. Lee S, Walker C, Wevrick R. Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain. Gene Expr Patterns. 2003;3:599-609 pubmed
    ..Snrpn, Ipw and Ndn are widely expressed at high levels throughout the mouse brain, whereas Magel2, Mkrn3 and the snoRNA MBII-85 are ..
  9. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem. 2002;277:22541-6 pubmed
    ..RING finger proteins, Praja1 and Neurodap-1, were isolated by yeast two-hybrid screening using the C-terminal necdin homology domain of Dlxin-1 as bait...

More Information


  1. Boccaccio I, Glatt Deeley H, Watrin F, Roeckel N, Lalande M, Muscatelli F. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Hum Mol Genet. 1999;8:2497-505 pubmed
    ..These are located in the human 15q11-q13 and mouse 7C regions, in close proximity to NDN / Ndn...
  2. Watrin F, Le Meur E, Roeckel N, Ripoche M, Dandolo L, Muscatelli F. The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin gene. BMC Genet. 2005;6:1 pubmed
    ..nucleolar RNAs (snoRNAs) MBII-85 and MBII-52 to the expression pattern of the two evolutionary related retroposons Ndn and Magel2, in the developing mouse embryo...
  3. MacDonald H, Wevrick R. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet. 1997;6:1873-8 pubmed
    ..We report that the human necdin-encoding gene (NDN) is within the centromeric portion of the PWS deletion region, between the two imprinted genes ..
  4. Ren J, Lee S, Pagliardini S, Gerard M, Stewart C, Greer J, et al. Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J Neurosci. 2003;23:1569-73 pubmed
    b>necdin (Ndn) is one of a cluster of genes deleted in the neurodevelopmental disorder Prader-Willi syndrome...
  5. Kurita M, Kuwajima T, Nishimura I, Yoshikawa K. Necdin downregulates CDC2 expression to attenuate neuronal apoptosis. J Neurosci. 2006;26:12003-13 pubmed
    ..b>Necdin is a potent mitotic suppressor expressed predominantly in postmitotic neurons and interacts with E2F1 to suppress ..
  6. Chai J, Locke D, Ohta T, Greally J, Nicholls R. Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site. Mamm Genome. 2001;12:813-21 pubmed
    ..Bioinformatic analyses identified a BAC containing four genes, Mkrn3, Magel2, Ndn, Frat3, and the Atp5l-ps1 pseudogene, the latter two genes derived from recent L1-mediated retrotransposition...
  7. Andrieu D, Meziane H, Marly F, Angelats C, Fernandez P, Muscatelli F. Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56 pubmed
    The human NECDIN gene is involved in a neurodevelopmental disorder, Prader-Willi syndrome (PWS). Previously we reported a mouse Necdin knock-out model with similar defects to PWS patients...
  8. Kuwako K, Taniura H, Yoshikawa K. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004;279:1703-12 pubmed
    b>Necdin is a growth suppressor expressed predominantly in postmitotic neurons and implicated in their terminal differentiation. Necdin shows a moderate homology to the MAGE family proteins, the functional roles of which are largely unknown...
  9. Taniura H, Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J Biol Chem. 1998;273:720-8 pubmed
    b>Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly suppresses the proliferation of NIH3T3 cells...
  10. Pagliardini S, Rent J, Wevrick R, Greer J. Neurodevelopmental abnormalities in the brainstem of prenatal mice lacking the Prader-Willi syndrome gene Necdin. Adv Exp Med Biol. 2008;605:139-43 pubmed
  11. Minamide R, Fujiwara K, Hasegawa K, Yoshikawa K. Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex. PLoS ONE. 2014;9:e84460 pubmed publisher
    ..b>Necdin, a mammal-specific MAGE (melanoma antigen) family protein that possesses anti-mitotic and pro-survival activities, ..
  12. Asai T, Liu Y, Di Giandomenico S, Bae N, Ndiaye Lobry D, Deblasio A, et al. Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells. Blood. 2012;120:1601-12 pubmed publisher
    ..a critical role for p53 in regulating the quiescence of adult hematopoietic stem cells (HSCs) and identified necdin as a candidate p53 target gene...
  13. Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, et al. Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005;25:7090-9 pubmed
    b>Necdin is a multifunctional signaling protein that stabilizes terminal differentiation of postmitotic neurons...
  14. Sciorati C, Touvier T, Buono R, Pessina P, Francois S, Perrotta C, et al. Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting. J Cell Sci. 2009;122:1119-25 pubmed publisher
    ..We have recently identified necdin as a key player in fetal and postnatal physiological myogenesis and in muscle regeneration...
  15. Tcherpakov M, Bronfman F, Conticello S, Vaskovsky A, Levy Z, Niinobe M, et al. The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002;277:49101-4 pubmed
    ..Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ..
  16. Bush J, Wevrick R. Loss of Necdin impairs myosin activation and delays cell polarization. Genesis. 2010;48:540-53 pubmed publisher
    ..We demonstrate that loss of Necdin in murine and human fibroblasts impairs polarity initiation through a Cdc42-myosin-dependent pathway, thereby ..
  17. Fujiwara K, Hasegawa K, Ohkumo T, Miyoshi H, Tseng Y, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PLoS ONE. 2012;7:e30948 pubmed publisher
    ..b>Necdin, which is expressed predominantly in postmitotic neurons, is a pleiotropic protein that possesses anti-mitotic and ..
  18. Tseng Y, Butte A, Kokkotou E, Yechoor V, Taniguchi C, Kriauciunas K, et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005;7:601-11 pubmed
    ..b>Necdin is also markedly increased in Irs knockout cells that cannot differentiate, and knockdown of necdin restores brown ..
  19. Taniura H, Matsumoto K, Yoshikawa K. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem. 1999;274:16242-8 pubmed
    b>Necdin is expressed in virtually all postmitotic neurons, and ectopic expression of this protein suppresses cell proliferation...
  20. Kuwajima T, Nishimura I, Yoshikawa K. Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. J Neurosci. 2006;26:5383-92 pubmed
    b>Necdin, a member of the MAGE (melanoma antigen) protein family, is expressed predominantly in terminally differentiated neurons...
  21. Tsai T, Armstrong D, Beaudet A. Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome. Nat Genet. 1999;22:15-6 pubmed
  22. Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, et al. Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis. J Neurosci. 2012;32:5562-72 pubmed publisher
    ..b>Necdin, a pleiotropic protein required for neuronal development and survival, interacts with both Sirt1 and p53 to ..
  23. Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. Gene. 1998;213:65-72 pubmed
    b>Necdin is a growth suppressor expressed in virtually all postmitotic neurons in the brain. The human necdin gene, NDN, is maternally imprinted and deleted in the Prader-Willi syndrome, a neurobehavioral contiguous gene disorder...
  24. Andrieu D, Watrin F, Niinobe M, Yoshikawa K, Muscatelli F, Fernandez P. Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression. Gene Expr Patterns. 2003;3:761-5 pubmed
    The expression pattern of Necdin, a gene involved in the etiology of Prader-Willi syndrome and a member of the MAGE family of genes, is described during mouse nervous system development...
  25. Kuwajima T, Taniura H, Nishimura I, Yoshikawa K. Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. J Biol Chem. 2004;279:40484-93 pubmed
    b>Necdin is a potent growth suppressor that is expressed predominantly in postmitotic cells such as neurons and skeletal muscle cells...
  26. Schaller F, Watrin F, Sturny R, Massacrier A, Szepetowski P, Muscatelli F. A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene. Hum Mol Genet. 2010;19:4895-905 pubmed publisher
    ..We propose that OT supply might constitute a promising avenue for the treatment of feeding difficulties in PW neonates and potentially of other newborns with impaired feeding onset. ..
  27. Niinobe M, Koyama K, Yoshikawa K. Cellular and subcellular localization of necdin in fetal and adult mouse brain. Dev Neurosci. 2000;22:310-9 pubmed
    b>Necdin is a 325-amino-acid residue protein encoded by a cDNA clone isolated from neurally differentiated embryonal carcinoma cells. Ectopic expression of necdin induces growth arrest of proliferative cells...
  28. Kuo C, Uetsuki T, Kim C, Tanaka H, Li B, Taira E, et al. Determination of a necdin cis-acting element required for neuron specific expression by using zebra fish. Biochem Biophys Res Commun. 1995;211:438-46 pubmed
    To determine cis-acting elements required for neuron specific expression of a necdin gene, we tried to use zebra fish assay system in vivo instead of cell lines in vitro...
  29. Maruyama E. Biochemical characterization of mouse brain necdin. Biochem J. 1996;314 ( Pt 3):895-901 pubmed
    b>Necdin is a protein encoded by neural differentiation-specific mRNA derived from embryonal carcinoma cells (P19)...
  30. Miller N, Wevrick R, Mellon P. Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet. 2009;18:248-60 pubmed publisher
    ..The NDN gene, encoding the MAGE family protein, necdin, maps to the PWS chromosome region and is highly expressed in mature hypothalamic neurons...
  31. Muscatelli F, Abrous D, Massacrier A, Boccaccio I, Le Moal M, Cau P, et al. Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum Mol Genet. 2000;9:3101-10 pubmed
    ..Here, we provide a detailed investigation of a mouse model deficient for NECDIN: Linked to the mutation, a neonatal lethality of variable penetrance is observed...
  32. Deponti D, Francois S, Baesso S, Sciorati C, Innocenzi A, Broccoli V, et al. Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation. J Cell Biol. 2007;179:305-19 pubmed
    ..An important cell type involved in muscle regeneration is the satellite cell. Necdin is a protein expressed in satellite cell-derived myogenic precursors during perinatal growth...
  33. Moon H, Ahn M, Park J, Min K, Kwon Y, Kim K. Negative regulation of hypoxia inducible factor-1alpha by necdin. FEBS Lett. 2005;579:3797-801 pubmed
    ..screening system, we found that the oxygen dependent degradation (ODD) domain of HIF-1alpha interacts with necdin, a growth suppressor...
  34. Tennese A, Gee C, Wevrick R. Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons. Dev Dyn. 2008;237:1935-43 pubmed publisher
    ..b>Necdin, one of several proteins genetically inactivated in individuals with Prader-Willi syndrome, is important for the ..
  35. Kubota Y, Osawa M, Jakt L, Yoshikawa K, Nishikawa S. Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration. Blood. 2009;114:4383-92 pubmed publisher
    ..b>Necdin (Ndn) is an evolutionally conserved multifunctional protein that has been implicated in cell-cycle regulation of ..
  36. Francois S, D Orlando C, Fatone T, Touvier T, Pessina P, Meneveri R, et al. Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. PLoS ONE. 2012;7:e43335 pubmed publisher
    ..Survival of the satellite cells is a critical requirement for efficient muscle reconstitution. Necdin, a member of the MAGE proteins family, is expressed in satellite cell-derived myogenic precursors during perinatal ..
  37. Huang Z, Fujiwara K, Minamide R, Hasegawa K, Yoshikawa K. Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner. J Neurosci. 2013;33:10362-73 pubmed publisher
    ..b>Necdin, a MAGE (melanoma antigen) family protein, is expressed abundantly in postmitotic neurons and possesses potent ..
  38. Skryabin B, Gubar L, Seeger B, Pfeiffer J, Handel S, Robeck T, et al. Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007;3:e235 pubmed publisher
    ..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype. ..
  39. Brunelli S, Tagliafico E, De Angelis F, Tonlorenzi R, Baesso S, Ferrari S, et al. Msx2 and necdin combined activities are required for smooth muscle differentiation in mesoangioblast stem cells. Circ Res. 2004;94:1571-8 pubmed
    ..Two transcription factors, msx2 and necdin, are expressed at least 100 times more in SMCs than in stem cells, are coexpressed in all SMCs and tissues, are ..
  40. Watrin F, Roeckel N, Lacroix L, Mignon C, Mattei M, Disteche C, et al. The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region. Eur J Hum Genet. 1997;5:324-32 pubmed
    ..A new human gene encoding a putative protein with high homology to the mouse NECDIN protein has recently been characterized and mapped to chromosome 15q11-q12...
  41. Liu X, Wang Y, Zhang Y, Zhu W, Xu X, Niinobe M, et al. Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm. Mol Cell Neurosci. 2009;41:51-61 pubmed publisher
    ..We identified a new interaction between Nogo-66 and necdin. Mutagenesis analysis revealed that the central region of necdin was indispensable for the interaction of necdin ..
  42. Kobayashi M, Taniura H, Yoshikawa K. Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells. J Biol Chem. 2002;277:42128-35 pubmed
    b>Necdin is expressed predominantly in postmitotic neurons, and ectopic expression of this protein strongly suppresses cell growth...
  43. Uetsuki T, Takagi K, Sugiura H, Yoshikawa K. Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter. J Biol Chem. 1996;271:918-24 pubmed
    b>Necdin is a 325 amino acid residue protein encoded by a cDNA clone isolated from neurally differentiated embryonal carcinoma cells...
  44. Gerard M, Hernandez L, Wevrick R, Stewart C. Disruption of the mouse necdin gene results in early post-natal lethality. Nat Genet. 1999;23:199-202 pubmed
    ..5), IPW (ref. 6) and NDN (which encodes the DNA-binding protein necdin; refs 7,8,9,10)...
  45. Zanella S, Watrin F, Mebarek S, Marly F, Roussel M, Gire C, et al. Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome. J Neurosci. 2008;28:1745-55 pubmed publisher
    ..is a neurogenetic disease resulting from the absence of paternal expression of several imprinted genes, including NECDIN. Prader-Willi children and adults have severe breathing defects with irregular rhythm, frequent sleep apneas, and ..
  46. Kozlov S, Bogenpohl J, Howell M, Wevrick R, Panda S, Hogenesch J, et al. The imprinted gene Magel2 regulates normal circadian output. Nat Genet. 2007;39:1266-72 pubmed
  47. Hasegawa K, Yoshikawa K. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci. 2008;28:8772-84 pubmed publisher
    ..b>Necdin, a p53-interacting protein expressed predominantly in postmitotic neurons, is a melanoma antigen family protein ..
  48. Ma X, Fei E, Fu C, Ren H, Wang G. Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. 2011;16:1105-16 pubmed publisher
    ..In this study, we identified necdin as a binding partner of dysbindin-1 using a yeast two-hybrid screen...
  49. Resnick J, Nicholls R, Wevrick R. Recommendations for the investigation of animal models of Prader-Willi syndrome. Mamm Genome. 2013;24:165-78 pubmed publisher
    ..Here, we summarize the goals of the AMWG, describe current animal models of PWS, and make recommendations for strategies to maximize the utility of animal models and for the development and use of new animal models of PWS. ..
  50. Buettner V, Walker A, Singer Sam J. Novel paternally expressed intergenic transcripts at the mouse Prader-Willi/Angelman Syndrome locus. Mamm Genome. 2005;16:219-27 pubmed
    ..element (LINE)-rich region midway between the PW/AS imprinting center and the paternally expressed genes Ndn, Magel2, and Mkrn3, which are under imprinting center control...
  51. Thompson P, Norton K, Niri F, Dawe C, McDermid H. CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. J Mol Biol. 2012;415:793-806 pubmed publisher
    ..Taken together, our results demonstrate a novel role of CECR2-containing complexes in spermatogenesis and show that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis. ..
  52. Rieusset A, Schaller F, Unmehopa U, Matarazzo V, Watrin F, Linke M, et al. Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences. PLoS Genet. 2013;9:e1003752 pubmed publisher
    ..Prader-Willi Syndrome (PWS) is a neurodevelopmental disease involving imprinted genes, including NDN, which are only expressed from the paternally inherited allele, with the maternally inherited allele silent...
  53. Ju H, Lee S, Kang S, Kim S, Ghil S. The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin. Cell Commun Signal. 2014;12:39 pubmed publisher
    ..A neurally differentiated embryonal carcinoma-derived protein (Necdin) was isolated as an interacting partner for G?o from a mouse brain cDNA library using yeast two-hybrid screening...
  54. Nakagaki A, Osanai H, Kishino T. Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014;553:63-8 pubmed publisher
    ..The imprinted domain contains paternally expressed genes, Snurf/Snrpn, Ndn, Magel2, Mkrn3, and Frat3, C/D-box small nucleolar RNAs (snoRNAs), and the maternally expressed gene, Ube3a...
  55. Gabory A, Ripoche M, Le Digarcher A, Watrin F, Ziyyat A, Forné T, et al. H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Development. 2009;136:3413-21 pubmed publisher
    ..Our results also bring further experimental evidence for the existence of the IGN and open new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies. ..
  56. McBurney M, Yang X, Jardine K, Hixon M, Boekelheide K, Webb J, et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003;23:38-54 pubmed
    ..The phenotype of the sir2alpha null animals suggests that the SIR2alpha protein is essential for normal embryogenesis and for normal reproduction in both sexes. ..
  57. de los Santos T, Schweizer J, Rees C, Francke U. Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain. Am J Hum Genet. 2000;67:1067-82 pubmed
    ..On a multispecies Southern blot, hybridization to an HMCR probe encoding the putative snoRNA is limited to mammals. ..
  58. Zanella S, Barthelemy M, Muscatelli F, Hilaire G. Necdin gene, respiratory disturbances and Prader-Willi syndrome. Adv Exp Med Biol. 2008;605:159-64 pubmed
    ..As PWS results from the absence of paternal expression of several imprinted genes among which NECDIN (Ndn), we examined whether Ndn deficiency in mice induced breathing and 5HT deficits...