Gene Symbol: Ncor2
Description: nuclear receptor co-repressor 2
Alias: N-CoR, SMRT, SMRTe, nuclear receptor corepressor 2, N-CoR2, T3 receptor-associating factor, TRAC, silencing mediator of retinoic acid and thyroid hormone receptor, silencing mediator of retinoid acid and thyroid hormone receptor, thyroid-, retinoic-acid-receptor-associated corepressor
Species: mouse
Products:     Ncor2

Top Publications

  1. Nofsinger R, Li P, Hong S, Jonker J, Barish G, Ying H, et al. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008;105:20021-6 pubmed publisher
    The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent transcriptional repression...
  2. Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, et al. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007;27:1280-95 pubmed
    ..Furthermore, the nuclear receptor corepressor SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) stimulated the deacetylase activity of HDAC3 towards MEF2 and PCAF...
  3. Jepsen K, Hermanson O, Onami T, Gleiberman A, Lunyak V, McEvilly R, et al. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000;102:753-63 pubmed diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting ..
  4. Short S, Malartre M, Sharpe C. SMRT has tissue-specific isoform profiles that include a form containing one CoRNR box. Biochem Biophys Res Commun. 2005;334:845-52 pubmed
    b>SMRT acts as a corepressor for a range of transcription factors...
  5. Goodson M, Jonas B, Privalsky M. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem. 2005;280:7493-503 pubmed
    ..The SMRT corepressor interacts directly with nuclear receptors and serves, in turn, as a platform for the assembly of a ..
  6. Li X, McDonnell D. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002;22:3663-73 pubmed we used biochemical and cell-based assays to demonstrate that the nuclear receptor corepressors N-CoR and SMRT interact with B-Myb...
  7. Ordentlich P, Downes M, Xie W, Genin A, Spinner N, Evans R. Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A. 1999;96:2639-44 pubmed recruited to nuclear receptors through the highly related corepressors SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor)...
  8. Guenther M, Barak O, Lazar M. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol. 2001;21:6091-101 pubmed
    ..In vivo, HDAC3 forms a stable complex with the SMRT corepressor...
  9. Ki S, Cho I, Choi D, Kim S. Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol. 2005;25:4150-65 pubmed
    ..and GST pull-down assays revealed that silencing mediator for retinoid and thyroid hormone receptors (SMRT), a corepressor recruited to steroid-GR complex for histone deacetylation, bound to TAD domain of C/EBPbeta and ..

More Information


  1. Sutanto M, Ferguson K, Sakuma H, Ye H, Brady M, Cohen R. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010;285:18485-95 pubmed publisher
    The silencing mediator of retinoid and thyroid hormone receptors (SMRT) serves as a corepressor for nuclear receptors and other factors...
  2. Klappacher G, Lunyak V, Sykes D, Sawka Verhelle D, Sage J, Brard G, et al. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002;109:169-80 pubmed
  3. He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab. 2011;300:E877-85 pubmed publisher
    ..response element in the VEGF gene promoter, and its function is inhibited by a corepressor composed of HDAC3 and SMRT. These observations suggest that of the three obesity-associated factors, all of them are able to augment HIF-1? ..
  4. Rubin W, LaMantia A. Age-dependent retinoic acid regulation of gene expression distinguishes the cervical, thoracic, lumbar, and sacral spinal cord regions during development. Dev Neurosci. 1999;21:113-25 pubmed
    ..and is not accompanied by changes in expression patterns of several retinoid receptors, binding proteins, or the SMRT nuclear corepressor...
  5. Sun Z, Feng D, Fang B, Mullican S, You S, Lim H, et al. Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013;52:769-82 pubmed publisher
    ..Mutations abolishing interactions with the nuclear receptor corepressor (NCOR or SMRT) render HDAC3 nonfunctional in vivo...
  6. Yang X, Li J, Qin H, Yang H, Li J, Zhou P, et al. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. J Biol Chem. 2005;280:18710-6 pubmed
    ..The present study shows that MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development. ..
  7. Jennewein C, Kuhn A, Schmidt M, Meilladec Jullig V, von Knethen A, Gonzalez F, et al. Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol. 2008;181:5646-52 pubmed
    ..This contributes to an antiinflammatory phenotype shift in macrophages responding to AC by lowering proinflammatory cytokine production. ..
  8. Shimizu H, Astapova I, Ye F, Bilban M, Cohen R, Hollenberg A. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015;35:555-65 pubmed publisher
    NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors; NCoR2) are well-recognized coregulators of nuclear receptor (NR) action...
  9. Pei L, Leblanc M, BARISH G, Atkins A, Nofsinger R, Whyte J, et al. Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011;17:1466-72 pubmed publisher
    ..Here we show that knock-in mutations of the nuclear co-repressor SMRT (silencing mediator of retinoid and thyroid hormone receptors) in C57BL/6 mice (SMRTmRID) produces a previously ..
  10. Hua G, Paulen L, Chambon P. GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression. Proc Natl Acad Sci U S A. 2016;113:E626-34 pubmed publisher the human GR N-terminal domain allows the formation of a GR-small ubiquitin-related modifiers (SUMOs)-NCoR1/SMRT-HDAC3 repressing complex mandatory for GC-induced IR nGRE-mediated direct repression in vitro, but does not affect ..
  11. Kao H, Downes M, Ordentlich P, Evans R. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000;14:55-66 pubmed
    The transcriptional corepressor SMRT functions by mediating the repressive effect of transcription factors involved in diverse signaling pathways...
  12. Jepsen K, Gleiberman A, Shi C, Simon D, Rosenfeld M. Cooperative regulation in development by SMRT and FOXP1. Genes Dev. 2008;22:740-5 pubmed publisher
    ..While the role of NCoR/SMRT corepressors in nuclear receptor actions is well documented, we here report that a previously unrecognized ..
  13. Kim M, Jeong B, Lee J, Kee H, Kook H, Kim N, et al. A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A. 2006;103:13074-9 pubmed
    ..Here, we report that the transcription factor AP4 and the corepressor geminin form a functional complex in which SMRT and histone deacetylase 3 are recruited...
  14. Guan H, Ishizuka T, Chui P, Lehrke M, Lazar M. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 2005;19:453-61 pubmed
    ..Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms. ..
  15. Narayanan R, Jiang J, Gusev Y, Jones A, Kearbey J, Miller D, et al. MicroRNAs are mediators of androgen action in prostate and muscle. PLoS ONE. 2010;5:e13637 pubmed publisher
    ..knock-down of DICER in LNCaP cells and in tissues in mice induced the expression of corepressors, NCoR and SMRT. These studies demonstrate a feedback loop between miRs, corepressors and AR and the imperative role of miRs in AR ..
  16. Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, et al. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell. 2016;36:316-30 pubmed publisher
  17. Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, et al. Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci. Genome Res. 2003;13:1654-64 pubmed
    ..and found significant mRNA expression differences for 12 (Nr1i3, Apoa2, Sap, Tgfb2, Fgfbp1, Prom, Ppargc1, Tcf1, Ncor2, Srb1, App, and Ifnar)...
  18. Sutanto M, Symons M, Cohen R. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2006;259:43-9 pubmed
    The silencing mediator of retinoid and thyroid hormone receptors (SMRT) has been shown to play an important role in adipogenesis and PPARgamma transcriptional activity...
  19. Martinez de Arrieta C, Koibuchi N, Chin W. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Endocrinology. 2000;141:1693-8 pubmed
    ..rat complementary DNA fragments corresponding to coactivators (SRC1, TIF2 and TRAM1) and corepressors (N-CoR and SMRT), and studied the ontogenic changes in their corresponding messenger RNAs in rat cerebellum of normal and ..
  20. Costa Y, Ding J, Theunissen T, Faiola F, Hore T, Shliaha P, et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013;495:370-4 pubmed publisher
    ..These results provide an insight into the reprogramming mechanism of NANOG and uncover a new role for 5-methylcytosine hydroxylases in the establishment of naive pluripotency. ..
  21. Williams J, Kondo N, Okabe T, Takeshita N, Pilchak D, Koyama E, et al. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009;328:315-27 pubmed publisher
    ..Since aggrecan is critical for growth plate function, its deficiency in RAR-mutant mice is likely to have contributed directly to their growth retardation. ..
  22. Raghav S, Waszak S, Krier I, Gubelmann C, Isakova A, Mikkelsen T, et al. Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBP? and KAISO. Mol Cell. 2012;46:335-50 pubmed publisher
    ..Here, we studied the transcriptional function of the corepressor SMRT during terminal adipogenesis...
  23. Hong S, Dvorak Ewell M, Stevens H, Barish G, Castro G, Nofsinger R, et al. Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. Proc Natl Acad Sci U S A. 2013;110:18820-5 pubmed publisher
    ..interaction domains of the epigenetic repressor silencing mediator of retinoid and thyroid hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bone growth, increased numbers of bone-..
  24. Emont M, Mantis S, Kahn J, Landeche M, Han X, Sargis R, et al. Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015;407:52-6 pubmed publisher
    ..Here we show that the silencing mediator of retinoid and thyroid hormone receptors (SMRT) is recruited to GR in adipocytes and regulates ligand-dependent GR function...
  25. You S, Lim H, Sun Z, Broache M, Won K, Lazar M. Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol. 2013;20:182-7 pubmed publisher
    ..with the conserved deacetylase-activating domain (DAD) contained in nuclear receptor co-repressors NCOR1 and SMRT. Here we show that HDAC3 enzyme activity is undetectable in mice bearing point mutations in the DAD of both NCOR1 ..
  26. Huang W, Ghisletti S, Perissi V, Rosenfeld M, Glass C. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009;35:48-57 pubmed publisher
    ..These findings reveal mechanisms for integration of TLR, calcium, and nuclear receptor signaling pathways that underlie pathogen-specific responses and disease-specific programs of inflammation. ..
  27. Jacobs F, van Erp S, van der Linden A, von Oerthel L, Burbach J, Smidt M. Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009;136:531-40 pubmed publisher
    ..In the absence of Pitx3, Nurr1 is kept in a repressed state through interaction with the co-repressor SMRT. Highly resembling the effect of ligand activation of nuclear receptors, recruitment of Pitx3 modulates the Nurr1 ..
  28. Hellsten K, Linden A, Korpi E. Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) α6 subunit. Neuroscience. 2015;293:123-35 pubmed publisher
    ..Our results suggest that the widespread neuronal inhibition as typically associated with benzodiazepines is not the exclusive mechanism of anxiolysis. ..
  29. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld M, et al. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009;23:681-93 pubmed publisher
    ..Here, we report that, while the nuclear receptor corepressor (NCoR) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressors establish repression checkpoints on broad sets of inflammatory ..
  30. Ishizuka T, Lazar M. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol Endocrinol. 2005;19:1443-51 pubmed
    ..Introduction of a single amino acid mutation in the DAD similarly disabled the corepressor function of N-CoR. Thus, the DAD domain of N-CoR is singularly essential for repression by TR. ..
  31. Yan M, Burel S, Peterson L, Kanbe E, Iwasaki H, Boyapati A, et al. Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Proc Natl Acad Sci U S A. 2004;101:17186-91 pubmed
    ..Here, we report that the loss of the molecular events of AML1-ETO C-terminal NCoR/SMRT-interacting domain transforms AML1-ETO into a potent leukemogenic protein...
  32. Cui W, Sun M, Zhang S, Shen X, Galeva N, Williams T, et al. A SUMO-acetyl switch in PXR biology. Biochim Biophys Acta. 2016;1859:1170-1182 pubmed publisher
    ..with the lysine de-acetylating enzyme histone de-acetylase (HDAC)3 in a complex with silencing mediator of retinoic acid and thyroid hormone receptor (SMRT)...
  33. Jiang Y, Ortega Molina A, Geng H, Ying H, Hatzi K, Parsa S, et al. CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Cancer Discov. 2017;7:38-53 pubmed publisher
    ..CREBBP-regulated enhancers are counter-regulated by the BCL6 transcriptional repressor in a complex with SMRT and HDAC3, which we found to bind extensively to MHC class II loci...
  34. Barish G, Yu R, Karunasiri M, Becerra D, Kim J, Tseng T, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012;15:554-62 pubmed publisher
    ..Disruption of the interaction between Bcl6 and SMRT or NCoR with a peptide inhibitor in vitro recapitulated atherogenic gene changes in mice transplanted with Bcl6-..
  35. Poleshko A, Shah P, Gupta M, Babu A, Morley M, Manderfield L, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017;171:573-587.e14 pubmed publisher
  36. Fuhrmann G, Chung A, Jackson K, Hummelke G, Baniahmad A, Sutter J, et al. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell. 2001;1:377-87 pubmed
    ..Our studies suggest that GCNF is critical in repressing Oct4 gene activity as pluripotent stem cells differentiate and in confining Oct4 expression to the germline. ..
  37. Hartman H, Yu J, Alenghat T, Ishizuka T, Lazar M. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep. 2005;6:445-51 pubmed
    ..As expected, repression is characterized by recruitment of N-CoR/SMRT-HDAC3 (histone deacetylase 3) co-repressor complexes, leading to local histone hypoacetylation...
  38. Kumar S, Cunningham T, Duester G. Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev Biol. 2016;418:204-215 pubmed publisher
    ..Here, we show that nuclear receptor corepressors NCOR1 and NCOR2 (SMRT) redundantly mediate the ability of RA to repress Fgf8...
  39. Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson J, Fletterick R, et al. TR surfaces and conformations required to bind nuclear receptor corepressor. Mol Endocrinol. 2002;16:271-86 pubmed
  40. Ueda A, Matsui K, Yamamoto Y, Pedersen L, Sueyoshi T, Negishi M. Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. Biochem J. 2005;388:623-30 pubmed
    ..Thr176, Thr248 and Ser230 are conserved residues in the NR1I (nuclear receptor 1I) subfamily members and determine their activity. ..
  41. Picard F, Kurtev M, Chung N, Topark Ngarm A, Senawong T, Machado De Oliveira R, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004;429:771-6 pubmed
    ..Sirt1 represses PPAR-gamma by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors)...
  42. Snyder C, Goodson M, Schroeder A, Privalsky M. Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling. Mol Cell Endocrinol. 2015;413:228-35 pubmed publisher
    Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci...
  43. Wu J, Bao J, Wang L, Hu Y, Xu C. MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis. BMC Dev Biol. 2011;11:64 pubmed publisher
    ..Moreover, miR-184 downregulated nuclear receptor corepressor 2 (Ncor2) by targeting its 3' untranslated region through inhibiting NCOR2 protein translation...
  44. Huang J, Bi Y, Zhu G, He Y, Su Y, He B, et al. Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009;29:1569-81 pubmed publisher
    ..RA was further shown to induce glycogen synthesis in HP14.5 cells, an important function of mature hepatocytes. Our results strongly suggest that RA signalling may play an important role in regulating hepatic differentiation. ..
  45. Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen R, et al. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016;15:651-665 pubmed publisher
    ..Thus, our findings uncover yet another layer of complexity of TEC lineage divergence and highlight Hdac3 as a major and specific molecular switch crucial for mTEC differentiation. ..
  46. Krogsdam A, Nielsen C, Neve S, Holst D, Helledie T, Thomsen B, et al. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002;363:157-65 pubmed
    ..transfection experiments, NCoR and the related silencing mediator for retinoid and thyroid hormone receptor (SMRT) were shown to exert a marked dose-dependent repression of ligand-induced PPAR delta-mediated transactivation; in ..
  47. Park E, Schroen D, Yang M, Li H, Li L, Chen J. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci U S A. 1999;96:3519-24 pubmed
    ..Here, we report the identification of SMRT-extended (SMRTe), which contains an N-terminal sequence that shows striking similarity with N-CoR...
  48. Potter G, Beaudoin G, DeRenzo C, Zarach J, Chen S, Thompson C. The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 2001;15:2687-701 pubmed
    ..cluster of hydrophobic residues similar to the binding motifs proposed for nuclear receptor corepressors (N-CoR and SMRT). Similarly, we show that Hr binds to the same region of TR as known corepressors...
  49. Peterson T, Karmakar S, Pace M, Gao T, Smith C. The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Mol Cell Biol. 2007;27:5933-48 pubmed
    ..Current models suggest that the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor functions within a histone deactylase-containing protein complex ..
  50. Fang S, Suh J, Atkins A, Hong S, Leblanc M, Nofsinger R, et al. Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108:3412-7 pubmed publisher
    ..Here we report the mouse model termed silencing mediator of retinoid and thyroid hormone receptors (SMRT)(mRID1) in which targeted disruption of the first receptor interaction domain (RID) of the nuclear corepressor SMRT ..
  51. Hua G, Ganti K, Chambon P. Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex. Proc Natl Acad Sci U S A. 2016;113:E635-43 pubmed publisher
    ..of this GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 repressing complex, which is indispensable for NF-κB/AP1-mediated GC-induced tethered indirect ..
  52. Faist F, Short S, Kneale G, Sharpe C. Alternative splicing determines the interaction of SMRT isoforms with nuclear receptor-DNA complexes. Biosci Rep. 2009;29:143-9 pubmed publisher
    ..act as ligand-dependent transcription factors, but, in the absence of signal, the receptors bind the co-repressors SMRT [silencing mediator for RAR (retinoic acid receptor) and TR (thyroid hormone receptor)] and NCoR (nuclear receptor ..
  53. Lyst M, Ekiert R, Ebert D, Merusi C, Nowak J, Selfridge J, et al. Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci. 2013;16:898-902 pubmed publisher
    ..We found that RTT mutations in this region abolished the interaction between MeCP2 and the NCoR/SMRT co-repressor complexes...
  54. Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, et al. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A. 2009;106:5819-24 pubmed publisher
    ..approaches, we show that Wnt/beta-catenin signaling activates the expression of COUP-TFII which recruits the SMRT corepressor complex to the first introns located downstream from the first exons of both PPARgamma1 and gamma2 ..
  55. Reilly S, Bhargava P, Liu S, Gangl M, Gorgun C, Nofsinger R, et al. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010;12:643-53 pubmed publisher
    The transcriptional corepressor SMRT utilizes two major receptor-interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification...