Ncoa3

Summary

Gene Symbol: Ncoa3
Description: nuclear receptor coactivator 3
Alias: 2010305B15Rik, AW321064, Actr, Aib1, KAT13B, Rac3, Src3, Tram-1, Tram1, bHLHe42, p/Cip, pCip, nuclear receptor coactivator 3, AIB-1, CBP-interacting protein, NCoA-3, RAC-3, SRC-3, amplified in breast cancer-1 protein homolog, receptor-associated coactivator 3, steroid receptor coactivator protein 3, thyroid hormone receptor activator molecule 1
Species: mouse
Products:     Ncoa3

Top Publications

  1. Chung A, Zhou S, Liao L, Tien J, Greenberg N, Xu J. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007;67:5965-75 pubmed
    Although the amplified-in-breast cancer 1 (AIB1; SRC-3, ACTR, or NCoA3) was defined as a coactivator for androgen receptor (AR) by in vitro studies, its role in AR-mediated prostate development and prostate cancer remained unexplored...
  2. Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy J, et al. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 2006;3:111-22 pubmed
    ..They exhibit increased basal metabolic rates and heightened levels of physical activity. Therefore, p/CIP and SRC-1 play critical roles in energy balance by controlling both energy intake and energy expenditure. ..
  3. Coste A, Louet J, Lagouge M, Lerin C, Antal M, Meziane H, et al. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A. 2008;105:17187-92 pubmed publisher
    ..Collectively, these data suggest that SRC-3 is a critical link in a cofactor network that uses PGC-1alpha as an effector to control mitochondrial function and energy homeostasis. ..
  4. Yan J, Yu C, Ozen M, Ittmann M, Tsai S, Tsai M. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway. Cancer Res. 2006;66:11039-46 pubmed
    ..Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells. ..
  5. Louet J, Coste A, Amazit L, Tannour Louet M, Wu R, Tsai S, et al. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A. 2006;103:17868-73 pubmed
    ..Collectively, these data suggest a crucial role for SRC-3 as an integrator of the complex transcriptional network controlling adipogenesis. ..
  6. Kuang S, Liao L, Wang S, Medina D, O Malley B, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005;65:7993-8002 pubmed
    Amplified in breast cancer 1 (AIB1; steroid receptor coactivator-3, p/CIP, RAC3, ACTR, TRAM-1, or NCoA-3) is a transcriptional coactivator for nuclear receptors and certain other transcription factors and is a newly defined oncogene ..
  7. York B, Yu C, Sagen J, Liu Z, Nikolai B, Wu R, et al. Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proc Natl Acad Sci U S A. 2010;107:11122-7 pubmed publisher
    ..Consequently, these mice displayed increased liver tumorigenesis, which likely results from elevated IGF1 signaling. ..
  8. Torchia J, Rose D, Inostroza J, Kamei Y, Westin S, Glass C, et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997;387:677-84 pubmed
  9. Wang Z, Rose D, Hermanson O, Liu F, Herman T, Wu W, et al. Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A. 2000;97:13549-54 pubmed
    ..One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-..

More Information

Publications79

  1. Torres Arzayus M, Font de Mora J, Yuan J, Vazquez F, Bronson R, Rue M, et al. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 2004;6:263-74 pubmed
    The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers...
  2. Liao L, Chen X, Wang S, Parlow A, Xu J. Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol. 2008;28:2460-9 pubmed publisher
    Steroid receptor coactivator 3 (SRC-3/AIB1/ACTR/NCoA-3) is a transcriptional coactivator for nuclear receptors including vitamin D receptor (VDR)...
  3. Ying H, Willingham M, Cheng S. The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer. Oncogene. 2008;27:823-30 pubmed
    ..Taken together, SRC-3 could play important roles through regulating multiple target genes and signaling pathways during thyroid carcinogenesis, understanding of which should direct future therapeutic options for thyroid cancer. ..
  4. Yu C, York B, Wang S, Feng Q, Xu J, O Malley B. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell. 2007;25:765-78 pubmed
    ..Collectively, our studies reveal an essential function of SRC-3 as a coordinator of inflammatory mRNA translation and as a physiologic protective factor against the lethal endotoxic shock triggered by an acute inflammatory response. ..
  5. Yi P, Xia W, Wu R, Lonard D, Hung M, O Malley B. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013;27:274-87 pubmed publisher
    ..Because of SRC-3's ability to abrogate p53 function, our results suggest that SRC-3 overexpression may be especially important in tumors in which p53 is not mutated. ..
  6. Liu Z, Liao L, Zhou S, Xu J. Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci. 2008;4:202-7 pubmed
    The steroid receptor coactivator-3 (SRC-3), also known as AIB1, ACTR, p/CIP and NCOA3, is a transcriptional coactivator for nuclear receptors and certain other transcription factors...
  7. Xu J, Liao L, Ning G, Yoshida Komiya H, Deng C, O Malley B. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000;97:6379-84 pubmed
    ..These results suggest that the physiological role of SRC-3 is different from that of SRC-1 and prove the diversity among coactivator family members. ..
  8. Kuang S, Liao L, Zhang H, Lee A, O Malley B, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004;64:1875-85 pubmed
    Although the amplified in breast cancer 1 (AIB1) coactivator is amplified and overexpressed in breast cancers, its role in mammary carcinogenesis remains unknown...
  9. Torres Arzayus M, Zhao J, Bronson R, Brown M. Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation. Cancer Res. 2010;70:4102-11 pubmed publisher
    We have previously reported the oncogenic properties of the gene amplified in breast cancer 1 (AIB1), a member of the p160 family of hormone receptor coactivators...
  10. Fereshteh M, Tilli M, Kim S, Xu J, O Malley B, Wellstein A, et al. The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res. 2008;68:3697-706 pubmed publisher
    Overexpression of the oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary tumorigenesis in mice...
  11. Liao L, Kuang S, Yuan Y, Gonzalez S, O Malley B, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002;83:3-14 pubmed
    ..The steroid receptor coactivator-3 (SRC-3), also known as p/CIP, RAC3, AIB1, ACTR and TRAM-1, is a cancer-amplified coactivator in the SRC gene family that also contains SRC-1 and TIF2/GRIP1...
  12. Ning G, Jurecic V, Baldini A, Xu J. Structure and chromosomal locations of mouse steroid receptor coactivator gene family. In Vitro Cell Dev Biol Anim. 1999;35:481-6 pubmed
    ..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions. ..
  13. Jin J, Wang Y, Wang J, Xu Y, Chen S, Wang J, et al. Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC?3 knockout mice. Mol Med Rep. 2014;9:1629-33 pubmed publisher
    ..In conclusion, the present study demonstrated that the hematopoietic ability in SRC-3 knockout mice is severely impaired following a sublethal dose of irradiation. ..
  14. Chien C, Kirilyuk A, Li J, Zhang W, Lahusen T, Schmidt M, et al. Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription. J Biol Chem. 2011;286:26813-27 pubmed publisher
    The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers...
  15. Qin L, Liu Z, Chen H, Xu J. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 2009;69:3819-27 pubmed publisher
    ..Therefore, SRC-1 promotes breast cancer invasiveness and metastasis by coactivating PEA3-mediated Twist expression. Intervention of SRC-1 function may provide new strategies to inhibit breast cancer metastasis. ..
  16. Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, et al. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia. 2010;58:932-42 pubmed publisher
    ..Our results build up a link between lipid metabolic regulation and immune functions, and the modulation of the expression of SRC-3 or PPAR-beta may hopefully has therapeutic modality in MS and possibly other neurodegenerative diseases. ..
  17. Coste A, Antal M, Chan S, Kastner P, Mark M, O Malley B, et al. Absence of the steroid receptor coactivator-3 induces B-cell lymphoma. EMBO J. 2006;25:2453-64 pubmed
    Steroid receptor coactivator 3 (SRC-3/ACTR/AIB-1/pCIP/RAC3/TRAM-1) is a member of the p160 family of nuclear receptor coactivators that plays an important role in mammary gland growth, development, and tumorigenesis...
  18. O Brien T, Liu J, Sylvester J, Mougey E, Fischel Ghodsian N, Thiede B, et al. Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences. J Biol Chem. 2000;275:18153-9 pubmed
    ..In one case, the corresponding human genomic DNA sequences were found in the data bases, and the exon/intron structure was determined. ..
  19. Lee Y, Moore D. Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem. 2002;277:2463-7 pubmed
    ..We conclude that the proposed central role of SHP in cholesterol metabolism is based on a two-step mechanism that is dependent on both coactivator competition and direct transcriptional repression. ..
  20. Chen X, Qin L, Liu Z, Liao L, Martin J, Xu J. Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype. Int J Biol Sci. 2015;11:1056-72 pubmed publisher
    ..In conclusion, SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC-like abnormalities in the hearts of newborn and adult mice. ..
  21. Ito M, Yuan C, Okano H, Darnell R, Roeder R. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell. 2000;5:683-93 pubmed
    ..These results indicate that TRAP220 is essential for a wide range of physiological processes but also that it has gene- and activator-selective functions. ..
  22. Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, et al. Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem. 2012;287:38295-304 pubmed publisher
    ..Here, we demonstrated that the nuclear receptor coactivator 3 (Ncoa3) is essential for pluripotency maintenance...
  23. Avivar A, García Macías M, Ascaso E, Herrera G, O Connor J, Font de Mora J. Moderate overexpression of AIB1 triggers pre-neoplastic changes in mammary epithelium. FEBS Lett. 2006;580:5222-6 pubmed
    ..new model of pre-clinical breast cancer which has been generated by overexpressing the steroid receptor coactivator AIB1 at moderate levels in breast epithelium...
  24. Wang Z, Shah O, Hunter T. The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. PLoS ONE. 2012;7:e36961 pubmed publisher
    ..Therefore, our studies indicate that p/CIP and SRC-1 are potential therapeutic targets not only for obesity but also for diabetes. ..
  25. Chitilian J, Thillainadesan G, Manias J, Chang W, Walker E, Isovic M, et al. Critical components of the pluripotency network are targets for the p300/CBP interacting protein (p/CIP) in embryonic stem cells. Stem Cells. 2014;32:204-15 pubmed publisher
    p/CIP, also known as steroid receptor coactivator 3 (SRC-3)/Nuclear Receptor Coactivator 3 (NCoA3), is a transcriptional coactivator that binds liganded nuclear hormone receptors, as well as other transcription factors, and facilitates ..
  26. Ying H, Furuya F, Willingham M, Xu J, O Malley B, Cheng S. Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone. Mol Cell Biol. 2005;25:7687-95 pubmed
    ..Thus, SRC-3 modulates RTH by at least two mechanisms, one via its role as a receptor coregulator and the other via its growth regulatory role through the IGF-1/PI3K/AKT/mTOR signaling. ..
  27. An B, Selva D, Hammond G, Rivero Muller A, Rahman N, Leung P. Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells. J Biol Chem. 2006;281:20817-24 pubmed
    ..Collectively, these data indicate that PR activation by GnRHs in alphaT3-1 cells is type I GnRH receptor-mediated and that trans-activation of PR-responsive genes requires SRC-3 in this context. ..
  28. Børud B, Hoang T, Bakke M, Jacob A, Lund J, Mellgren G. The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1. Mol Endocrinol. 2002;16:757-73 pubmed
    ..Thus, in contrast to the regulation of p/CIP and steroid receptor coactivator 1, we suggest that activation of PKA leads to selective down-regulation of TIF2 and subsequently repression of TIF2 coactivator function. ..
  29. Ma X, Xu L, Wang S, Chen H, Xu J, Li X, et al. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Lab Invest. 2009;89:903-14 pubmed publisher
    ..Our results established an essential involvement of SRC-3 in liver fibrogenesis, which might provide new clues to the future treatment of hepatic fibrosis. ..
  30. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, et al. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008;28:5937-50 pubmed publisher
    Amplified-in-breast cancer 1 (AIB1) is an overexpressed transcriptional coactivator in breast cancer. Although overproduced AIB1 is oncogenic, its role and underlying mechanisms in metastasis remain unclear...
  31. Al Otaiby M, Tassi E, Schmidt M, Chien C, Baker T, Salas A, et al. Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing. Am J Pathol. 2012;180:1474-84 pubmed publisher
    The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC-3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells...
  32. York B, Reineke E, Sagen J, Nikolai B, Zhou S, Louet J, et al. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012;15:752-63 pubmed publisher
    ..Moreover, these findings allow us to consider platform coactivators such as the SRCs as potential contributors to syndromes such as CACT deficiency, previously considered as monogenic. ..
  33. Xu J, Qiu Y, DeMayo F, Tsai S, Tsai M, O Malley B. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998;279:1922-5 pubmed
    ..The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone. ..
  34. Torres Arzayus M, Yuan J, DellaGatta J, Lane H, Kung A, Brown M. Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. Cancer Res. 2006;66:11381-8 pubmed
    Amplified in breast cancer 1 (AIB1), an estrogen receptor (ER) coactivator, is frequently amplified or overexpressed in human breast cancer...
  35. Han S, DeMayo F, Xu J, Tsai S, Tsai M, O Malley B. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 2006;20:45-55 pubmed
    ..SRC-3 is the primary coactivator for PR in breast and SRC-1 is the primary coactivator for PR in uterus. ..
  36. Nishihara E, Yoshida Komiya H, Chan C, Liao L, Davis R, O Malley B, et al. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci. 2003;23:213-22 pubmed
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood. ..
  37. Jeong J, Kwak I, Lee K, White L, Wang X, Brunicardi F, et al. The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism. Mol Endocrinol. 2006;20:1138-52 pubmed
    ..SRC) family, which include SRC-1 (NcoA-1/p160), SRC-2(TIF2/GRIP1/NcoA-2) and SRC-3(pCIP/RAC3/ACTR/pCIP/ AIB1/TRAM1), are critical mediators of steroid receptor action...
  38. Chen X, Liu Z, Xu J. The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010;24:1917-34 pubmed publisher
    Nuclear receptor coactivator 1 [NCOA1/steroid receptor coactivator (SRC)-1] and NCOA3 (SRC-3/AIB1/ACTR) constitute two thirds of the SRC (steroid receptor coactivator) family...
  39. Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, et al. Steroid receptor coactivator 3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis. J Immunol. 2010;185:5444-52 pubmed publisher
  40. Xia J, Liao L, Sarkar J, Matsumoto K, Reddy J, Xu J, et al. Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members. Arch Biochem Biophys. 2007;468:49-57 pubmed
    ..SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment. ..
  41. Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B, et al. Regulation of transcription by a protein methyltransferase. Science. 1999;284:2174-7 pubmed
    ..Thus, coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation. ..
  42. Tien J, Liao L, Liu Y, Liu Z, Lee D, Wang F, et al. The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate. Int J Biol Sci. 2014;10:1116-27 pubmed publisher
    ..In summary, SRC-3 is required for both AR+/Syp- AH tumor growth and AR-/Syp+ NETC development, suggesting SRC-3 is a target for inhibiting aggressive prostate cancer containing NETCs. ..
  43. Tien J, Liu Z, Liao L, Wang F, Xu Y, Wu Y, et al. The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. Cancer Res. 2013;73:3997-4008 pubmed publisher
    ..Together, our results show that SRC-3 drives CRPC formation and offer preclinical proof of concept for a transcriptional coactivator as a therapeutic target to abrogate CRPC progression. ..
  44. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson B, et al. A transcriptional switch mediated by cofactor methylation. Science. 2001;294:2507-11 pubmed
    ..These results provide strong in vivo and in vitro evidence that histone methylation plays a key role in hormone-induced gene activation and define cofactor methylation as a new regulatory mechanism in hormone signaling. ..
  45. Wu H, Hamamori Y, Xu J, Chang S, Saluna T, Chang M, et al. Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD. J Biol Chem. 2005;280:3129-37 pubmed
    ..This suggests that competition by GRIP1 for SRC1A, p/CIP, and p300 binding sites on a transcription factor may regulate the activity of the factor. ..
  46. Gehin M, Mark M, Dennefeld C, Dierich A, Gronemeyer H, Chambon P. The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002;22:5923-37 pubmed
    ..Thus, even though the three p160 coactivators exhibit strong sequence homology and similar activity in assays in vitro, they play distinct physiological roles in vivo, as their genetic eliminations result in distinct pathologies. ..
  47. Grenier J, Trousson A, Chauchereau A, Amazit L, Lamirand A, Leclerc P, et al. Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells. Mol Endocrinol. 2004;18:2866-79 pubmed
    ..We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system. ..
  48. Nakles R, Shiffert M, Diaz Cruz E, Cabrera M, Alotaiby M, Miermont A, et al. Altered AIB1 or AIB1?3 expression impacts ER? effects on mammary gland stromal and epithelial content. Mol Endocrinol. 2011;25:549-63 pubmed publisher
    Amplified in breast cancer 1 (AIB1) (also known as steroid receptor coactivator-3) is a nuclear receptor coactivator enhancing estrogen receptor (ER)? and progesterone receptor (PR)-dependent transcription in breast cancer...
  49. Paramanik V, Thakur M. AIB1 shows variation in interaction with ER?TAD and expression as a function of age in mouse brain. Biogerontology. 2011;12:321-8 pubmed publisher
    ..interacting nuclear protein of estrogen receptor (ER)?-transactivation domain (TAD) as amplified in breast cancer 1(AIB1) by pull down assay, immunoblotting, far-western analysis and immunoprecipitation...
  50. Duteil D, Chambon C, Ali F, Malivindi R, Zoll J, Kato S, et al. The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles. Cell Metab. 2010;12:496-508 pubmed publisher
    ..Thus, modulation of the expression and/or activity of these coregulators represents an attractive way to prevent or treat metabolic disorders. ..
  51. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford M, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007;27:120-34 pubmed
    ..In the present study, we have established that recombinant p/CIP (p300/CBP interacting protein) is robustly methylated by CARM1 in vitro but not by other protein arginine methyltransferase family ..
  52. Chen W, Lü X, Chen Y, Li M, Mo P, Tong Z, et al. Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression. J Immunol. 2017;198:1606-1615 pubmed publisher
    ..Collectively, we show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 expression to recruit neutrophils. ..
  53. Arimura A, vn Peer M, Schroder A, Rothman P. The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6. J Biol Chem. 2004;279:31105-12 pubmed
    ..These results suggest that p/CIP positively regulates STAT6 transcriptional activation through formation of a STAT6, p300/CBP, and p/CIP complex. ..
  54. Shi J, Liu W, Sui F, Lu R, He Q, Yang Q, et al. Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer. Oncotarget. 2015;6:14344-59 pubmed
    Amplified in breast cancer 1 (AIB1) is a member of p160 steroid receptor coactivator (SRC) family that mediates the transcriptional activities of nuclear receptors and other transcription factors...
  55. Oh A, Lahusen J, Chien C, Fereshteh M, Zhang X, Dakshanamurthy S, et al. Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Mol Cell Biol. 2008;28:6580-93 pubmed publisher
    Overexpression and activation of the steroid receptor coactivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been shown to have a critical role in oncogenesis and are required for both steroid and ..
  56. Stashi E, Wang L, Mani S, York B, O Malley B. Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences. Mol Endocrinol. 2013;27:1776-87 pubmed publisher
    ..Additionally, SRC2(-/-) males were shown to have deficits in sensorimotor gating. Loss of SRC3 also shows sex differences in anxiety and exploratory behaviors...
  57. Huang J, Bi Y, Zhu G, He Y, Su Y, He B, et al. Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009;29:1569-81 pubmed publisher
    ..RA was further shown to induce glycogen synthesis in HP14.5 cells, an important function of mature hepatocytes. Our results strongly suggest that RA signalling may play an important role in regulating hepatic differentiation. ..
  58. Louet J, Chopra A, Sagen J, An J, York B, Tannour Louet M, et al. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 2010;12:606-18 pubmed publisher
    ..We propose that SRC-1 acts as a critical mediator of glucose homeostasis in the liver by adjusting the transcriptional activity of key genes involved in the hepatic glucose production machinery. ..
  59. Story G, DiCarlo S, Rodenbaugh D, Dluzen D, Kucera J, Maron M, et al. Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits. Physiol Genomics. 2000;2:129-36 pubmed
    ..Thus deletion of one copy of the NT3 gene translates into anatomical, biochemical, and functional deficits in cardiac sympathetic innervation of postnatal mice, thereby indicating a gene-dosage effect for the NT3 gene...
  60. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias P, Bikle D. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009;129:1367-78 pubmed publisher
    ..Silencing of either VDR, SRC2, or SRC3 resulted in decreases in specific glucosylceramide (GlcCer) species but not other lipids such as cholesterol and ..
  61. Tilli M, Reiter R, Oh A, Henke R, McDonnell K, Gallicano G, et al. Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice. Mol Endocrinol. 2005;19:644-56 pubmed
    Amplified in breast cancer 1 (AIB1, also known as ACTR, SRC-3, RAC-3, TRAM-1, p/CIP) is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of genes activated through steroid receptors, such as ..
  62. Xu L, Ma X, Li J, Li X, Xu J, Wang S, et al. SRC-3 deficient mice developed fat redistribution under high-fat diet. Endocrine. 2010;38:60-6 pubmed publisher
    ..Our results presented in vivo evidence that SRC-3 deficiency could lead to fat redistribution under HFD in mice and provided new clues to researches on the pathogenesis of fat redistribution. ..
  63. Percharde M, Lavial F, Ng J, Kumar V, Tomaz R, Martin N, et al. Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 2012;26:2286-98 pubmed publisher
    ..Here, we show that Ncoa3, an essential coactivator, is required to mediate Esrrb function in ESCs...
  64. Wansa K, Harris J, Yan G, Ordentlich P, Muscat G. The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003;278:24776-90 pubmed
    ..We hypothesize that the NR4A subgroup mediates the genotoxic stress response and suggest that this subgroup may function as sensors that respond to genotoxicity. ..
  65. Martinez de Arrieta C, Koibuchi N, Chin W. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Endocrinology. 2000;141:1693-8 pubmed
    ..examine this hypothesis, we cloned rat complementary DNA fragments corresponding to coactivators (SRC1, TIF2 and TRAM1) and corepressors (N-CoR and SMRT), and studied the ontogenic changes in their corresponding messenger RNAs in rat ..
  66. Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, et al. SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism. J Hepatol. 2012;56:210-7 pubmed publisher
    ..Our study demonstrates that SRC-3 is the predominant transcriptional co-activator among the three SRC family members for CAR activation to promote hepatocyte proliferation and drug metabolism. ..
  67. Du C, Xu Y, Yang K, Chen S, Wang X, Wang S, et al. Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1. Leukemia. 2017;31:945-956 pubmed publisher
    ..Steroid receptor coactivator 3 (SRC3) is involved in ER?-mediated GATA1 transcription...
  68. Winnay J, Hammer G. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol. 2006;20:147-66 pubmed
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  69. Zhou G, Hashimoto Y, Kwak I, Tsai S, Tsai M. Role of the steroid receptor coactivator SRC-3 in cell growth. Mol Cell Biol. 2003;23:7742-55 pubmed
    Steroid receptor coactivator 3 (SRC-3/p/CIP/AIB1/ACTR/RAC3/TRAM-1) is a member of the p160 family of nuclear receptor coactivators, which includes SRC-1 (NCoA-1) and SRC-2 (TIF2/GRIP1/NCoA2)...
  70. Leung K, Nagy A, Gonzalez Gomez I, Groffen J, Heisterkamp N, Kaartinen V. Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions. Cells Tissues Organs. 2003;175:72-83 pubmed
    b>Rac3, a novel member of the Rho subfamily of the small GTPases, is frequently activated in cultured breast cancer cells and has been shown to mediate its effect via the p21-activated kinase (Pak) pathway...