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| Ncoa2SummaryGene Symbol: Ncoa2 Description: nuclear receptor coactivator 2 Alias: 9530095N19, D1Ertd433e, GRIP-1, Grip1, KAT13C, SRC-2, TIF-2, TIF2, bHLHe75, NCoA-2, TIF2/GRIP-1, glucocorticoid receptor interacting protein 1, glucocorticoid receptor-interacting protein 1, transcriptional intermediary factor 2 Species: mouse Top Publications
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SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cellsEijun Nishihara
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:213-22. 2003..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood...
Absence of the steroid receptor coactivator-3 induces B-cell lymphomaAgnes Coste
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
EMBO J 25:2453-64. 2006....- The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolismJae Wook Jeong
Department of Molecular and Cellular Biology, Microarray Core Facility, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 20:1138-52. 2006Members of the steroid receptor coactivator (SRC) family, which include SRC-1 (NcoA-1/p160), SRC-2(TIF2/GRIP1/NcoA-2) and SRC-3(pCIP/RAC3/ACTR/pCIP/ AIB1/TRAM1), are critical mediators of steroid receptor action... - SRC-1 and TIF2 control energy balance between white and brown adipose tissuesFrederic Picard
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
Cell 111:931-41. 2002We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to .. - Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouseAtish Mukherjee
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 26:6571-83. 2006..We conclude that SRC-2 is appropriated by PR in a subset of transcriptional cascades obligate for normal uterine and mammary morphogenesis and function... - CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivatorsJeong Hoon Kim
Department of Pathology, University of Southern California, Los Angeles, CA 90089, USA
Mol Cell 12:1537-49. 2003..Moreover, CoCoA cooperated synergistically with GRIP1, CARM1, and p300 to enhance ER-mediated transcription... - Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproductionManuel Mark
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:4453-8. 2004Both SRC-1 and TIF2 are members of the p160 steroid receptor coactivator family. Genetic analyses have shown that inactivation of TIF2, but not SRC-1, reduces postnatal survival, growth, and male reproductive function... - Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activationJonathon N Winnay
Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
Mol Endocrinol 20:147-66. 2006..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response... - Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in miceXiangcang Ye
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:9487-92. 2005..vivo, we generated a unique transgenic AR-reporter mouse and analyzed the cell-specific contributions of SRC-1 and TIF2 to the activity of AR in mouse testis... - Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) geneJ Xu
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 279:1922-5. 1998..Expression of RNA encoding TIF2, a member of the SRC-1 family, was increased in the SRC-1 null mutant, perhaps compensating partially for the loss .. - Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient miceAlexandre V Patchev
Institute of Experimental Endocrinology, Charite School of Medicine, Humboldt University, Schumannstr 20 21, Berlin 10117, Germany
FASEB J 21:231-8. 2007..Thus, hyperactivity of the hypothalamo-pituitary unit is ascribed to insidious adrenal insufficiency and impaired glucocorticoid feedback... - Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivoGyesik Min
Department of Molecular and Integrative Physiology, College of Medicine at Urbana Champaign, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 277:26356-63. 2002..present studies, the interaction of CAR with the p160 coactivator glucocorticoid receptor-interacting protein 1 (GRIP1) was examined in vitro and in vivo... - GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptorsH Hong
Department of Pathology, University of Southern California, Los Angeles 90033, USA
Mol Cell Biol 17:2735-44. 1997..A search for possible coactivators for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1)... - The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIPMartine Gehin
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, 67404 Illkirch Cedex, France
Mol Cell Biol 22:5923-37. 2002..Although the functions of hTIF2 and of its mouse homolog (GRIP1 or mTIF2) have been clearly established in vitro, their physiological role remains elusive... - The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1Bente Børud
Department of Anatomy and Cell Biology, University of Bergen, N 5009 Bergen, Norway
Mol Endocrinol 16:757-73. 2002..Steroid receptor coactivator 1 and transcription intermediary factor 2 (TIF2) belong to the p160 coactivator family that mediates transcriptional activation by several nuclear receptors, .. - Regulation of somatic growth by the p160 coactivator p/CIPZ Wang
Howard Hughes Medical Institute and Department of Biology, University of California, School of Medicine at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 97:13549-54. 2000..The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals... - Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1Yong Li
Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
Mol Cell 17:491-502. 2005..These findings provide evidence that SF-1 is regulated by endogenous ligands and suggest an unexpected relationship between phospholipids and endocrine development and function... - The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppressionMichael M Reily
Hospital for Special Surgery, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
EMBO J 25:108-17. 2006..activities of other DNA-bound regulators, activator protein 1 and nuclear factor kappaB, utilizing a p160 GRIP1 as a corepressor... - Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouseMichael Schuler
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, College de France, Illkirch Cedex, France
Genesis 41:165-70. 2005..HSA-Cre-ER(T2) mice should be of great value to analyze gene function in skeletal muscles, and to establish animal models of human skeletal muscle disorders... - Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsivenessEric Batsche
Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
J Biol Chem 280:19746-56. 2005..Increased Rb expression upon cell differentiation may promote differentiated functions, at least in part, by potentiation of NR activity... - The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expressionJae Wook Jeong
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 148:4238-50. 2007..This analysis indicates that SRC-2 regulates uterine function by modulating the regulation of developmentally important signaling molecules and the ability of P4 to repress specific genes... - Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorptionAtul R Chopra
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cell Metab 13:35-43. 2011..Our results position the hepatic AMPK-SRC-2 axis as an energy rheostat, which upon cellular energy depletion resets whole-body energy by promoting absorption of dietary fuel... - Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis functionMathias V Schmidt
Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Leiden University, The Netherlands
Brain Res 1174:1-6. 2007.... - The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal musclesDelphine Duteil
Department of Physiological Genetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
Cell Metab 12:496-508. 2010The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver... 
Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cellsJiayi Huang
Key Laboratory of Diagnostic Medicine designated by the Ministry of Education of China, The Affiliated Hospitals of Chongqing Medical University, Chongqing, China
Liver Int 29:1569-81. 2009..Retinoic acid (RA) signalling plays an important role in development, although the role of RA signalling in liver-specific progenitors is poorly understood...- Identification of novel oocyte and granulosa cell markersChristopher Malcuit
Department of Veterinary and Animal Science, University of Massachusetts, Amherst, MA 01003, USA
Gene Expr Patterns 9:404-10. 2009.... - [Liver X receptor alpha inhibits LPS-induced inflammation by down-regulating IFR3 and GRIP1 in mouse Kupffer cells]Zhi Bing Ou
Chongqing Key Laboratory of Hepatobliliary Surgery, Department of Hepatobliliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
Nan Fang Yi Ke Da Xue Xue Bao 29:848-51. 2009..To explore the possible mechanism of the inhibitory effect of liver X receptor alpha (LXRalpha) on lipopolysaccharide (LPS)-induced inflammation in mouse Kupffer cells (KCs)... - Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2Ulrike I Mödder
Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 284:18767-77. 2009..Modulating SRC-2 action may, thus, represent a novel therapeutic target for osteoporosis... - Foxa2-dependent hepatic gene regulatory networks depend on physiological stateIrina M Bochkis
Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Physiol Genomics 38:186-95. 2009..We show that Foxa2 interacts with different transcription factors to achieve gene expression responses appropriate for each physiologic state... - Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?Petros D Grivas
Division of Oncology and Clinical Oncology Laboratory, Medical School, University of Patras, 26504, Patras, Greece
Int J Colorectal Dis 24:613-22. 2009..Estrogen receptor coregulators, amplified in breast cancer 1 (AIB1) and transcription intermediary factor 2 (TIF2), have been well-characterized, but their expression in colorectal carcinomas has not been investigated. - Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formationYuko Oda
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 129:1367-78. 2009..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized... - The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32E J Dettman
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 3:e3823. 2008..Common sites of retroviral insertion (CIS) identify genes causally associated with the development or initiation of lymphoma... - Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's diseaseAtul R Chopra
Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Science 322:1395-9. 2008..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production... - Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the humanAtish Mukherjee
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Nucl Recept Signal 5:e011. 2007..Finally, the recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer... - Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family membersJun Xia
Department of Cell and Development Biology, University of Illinois at Urbana Champaign, Urbana, IL 60801, USA
Arch Biochem Biophys 468:49-57. 2007..SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment... - Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferaseWyatt W Yue
Cancer Research UK DNA Repair Enzyme Research Group, Section of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
EMBO J 26:4402-12. 2007..Together with the absence of specificity subsites in the structure, this suggests an electrostatic sensing mechanism for communicating the modification status of vicinal residues as part of the syntax of the 'histone code.'.. - Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulationJun Xia
Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Biol Chem 280:7285-93. 2005..We have shown that exogenous expression of the p160 coactivator glucocorticoid receptor interacting protein-1 (GRIP1) in hepatocytes in vivo can mediate PB-independent nuclear accumulation of murine CAR (mCAR)... - Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoDHung Yi Wu
Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 280:3129-37. 2005..Both SRC1A and p/CIP function as coactivators for MyoD-mediated transcription whereas GRIP1 acts negatively as a (co)repressor... - Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcriptionJeong Hoon Kim
Department of Pathology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 279:49842-8. 2004..Our data support a physiological role for CoCoA as a transcriptional coactivator in AHR/ARNT-mediated transcription... - Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiencyRoy E Weiss
Department of Medicine, University of Chicago, Chicago, Illinois 60037, USA
Endocrinology 143:1554-7. 2002..This work demonstrates gene dosage effect in nuclear coactivators manifesting as haploinsufficiency and functional redundancy of SRC-1 and TIF-2... - The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2Shen Liang Chen
Center for Molecular and Cellular Biology, Institute for Molecular Bioscience, University of Queensland, St Lucia 4072, Queensland, Australia
J Biol Chem 277:4324-33. 2002..This work clearly demonstrates that the arginine methyltransferase CARM1 potentiates myogenesis and supports the positive role of arginine methylation in mammalian differentiation... - Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteinsG Yu
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
Brain Res Dev Brain Res 130:217-30. 2001..DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b... - Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodiesR Puustinen
Department of Cell Biology, Medical School, University of Tampere, FIN 33014, Tampere, Finland
Eur J Endocrinol 145:323-33. 2001b>Glucocorticoid receptor interacting protein 1 (GRIP1) is a coactivator that binds to the nuclear hormone receptors in a ligand-dependent manner and mediates transcriptional activation of the target genes... - Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcriptionC Zhang
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 276:40614-20. 2001.... - Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone actionM Ito
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
Mol Cell 5:683-93. 2000..These results indicate that TRAP220 is essential for a wide range of physiological processes but also that it has gene- and activator-selective functions... - Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid statusC Martinez de Arrieta
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 141:1693-8. 2000..To examine this hypothesis, we cloned rat complementary DNA fragments corresponding to coactivators (SRC1, TIF2 and TRAM1) and corepressors (N-CoR and SMRT), and studied the ontogenic changes in their corresponding messenger .. - Structure and chromosomal locations of mouse steroid receptor coactivator gene familyG Ning
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
In Vitro Cell Dev Biol Anim 35:481-6. 1999..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions... - Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3H Hong
Department of Pathology, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 274:22618-26. 1999..3 (ERR3), was identified by yeast two-hybrid screening, using the transcriptional coactivator glucocorticoid receptor interacting protein 1 (GRIP1) as bait... - Regulation of transcription by a protein methyltransferaseD Chen
Department of Pathology HMR 301, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
Science 284:2174-7. 1999The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors... - Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysisC L Welch
Department of Medicine, University of California, Los Angeles, California 90095, USA
Mamm Genome 8:620-1. 1997 - The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor functionJ Torchia
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
Nature 387:677-84. 1997..p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways... - Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activitiesYoung Ho Lee
Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
Mol Cell Biol 22:3621-32. 2002..The p160 coactivators (e.g., SRC-1, GRIP1, and ACTR) bind directly to activated NR and can recruit a variety of secondary coactivators... - Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiationJean Bernard Lazaro
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 16:1792-805. 2002.... - The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2S M Huang
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan 114, Republic of China
J Mol Endocrinol 32:481-96. 2004The p160 coactivators, steroid receptor coactivator 1, glucocorticoid receptor interacting protein 1 (GRIP1) and the activator of thyroid and retinoic acid receptor, have two activation domains, AD1 and AD2, which transmit the activation .. - The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor bindingP H Giangrande
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 20:3102-15. 2000..effect, we observed that hPRA, unlike hPRB, was unable to efficiently recruit the transcriptional coactivators GRIP1 and SRC-1 upon agonist binding... - Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cellsBénédicte Mascrez
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
EMBO Rep 5:285-90. 2004..molecular evidence that cholesterol homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active... - Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activityYoung Ho Lee
Department of Pathology, University of Southern California, Los Angeles, California 90089 9092, USA
Mol Cell Biol 24:2103-17. 2004..One important coactivator complex includes a p160 coactivator (e.g., GRIP1, SRC-1, or ACTR) that binds directly to activated NR, the histone acetyltransferase p300 or CBP, and the arginine-.. - GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptorsH Hong
Department of Pathology, University of Southern California, Los Angeles, 90033, USA
Proc Natl Acad Sci U S A 93:4948-52. 1996..cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor... - Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancerChristopher W Gregory
Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7500, USA
J Biol Chem 279:7119-30. 2004..a post-transcriptional increase in the p160 coactivator transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1 (TIF2/GRIP1)... - Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gammaSabyasachi Sanyal
Department of Biosciences at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
Mol Endocrinol 18:312-25. 2004.... - Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator functionCatherine Teyssier
Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 277:46066-72. 2002..The complex contains at least one of three p160 coactivators (SRC-1, GRIP1/TIF2, or pCIP/RAC3/ACTR/AIB1/TRAM1), a histone acetyltransferase such as CBP or p300, and the histone .. - PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2Ana M Jimenez-Lara
Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, P O Box 10142, 67404 Illkirch Cedex, France
FEBS Lett 526:142-6. 2002PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors... - Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivatorsTomoshige Kino
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
J Biol Chem 278:3023-9. 2003..we performed yeast two-hybrid screening using the NRB domain of the glucocorticoid receptor-interacting protein 1 (GRIP1) as bait... - Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the humanAtish Mukherjee
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Steroid Biochem Mol Biol 102:22-31. 2006.... - cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1Tuyen Hoang
Hormone Laboratory, Section of Endocrinology, Institute of Medicine, Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen and Haukeland University Hospital, Bergen N 5021, Norway
J Biol Chem 279:49120-30. 2004Nuclear receptors and their coactivators are key regulators of numerous physiological functions. GRIP1 (glucocorticoid receptor-interacting protein) is a member of the steroid receptor coactivator family... - RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathwaysDavid A Gold
Biomedical Sciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Neuron 40:1119-31. 2003....
Research Grants
- Thyroid Hormone Receptor Isoforms & Coactivators In VivoRoy Weiss; Fiscal Year: 2005..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
- Nuclear cofactors in Human Thyroid DiseaseRoy Weiss; Fiscal Year: 2007..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..