Ncoa2

Summary

Gene Symbol: Ncoa2
Description: nuclear receptor coactivator 2
Alias: 9530095N19, D1Ertd433e, GRIP-1, Grip1, KAT13C, SRC-2, TIF-2, TIF2, bHLHe75, NCoA-2, TIF2/GRIP-1, glucocorticoid receptor interacting protein 1, glucocorticoid receptor-interacting protein 1, transcriptional intermediary factor 2
Species: mouse

Top Publications

  1. pmc Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 13:35-43. 2011
  2. pmc The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles
    Delphine Duteil
    Department of Physiological Genetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Cell Metab 12:496-508. 2010
  3. pmc The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP
    Martine Gehin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, 67404 Illkirch Cedex, France
    Mol Cell Biol 22:5923-37. 2002
  4. pmc Regulation of somatic growth by the p160 coactivator p/CIP
    Z Wang
    Howard Hughes Medical Institute and Department of Biology, University of California, School of Medicine at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 97:13549-54. 2000
  5. pmc Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 322:1395-9. 2008
  6. pmc Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice
    Xiangcang Ye
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:9487-92. 2005
  7. ncbi SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:213-22. 2003
  8. pmc Absence of the steroid receptor coactivator-3 induces B-cell lymphoma
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    EMBO J 25:2453-64. 2006
  9. pmc GAC63, a GRIP1-dependent nuclear receptor coactivator
    Yong Heng Chen
    Department of Pathology, HMR301, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 25:5965-72. 2005
  10. ncbi CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators
    Jeong Hoon Kim
    Department of Pathology, University of Southern California, Los Angeles, CA 90089, USA
    Mol Cell 12:1537-49. 2003

Research Grants

Scientific Experts

  • Kathryn A O'Donnell
  • T Kino
  • Mathias V Schmidt
  • R Puustinen
  • Roy Weiss
  • Sabyasachi Sanyal
  • Yuko Oda
  • Alexandre V Patchev
  • BERT W O'MALLEY
  • Jianming Xu
  • Pierre Chambon
  • Atul R Chopra
  • Atish Mukherjee
  • Francesco J DeMayo
  • Michael R Stallcup
  • Martine Gehin
  • Brian York
  • Manuel Mark
  • Jeong Hoon Kim
  • John P Lydon
  • Erin L Reineke
  • Jae Wook Jeong
  • Jun Xia
  • Christopher B Newgard
  • Jean Francois Louet
  • H Hong
  • Yurii Chinenov
  • Young Ho Lee
  • Lan Liao
  • Byron Kemper
  • Anna Tsimelzon
  • Xian Chen
  • Johan Auwerx
  • Delphine Duteil
  • Tuyen Hoang
  • Pradip Saha
  • Lawrence Chan
  • Franco DeMayo
  • Milton Finegold
  • Christopher Malcuit
  • Bente Børud
  • Inez Rogatsky
  • M R Stallcup
  • Petros D Grivas
  • Ulrike I Mödder
  • Jiayi Huang
  • Irina M Bochkis
  • Zhi Bing Ou
  • S M Huang
  • E J Dettman
  • Faisal Ali
  • Daniel Metzger
  • Wyatt W Yue
  • Kevin Y Lee
  • D Craig Allred
  • Paula Amato
  • Agnes Coste
  • Michael M Reily
  • Sang Jun Han
  • Rodrigo Fernandez-Valdivia
  • Jonathon N Winnay
  • Hung Yi Wu
  • Michael Schuler
  • Xiangcang Ye
  • Yong Li
  • Eric Batsche
  • Yong Heng Chen
  • Ming Jer Tsai
  • Julien Grenier
  • Christopher W Gregory
  • Bénédicte Mascrez
  • Hiromi Yoshida-Komiya
  • Eijun Nishihara
  • Jean Sebastien Annicotte
  • Gunnar Mellgren
  • David A Gold
  • Marit Bakke
  • J Xu
  • Gyesik Min
  • Frederic Picard
  • Catherine Teyssier
  • Jean Bernard Lazaro
  • Shen Liang Chen
  • Dagang Chen
  • Ana M Jimenez-Lara
  • Hinrich Gronemeyer
  • Suoling Zhou
  • Adekunle M Adesina
  • Lee Jun C Wong
  • Brett R Wenner

Detail Information

Publications72

  1. pmc Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 13:35-43. 2011
    ..Our results position the hepatic AMPK-SRC-2 axis as an energy rheostat, which upon cellular energy depletion resets whole-body energy by promoting absorption of dietary fuel...
  2. pmc The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles
    Delphine Duteil
    Department of Physiological Genetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Cell Metab 12:496-508. 2010
    The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver...
  3. pmc The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP
    Martine Gehin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, 67404 Illkirch Cedex, France
    Mol Cell Biol 22:5923-37. 2002
    ..Although the functions of hTIF2 and of its mouse homolog (GRIP1 or mTIF2) have been clearly established in vitro, their physiological role remains elusive...
  4. pmc Regulation of somatic growth by the p160 coactivator p/CIP
    Z Wang
    Howard Hughes Medical Institute and Department of Biology, University of California, School of Medicine at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 97:13549-54. 2000
    ..The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals...
  5. pmc Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 322:1395-9. 2008
    ..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production...
  6. pmc Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice
    Xiangcang Ye
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:9487-92. 2005
    ..vivo, we generated a unique transgenic AR-reporter mouse and analyzed the cell-specific contributions of SRC-1 and TIF2 to the activity of AR in mouse testis...
  7. ncbi SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:213-22. 2003
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood...
  8. pmc Absence of the steroid receptor coactivator-3 induces B-cell lymphoma
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    EMBO J 25:2453-64. 2006
    ....
  9. pmc GAC63, a GRIP1-dependent nuclear receptor coactivator
    Yong Heng Chen
    Department of Pathology, HMR301, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 25:5965-72. 2005
    ..One important coactivator complex includes a p160 coactivator (GRIP1, SRC-1, or ACTR) and its downstream coactivators (e.g...
  10. ncbi CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators
    Jeong Hoon Kim
    Department of Pathology, University of Southern California, Los Angeles, CA 90089, USA
    Mol Cell 12:1537-49. 2003
    ..Moreover, CoCoA cooperated synergistically with GRIP1, CARM1, and p300 to enhance ER-mediated transcription...
  11. pmc Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
    Manuel Mark
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4453-8. 2004
    Both SRC-1 and TIF2 are members of the p160 steroid receptor coactivator family. Genetic analyses have shown that inactivation of TIF2, but not SRC-1, reduces postnatal survival, growth, and male reproductive function...
  12. ncbi Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice
    Alexandre V Patchev
    Institute of Experimental Endocrinology, Charite School of Medicine, Humboldt University, Schumannstr 20 21, Berlin 10117, Germany
    FASEB J 21:231-8. 2007
    ..Thus, hyperactivity of the hypothalamo-pituitary unit is ascribed to insidious adrenal insufficiency and impaired glucocorticoid feedback...
  13. pmc GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
    H Hong
    Department of Pathology, University of Southern California, Los Angeles 90033, USA
    Mol Cell Biol 17:2735-44. 1997
    ..A search for possible coactivators for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1)...
  14. ncbi Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
    J Xu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 279:1922-5. 1998
    ..Expression of RNA encoding TIF2, a member of the SRC-1 family, was increased in the SRC-1 null mutant, perhaps compensating partially for the loss ..
  15. pmc Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse
    Atish Mukherjee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 26:6571-83. 2006
    ..We conclude that SRC-2 is appropriated by PR in a subset of transcriptional cascades obligate for normal uterine and mammary morphogenesis and function...
  16. ncbi The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism
    Jae Wook Jeong
    Department of Molecular and Cellular Biology, Microarray Core Facility, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 20:1138-52. 2006
    Members of the steroid receptor coactivator (SRC) family, which include SRC-1 (NcoA-1/p160), SRC-2(TIF2/GRIP1/NcoA-2) and SRC-3(pCIP/RAC3/ACTR/pCIP/ AIB1/TRAM1), are critical mediators of steroid receptor action...
  17. ncbi The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1
    Bente Børud
    Department of Anatomy and Cell Biology, University of Bergen, N 5009 Bergen, Norway
    Mol Endocrinol 16:757-73. 2002
    ..Steroid receptor coactivator 1 and transcription intermediary factor 2 (TIF2) belong to the p160 coactivator family that mediates transcriptional activation by several nuclear receptors, ..
  18. pmc Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy
    Brian York
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 15:752-63. 2012
    ..Moreover, these findings allow us to consider platform coactivators such as the SRCs as potential contributors to syndromes such as CACT deficiency, previously considered as monogenic...
  19. ncbi Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo
    Gyesik Min
    Department of Molecular and Integrative Physiology, College of Medicine at Urbana Champaign, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 277:26356-63. 2002
    ..present studies, the interaction of CAR with the p160 coactivator glucocorticoid receptor-interacting protein 1 (GRIP1) was examined in vitro and in vivo...
  20. pmc SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart
    Erin L Reineke
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53395. 2012
    ....
  21. ncbi SRC-1 and TIF2 control energy balance between white and brown adipose tissues
    Frederic Picard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 111:931-41. 2002
    We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to ..
  22. ncbi Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells
    Julien Grenier
    Institut National de la Santé et de la Recherche Médicale Unité 488, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Mol Endocrinol 18:2866-79. 2004
    ..We have shown that SRC-1 unexpectedly interacts with GR via its two nuclear receptor binding domains, thus providing a novel mechanism of GR signaling within the nervous system...
  23. ncbi Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1
    Yong Li
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
    Mol Cell 17:491-502. 2005
    ..These findings provide evidence that SF-1 is regulated by endogenous ligands and suggest an unexpected relationship between phospholipids and endocrine development and function...
  24. pmc Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids
    Yurii Chinenov
    Hospital for Special Surgery Research Division, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 109:11776-81. 2012
    ..We created a mouse strain enabling a conditional hematopoietic cell-restricted deletion of GRIP1 in adult animals...
  25. ncbi Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation
    Jonathon N Winnay
    Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Mol Endocrinol 20:147-66. 2006
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  26. pmc A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
    Kathryn A O'Donnell
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E1377-86. 2012
    ..RNAi-mediated knockdown in a liver progenitor cell line further validate three of these genes, Ncoa2/Src-2, Zfx, and Dtnb, as tumor suppressors in liver cancer...
  27. pmc The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
    Michael M Reily
    Hospital for Special Surgery, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 25:108-17. 2006
    ..activities of other DNA-bound regulators, activator protein 1 and nuclear factor kappaB, utilizing a p160 GRIP1 as a corepressor...
  28. ncbi Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse
    Michael Schuler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, College de France, Illkirch Cedex, France
    Genesis 41:165-70. 2005
    ..HSA-Cre-ER(T2) mice should be of great value to analyze gene function in skeletal muscles, and to establish animal models of human skeletal muscle disorders...
  29. ncbi Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function
    Mathias V Schmidt
    Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Leiden University, The Netherlands
    Brain Res 1174:1-6. 2007
    ....
  30. ncbi The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression
    Jae Wook Jeong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 148:4238-50. 2007
    ..This analysis indicates that SRC-2 regulates uterine function by modulating the regulation of developmentally important signaling molecules and the ability of P4 to repress specific genes...
  31. ncbi Identification of novel oocyte and granulosa cell markers
    Christopher Malcuit
    Department of Veterinary and Animal Science, University of Massachusetts, Amherst, MA 01003, USA
    Gene Expr Patterns 9:404-10. 2009
    ....
  32. ncbi [Liver X receptor alpha inhibits LPS-induced inflammation by down-regulating IFR3 and GRIP1 in mouse Kupffer cells]
    Zhi Bing Ou
    Chongqing Key Laboratory of Hepatobliliary Surgery, Department of Hepatobliliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:848-51. 2009
    ..To explore the possible mechanism of the inhibitory effect of liver X receptor alpha (LXRalpha) on lipopolysaccharide (LPS)-induced inflammation in mouse Kupffer cells (KCs)...
  33. pmc Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2
    Ulrike I Mödder
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:18767-77. 2009
    ..Modulating SRC-2 action may, thus, represent a novel therapeutic target for osteoporosis...
  34. pmc Foxa2-dependent hepatic gene regulatory networks depend on physiological state
    Irina M Bochkis
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Physiol Genomics 38:186-95. 2009
    ..We show that Foxa2 interacts with different transcription factors to achieve gene expression responses appropriate for each physiologic state...
  35. doi Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?
    Petros D Grivas
    Division of Oncology and Clinical Oncology Laboratory, Medical School, University of Patras, 26504, Patras, Greece
    Int J Colorectal Dis 24:613-22. 2009
    ..Estrogen receptor coregulators, amplified in breast cancer 1 (AIB1) and transcription intermediary factor 2 (TIF2), have been well-characterized, but their expression in colorectal carcinomas has not been investigated.
  36. pmc The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32
    E J Dettman
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e3823. 2008
    ..Common sites of retroviral insertion (CIS) identify genes causally associated with the development or initiation of lymphoma...
  37. pmc Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human
    Atish Mukherjee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Nucl Recept Signal 5:e011. 2007
    ..Finally, the recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer...
  38. pmc Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members
    Jun Xia
    Department of Cell and Development Biology, University of Illinois at Urbana Champaign, Urbana, IL 60801, USA
    Arch Biochem Biophys 468:49-57. 2007
    ..SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment...
  39. pmc Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase
    Wyatt W Yue
    Cancer Research UK DNA Repair Enzyme Research Group, Section of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    EMBO J 26:4402-12. 2007
    ..Together with the absence of specificity subsites in the structure, this suggests an electrostatic sensing mechanism for communicating the modification status of vicinal residues as part of the syntax of the 'histone code.'..
  40. pmc Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    Yuko Oda
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 129:1367-78. 2009
    ..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized...
  41. doi Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells
    Jiayi Huang
    Key Laboratory of Diagnostic Medicine designated by the Ministry of Education of China, The Affiliated Hospitals of Chongqing Medical University, Chongqing, China
    Liver Int 29:1569-81. 2009
    ..Retinoic acid (RA) signalling plays an important role in development, although the role of RA signalling in liver-specific progenitors is poorly understood...
  42. ncbi Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness
    Eric Batsche
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Biol Chem 280:19746-56. 2005
    ..Increased Rb expression upon cell differentiation may promote differentiated functions, at least in part, by potentiation of NR activity...
  43. ncbi Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation
    Jun Xia
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 280:7285-93. 2005
    ..We have shown that exogenous expression of the p160 coactivator glucocorticoid receptor interacting protein-1 (GRIP1) in hepatocytes in vivo can mediate PB-independent nuclear accumulation of murine CAR (mCAR)...
  44. ncbi Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency
    Roy E Weiss
    Department of Medicine, University of Chicago, Chicago, Illinois 60037, USA
    Endocrinology 143:1554-7. 2002
    ..This work demonstrates gene dosage effect in nuclear coactivators manifesting as haploinsufficiency and functional redundancy of SRC-1 and TIF-2...
  45. ncbi The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2
    Shen Liang Chen
    Center for Molecular and Cellular Biology, Institute for Molecular Bioscience, University of Queensland, St Lucia 4072, Queensland, Australia
    J Biol Chem 277:4324-33. 2002
    ..This work clearly demonstrates that the arginine methyltransferase CARM1 potentiates myogenesis and supports the positive role of arginine methylation in mammalian differentiation...
  46. ncbi Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins
    G Yu
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
    Brain Res Dev Brain Res 130:217-30. 2001
    ..DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b...
  47. ncbi Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies
    R Puustinen
    Department of Cell Biology, Medical School, University of Tampere, FIN 33014, Tampere, Finland
    Eur J Endocrinol 145:323-33. 2001
    b>Glucocorticoid receptor interacting protein 1 (GRIP1) is a coactivator that binds to the nuclear hormone receptors in a ligand-dependent manner and mediates transcriptional activation of the target genes...
  48. ncbi Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription
    C Zhang
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 276:40614-20. 2001
    ....
  49. ncbi Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
    M Ito
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell 5:683-93. 2000
    ..These results indicate that TRAP220 is essential for a wide range of physiological processes but also that it has gene- and activator-selective functions...
  50. ncbi Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status
    C Martinez de Arrieta
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 141:1693-8. 2000
    ..To examine this hypothesis, we cloned rat complementary DNA fragments corresponding to coactivators (SRC1, TIF2 and TRAM1) and corepressors (N-CoR and SMRT), and studied the ontogenic changes in their corresponding messenger ..
  51. pmc The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding
    P H Giangrande
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 20:3102-15. 2000
    ..effect, we observed that hPRA, unlike hPRB, was unable to efficiently recruit the transcriptional coactivators GRIP1 and SRC-1 upon agonist binding...
  52. ncbi Structure and chromosomal locations of mouse steroid receptor coactivator gene family
    G Ning
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    In Vitro Cell Dev Biol Anim 35:481-6. 1999
    ..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions...
  53. ncbi Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
    H Hong
    Department of Pathology, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 274:22618-26. 1999
    ..3 (ERR3), was identified by yeast two-hybrid screening, using the transcriptional coactivator glucocorticoid receptor interacting protein 1 (GRIP1) as bait...
  54. ncbi Regulation of transcription by a protein methyltransferase
    D Chen
    Department of Pathology HMR 301, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Science 284:2174-7. 1999
    The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors...
  55. ncbi Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis
    C L Welch
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Mamm Genome 8:620-1. 1997
  56. ncbi The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
    J Torchia
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 387:677-84. 1997
    ..p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways...
  57. pmc Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 22:3621-32. 2002
    ..The p160 coactivators (e.g., SRC-1, GRIP1, and ACTR) bind directly to activated NR and can recruit a variety of secondary coactivators...
  58. pmc Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation
    Jean Bernard Lazaro
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1792-805. 2002
    ....
  59. ncbi Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD
    Hung Yi Wu
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 280:3129-37. 2005
    ..Both SRC1A and p/CIP function as coactivators for MyoD-mediated transcription whereas GRIP1 acts negatively as a (co)repressor...
  60. ncbi Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription
    Jeong Hoon Kim
    Department of Pathology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 279:49842-8. 2004
    ..Our data support a physiological role for CoCoA as a transcriptional coactivator in AHR/ARNT-mediated transcription...
  61. ncbi Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gamma
    Sabyasachi Sanyal
    Department of Biosciences at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
    Mol Endocrinol 18:312-25. 2004
    ....
  62. ncbi The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2
    S M Huang
    Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan 114, Republic of China
    J Mol Endocrinol 32:481-96. 2004
    The p160 coactivators, steroid receptor coactivator 1, glucocorticoid receptor interacting protein 1 (GRIP1) and the activator of thyroid and retinoic acid receptor, have two activation domains, AD1 and AD2, which transmit the activation ..
  63. pmc Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells
    Bénédicte Mascrez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:285-90. 2004
    ..molecular evidence that cholesterol homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active...
  64. pmc Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity
    Young Ho Lee
    Department of Pathology, University of Southern California, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 24:2103-17. 2004
    ..One important coactivator complex includes a p160 coactivator (e.g., GRIP1, SRC-1, or ACTR) that binds directly to activated NR, the histone acetyltransferase p300 or CBP, and the arginine-..
  65. ncbi Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer
    Christopher W Gregory
    Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7500, USA
    J Biol Chem 279:7119-30. 2004
    ..a post-transcriptional increase in the p160 coactivator transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1 (TIF2/GRIP1)...
  66. ncbi Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function
    Catherine Teyssier
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 277:46066-72. 2002
    ..The complex contains at least one of three p160 coactivators (SRC-1, GRIP1/TIF2, or pCIP/RAC3/ACTR/AIB1/TRAM1), a histone acetyltransferase such as CBP or p300, and the histone ..
  67. ncbi PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2
    Ana M Jimenez-Lara
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, P O Box 10142, 67404 Illkirch Cedex, France
    FEBS Lett 526:142-6. 2002
    PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors...
  68. pmc GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
    H Hong
    Department of Pathology, University of Southern California, Los Angeles, 90033, USA
    Proc Natl Acad Sci U S A 93:4948-52. 1996
    ..cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor...
  69. ncbi Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human
    Atish Mukherjee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 102:22-31. 2006
    ....
  70. pmc RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways
    David A Gold
    Biomedical Sciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neuron 40:1119-31. 2003
    ....
  71. ncbi Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Biol Chem 278:3023-9. 2003
    ..we performed yeast two-hybrid screening using the NRB domain of the glucocorticoid receptor-interacting protein 1 (GRIP1) as bait...
  72. ncbi cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1
    Tuyen Hoang
    Hormone Laboratory, Section of Endocrinology, Institute of Medicine, Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen and Haukeland University Hospital, Bergen N 5021, Norway
    J Biol Chem 279:49120-30. 2004
    Nuclear receptors and their coactivators are key regulators of numerous physiological functions. GRIP1 (glucocorticoid receptor-interacting protein) is a member of the steroid receptor coactivator family...

Research Grants10

  1. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  2. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..